The DOI matches its Crossref record; 178 of the 178 references it cites were found in a registry or an index.
Perspectives for Cancer Prevention With Natural Compounds
Open accessAbstract
Cancer is the second leading cause of death in the United States. Despite the estimated 565,650 deaths in 2008 of Americans as a result of cancer, it is mostly a preventable disease. Simply by modification of diet, maintenance of optimum body weight, and regular physical activity, 30% to 40% of all instances of cancer could be prevented. Modification of diet alone by increasing vegetable and fruit intake could prevent 20% or more of all cases of cancer and may potentially prevent approximately 200,000 cancer-related deaths annually. Because of their safety, low toxicity, antioxidant properties, and general acceptance as dietary supplements, fruits, vegetables, and other dietary elements (phytochemicals and minerals) are being investigated for the prevention of cancer. Extensive research over the past several decades has identified numerous dietary and botanical natural compounds that have chemopreventive potential. In this review, we discuss promising natural chemopreventive compounds, their molecular targets, and their mechanisms, which may help the further design and conduct of preclinical and clinical trials.
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5 retracted
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Metadata
- Authors
- Amin, A. R. M. R., Kucuk, O., Khuri, F. R., & Shin, D. M.
- Venue
- Journal of Clinical Oncology
- Published
- 2009-06-01
- Volume
- 27
- Issue
- 16
- Pages
- 2712-2725
- ISSN
- 0732-183X (ISSN-L)
- 1527-7755
- OpenAlex
- W2012780861
- Cited by
- 572
- References
- 178
- FWCI
- 17.75
- Type
- journal article
- Language
- en
- Open access
- green
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- Amin, A. R. M. R., Kucuk, O., Khuri, F. R., & Shin, D. M. (2009). Perspectives for Cancer Prevention With Natural Compounds. Journal of Clinical Oncology. https://doi.org/10.1200/jco.2008.20.6235
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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