The DOI matches its Crossref record; 74 of the 74 references it cites were found in a registry or an index.
Curcumin suppresses growth and chemoresistance of human glioblastoma cells via AP‐1 and NFκB transcription factors
Abstract
Malignant gliomas are a debilitating class of brain tumors that are resistant to radiation and chemotherapeutic drugs, contributing to the poor prognosis associated with these tumors. Over‐expression of transcription factors such as NFκB and AP‐1 contribute to the enhanced glioma survival, radioresistance, and chemoresistance. Curcumin, which may inhibit these pathways, was therefore investigated for a potential therapeutic role in glioma. The effect of curcumin on glioma survival was investigated in human (T98G, U87MG, and T67) and rat (C6) glioma cell lines. The ability of curcumin to overcome glioma cell radioresistance and chemoresistance was also explored. Curcumin reduced cell survival in a p53‐ and caspase‐independent manner, an effect correlated with the inhibition of AP‐1 and NFκB signaling pathways via prevention of constitutive JNK and Akt activation. Curcumin‐sensitized glioma cells to several clinically utilized chemotherapeutic agents (cisplatin, etoposide, camptothecin, and doxorubicin) and radiation, effects correlated with reduced expression of bcl‐2 and IAP family members as well as DNA repair enzymes (MGMT, DNA‐PK, Ku70, Ku80, and ERCC‐1). These findings support a role for curcumin as an adjunct to traditional chemotherapy and radiation in the treatment of brain cancer.
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Cancer Prevention With Natural Compounds
Gullett, N. P., Ruhul Amin, A. R. M., Bayraktar, S., Pezzuto, J. M., Shin, D. M., Khuri, F. R., Aggarwal, B. B., Surh, Y.-J., & Kucuk, O. (2010) · Seminars in Oncology · doi:10.1053/j.seminoncol.2010.06.014 · Cited by 485
A Review of Therapeutic Effects of Curcumin
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Glioblastoma Therapy: Past, Present and Future
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Metadata
- Authors
- Dhandapani, K. M., Mahesh, V. B., & Brann, D. W.
- Venue
- Journal of Neurochemistry
- Publisher
- Wiley
- Published
- 2007-04-05
- Volume
- 102
- Issue
- 2
- Pages
- 522-538
- ISSN
- 0022-3042 (ISSN-L)
- 1471-4159
- OpenAlex
- W1520204166
- Cited by
- 298
- References
- 74
- FWCI
- 7.99
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Curcumin suppresses growth and chemoresistance of human glioblastoma cells via AP‐1 and NFκB transcription factors. https://app.cochat.ai/papers/10.1111/j.1471-4159.2007.04633.x
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- Dhandapani, K. M., Mahesh, V. B., & Brann, D. W. (2007). Curcumin suppresses growth and chemoresistance of human glioblastoma cells via AP‐1 and NFκB transcription factors. Journal of Neurochemistry. https://doi.org/10.1111/j.1471-4159.2007.04633.x
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