Cited by 322Parkinson's Disease Mechanisms and TreatmentsNeuroinflammation and Neurodegeneration MechanismsNuclear Receptors and Signaling

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Inflammation induces mitochondrial dysfunction and dopaminergic neurodegeneration in the nigrostriatal system

Hunter, Randy L., Dragicevic, Natasa, Seifert, Kristen, Choi, Dong Young, Liu, Mei, Kim, Hyoung‐Chun, Cass, Wayne A., Sullivan, Patrick G., Bing, Guoying·2007·Journal of Neurochemistry

DOI 10.1111/j.1471-4159.2006.04327.x

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Abstract

Evidence suggests that chronic inflammation, mitochondrial dysfunction, and oxidative stress play significant and perhaps synergistic roles in Parkinson’s disease (PD), where the primary pathology is significant loss of the dopaminergic neurons in the substantia nigra. The use of anti‐inflammatory drugs for PD treatment has been proposed, and inhibition of cyclo‐oxygenase‐2 (COX‐2) or activation of peroxisome proliferator‐activated receptor gamma (PPAR‐γ) yields neuroprotection in MPTP‐induced PD. Lipopolysaccharide (LPS) induces inflammation‐driven dopaminergic neurodegeneration. We tested the hypothesis that celecoxib (Celebrex, COX‐2 inhibitor) or pioglitazone (Actos, PPAR‐γ agonist) will reduce the LPS‐induced inflammatory response, spare mitochondrial bioenergetics, and improve nigral dopaminergic neuronal survival. Rats were treated with vehicle, celecoxib, or pioglitazone and were intrastriatally injected with LPS. Inflammation, mitochondrial dysfunction, oxidative stress, decreased dopamine, and nigral dopaminergic neuronal loss were observed post‐LPS. Celecoxib and pioglitazone provided neuroprotective properties by decreasing inflammation and restoring mitochondrial function. Pioglitazone also attenuated oxidative stress and partially restored striatal dopamine as well as demonstrated dopaminergic neuroprotection and reduced nigral microglial activation. In summary, intrastriatal LPS served as a model for inflammation‐induced dopaminergic neurodegeneration, anti‐inflammatory drugs provided protective properties, and pioglitazone or celecoxib may have therapeutic potential for the treatment of neuro‐inflammation and PD.

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The Rat Brain in Stereotaxic Coordinates
Paxinos, G., & Watson, C. (1983) · Elsevier eBooks · doi:10.1016/c2009-0-63235-9 · Cited by 28,585
Reactive microglia are positive for HLA‐DR in the substantia nigra of Parkinson's and Alzheimer's disease brains
McGeer, P. L., Itagaki, S., Boyes, B. E., & McGeer, E. G. (1988) · Neurology · doi:10.1212/wnl.38.8.1285 · Cited by 2,990
Parkinson's Disease
Lang, A. E., & Lozano, A. M. (1998) · New England Journal of Medicine · doi:10.1056/nejm199810083391506 · Cited by 2,072
Heterogeneity in the distribution and morphology of microglia in the normal adult mouse brain
Lawson, L. J., Perry, V. H., Dri, P., & Gordon, S. (1990) · Neuroscience · doi:10.1016/0306-4522(90)90229-w · Cited by 2,045
Neuropathology of Parkinson's Disease
Forno, L. (1996) · Journal of Neuropathology and Experimental Neurology · doi:10.1097/00005072-199603000-00001 · Cited by 1,556
ETIOLOGY AND PATHOGENESIS OF PARKINSON'S DISEASE
Olanow, C. W., & Tatton, W. G. (1999) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.22.1.123 · Cited by 1,409
Cytotoxicity of microglia
Banati, R. B., Gehrmann, J., Schubert, P., & Kreutzberg, G. W. (1993) · Glia · doi:10.1002/glia.440070117 · Cited by 1,032
Regional Difference in Susceptibility to Lipopolysaccharide-Induced Neurotoxicity in the Rat Brain: Role of Microglia
Kim, W., Mohney, R. P., Wilson, B. C., Jeohn, G., Liu, B., & Hong, J. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-16-06309.2000 · Cited by 881
Suppressor of Cytokine Signaling 1 (SOCS-1) and SOCS-3 Cause Insulin Resistance through Inhibition of Tyrosine Phosphorylation of Insulin Receptor Substrate Proteins by Discrete Mechanisms
Ueki, K., Kondo, T., & Kahn, C. R. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.12.5434-5446.2004 · Cited by 686
Cyclooxygenase-2 is instrumental in Parkinson's disease neurodegeneration
Teismann, P., Tieu, K., Choi, D., Wu, D., Naini, A., Hunot, S., Vila, M., Jackson-Lewis, V. R., & Przedborski, S. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0837397100 · Cited by 671
Self-citation
Prevalence of Parkinsonian Signs and Associated Mortality in a Community Population of Older People
Bennett, D. A., Beckett, L. A., Murray, A. M., Shannon, K. M., Goetz, C. G., Pilgrim, D. M., & Evans, D. A. (1996) · New England Journal of Medicine · doi:10.1056/nejm199601113340202 · Cited by 659
Nonsteroidal Anti-inflammatory Drugs and the Risk of Parkinson Disease
Chen, H., Zhang, S. M., Hernán, M. Á., Schwarzschild, M. A., Willett, W. C., Colditz, G. A., Speizer, F. E., & Ascherio, A. (2003) · Archives of Neurology · doi:10.1001/archneur.60.8.1059 · Cited by 641
Microglia as effector cells in brain damage and repair: focus on prostanoids and nitric oxide
Minghetti, L. (1998) · Progress in Neurobiology · doi:10.1016/s0301-0082(97)00052-x · Cited by 562
Insulin, insulin-degrading enzyme and amyloid-β peptide in Alzheimer's disease: review and hypothesis
Qiu, W. Q., & Folstein, M. F. (2005) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.01.004 · Cited by 557
Oxidative mechanisms in nigral cell death in Parkinson's disease.
Jenner, P. G. (1998) · PubMed · doi:10.1002/mds.870131304 · Cited by 511
Distinct Role for Microglia in Rotenone-Induced Degeneration of Dopaminergic Neurons
Gao, H., Hong, J., Zhang, W., & Liu, B. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-03-00782.2002 · Cited by 439
Insulin receptors in the central nervous system: Localization, signalling mechanisms and functional aspects
UNGER, J., Livingston, J. H., & Moss, A. (1991) · Progress in Neurobiology · doi:10.1016/0301-0082(91)90015-s · Cited by 399
Lipopolysaccharide Intranigral Injection Induces Inflammatory Reaction and Damage in Nigrostriatal Dopaminergic System
Castaño, A., Herrera, A. J., Cano, J., & Machado, A. (1998) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1998.70041584.x · Cited by 393
The Single Intranigral Injection of LPS as a New Model for Studying the Selective Effects of Inflammatory Reactions on Dopaminergic System
Herrera, A. J., Castaño, A., Venero, J. L., Cano, J., & Machado, A. (2000) · Neurobiology of Disease · doi:10.1006/nbdi.2000.0289 · Cited by 392
Protection by pioglitazone in the MPTP model of Parkinson's disease correlates with IκBα induction and block of NFκB and iNOS activation
Dehmer, T., Heneka, M. T., Sastre, M., DICHGANS, J., & Schulz, J. B. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.02210.x · Cited by 387
Protective action of the peroxisome proliferator‐activated receptor‐γ agonist pioglitazone in a mouse model of Parkinson's disease
Breidert, T., Callebert, J., Heneka, M. T., Landreth, G. E., Launay, J., & Hirsch, É. C. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.00990.x · Cited by 381
Minocycline inhibits microglial activation and protects nigral cells after 6-hydroxydopamine injection into mouse striatum
He, Y., Appel, S. H., & Le, W. (2001) · Brain Research · doi:10.1016/s0006-8993(01)02681-6 · Cited by 350
The role of glial cells in Parkinsonʼs disease
Vila, M., Jackson-Lewis, V., Guégan, C., Chu Wu, D., Teismann, P., Choi, D.-K., Tieu, K., & Przedborski, S. (2001) · Current Opinion in Neurology · doi:10.1097/00019052-200108000-00009 · Cited by 326
Self-citation
Synaptic Mitochondria Are More Susceptible to Ca2+Overload than Nonsynaptic Mitochondria
Brown, M. R., Sullivan, P. G., & Geddes, J. W. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m510303200 · Cited by 301
Self-citation
Endotoxin-induced mitochondrial damage correlates with impaired respiratory activity
Crouser, E. D., JULIAN, M. W., Blaho, D. V., & Pfeiffer, D. R. (2002) · Critical Care Medicine · doi:10.1097/00003246-200202000-00002 · Cited by 277
Mitochondrial uncoupling protein‐2 protects the immature brain from excitotoxic neuronal death
Sullivan, P. G., Dubé, C. M., Dorenbos, K., Steward, O., & Baram, T. Z. (2003) · Annals of Neurology · doi:10.1002/ana.10543 · Cited by 253
Self-citation
Mitochondrial dysfunction in Parkinson's disease
Greenamyre, J. T., MacKenzie, G. M., Peng, T., & Stephans, S. E. (1999) · Biochemical Society Symposia · doi:10.1042/bss0660085 · Cited by 248
Involvement of inducible nitric oxide synthase in inflammation-induced dopaminergic neurodegeneration.
Iravani, M. M., Kashefi, K., Mander, P., Rose, S., & Jenner, P. (2002) · Neuroscience · doi:10.1016/s0306-4522(01)00562-0 · Cited by 247
Cyclooxygenase-2 mediates microglial activation and secondary dopaminergic cell death in the mouse MPTP model of Parkinson's disease
Vijitruth, R., Liu, M., Choi, D., Nguyen, X. V., Hunter, R. L., & Bing, G. (2006) · Journal of Neuroinflammation · doi:10.1186/1742-2094-3-6 · Cited by 236
Self-citation
Chapter 36: Astrocytes and Parkinson's disease
Forno, L. S., DeLanney, L. E., Irwin, I., Monte, D. A. D., & Langston, J. W. (1992) · Progress in brain research · doi:10.1016/s0079-6123(08)61770-7 · Cited by 230
Ciliary neurotrophic factor prevents degeneration of adult rat substantia nigra dopaminergic neurons in vivo.
Hagg, T., & Varon, S. S. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.13.6315 · Cited by 229
Up-regulation of inducible nitric oxide synthase in the substantia nigra by lipopolysaccharide causes microglial activation and neurodegeneration.
Arimoto, T., & Bing, G. (2003) · Neurobiology of Disease · doi:10.1016/s0969-9961(02)00017-7 · Cited by 202
Self-citation
Neuronal vulnerability in Parkinson’s disease
Hirsch, É. C., Faucheux, B. A., Damier, P., Prigent, A., & Agid, Y. (1997) · Journal of neural transmission. Supplementum · doi:10.1007/978-3-7091-6842-4_9 · Cited by 192
Pioglitazone: mechanism of action.
Smith, U. (2001) · PubMed · Cited by 171
Systemic Infusion of Naloxone Reduces Degeneration of Rat Substantia Nigral Dopaminergic Neurons Induced by Intranigral Injection of Lipopolysaccharide
Liu, B., Jiang, J., Wilson, B. C., Du, L., Yang, S., Wang, J., Wu, G.-C., Cao, X.-D., & Hong, J. (2000) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)38877-9 · Cited by 167
Activated glia induce neuron death via MAP kinase signaling pathways involving JNK and p38
Xie, Z., Smith, C. J., & Eldik, L. J. V. (2003) · Glia · doi:10.1002/glia.10314 · Cited by 164
Cyclooxygenase-2-deficient mice are resistant to 1-methyl-4-phenyl1, 2, 3, 6-tetrahydropyridine-induced damage of dopaminergic neurons in the substantia nigra
Feng, Z.-H., Wang, T.-G., Li, D.-D., Fung, P. C. W., Wilson, B. C., Liu, B., Ali, S. F., Langenbach, R. J., & Hong, J. (2002) · Neuroscience Letters · doi:10.1016/s0304-3940(02)00704-8 · Cited by 160
Loss of insulin receptor immunoreactivity from the substantia nigra pars compacta neurons in Parkinson's disease
Moroo, I., Yamada, T., Makino, H., Tooyama, I., McGeer, P., Mcgeer, E., & Hirayama, K. (1994) · Acta Neuropathologica · doi:10.1007/bf00313602 · Cited by 149
Interleukin-10 protects against inflammation-mediated degeneration of dopaminergic neurons in substantia nigra
Arimoto, T., Choi, D., Lü, X., Liu, M., Nguyen, X. V., Zheng, N., Stewart, C. A., Kim, H., & Bing, G. (2006) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2006.04.011 · Cited by 149
Self-citation
Insulin receptor mRNA in the substantia nigra in Parkinson's disease.
Takahashi, M., Yamada, T., Tooyama, I., Moroo, I., Kimura, H., Yamamoto, T., & Okada, H. (1996) · Neuroscience Letters · doi:10.1016/0304-3940(96)12357-0 · Cited by 131
Nitrogen disruption of synaptoneurosomes: an alternative method to isolate brain mitochondria
Brown, M. R., Sullivan, P. G., Dorenbos, K., Modafferi, E. F., Geddes, J. W., & Steward, O. (2004) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2004.02.028 · Cited by 114
Self-citation
Postencephalitic parkinsonism – a review
Casals, J., Elizan, T. S., & Yahr, M. D. (1998) · Journal of Neural Transmission · doi:10.1007/s007020050086 · Cited by 108
HIV-1 protein Tat potentiation of methamphetamine-induced decreases in evoked overflow of dopamine in the striatum of the rat
Cass, W. A., Harned, M. E., Peters, L. E., Nath, A., & Maragos, W. F. (2003) · Brain Research · doi:10.1016/s0006-8993(03)03122-6 · Cited by 100
Self-citation
Naloxone prevents microglia-induced degeneration of dopaminergic substantia nigra neurons in adult rats
Lu, X., Bing, G., & Hagg, T. (2000) · Neuroscience · doi:10.1016/s0306-4522(00)00033-6 · Cited by 89
Self-citation
Inhibitory action of minocycline on lipopolysaccharide-lnduced release of nitric oxide and prostaglandin E2 in BV2 microglial cells
Kim, S., Kong, P., Kim, B.-S., Sheen, D., Nam, S.-Y., & Chun, W. (2004) · Archives of Pharmacal Research · doi:10.1007/bf02980066 · Cited by 81
Intrapallidal lipopolysaccharide injection increases iron and ferritin levels in glia of the rat substantia nigra and induces locomotor deficits
Zhang, J., Stanton, D. M., Nguyen, X. V., Liu, M., Zhang, Z., Gash, D. M., & Bing, G. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.06.049 · Cited by 64
Self-citation
ULTRASTRUCTURAL CHANGES IN SKELETAL MUSCLE MITOCHONDRIA IN GRAM-NEGATIVE SEPSIS
Welty‐Wolf, K. E., Simonson, G., Huang, Y.-C. T., Fracica, P. J., Patterson, J., & Piantadosi, C. A. (1996) · Shock · doi:10.1097/00024382-199605000-00011 · Cited by 52
LPS-induced apoptosis is dependent upon mitochondrial dysfunction
Kuwabara, T., & Imajoh‐Ohmi, S. (2004) · APOPTOSIS · doi:10.1023/b:appt.0000031453.90821.6a · Cited by 41
Behavior, neurochemistry and histology after intranigral lipopolysaccharide injection
Hsieh, P. F., Chia, L., Ni, D.-R., Cheng, L.-J., Ho, Y.-P., Tzeng, S., Chang, M.-H., & Hong, J. (2002) · Neuroreport · doi:10.1097/00001756-200203040-00006 · Cited by 36
Nonsteroidal Anti-inflammatory Drugs Protect Against Parkinson Neurodegeneration
Schiess, M. C. (2003) · Archives of Neurology · doi:10.1001/archneur.60.8.1043 · Cited by 34
Parkinson's disease: Neurodegenerative mechanisms and neuroprotective interventions—report of a workshop
Fahn, S., Clarence‐Smith, K., & Chase, T. N. (1998) · Movement Disorders · doi:10.1002/mds.870130502 · Cited by 28
Injections of an opioid antagonist into the locus coeruleus and periaqueductal gray but not the amygdala precipitates morphine withdrawal in the 7‐day‐old rat
Jones, K. L., & Barr, G. A. (2000) · Synapse · doi:10.1002/1098-2396(200102)39:2 · Cited by 11
Microglia mediated dopaminergic cell death in the substantia nigra: A new animal model for Parkinson's disease
Floyd, R. A. (1998) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(98)90128-9 · Cited by 10
Clinical neurovirology
Davis, L. E. (2004) · Annals of Neurology · doi:10.1002/ana.20132 · Cited by 10
[Diabetes mellitus in parkinsonism patients].
Chalmanov, V., & Vŭrbanova, M. (1987) · PubMed · Cited by 9
Untitled work
(2000) · doi:10.1002/1531-8249(200011)48:5
Self-citation

Research works printed but not linked: 2

Niehaus I., 2004, New Trends in Alzheimer and Parkinson Related Disorders, 36
10.1002/1098-2396(200102)39:2<167::AID-SYN8>3.0.CO;2-U · DOI

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Glass, C. K., Saijo, K., Winner, B., Marchetto, M. C., & Gage, F. H. (2010) · Cell · doi:10.1016/j.cell.2010.02.016 · Cited by 3,580
Neuroinflammation in Parkinson’s disease: A target for neuroprotection?
Hirsch, E. C., & Hunot, S. (2009) · The Lancet Neurology · doi:10.1016/s1474-4422(09)70062-6 · Cited by 1,984
Mechanistic explanations how cell-mediated immune activation, inflammation and oxidative and nitrosative stress pathways and their sequels and concomitants play a role in the pathophysiology of unipolar depression
Leonard, B., & Maes, M. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2011.12.005 · Cited by 805
Basic mechanisms of neurodegeneration: a critical update
Jellinger, K. A. (2010) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2010.01010.x · Cited by 640
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Authors: Hunter, R. L., Dragicevic, N., Seifert, K., Choi, D. Y., Liu, M., Kim, H., Cass, W. A., Sullivan, P. G., & Bing, G.
Affiliations: University of Kentucky (US)
Kangwon National University (KR)
Corresponding author: Bing, Guoying
ORCID: Liu, Mei
Kim, Hyoung‐Chun
Cass, Wayne A.
Sullivan, Patrick G.
Bing, Guoying
Venue: Journal of Neurochemistry
Publisher: Wiley
Published: 2006-11-20
Volume: 100
Issue: 5
Pages: 1375-1386
ISSN: 0022-3042 (ISSN-L)
1471-4159
DOI: 10.1111/j.1471-4159.2006.04327.x
OpenAlex: W1629697287
Cited by: 322
References: 56
Citations by year: 2026: 7 · 2025: 7 · 2024: 11 · 2023: 13 · 2022: 18 · 2021: 21 · 2020: 13 · 2019: 20 · 2018: 7 · 2017: 20 · 2016: 23 · 2015: 17 · 2014: 17 · 2013: 17 · 2012: 26
FWCI: 11.34
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Journal of Neurochemistry (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute on Aging (AG017963, R01AG017963)
National Institute of Neurological Disorders and Stroke (NS 044157, R01NS048191, NS 046426, NS 048191, R01NS044157, R21NS046426)
Topics: Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Receptors and Signaling
Keywords: Parkinson's disease, neuroinflammation, dopaminergic neuron loss, substantia nigra, mitochondrial dysfunction, oxidative stress, lipopolysaccharide, celecoxib, pioglitazone, COX-2 inhibition, PPARγ agonism, neuroprotection, microglial activation, striatal dopamine, MPTP model
MeSH terms: Celecoxib, Pioglitazone, Animals, Corpus Striatum, Dopamine, Inflammation, Lipopolysaccharides, Male, Mitochondria, Nerve Degeneration, Neurons, Pyrazoles, Receptor, Insulin, Substantia Nigra, Sulfonamides, Cell Death, Rats, Sprague-Dawley, Microglia, Thiazolidinediones, PPAR gamma, Rats, Cyclooxygenase 2 Inhibitors, In Vitro Techniques

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Inflammation induces mitochondrial dysfunction and dopaminergic neurodegeneration in the nigrostriatal system

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