The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
THE EFFECT OF MODERATE AND MARKED HYPERCAPNIA UPON THE ENERGY STATE AND UPON THE CYTOPLASMIC NADH/NAD+ RATIO OF THE RAT BRAIN
Abstract
Abstract— The energy state of brain tissue was evaluated from the tissue concentrations of ATP, ADP and AMP and the cytoplasmic NADH/NAD+ ratio from the tissue, CSF and blood concentrations of lactate and pyruvate, and from the intracellular pH′, in rats exposed to carbon dioxide concentrations of 640 per cent. The hypercapnia had no significant effect on the energy state of the tissue. Hypercapnia of increasing severity gave rise to a progressive decrease in the pyruvate concentration; the lactate concentration fell at low CO 2 concentrations, but no further decrease was observed at CO 2 concentrations greater than 20 per cent. There was a progressive rise in the intracellular lactate/pyruvate ratio at increasing CO 2 concentrations, corresponding to the fall in intracellular pH, i.e. the calculated NADH/NAD+ ratios remained normal. It is therefore concluded that hypercapnia does not affect the cytoplasmic redox state.
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Cites
Energy charge of the adenylate pool as a regulatory parameter. Interaction with feedback modifiers
Atkinson, D. E. (1968) · Biochemistry · doi:10.1021/bi00851a033 · Cited by 2,401
Effect of Ischemia on Known Substrates and Cofactors of the Glycolytic Pathway in Brain
Lowry, O. H., Passonneau, J. V., Hasselberger, F. X., & Schulz, D. W. (1964) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)51740-3 · Cited by 2,221
Kety, S. S., & Schmidt, C. F. (1948) · Journal of Clinical Investigation · doi:10.1172/jci101994 · Cited by 2,059
Williamson, D., Lund, P., & Krebs, H. (1967) · Biochemical Journal · doi:10.1042/bj1030514 · Cited by 1,871
Wege des Wasserstoffs in der lebendigen Organisation
Bücher, T., & Klingenberg, M. (1958) · Angewandte Chemie · doi:10.1002/ange.19580701707 · Cited by 624
Effects of Changes in Brain Metabolism on the Levels of Citric Acid Cycle Intermediates
Goldberg, N. D., Passonneau, J. V., & Lowry, O. H. (1966) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)99802-9 · Cited by 392
Siesjö, B. K., Folbergrová, J., & MacMillan, V. (1972) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1972.tb01308.x · Cited by 249
Self-citationFolbergrová, J., Passonneau, J. V., Lowry, O. H., & Schulz, D. W. (1969) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1969.tb05937.x · Cited by 243
CONTROL OF GLYCOGEN LEVELS IN BRAIN1
Nelson, S. R., Schulz, D. W., Passonneau, J. V., & Lowry, O. H. (1968) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1968.tb05904.x · Cited by 215
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Cited by
Brain Lactic Acidosis and Ischemic Cell Damage: 1. Biochemistry and Neurophysiology
Rehncrona, S., Rosén, I., & Siesjö, B. K. (1981) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1981.34 · Cited by 586
Self-citationChemical monitoring of neurosurgical intensive care patients using intracerebral microdialysis
Persson, L., & Hillered, L. (1992) · Journal of Neurosurgery · doi:10.3171/jns.1992.76.1.0072 · Cited by 391
The distribution of hypoglycemic brain damage
Auer, R. N., Wieloch, T., Olsson, Y., & Siesj�, B. K. (1984) · Acta Neuropathologica · doi:10.1007/bf00688108 · Cited by 379
Self-citationLjunggren, B., Schutz, H., & Siesjo¨, B. K. (1974) · Brain Research · doi:10.1016/0006-8993(74)91049-x · Cited by 290
CEREBRAL ENERGY METABOLISM DURING EXPERIMENTAL STATUS EPILEPTICUS 1
Duffy, T. E., Howse, D. C., & Plum, F. (1975) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1975.tb03657.x · Cited by 220
Metadata
- Authors
- Eolbergrová, J., MacMillan, V., & Siesjö, B. K.
- Venue
- Journal of Neurochemistry
- Publisher
- Wiley
- Published
- 1972-11
- Volume
- 19
- Issue
- 11
- Pages
- 2497-2505
- ISSN
- 0022-3042 (ISSN-L)
- 1471-4159
- OpenAlex
- W2077450279
- Cited by
- 287
- References
- 13
- FWCI
- 11.63
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: THE EFFECT OF MODERATE AND MARKED HYPERCAPNIA UPON THE ENERGY STATE AND UPON THE CYTOPLASMIC NADH/NAD+ RATIO OF THE RAT BRAIN. https://app.cochat.ai/papers/10.1111/j.1471-4159.1972.tb01309.x
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- Eolbergrová, J., MacMillan, V., & Siesjö, B. K. (1972). THE EFFECT OF MODERATE AND MARKED HYPERCAPNIA UPON THE ENERGY STATE AND UPON THE CYTOPLASMIC NADH/NAD+ RATIO OF THE RAT BRAIN. Journal of Neurochemistry. https://doi.org/10.1111/j.1471-4159.1972.tb01309.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
