Cited by 273Epigenetics and DNA MethylationNeuroendocrine regulation and behaviorAnimal Behavior and Reproduction

Epigenetic influence of social experiences across the lifespan

Champagne, Frances A.·2010·Developmental Psychobiology

Abstract

The critical role of social interactions in driving phenotypic variation has long been inferred from the association between early social deprivation and adverse neurodevelopmental outcomes. Recent evidence has implicated molecular pathways involved in the regulation of gene expression as one possible route through which these long-term outcomes are achieved. These epigenetic effects, though not exclusive to social experiences, may be a mechanism through which the quality of the social environment becomes embedded at a biological level. Moreover, there is increasing evidence for the transgenerational impact of these early experiences mediated through changes in social and reproductive behavior exhibited in adulthood. In this review, recent studies which highlight the epigenetic effects of parent-offspring, peer and adult social interactions both with and across generations will be discussed and the implications of this research for understanding the developmental origins of individual differences in brain and behavior will be explored.

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Crossref · 10.1002/dev.20436

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Authors
Champagne, F. A.
Affiliations
Columbia University (US)
Corresponding author
Champagne, Frances A.
Venue
Developmental Psychobiology
Publisher
Wiley
Published
2010-04-16
Volume
52
Issue
4
Pages
299-311
ISSN
  • 0012-1630 (ISSN-L)
  • 1098-2302
OpenAlex
W2103953926
Cited by
273
References
117
Citations by year
2026: 6 · 2025: 8 · 2024: 5 · 2023: 9 · 2022: 8 · 2021: 13 · 2020: 13 · 2019: 15 · 2018: 30 · 2017: 18 · 2016: 24 · 2015: 30 · 2014: 23 · 2013: 25 · 2012: 26
FWCI
1.96
Type
journal article
Language
en
Open access
closed
Locations
  • Developmental Psychobiology (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institutes of Health (1dp2od001674-01)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
  • Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
  • Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Animal Behavior and Reproduction
Keywords
epigenetics, social experience, social deprivation, brain development, gene expression regulation, transgenerational effects, parent-offspring interactions, peer interaction, lifespan development
MeSH terms
Animals, Humans, Interpersonal Relations, Social Behavior, Social Environment, Stress, Psychological, Epigenesis, Genetic

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