Epigenetic influence of social experiences across the lifespan
Abstract
The critical role of social interactions in driving phenotypic variation has long been inferred from the association between early social deprivation and adverse neurodevelopmental outcomes. Recent evidence has implicated molecular pathways involved in the regulation of gene expression as one possible route through which these long-term outcomes are achieved. These epigenetic effects, though not exclusive to social experiences, may be a mechanism through which the quality of the social environment becomes embedded at a biological level. Moreover, there is increasing evidence for the transgenerational impact of these early experiences mediated through changes in social and reproductive behavior exhibited in adulthood. In this review, recent studies which highlight the epigenetic effects of parent-offspring, peer and adult social interactions both with and across generations will be discussed and the implications of this research for understanding the developmental origins of individual differences in brain and behavior will be explored.
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Experience in childhood influences long-term developmental paths.
“Experience in childhood has shown to influence long-term developmental paths (Champagne 2010).”
From Developmental Changes in Organization of Structural Brain Networks (2013) · cites this paper as Champagne 2010
Parenting styles in humans are likely to be transmitted across generations (Belsky, 2005; Champagne, 2010).
“Parenting styles in humans are likely to be transmitted across generations (Belsky, 2005; Champagne, 2010)”
From Approaching the biology of human parental attachment: Brain imaging, oxytocin and coordinated assessments of mothers and fathers (2014) · cites this paper as Champagne, 2010
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The effect of interspecific oocytes on demethylation of sperm DNA
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Methyl-CpG binding proteins in the nervous system
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Protamine–histone replacement and DNA replication in the male mouse pronucleus
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Temporal patterns of embryonic gene expression and their dependence on oogenetic factors
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Transgenerational effects of impaired maternal care on behaviour of offspring and grandoffspring
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Social separation and reunion affects immune system in juvenile rhesus monkeys
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Kundakovic, M., Gudsnuk, K., Franks, B., Madrid, J., Miller, R. L., Perera, F. P., & Champagne, F. A. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1214056110 · Cited by 490 · see citing works
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“…mechanisms at play in social affective processing, learning, and bonding (Insel and Young, 2001; Meyer-Lindenberg, 2008; Heinrichs et al., 2009; Champagne, 2010; Insel, 2010; Bakermans-Kranenburg and van Ijzendoorn, 2011; MacDonald and MacDonald, 2011), as well as those implicated in disorders…”
BackgroundDevelopmental Changes in Organization of Structural Brain Networks
Khundrakpam, B. S., Reid, A., Brauer, J., Carbonell, F., Lewis, J., Ameis, S., Karama, S., Lee, J., Chen, Z., Das, S., et al. (2013) · Cerebral Cortex · doi:10.1093/cercor/bhs187 · Cited by 234 · see citing works
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Longitudinal associations between glucocorticoid receptor methylation and late-life depression
Kang, H.-J., Bae, K.-Y., Kim, S.-W., Shin, I.-S., Kim, H.-R., Shin, M.-G., Yoon, J.-S., & Kim, J.-M. (2018) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2018.02.004 · Cited by 30 · see citing works
- Authors
- Champagne, F. A.
- Affiliations
- Columbia University (US)
- Corresponding author
- Champagne, Frances A.
- Venue
- Developmental Psychobiology
- Publisher
- Wiley
- Published
- 2010-04-16
- Volume
- 52
- Issue
- 4
- Pages
- 299-311
- ISSN
- 0012-1630 (ISSN-L)
- 1098-2302
- OpenAlex
- W2103953926
- Cited by
- 273
- References
- 117
- Citations by year
- 2026: 6 · 2025: 8 · 2024: 5 · 2023: 9 · 2022: 8 · 2021: 13 · 2020: 13 · 2019: 15 · 2018: 30 · 2017: 18 · 2016: 24 · 2015: 30 · 2014: 23 · 2013: 25 · 2012: 26
- FWCI
- 1.96
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Developmental Psychobiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (1dp2od001674-01)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Animal Behavior and Reproduction
- Keywords
- epigenetics, social experience, social deprivation, brain development, gene expression regulation, transgenerational effects, parent-offspring interactions, peer interaction, lifespan development
- MeSH terms
- Animals, Humans, Interpersonal Relations, Social Behavior, Social Environment, Stress, Psychological, Epigenesis, Genetic
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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