Diurnal variation is lost in preterm deliveries before 28 weeks of gestation
Abstract
Please cite this paper as: Vatish M, Steer P, Blanks A, Hon M, Thornton S. Diurnal variation is lost in preterm deliveries before 28 weeks of gestation. BJOG 2010; DOI: 10.1111/j.1471‐0528.2010.02526.x. Preterm delivery is the primary cause of neonatal mortality and morbidity worldwide. Labour at term occurs as a culmination of maturational events in both the fetus and maternal uterus. This process exhibits diurnal variation, with the onset of labour being more common at night. We have confirmed that this diurnal variation is present in gestations between 28 and 36 weeks, but is absent below 28 weeks. We hypothesise that this is because before 28 weeks of gestation, the onset of labour may result from a pathological rather than a physiological process. This may have important implications regarding any pharmacological approach to the prevention and/or treatment of very early preterm labour.
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Prior studies on circadian patterns on the time of the onset of preterm labour provide conflicting results.
“Prior studies on circadian patterns on the time of the onset of preterm labour provide conflicting results.34–36”
From Triggers of Spontaneous Preterm Delivery – Why Today? (2014) · cites this paper as [34]
Both normal labour onset and term premature rupture of membranes are more common at night; some authors have suggested an altered diurnal circadian pattern for PTL or very preterm spontaneous onset of labour, but not for PPROM.
“Both normal labour onset and term premature rupture of membranes are more common at night; some authors have suggested an altered diurnal circadian pattern for PTL34, or very preterm spontaneous onset of labour,36 but not for PPROM.37”
From Triggers of Spontaneous Preterm Delivery – Why Today? (2014) · cites this paper as [34]
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- Authors
- Vatish, M., Steer, P., Blanks, A., Hon, M., & Thornton, S.
- Affiliations
- Albert Einstein College of Medicine (US)
- Chelsea and Westminster Hospital (GB)
- University of Warwick (GB)
- Corresponding author
- Thornton, S
- ORCID
- Venue
- BJOG: An International Journal of Obstetrics & Gynaecology
- Publisher
- Wiley
- Published
- 2010-04-08
- Volume
- 117
- Issue
- 6
- Pages
- 765-767
- ISSN
- 0306-5456 (ISSN-L)
- 1470-0328
- 1471-0528
- OpenAlex
- W1569880928
- Cited by
- 24
- References
- 8
- Citations by year
- 2024: 2 · 2022: 4 · 2021: 1 · 2020: 1 · 2019: 1 · 2018: 1 · 2015: 3 · 2014: 5 · 2013: 3 · 2012: 1
- FWCI
- 1.40
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- BJOG An International Journal of Obstetrics & Gynaecology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- University Hospitals Coventry and Warwickshire NHS Trust
- Medical Research Council
- Topics
- Health Sciences › Medicine › Epidemiology › Preterm Birth and Chorioamnionitis
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Infant Development and Preterm Care
- Health Sciences › Medicine › Obstetrics and Gynecology › Maternal and Perinatal Health Interventions
- Keywords
- preterm labour, diurnal variation, labor onset, very preterm birth, gestational age, preterm birth prevention, preterm birth treatment
- MeSH terms
- Circadian Rhythm, Female, Humans, Labor Onset, Obstetric Labor, Premature, Pregnancy, Pregnancy Trimester, Second, Pregnancy Trimester, Third
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