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Cited by 45Epilepsy research and treatmentCerebral Palsy and Movement DisordersNeurological and metabolic disorders

HEMISPHERECTOMY FOR INTRACTABLE SEIZURES: PRESURGICAL CEREBRAL GLUCOSE METABOLISM AND POST‐ SURGICAL N0N‐VERBAL COMMUNICATION

Caplan, Rochelle, Chugairi, Harry T., Messa, Cristina, Guthrie, Donald, Sigtnan, Marian, de Traversay, Jean, Mundy, Peter·1993·Developmental Medicine & Child Neurology
DOI 10.1111/j.1469-8749.1993.tb11695.x
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Abstract

SUMMARY: This study examinec the presurgical 2‐deoxy‐2[18 F]‐fluoro‐D‐glucose positron emission tomography (PET) patterns of regional cerebral glucose metabolism in the non‐resected hemisphere of 13 children who underwent hemispherectomy for early‐onset intractable seizures. These patterns were compared with the rate of change in the children's non‐verbal communication scores, measured before and after surgery. Irrespective of the side of surgery, the pre‐operative glucose metabolism in the non‐resected prefrontal cortex correlated significantly with the postoperative rate of change in the children's ability to focus the attention of an adult on an object or event (joint attention). These preliminary findings suggest that pre‐operative PET patterns might be associated with certain aspects of the developmental outcome of children undergoing hemispherectomy. RÉSUMÉ: Hémisphérectomie pour crises irréducribles à debur précoce: mérabolistne préchirurgical du glucose cérébral et allures postchirurgicales des communications non verbales Cette étude apprécie les aspects de la tomographie préchirurgicale àémission de positron au 2‐désoxy‐2[18 F] fluoro‐D‐glucose résvélant le métabolisme cérébral régional du glucose dans I'hémisphère non réséqué de 13 enfants chez qui fut pratiquée une hémisphérectomie pour crises irréductibles a début précoce. Ces aspects ont été comparés avec I'importance des modifications des scores de communication non verbale, mesurés avant et après chirurgie. Quel que soit le cǒté de I'hémisphérectomie, il y avait une correlation significative entre le métabolisme pré‐opératoire du glucose dans le cortes préfrontal non réséqué et I'importance de la modification post‐opératoire dans la capacité des enfants à fixer leur attention sur un adulte, un objet ou un événement (attention jointe). Ces données préliminaires suggérent que les aspects PET pré‐opératoires peuvent ětre associés á certains aspects du devenir développemental d'enfants ayant subi une hémisphérectomie. ZUSAMMENFASSUNG: Hemisphärekromie bei früh einsetzenden therapieresistenten Anfällen: pröperativer cerebraler Glukosenterabolismirs und posroperative non‐verbale Kommunikationsmuster In dieser Studie wurden die präoperativen 2‐deosy‐2[18 F] fluoro‐D‐glucose positron emission tomography (PET) Muster des cerebralen Glukosemetabolismus in der nicht resezierten Hemisphäre bei 13 Kindern untersucht, bei denen eine Hemispärektomie wegen früh einsetzender, therapieresistenter Anfälle durchgeführt wurde. Diese Muster wurden mit den Veränderungen bei den non‐verbalen Kommunikationsscores der Kinder verglichen, die vor und nach der Operation gemessen worden waren. Man fand eine signifikante Korrelation zwischen dem präoperativen Glukosemetabolismus im nicht resezierten präfrontalen Kortex und den postoperativen Veränderungen in der Fähigkeit der Kinder, die Aufmerksamkeit eines Erwachsenen auf ein Objekt oder einen Vorgang zu lenken (joint attention), unabhängig davon welche Seite operiert worden war. Diese vorläufigen Befunde lassen vermuten, daβ zwischen präoperativen PET Mustern und bestimmten Aspekten der Entwicklung von Kindern mit Hemisphärektomie ein Zusammenhang besteht. RESUMEN: Hemisferectomia por convulsiones intratables de comienzo precoz: patrones del metabolismo de la glucosa cerebral y de comunicación no verbal post‐quirúrgica Este estudio examina los patrones prequirúrgicos de la tomografia por emisión de positrones de 2‐deoxi‐2(18 F) fluora‐D‐Glucosa (PET), en el metabolismo regional cerebral de la glucosa, en el hemisfério no extirpado de 13 nin̂os, a los que se les practicó una hemisferectomia por padecer convulsiones intratables de comienzo precoz. Estos patrones se compararon con las modificaciones, de los puntajes de la comunicación no verbal medidos antes y después de la intervención. Sin guardar relación con el lado intervenido, el metabolismo de la glucosa preoperatorio en el córtex prefrontal no resecado, se correlacionaba significativamente con el cambio postoperatorio en la habilidad de los nin̂os para concentrar la atención de un adulto sobre un objecto acontecimiento (atención conjunta). Estos hallazgos preliminares sugieren que los patrones PET preoperatorios pueden estar asociados con ciertos aspectos del desarrollo de nin̂os a los que se les practica una hemisferectomia.

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Crossref · 10.1111/j.1469-8749.1993.tb11695.x

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  • Previous task-based studies in infants using PET or EEG indicated that IJA may be supported by prefrontal areas, while adult fMRI and eye-tracking studies implicated a distributed set of regions throughout prefrontal, temporal, and parietal cortices.

    “Previous foundational task-based studies in infants using positron emission tomography (PET) (Caplan et al. 1993) or electroencephalography (EEG) (Mundy et al. 2000; Henderson et al. 2002), indicated that IJA may be supported by prefrontal areas, while groundbreaking studies in adults using novel fMRI and eye tracking paradigms (Redcay et al. 2012; Caruana et al. 2015) implicated a distributed set”

    From Joint attention and brain functional connectivity in infants and toddlers (2017) · cites this paper as Caplan et al. 1993

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Authors
Caplan, R., Chugairi, H. T., Messa, C., Guthrie, D., Sigtnan, M., de Traversay, J., & Mundy, P.
Affiliations
  • University of California, Los Angeles (US)
  • University of Miami (US)
Corresponding author
Caplan, Rochelle
ORCID
Mundy, Peter
Venue
Developmental Medicine & Child Neurology
Publisher
Wiley
Published
1993-07
Volume
35
Issue
7
Pages
582-592
ISSN
  • 0012-1622 (ISSN-L)
  • 1469-8749
DOI
10.1111/j.1469-8749.1993.tb11695.x
OpenAlex
W2010768574
Cited by
45
References
47
Citations by year
2025: 1 · 2020: 1 · 2018: 1 · 2017: 1 · 2016: 2 · 2015: 4 · 2014: 2 · 2013: 3
FWCI
0.96
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 5613 d)
Locations
  • Developmental Medicine & Child Neurology (publishedVersion)
  • PubMed (publishedVersion)
  • BOA (University of Milano-Bicocca) (submittedVersion)
Funders
  • National Institutes of Health (5k01mh000538-03)
  • National Institute of Mental Health (KO1-MH00538)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Epilepsy research and treatment
  • Health Sciences › Medicine › Psychiatry and Mental health › Cerebral Palsy and Movement Disorders
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Neurological and metabolic disorders
Keywords
hemispherectomy, refractory seizures, early-onset epilepsy, brain glucose metabolism, 2-deoxy-2-[18F]fluoro-D-glucose, nonverbal communication, joint attention, prefrontal cortex, developmental outcomes, children, epilepsy surgery outcomes, attention development
MeSH terms
Brain, Cerebral Cortex, Child, Child, Preschool, Epilepsy, Female, Glucose, Humans, Infant, Functional Laterality, Male, Nonverbal Communication, Postoperative Complications, Seizures, Tomography, Emission-Computed, Radiopharmaceuticals, Fluorodeoxyglucose F18

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