The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Long‐lasting depression‐like behavior and epigenetic changes of BDNF gene expression induced by perinatal exposure to methylmercury
Abstract
Substantial evidence indicates that predisposition to diseases can be acquired during early stages of development and interactions between environmental and genetic factors may be implicated in the onset of many pathological conditions. Data collected over several decades have shown that chemicals are among the relevant factors that can endanger CNS. We previously showed that perinatal exposure to methylmercury (MeHg) causes persistent changes in learning and motivational behavior in mice. In this study, we report that the depression‐like behavior in MeHg‐exposed male mice is reversed by chronic treatment with the antidepressant fluoxetine. Behavioral alterations are associated with a decrease in brain‐derived neurotrophic factor (BDNF) mRNA in the hippocampal dentate gyrus and fluoxetine treatment restores BDNF mRNA expression. We also show that MeHg‐exposure induces long‐lasting repressive state of the chromatin structure at the BDNF promoter region, in particular DNA hypermethylation, an increase in histone H3‐K27 tri‐methylation and a decrease in H3 acetylation at the promoter IV. While fluoxetine treatment does not alter hypermethylation of H3‐K27, it significantly up‐regulates H3 acetylation at the BDNF promoter IV in MeHg‐exposed mice. Our study shows that developmental exposure to low levels of MeHg predisposes mice to depression and induces epigenetic suppression of BDNF gene expression in the hippocampus.
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Cites
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Sustained hippocampal chromatin regulation in a mouse model of depression and antidepressant action
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Assessing antidepressant activity in rodents: recent developments and future needs
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DNA Methylation-Related Chromatin Remodeling in Activity-Dependent Bdnf Gene Regulation
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Epigenetic regulation in psychiatric disorders
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Derepression of BDNF Transcription Involves Calcium-Dependent Phosphorylation of MeCP2
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Regulation of histone acetylation during memory formation in the hippocampus
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Cited by
DNA methylation of BDNF as a biomarker of early-life adversity
Kundakovic, M., Gudsnuk, K., Herbstman, J. B., Tang, D., Perera, F. P., & Champagne, F. A. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1408355111 · Cited by 426
Epigenetics of the depressed brain: role of histone acetylation and methylation
Sun, H., Kennedy, P. J., & Nestler, E. J. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2012.73 · Cited by 413
Increased BDNF Promoter Methylation in the Wernicke Area of Suicide Subjects
Keller, S., Sarchiapone, M., Zarrilli, F., Videtič, A., Ferraro, A., Carli, V., Sacchetti, S., Lembo, F., Angiolillo, A., Jovanovic, N., et al. (2010) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2010.9 · Cited by 379
Epigenetic Regulation of the BDNF Gene: Implications for Psychiatric Disorders
Boulle, F., van den Hove, D. L. A., Jakob, S. B., Rutten, B. P., Hamon, M., van Os, J., Lesch, K.-P., Lanfumey, L., Steinbusch, H. W., & Kenis, G. (2012) · Molecular Psychiatry · doi:10.1038/mp.2011.107 · Cited by 282
Epigenetic influence of social experiences across the lifespan
Champagne, F. A. (2010) · Developmental Psychobiology · doi:10.1002/dev.20436 · Cited by 273
Metadata
- Authors
- Onishchenko, N., Karpova, N., Sabri, F., Castrén, E., & Ceccatelli, S.
- Venue
- Journal of Neurochemistry
- Publisher
- Wiley
- Published
- 2008-07-15
- Volume
- 106
- Issue
- 3
- Pages
- 1378-1387
- ISSN
- 0022-3042 (ISSN-L)
- 1471-4159
- OpenAlex
- W2094839705
- Cited by
- 263
- References
- 11
- FWCI
- 8.20
- Type
- journal article
- Language
- en
- Open access
- closed
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- Onishchenko, N., Karpova, N., Sabri, F., Castrén, E., & Ceccatelli, S. (2008). Long‐lasting depression‐like behavior and epigenetic changes of BDNF gene expression induced by perinatal exposure to methylmercury. Journal of Neurochemistry. https://doi.org/10.1111/j.1471-4159.2008.05484.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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