The DOI matches its Crossref record; 163 of the 163 references it cites were found in a registry or an index.
Inflammation mediates varying effects in neurogenesis: relevance to the pathogenesis of brain injury and neurodegenerative disorders
Open accessAbstract
Brain inflammation is a complex cellular and molecular response to stress, injury or infection of the CNS in attempt to defend against insults, clear dead and damaged neurons and return the CNS to a normal state. Inflammation in the CNS is driven by the activation of resident microglia, astrocytes and infiltrating peripheral macrophages, which release a plethora of anti‐ and pro‐inflammatory cytokines, chemokines, neurotransmitters and reactive oxygen species. This inflammatory state inadvertently causes further bystander damage to neurons and produces both detrimental and favorable conditions for neurogenesis. Inflammatory factors have varying effects on neural progenitor cell proliferation, migration, differentiation, survival and incorporation of newly born neurons into the CNS circuitry. The unique profile of inflammatory factors, which depends on the severity of inflammation, can have varying consequences on neurogenesis. Inflammatory factors released during mild acute inflammation usually stimulate neurogenesis; where as the factors released by uncontrolled inflammation create an environment that is detrimental to neurogenesis. This review will provide a summary of current progress in this emerging field and examine the potential mechanisms through which inflammation affects neurogenesis during neurological complications.
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Cites
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Cited by
The far-reaching scope of neuroinflammation after traumatic brain injury
Simon, D. W., McGeachy, M. J., Bayır, H., Clark, R. S. B., Loane, D. J., & Kochanek, P. M. (2017) · Nature Reviews Neurology · doi:10.1038/nrneurol.2017.13 · Cited by 1,190
Garwood, C. J., Pooler, A. M., Atherton, J., Hanger, D. P., & Noble, W. (2011) · Cell Death & Disease · doi:10.1038/cddis.2011.50 · Cited by 379
The role of inflammatory cytokines as key modulators of neurogenesis
Borsini, A., Zunszain, P. A., Thuret, S., & Pariante, C. M. (2015) · Trends in Neurosciences · doi:10.1016/j.tins.2014.12.006 · Cited by 381
Sankowski, R., Mader, S., & Valdés-Ferrer, S. I. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00028 · Cited by 351
Neuroplastic changes in depression: A role for the immune system
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Metadata
- Authors
- Whitney, N. P., Eidem, T. M., Peng, H., Huang, Y., & Zheng, J. C.
- Venue
- Journal of Neurochemistry
- Publisher
- Wiley
- Published
- 2009-02-23
- Volume
- 108
- Issue
- 6
- Pages
- 1343-1359
- ISSN
- 0022-3042 (ISSN-L)
- 1471-4159
- OpenAlex
- W2083268412
- Cited by
- 373
- References
- 163
- FWCI
- 10.48
- Type
- journal article
- Language
- en
- Open access
- green
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- Whitney, N. P., Eidem, T. M., Peng, H., Huang, Y., & Zheng, J. C. (2009). Inflammation mediates varying effects in neurogenesis: relevance to the pathogenesis of brain injury and neurodegenerative disorders. Journal of Neurochemistry. https://doi.org/10.1111/j.1471-4159.2009.05886.x
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
