The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
THE EFFECT OF HYPERCAPNIA UPON INTRACELLULAR pH IN THE BRAIN, EVALUATED BY THE BICARBONATE‐ CARBONIC ACID METHOD AND FROM THE CREATINE PHOSPHOKINASE EQUILIBRIUM
Abstract
Abstract— Abstract‐Intracellular pH in the brain was evaluated by the bicarbonate‐carbonic acid method and from the creatine phosphokinase equilibrium, in rats exposed to 6–40 % CO 2 for 45 min. There was a very good agreement between the two methods, indicating that the creatine phosphokinase equilibrium in vivo shows the pH dependence predicted from previous in vitro studies. The stepwise increase in the tissue CO 2 tension from 45 to 265 mm Hg resulted in a lowering of the intracellular pH from 7.04 to 6.68. The regulation of intracellular pH in hypercapnia was far better than that which can be predicted from physicochemical buffering alone, and calculations indicate that the intracellular buffer base concentration increased by more than 10 mequiv./kg at the maximal P co2 values encountered.
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Citations
Cites
Williamson, D., Lund, P., & Krebs, H. (1967) · Biochemical Journal · doi:10.1042/bj1030514 · Cited by 1,871
Cited by
Brain Lactic Acidosis and Ischemic Cell Damage: 1. Biochemistry and Neurophysiology
Rehncrona, S., Rosén, I., & Siesjö, B. K. (1981) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1981.34 · Cited by 586
Self-citationCerebral circulation and metabolism
Siesjö, B. K. (1984) · Journal of Neurosurgery · doi:10.3171/jns.1984.60.5.0883 · Cited by 585
Self-citationBrain Lactic Acidosis and Ischemic Cell Damage: 2. Histopathology
Kalimo, H., Rehncrona, S., Söderfeldt, B., Olsson, Y., & Siesjö, B. K. (1981) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1981.35 · Cited by 400
Self-citationLjunggren, B., Schutz, H., & Siesjo¨, B. K. (1974) · Brain Research · doi:10.1016/0006-8993(74)91049-x · Cited by 290
Eolbergrová, J., MacMillan, V., & Siesjö, B. K. (1972) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1972.tb01309.x · Cited by 287
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Metadata
- Authors
- Siesjö, B. K., Folbergrová, J., & MacMillan, V.
- Venue
- Journal of Neurochemistry
- Publisher
- Wiley
- Published
- 1972-11
- Volume
- 19
- Issue
- 11
- Pages
- 2483-2495
- ISSN
- 0022-3042 (ISSN-L)
- 1471-4159
- OpenAlex
- W2125185978
- Cited by
- 249
- References
- 1
- FWCI
- 11.63
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: THE EFFECT OF HYPERCAPNIA UPON INTRACELLULAR pH IN THE BRAIN, EVALUATED BY THE BICARBONATE‐ CARBONIC ACID METHOD AND FROM THE CREATINE PHOSPHOKINASE EQUILIBRIUM. https://app.cochat.ai/papers/10.1111/j.1471-4159.1972.tb01308.x
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- Siesjö, B. K., Folbergrová, J., & MacMillan, V. (1972). THE EFFECT OF HYPERCAPNIA UPON INTRACELLULAR pH IN THE BRAIN, EVALUATED BY THE BICARBONATE‐ CARBONIC ACID METHOD AND FROM THE CREATINE PHOSPHOKINASE EQUILIBRIUM. Journal of Neurochemistry. https://doi.org/10.1111/j.1471-4159.1972.tb01308.x
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