Carrier-mediated blood-brain barrier transport of short-chain monocarboxylic organic acids
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Abundant expression of monocarboxylate transporters in endothelial cells might facilitate crossing of the blood-brain barrier by short-chain fatty acids, since brain uptake of short-chain fatty acids has been demonstrated in rats following injection of 14C-SCFAs into the carotid artery.
“The abundant expression of MCTs in endothelial cells (75, 92) might facilitate crossing of the BBB by SCFAs since brain uptake of SCFAs has previously been demonstrated in rats following injection of 14C-SCFAs into the carotid artery (93).”
From The Role of Short-Chain Fatty Acids From Gut Microbiota in Gut-Brain Communication (2020) · cites this paper as [93]
A small fraction of short-chain fatty acids reaches the systemic circulation and can cross the blood-brain barrier using their own transporters located on brain vascular epithelial cells.
“A small fraction reaches the systemic circulation and can cross the tightly regulated BBB using their own transporters located on brain vascular epithelial cells (100, 101).”
From The gut-brain axis: how microbiota and host inflammasome influence brain physiology and pathology (2020) · cites this paper as [100]
Cited by
Sorted by citations
The role of short-chain fatty acids in microbiota–gut–brain communication
Dalile, B., Van Oudenhove, L., Vervliet, B., & Verbeke, K. (2019) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-019-0157-3 · Cited by 3,357 · see citing works
The Role of Short-Chain Fatty Acids From Gut Microbiota in Gut-Brain Communication
Silva, Y. P., Bernardi, A., & Frozza, R. L. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00025 · Cited by 3,043 · see citing works
“The abundant expression of MCTs in endothelial cells (75, 92) might facilitate crossing of the BBB by SCFAs since brain uptake of SCFAs has previously been demonstrated in rats following injection of 14C-SCFAs into the carotid artery (93).”
BackgroundThe neuropharmacology of butyrate: the bread and butter of the microbiota-gut-brain axis
Stilling, R. M., van de Wouw, M., Clarke, G., Stanton, C., Dinan, T. G., & Cryan, J. F. (2016) · Neurochemistry International · doi:10.1016/j.neuint.2016.06.011 · Cited by 891 · see citing works
“Studies using isotope-labelled butyrate were able to demonstrate carrier-mediated uptake of butyrate and other monocarboxylates into the brain as far back as the 1970s (Oldendorf, 1973; Sarna et al., 1979), although more”
Brain Glucose Metabolism: Integration of Energetics with Function.
Dienel, G. (2019) · Physiological Reviews · doi:10.1152/physrev.00062.2017 · Cited by 806 · see citing works
Helms, H. C., Abbott, N. J., Burek, M., Cecchelli, R., Couraud, P.-O., Deli, M. A., Förster, C., Galla, H. J., Romero, I. A., Shusta, E. V., et al. (2016) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x16630991 · Cited by 843 · see citing works
The gut-brain axis: how microbiota and host inflammasome influence brain physiology and pathology
Rutsch, A., Kantsjö, J. B., & Ronchi, F. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.604179 · Cited by 821 · see citing works
“A small fraction reaches the systemic circulation and can cross the tightly regulated BBB using their own transporters located on brain vascular epithelial cells (100, 101).”
BackgroundShort chain fatty acids: Microbial metabolites for gut-brain axis signalling
O’Riordan, K. J., Collins, M., Moloney, G. M., Knox, E. G., Aburto, M. R., Fülling, C., Morley, S. J., Clarke, G. A., Schellekens, H., & Cryan, J. F. (2022) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2022.111572 · Cited by 742 · see citing works
Stewart, P. A., & Wiley, M. J. (1981) · Developmental Biology · doi:10.1016/0012-1606(81)90382-1 · Cited by 684 · see citing works
Allen, M. S., Bradford, B. J., & Oba, M. (2009) · Journal of Animal Science · doi:10.2527/jas.2009-1779 · Cited by 633 · see citing works
Regulation of retinal blood flow in health and disease
Pournaras, C. J., Rungger‐Brändle, E., Riva, C. E., Hardarson, S. H., & Stefánsson, E. (2008) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2008.02.002 · Cited by 616 · see citing works
TRANSPORT OF METABOLIC SUBSTRATES THROUGH THE BLOOD‐BRAIN BARRIER1
Pardridge, W. M., & Oldendorf, W. H. (1977) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1977.tb07702.x · Cited by 535 · see citing works
Self-citationEbert, D., Haller, R. G., & Walton, M. E. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-13-05928.2003 · Cited by 427 · see citing works
“The higher proportion may be explained by differences in transport rates and mechanisms of the two substrates (Oldendorf, 1971, 1973), or it could be a consequence of anesthesia, fasting, or species differences.”
BackgroundInfluentialMechanisms of Blood–Brain Barrier Protection by Microbiota-Derived Short-Chain Fatty Acids
Fock, E. M., & Parnova, R. G. (2023) · Cells · doi:10.3390/cells12040657 · Cited by 418 · see citing works
“Its uptake by the brain was 6 times lower but was at the same level as in the heart [62].”
BackgroundMonographs on fragrance raw materials
Opdyke, D. L. J. (1981) · Food and Cosmetics Toxicology · doi:10.1016/0015-6264(81)90363-1 · Cited by 383 · see citing works
Preferential Utilization of Acetate by Astrocytes Is Attributable to Transport
Waniewski, R. A., & Martin, D. L. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-14-05225.1998 · Cited by 378 · see citing works
“Research on acetate transport in the nervous system has focused primarily on movement across the blood–brain barrier; previous studies suggest that uptake occurs by passive diffusion (Oldendorf, 1973; Terasaki et al., 1991).”
BackgroundPyruvate Protects Neurons against Hydrogen Peroxide-Induced Toxicity
Desagher, S., Glowinski, J., & Prémont, J. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-23-09060.1997 · Cited by 370 · see citing works
“Unlike exogenous catalase, pyruvate and other a-ketoacids can cross the blood–brain barrier (Oldendorf, 1973; Conn et al., 1983).”
BackgroundButyrate in Energy Metabolism: There Is Still More to Learn
Zhang, L., Liu, C.-D., Jiang, Q., & Yin, Y. (2021) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2020.12.003 · Cited by 374 · see citing works
Transporter-Mediated Permeation of Drugs Across the Blood–Brain Barrier
Tamai, I., & Tsuji, A. (2000) · Journal of Pharmaceutical Sciences · doi:10.1002/1520-6017(200011)89:11 · Cited by 363 · see citing works
Boumezbeur, F., Petersen, K. F., Cline, G. W., Mason, G. F., Behar, K. L., Shulman, G. I., & Rothman, D. L. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.2040-10.2010 · Cited by 362 · see citing works
“However, lactate can cross the blood– brain barrier through monocarboxylate transporters (MCTs) (Oldendorf, 1973; Simpson et al., 2007), and recent studies have provided evidence that lactate can become a significant fuel source when elevated in the blood (Smith et al.”
BackgroundHu, Y., & Wilson, G. S. (1997) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1997.69041484.x · Cited by 337 · see citing works
Cerebral metabolism of [1,2-13C2]acetate as detected by in vivo and in vitro 13C NMR.
Cerdán, S., Künnecke, B., & Seelig, J. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)38247-x · Cited by 336 · see citing works
Regulation of Ketone Body Metabolism and the Role of PPARα
Grabacka, M., Pierzchalska, M., Dean, M., & Reiss, K. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17122093 · Cited by 305 · see citing works
“The difficulties in crossing BBB are no concern for ketone bodies, which are efficiently absorbed through monocarboxylate transporters (MCT1, MCT2), the expression of which increases significantly during fasting [100,101].”
BackgroundWidner, H., & Brundin, P. (1988) · Brain Research Reviews · doi:10.1016/0165-0173(88)90010-0 · Cited by 287 · see citing works
Effect of aging on the blood-brain barrier
Mooradian, A. D. (1988) · Neurobiology of Aging · doi:10.1016/s0197-4580(88)80013-7 · Cited by 296 · see citing works
Hladky, S. B., & Barrand, M. A. (2016) · Fluids and Barriers of the CNS · doi:10.1186/s12987-016-0040-3 · Cited by 291 · see citing works
Delivery of peptide and protein drugs over the blood–brain barrier
Brasnjevic, I., Steinbusch, H. W. M., Schmitz, C., & Martinez-Martinez, P. (2009) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2008.12.002 · Cited by 279 · see citing works
Transport of small molecules through the blood-brain barrier: biology and methodology
Pardridge, W. M. (1995) · Advanced Drug Delivery Reviews · doi:10.1016/0169-409x(95)00003-p · Cited by 279 · see citing works
Glucose and ketone body utilization by the brain of neonatal rats
Nehlig, A., & de Vasconcelos, A. P. (1993) · Progress in Neurobiology · doi:10.1016/0301-0082(93)90022-k · Cited by 277 · see citing works
Pathways for Small Molecule Delivery to the Central Nervous System across the Blood-Brain Barrier
Mikitsh, J. L., & Chacko, A. (2014) · Perspectives in Medicinal Chemistry · doi:10.4137/pmc.s13384 · Cited by 271 · see citing works
Peptides and the blood–brain barrier
Banks, W. A. (2015) · Peptides · doi:10.1016/j.peptides.2015.03.010 · Cited by 267 · see citing works
Cremer, J. E., Cunningham, V. J., Pardridge, W. M., Braun, L. D., & Oldendorf, W. H. (1979) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1979.tb05173.x · Cited by 263 · see citing works
Self-citationSchurr, A., Payne, R. S., Miller, J. J., & Rigor, B. M. (1997) · Brain Research · doi:10.1016/s0006-8993(96)01106-7 · Cited by 262 · see citing works
Blood-brain barrier transport machineries and targeted therapy of brain diseases
Barar, J., Rafi, M. A., Pourseif, M. M., & Omidi, Y. (2016) · Bioimpacts · doi:10.15171/bi.2016.30 · Cited by 259 · see citing works
Sleeth, M., Thompson, E. L., Ford, H. E., Zac‐Varghese, S., & Frost, G. S. (2010) · Nutrition Research Reviews · doi:10.1017/s0954422410000089 · Cited by 251 · see citing works
“Although it is likely that SCFA pass across the blood– brain barrier via a carrier-mediated mechanism((96)), there is little or no apparent expression of FFA2 in the hypothalamus((59)).”
BackgroundKinetics of blood-brain barrier transport of hexoses
Pardridge, W. M., & Oldendorf, W. H. (1975) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(75)90279-5 · Cited by 244 · see citing works
Self-citationMolecular Anatomy of the Blood-Brain Barrier as Defined by Immunocytochemistry
Dermietzel, R., & Krause, D. (1991) · International review of cytology · doi:10.1016/s0074-7696(08)60692-0 · Cited by 237 · see citing works
Fatty Acid Oxidation and Ketogenesis by Astrocytes in Primary Culture
Auestad, N., Korsak, R. A., Morrow, J. W., & Edmond, J. (1991) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1991.tb11435.x · Cited by 245 · see citing works
Independent blood-brain barrier transport systems for nucleic acid precursors
Cornford, E. M., & Oldendorf, W. H. (1975) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(75)90259-x · Cited by 238 · see citing works
Self-citationSeizure control by decanoic acid through direct AMPA receptor inhibition
Chang, P., Augustin, K., Boddum, K., Williams, S., Sun, M., Terschak, J. A., Hardege, J. D., Chen, P. E., Walker, M. C., & Williams, R. S. B. (2015) · Brain · doi:10.1093/brain/awv325 · Cited by 231 · see citing works
“…2013; Wlaz et al., 2015) but octanoic acid does not, and with previous in vivo pharmacokinetic data indicating that decanoic acid penetrates the blood–brain barrier (Oldendorf, 1973), these data suggest that decanoic acid directly contributes to the therapeutic effect of the MCT ketogenic diet.”
BackgroundA Historical Review of Brain Drug Delivery
Pardridge, W. M. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14061283 · Cited by 219 · see citing works
Enerson, B. E., & Drewes, L. R. (2003) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.10389 · Cited by 214 · see citing works
Methods for quantifying the transport of drugs across brain barrier systems
Fenstermacher, J. D., Blasberg, R. G., & Patlak, C. S. (1981) · Pharmacology & Therapeutics · doi:10.1016/0163-7258(81)90062-0 · Cited by 214 · see citing works
Mechanisms of Short-Chain Fatty Acids Derived from Gut Microbiota in Alzheimer's Disease
Qian, X., Xie, R.-Y., Liu, X., Chen, S., & Tang, H. (2022) · Aging and Disease · doi:10.14336/ad.2021.1215 · Cited by 219 · see citing works
Small molecular drug transfer across the blood-brain barrier via carrier-mediated transport systems
Tsuji, A. (2004) · NeuroRx · doi:10.1602/neurorx.2.1.54 · Cited by 209 · see citing works
Microbial-derived metabolites as a risk factor of age-related cognitive decline and dementia
Connell, E., Le Gall, G., Pontifex, M. G., Sami, S., Cryan, J. F., Clarke, G., Müller, M., & Vauzour, D. (2022) · Molecular Neurodegeneration · doi:10.1186/s13024-022-00548-6 · Cited by 208 · see citing works
“In fact, the uptake of SCFAs into the brain has formerly been exhibited in rodents following the injection of 14C-SCFAs into the carotid artery [293].”
BackgroundThe energetic brain—A review from students to students
Bordone, M. P., Salman, M. M., Titus, H. E., Amini, E., Andersen, J. V., Chakraborti, B., Diuba, A. V., Dubouskaya, T. G., Ehrke, E., Espindola de Freitas, A., et al. (2019) · Journal of Neurochemistry · doi:10.1111/jnc.14829 · Cited by 205 · see citing works
Changes during development in transport processes of the blood-brain barrier
Cremer, J. E., Braun, L. D., & Oldendorf, W. H. (1976) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(76)90120-6 · Cited by 197 · see citing works
Self-citationPhysiology and pathophysiology of organic acids in cerebrospinal fluid
Hoffmann, G. F., Meier‐Augenstein, W., Stöckler, S., Surtees, R. A. H., Rating, D., & Nyhan, W. L. (1993) · Journal of Inherited Metabolic Disease · doi:10.1007/bf00711898 · Cited by 191 · see citing works
Functional expression and localization of P‐glycoprotein at the blood brain barrier
Bendayan, R., Lee, G. S., & Bendayan, M. (2002) · Microscopy Research and Technique · doi:10.1002/jemt.10090 · Cited by 186 · see citing works
“…information into the transport properties of amino acids (Betz and Goldstein, 1978), glucose (Pardridge et al., 1990), monocarboxylic acids (Oldendorf, 1973), choline (Estrada et al., 1990), nucleosides (Cornford and Oldendorf, 1975), neurotransmitters (Hardebo et al., 1979), as well as a…”
BackgroundFellows, L. K., Boutelle, M. G., & Fillenz, M. (1993) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1993.tb03285.x · Cited by 176 · see citing works
“Abbreviations used: aCSF, artificial cerebrospinal fluid; AP-5, 2- amino-5-phosphonopentanoic acid; AP-7, 2-amino-7-phosphono- heptanoic acid; BBB, blood-brain barrier; HRP, horseradish peroxidase ; MK-801, (+)-”
BackgroundInfluentialSubstrate Utilization and Brain Development
Cremer, J. E. (1982) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1982.45 · Cited by 173 · see citing works
Snigdha, S., Ha, K., Tsai, P., Dinan, T. G., Bartos, J. D., & Shahid, M. (2021) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2021.107978 · Cited by 171 · see citing works
Ketone Bodies Are Selectively Used by Individual Brain Regions
Hawkins, R. A., & Biebuyck, J. F. (1979) · Science · doi:10.1126/science.451608 · Cited by 168 · see citing works
The Role of Compartmentation in the Control of Glycolysis
Ottaway, J. H., & Mowbray, J. (1977) · Current topics in cellular regulation · doi:10.1016/b978-0-12-152812-6.50010-x · Cited by 168 · see citing works
Kalyanaraman, B., Cheng, G., & Hardy, M. (2024) · Redox Biology · doi:10.1016/j.redox.2024.103092 · Cited by 174 · see citing works
“SCFAs — the byproducts of bacterial fermentation of dietary fiber-— get into the systemic circulation, cross the blood – brain barrier, and exert their effects on microglia in the brain [57,58].”
BackgroundMori, S., Takanaga, H., Ohtsuki, S., Deguchi, T., Kang, Y., Hosoya, K., & Terasaki, T. (2003) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/01.wcb.0000050062.57184.75 · Cited by 172 · see citing works
“In patients with Reye’s syndrome and medium-chain acyl-CoA dehydrogenase deficiency, octanoic acid concentrations in the blood increase dramatically with concomitant increases in the brain because of the transport of octanoic acid across the BBB (Oldendorf, 1973).”
BackgroundPardridge, W. M. (2015) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2015.1042364 · Cited by 159 · see citing works
“The STP of BBB MCT was defined in vivo in the rat [29-31], and is:”
BackgroundChanges in the Blood-Brain Barrier in Hepatic Coma After Hepatectomy in the Rat
Livingstone, A. S., Potvin, M.-J., Goresky, C. A., Finlayson, M. H., & Hinchey, E. J. (1977) · Gastroenterology · doi:10.1016/s0016-5085(19)31768-8 · Cited by 155 · see citing works
Blood-brain barrier transport of caffeine: Dose-related restriction of adenine transport
McCall, A. L., Millington, W. R., & Wurtman, R. J. (1982) · Life Sciences · doi:10.1016/0024-3205(82)90715-9 · Cited by 158 · see citing works
Fatty Acid Transport Through the Blood‐Brain Barrier
Spector, R. (1988) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1988.tb02958.x · Cited by 155 · see citing works
Deficiency in short-chain fatty acid β-oxidation affects theta oscillations during sleep
Tafti, M., Petit, B., Chollet, D., Neidhart, E., de Bilbao, F., Kiss, J. Z., Wood, P. A., & Franken, P. (2003) · Nature Genetics · doi:10.1038/ng1174 · Cited by 150 · see citing works
Vector-mediated drug delivery to the brain
Pardridge, W. M. (1999) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(98)00087-8 · Cited by 146 · see citing works
Shank, R. P., & Campbell, G. L. M. (1984) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1984.tb12724.x · Cited by 144 · see citing works
Specialized Properties and Solute Transport in Brain Capillaries
Betz, A. L., & Goldstein, G. W. (1986) · Annual Review of Physiology · doi:10.1146/annurev.ph.48.030186.001325 · Cited by 143 · see citing works
Oldendorf, W. H., & Braun, L. D. (1976) · Brain Research · doi:10.1016/0006-8993(76)90024-x · Cited by 141 · see citing works
Self-citationPekmeability Changes in the Blood-Brain Barrier: Causes and Consequences
Pardridge, W. M., Connor, J. D., Crawford, I. L., & Oldendorf, W. H. (1975) · Critical Reviews in Toxicology · doi:10.3109/10408447509079857 · Cited by 138 · see citing works
Self-citationOldendorf, W. H. (1977) · Experimental Eye Research · doi:10.1016/s0014-4835(77)80016-x · Cited by 141 · see citing works
Self-citationAckermann, R. F., & Lear, J. L. (1989) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1989.111 · Cited by 134 · see citing works
Pyruvate Administered After Severe Hypoglycemia Reduces Neuronal Death and Cognitive Impairment
Suh, S. W., Aoyama, K., Matsumori, Y., Liu, J., & Swanson, R. A. (2005) · Diabetes · doi:10.2337/diabetes.54.5.1452 · Cited by 135 · see citing works
“Because pyruvate crosses the blood-brain barrier by both facilitated transport and diffusion (25,26), this increase in plasma concentration should substantially increase pyruvate transport into brain.”
13C MR Spectroscopy Study of Lactate as Substrate for Rat Brain
Qu, H., Haberg, A. K., Haraldseth, O., Unsgård, G., & Sonnewald, U. (2000) · Developmental Neuroscience · doi:10.1159/000017472 · Cited by 132 · see citing works
“Earlier studies with 14C-labeled lactate indicated that the bloodbrain barrier contains a saturable lactate carrier with Lstereospecificity [Oldendorf, 1973; Nemoto and Severinghaus, 1974].”
BackgroundShort chain fatty acids: the messengers from down below
Mansuy‐Aubert, V., & Ravussin, Y. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1197759 · Cited by 133 · see citing works
“Some SCFA have been demonstrated to cross the blood brain barrier in rats (Oldendorf, 1973) and in humans (Bachmann et al., 1979), possibly due to high expression of their transporter, monocarboxylate transporters (MCTs) in blood cells and astrocytes (Bachmann et al., 1979; Dalile et al., 2019).”
BackgroundDeüticke, B., Beyer, E. C., & Forst, B. (1982) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(82)90053-0 · Cited by 128 · see citing works
Allen, R. H., Stabler, S. P., Savage, D. G., et al. (1993) · Metabolism · doi:10.1016/0026-0495(93)90010-l · Cited by 127 · see citing works
Kido, Y., Tamai, I., Okamoto, M., Suzuki, F., & Tsuji, A. (2000) · Pharmaceutical Research · doi:10.1023/a:1007518525161 · Cited by 123 · see citing works
“short-chain fatty acids are transported across the BBB (12).”
BackgroundMethodDietary Cholesterol and the Origin of Cholesterol in the Brain of Developing Rats
Edmond, J., Korsak, R. A., Morrow, J. W., et al. (1991) · Journal of Nutrition · doi:10.1093/jn/121.9.1323 · Cited by 123 · see citing works
Short-chain fatty acids and gut microbiota in multiple sclerosis
Melbye, P., Olsson, A., Hansen, T. H., Søndergaard, H. B., & Oturai, A. B. (2018) · Acta Neurologica Scandinavica · doi:10.1111/ane.13045 · Cited by 121 · see citing works
Logan, S., Arzua, T., Canfield, S. G., Seminary, E. R., Sison, S. L., Ebert, A. D., & Bai, X. (2019) · Comprehensive physiology · doi:10.1002/cphy.c180025 · Cited by 139 · see citing works
Stereoselective, SH-dependent transfer of lactate in mammalian erythrocytes
Deüticke, B., Rickert, I., & Beyer, E. C. (1978) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(78)90381-4 · Cited by 119 · see citing works
Age-related changes in the blood-brain barrier
Shah, G. N., & Mooradian, A. D. (1997) · Experimental Gerontology · doi:10.1016/s0531-5565(96)00158-1 · Cited by 115 · see citing works
Human Serum Metabolites Associate With Severity and Patient Outcomes in Traumatic Brain Injury
Orešič, M., Posti, J. P., Kamstrup‐Nielsen, M. H., Takala, R. S. K., Lingsma, H. F., Mattila, I. M., Jäntti, S. E., Katila, A. J., Carpenter, K. L. H., Ala-Seppälä, H. M., et al. (2016) · EBioMedicine · doi:10.1016/j.ebiom.2016.07.015 · Cited by 116 · see citing works
“Several other metabolites, which are present at high concentrations in cerebrospinal fluid (Hartonen et al., 2013) and BMD,were also upregulated in serum of the TBI patients, indicative of disruption of the BBB.”
BackgroundInfluentialBlood–Brain Barrier Transport of Valproic Acid
Cornford, E. M., Diep, C. P., & Pardridge, W. M. (1985) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1985.tb08793.x · Cited by 113 · see citing works
Butyrate ameliorates quinolinic acid–induced cognitive decline in obesity models
Ge, X., Zheng, M., Hu, M., Fang, X., Geng, D., Liu, S., Wang, L., Zhang, J., Guan, L., Zheng, P., et al. (2023) · Journal of Clinical Investigation · doi:10.1172/jci154612 · Cited by 117 · see citing works
“…in the frontal cortex (Figure 2E) as a result of a decrease in the sum and maximum number of dendritic inter-sections ( P < 0.01; P < 0.01; Figure 2, F and G), but no alteration is the SCFA most abundantly uptaken by the brain (22) compared with other SCFAs, including acetate and propionate.”
InfluentialGJEDDE, A. H., & Marrett, S. (2001) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-200112000-00002 · Cited by 112 · see citing works
“Third, although the lactate dehydrogenase and monocarboxylate transporter proteins have been presented as recently discovered key elements in the operation of the shuttle, neither protein, as catalyst of a near-equilibrium reaction, can be claimed to indicate a net direction of flux in vivo, nor is the discovery of th…”
BackgroundGut microbiota-derived metabolites and their importance in neurological disorders
Swer, N. M., Venkidesh, B. S., Murali, T. S., & Mumbrekar, K. D. (2022) · Molecular Biology Reports · doi:10.1007/s11033-022-08038-0 · Cited by 111 · see citing works
“[39], where SCFAs were injected into the common carotid artery of Wistar rats, and all the three significant SCFAs were detected in the Cerebrospinal fluid (CSF) in varying ratios.”
MethodBoundaries and integration between microbiota, the nervous system, and immunity
Macpherson, A. J., Pachnis, V., & Prinz, M. (2023) · Immunity · doi:10.1016/j.immuni.2023.07.011 · Cited by 117 · see citing works
Quantitative assessment of dynamic PET imaging data in cancer imaging
Muzi, M., O’Sullivan, F., Mankoff, D. A., Doot, R. K., Pierce, L. A., Kurland, B. F., Linden, H. M., & Kinahan, P. E. (2012) · Magnetic Resonance Imaging · doi:10.1016/j.mri.2012.05.008 · Cited by 109 · see citing works
Ghersi‐Egea, J., Minn, A., & Siest, G. (1988) · Life Sciences · doi:10.1016/0024-3205(88)90351-7 · Cited by 109 · see citing works
Kuhr, W. G., den Berg, C. J. V., & Korf, J. (1988) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1988.142 · Cited by 106 · see citing works
Standardized method for high-resolution 1H-NMR of cerebrospinal fluid
Wevers, R. A., Engelke, U. F. H., Wendel, U., et al. (1995) · Clinical Chemistry · doi:10.1093/clinchem/41.5.744 · Cited by 103 · see citing works
Sympathetic influence on cerebral blood flow and metabolism during exercise in humans
Seifert, T., & Secher, N. H. (2011) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2011.09.008 · Cited by 100 · see citing works
“Lactate is transported across the BBB via MCTs and the transport is specific for L-lactate that demonstrates Michaelis-Menten kinetics (Oldendorf, 1971, 1973).”
BackgroundEDLUND, G. L., & Halestrap, A. P. (1988) · Biochemical Journal · doi:10.1042/bj2490117 · Cited by 102 · see citing works
Drug delivery through the blood-brain barrier
Tamai, I., & Tsuji, A. (1996) · Advanced Drug Delivery Reviews · doi:10.1016/0169-409x(96)00011-7 · Cited by 101 · see citing works
Ischemic stroke and intestinal flora: an insight into brain–gut axis
Hu, W., Kong, X., Wang, H., Li, Y., & Luo, Y. (2022) · European journal of medical research · doi:10.1186/s40001-022-00691-2 · Cited by 100 · see citing works
Lactulose, Disaccharides and Colonic Flora
Clausen, M. R., & Mortensen, P. B. (1997) · Drugs · doi:10.2165/00003495-199753060-00003 · Cited by 98 · see citing works
Interactions of Lipids, Lipoproteins, and Apolipoproteins with the Blood-Brain Barrier
Rhea, E. M., & Banks, W. A. (2021) · Pharmaceutical Research · doi:10.1007/s11095-021-03098-6 · Cited by 97 · see citing works
Tang, C., Wang, C., Wang, J., Wang, Q., Li, S., Wang, H., Zhou, F., & Li, J. (2022) · Nutrients · doi:10.3390/nu14091882 · Cited by 99 · see citing works
“SCFAs can reach the brain, as they were shown to cross the BBB in a cell culture model and in rats following injection of SCFAs [51,52].”
BackgroundJoseph, J., Depp, C. A., Shih, P.-A. B., Cadenhead, K. S., & Schmid‐Schönbein, G. W. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00155 · Cited by 95 · see citing works
“Circulating levels of SCFA are able to cross the blood brain barrier, and the primary SCFA uptake by the brain is for butyrate, followed by propionate and acetate (Oldendorf, 1973).”
BackgroundOhtsuki, S. (2004) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.27.1489 · Cited by 94 · see citing works
Inhibition of brain energy metabolism by the α-keto acids accumulating in maple syrup urine disease
Sgaravatti, Â. M., Rosa, R. B., Schuck, P. F., et al. (2003) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2003.09.010 · Cited by 94 · see citing works
Applications of Medium-Chain Triglycerides in Foods
Watanabe, S., & Tsujino, S. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.802805 · Cited by 102 · see citing works
“There are in vivo data supporting this hypothesis that decanoic acid crosses the blood-brain barrier (54).”
Background
- Authors
- Oldendorf, W.
- Corresponding author
- Oldendorf, WH
- Venue
- American Journal of Physiology-Legacy Content
- Publisher
- American Physiological Society
- Published
- 1973-06-01
- Volume
- 224
- Issue
- 6
- Pages
- 1450-1453
- ISSN
- 0002-9513 (ISSN-L)
- OpenAlex
- W2294335852
- Cited by
- 463
- References
- 0
- Citations by year
- 2026: 16 · 2025: 17 · 2024: 21 · 2023: 20 · 2022: 32 · 2021: 13 · 2020: 7 · 2019: 5 · 2018: 9 · 2017: 2 · 2016: 9 · 2015: 4 · 2014: 4 · 2013: 9 · 2012: 6
- FWCI
- 4.23
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Physiology-Legacy Content (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Amino Acid Enzymes and Metabolism
- Keywords
- blood-brain barrier, carrier-mediated transport, organic acids, brain uptake, monocarboxylate transporters
- MeSH terms
- Acetates, Amino Acids, Animals, Biological Transport, Blood-Brain Barrier, Brain, Butyrates, Carbon Isotopes, Carboxylic Acids, Dicarboxylic Acids, Female, Glucose, Lactates, Male, Propionates, Pyruvates, Tricarboxylic Acids, Tritium, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
