The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Two Forms of the γ‐Aminobutyric Acid Synthetic Enzyme Glutamate Decarboxylase Have Distinct Intraneuronal Distributions and Cofactor Interactions
Open accessAbstract
Abstract: Glutamate decarboxylase (GAD) catalyzes the production of γ‐aminobutyric acid (GABA), a major inhibitory neurotransmitter. The mammalian brain contains two forms of GAD, with Ms of 67,000 and 65,000 (GAD 67 and GAD 65). Using a new antiserum specific for GAD 67 and a monoclonal antibody specific for GAD 65, we show that the two forms of GAD differ in their intraneuronal distributions: GAD 67 is widely distributed throughout the neuron, whereas GAD 65 lies primarily in axon terminals. In brain extracts, almost all GAD 67 is in an active holoenzyme form, saturated with its cofactor, pyridoxal phosphate. In contrast, only about half of GAD 65 (which is found in synaptic terminals) exists as active holoenzyme. We suggest that the relative levels of apo‐GAD 65 and holo‐GAD 65 in synaptic terminals may couple GABA production to neuronal activity.
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Cites
Co-release of acetylcholine and gamma-aminobutyric acid by a retinal neuron
O'Malley, D. M., & Masland, R. H. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.9.3414 · Cited by 150
Cited by
Two genes encode distinct glutamate decarboxylases
Erlander, M. G., Tillakaratne, N. J. K., Feldblum, S., Patel, N., & Tobin, A. J. (1991) · Neuron · doi:10.1016/0896-6273(91)90077-d · Cited by 1,213
Self-citationGABAergic Interneurons Implications for Understanding Schizophrenia and Bipolar Disorder
Benes, F. (2001) · Neuropsychopharmacology · doi:10.1016/s0893-133x(01)00225-1 · Cited by 1,082
Local GABA Circuit Control of Experience-Dependent Plasticity in Developing Visual Cortex
Hensch, T. K., Fagiolini, M., Mataga, N., Stryker, M. P., Baekkeskov, S., & Kash, S. F. (1998) · Science · doi:10.1126/science.282.5393.1504 · Cited by 910
Emerging principles of altered neural circuitry in schizophrenia
Benes, F. (2000) · Brain Research Reviews · doi:10.1016/s0165-0173(99)00041-7 · Cited by 513
Autoimmunity to two forms of glutamate decarboxylase in insulin-dependent diabetes mellitus
Kaufman, D. L., Erlander, M. G., Clare-Salzler, M., Atkinson, M. A., Maclaren, N. K., & Tobin, A. J. (1992) · Journal of Clinical Investigation · doi:10.1172/jci115573 · Cited by 490
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Metadata
- Authors
- Kaufman, D. L., Houser, C. R., & Tobin, A. J.
- Venue
- Journal of Neurochemistry
- Publisher
- Wiley
- Published
- 1991-02
- Volume
- 56
- Issue
- 2
- Pages
- 720-723
- ISSN
- 0022-3042 (ISSN-L)
- 1471-4159
- OpenAlex
- W2068420002
- Cited by
- 789
- References
- 1
- FWCI
- 12.41
- Type
- journal article
- Language
- en
- Open access
- green
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- Kaufman, D. L., Houser, C. R., & Tobin, A. J. (1991). Two Forms of the γ‐Aminobutyric Acid Synthetic Enzyme Glutamate Decarboxylase Have Distinct Intraneuronal Distributions and Cofactor Interactions. Journal of Neurochemistry. https://doi.org/10.1111/j.1471-4159.1991.tb08211.x
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