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Cited by 255

The DOI matches its Crossref record.

Changes of Biogenic Amines and Their Metabolites in Postmortem Brains from Patients with Alzheimer‐Type Dementia

Aral, Heii, Kosaka, Kenji, Iizuka, Reiji·1984·Journal of Neurochemistry
DOI 10.1111/j.1471-4159.1984.tb00913.x
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Abstract

Abstract: Noradrenaline (NA), 3,4‐dihydroxyphenyl‐ethylamine (dopamine, DA), 5‐hydroxytryptamine (serotonin, 5‐HT), homovanillic acid (HVA), and 5‐hydroxy‐indoleacetic acid (5‐HIAA) were measured in 22 regions of postmortem brains from four histologically verified cases with Alzheimer‐type dementia (AID) and nine histologically normal controls. Compared with the controls, concentrations of 5‐HT and 5‐HIAA in the ATD brains were significantly reduced in nine regions (superior frontal gyrus, insula, cingulate gyrus, amygdala, putamen, medial and lateral segments of globus pallidus, substantia nigra, lateral nucleus of thalamus) and in eight regions (amygdala, substantia innominata, caudate, putamen, medial and lateral segments of globus pallidus, medial and lateral nuclei of thalamus), respectively. NA concentrations of the ATD brains were significantly reduced in six regions (cingulate gyrus, substantia innominata, putamen, hypothalamus, medial nucleus of thalamus, raphe area). In contrast, significant reductions of DA and HVA concentrations in the ATD brains were found only in putamen and amygdala, respectively. The 5‐HIAA/5‐HT ratio in the ATD brains decreased significantly in locus coeruleus, while the HYA/DA ratio increased significantly in putamen and medial segment of globus pallidus. These findings suggest that the serotonergic and noradrenergic systems are affected, while the dopaminergic system is relatively unaffected in ATD brains.

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Metadata

Authors
Aral, H., Kosaka, K., & Iizuka, R.
Venue
Journal of Neurochemistry
Publisher
Wiley
Published
1984-08
Volume
43
Issue
2
Pages
388-393
ISSN
  • 0022-3042
  • 1471-4159
DOI
10.1111/j.1471-4159.1984.tb00913.x
Cited by
255
References
0
Language
en
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 8100 d)

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CoChat. (2026). Citation check: Changes of Biogenic Amines and Their Metabolites in Postmortem Brains from Patients with Alzheimer‐Type Dementia. https://app.cochat.ai/papers/10.1111/j.1471-4159.1984.tb00913.x
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Aral, H., Kosaka, K., & Iizuka, R. (1984). Changes of Biogenic Amines and Their Metabolites in Postmortem Brains from Patients with Alzheimer‐Type Dementia. Journal of Neurochemistry. https://doi.org/10.1111/j.1471-4159.1984.tb00913.x

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.