The role of inflammatory cytokines as key modulators of neurogenesis
Open accessAbstract
Neurogenesis is an important process in the regulation of brain function and behaviour, highly active in early development and continuing throughout life. Recent studies have shown that neurogenesis is modulated by inflammatory cytokines in response to an activated immune system. To disentangle the effects of the different cytokines on neurogenesis, here we summarise and discuss in vitro studies on individual cytokines. We show that inflammatory cytokines have both a positive and negative role on proliferation and neuronal differentiation. Hence, this strengthens the notion that inflammation is involved in molecular and cellular mechanisms associated with complex cognitive processes and, therefore, that alterations in brain-immune communication are relevant to the development of neuropsychiatric disorders.
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In response to damage and disease, microglia transition to a proinflammatory state where they release cytokines such as IL-1β, IL-6, and TNF-α, which can impair new neuron production and cell survival.
“In response to damage and disease, microglia transition to a proinflammatory state where they release cytokines, such as IL-1β, 1L-6, and TNF-α, which can impair new neuron production and cell survival (reviewed in Borsini et al., 2015) (Figure 2A).”
From Adult neurogenesis, glia, and the extracellular matrix (2019) · cites this paper as Borsini et al., 2015
Microglia participate in stem cell proliferation and survival through their release of trophic factors and anti-inflammatory cytokines.
“Microglia participate in stem cell proliferation and survival through their release of important trophic factors and anti-inflammatory cytokines (Battista et al., 2006; Borsini et al., 2015).”
From Adult neurogenesis, glia, and the extracellular matrix (2019) · cites this paper as Borsini et al., 2015
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From inflammation to sickness and depression: when the immune system subjugates the brain
Dantzer, R., O'Connor, J. C., Freund, G. G., Johnson, R. W., & Kelley, K. W. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2297 · Cited by 7,395 · see citing works
Astrocytes: Biology and pathology
Sofroniew, M. V., & Vinters, H. V. (2010) · Acta Neuropathologica · doi:10.1007/s00401-009-0619-8 · Cited by 5,196 · see citing works
A Meta-Analysis of Cytokines in Major Depression
Dowlati, Y., Herrmann, N., Swardfager, W., Liu, H., Sham, L., Reim, E. K., & Lanctôt, K. L. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.09.033 · Cited by 4,729 · see citing works
Interferon-γ: an overview of signals, mechanisms and functions
Schroder, K., Hertzog, P. J., Ravasi, T., & Hume, D. A. (2004) · Journal of Leukocyte Biology · doi:10.1189/jlb.0603252 · Cited by 4,120 · see citing works
Gage, F. H. (2000) · Science · doi:10.1126/science.287.5457.1433 · Cited by 3,949 · see citing works
Mechanisms and Functional Implications of Adult Neurogenesis
Zhao, C., Deng, W., & Gage, F. H. (2008) · Cell · doi:10.1016/j.cell.2008.01.033 · Cited by 3,007 · see citing works
Inflammatory Blockade Restores Adult Hippocampal Neurogenesis
Monje, M. L., Toda, H., & Palmer, T. D. (2003) · Science · doi:10.1126/science.1088417 · Cited by 2,426 · see citing works
New neurons and new memories: how does adult hippocampal neurogenesis affect learning and memory?
Deng, W., Aimone, J. B., & Gage, F. H. (2010) · Nature reviews. Neuroscience · doi:10.1038/nrn2822 · Cited by 2,120 · see citing works
Dinarello, C. A. (2000) · CHEST Journal · doi:10.1378/chest.118.2.503 · Cited by 2,047 · see citing works
Dynamics of hippocampal neurogenesis in adult humans
Spalding, K. L., Bergmann, O., Alkass, K., Bernard, S., Salehpour, M., Huttner, H. B., Boström, E., Westerlund, I., Vial, C., Buchholz, B. A., et al. (2013) · Cell · doi:10.1016/j.cell.2013.05.002 · Cited by 1,841 · see citing works
Astrocytes give rise to new neurons in the adult mammalian hippocampus
Seri, B., Garcı́a-Verdugo, J. M., McEwen, B. S., & Alvarez-Buylla, A. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-18-07153.2001 · Cited by 1,495 · see citing works
Transient expression of doublecortin during adult neurogenesis
Brown, J. P., Couillard‐Després, S., Cooper‐Kuhn, C. M., Winkler, J., Aigner, L., & Kuhn, H. G. (2003) · The Journal of Comparative Neurology · doi:10.1002/cne.10874 · Cited by 1,494 · see citing works
SOX2 Functions to Maintain Neural Progenitor Identity
Graham, V., Khudyakov, J. I., Ellis, P., & Pevny, L. (2003) · Neuron · doi:10.1016/s0896-6273(03)00497-5 · Cited by 1,344 · see citing works
Garcia, A. D. R., Doan, N., Imura, T., Bush, T. G., & Sofroniew, M. V. (2004) · Nature Neuroscience · doi:10.1038/nn1340 · Cited by 990 · see citing works
Increasing p16INK4a expression decreases forebrain progenitors and neurogenesis during ageing
Molofsky, A. V., Slutsky, S. G., Joseph, N. M., He, S., Pardal, R., Krishnamurthy, J., Sharpless, N. E., & Morrison, S. J. (2006) · Nature · doi:10.1038/nature05091 · Cited by 972 · cited 1× · see citing works
“The ability of stem cells to self-renew and then differentiate into specific cell subtypes has been demonstrated both in vitro [2] and, more recently, in vivo [3].”
Doublecortin expression levels in adult brain reflect neurogenesis
Couillard‐Després, S., Winner, B., Schaubeck, S., Aigner, R., Vroemen, M., Weidner, N., Bogdahn, U., Winkler, J., Kuhn, H. G., & Aigner, L. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03813.x · Cited by 967 · see citing works
Neurogenesis in the striatum of the adult human brain
Ernst, A., Alkass, K., Bernard, S., Salehpour, M., Perl, S., Tisdale, J., Possnert, G., Druid, H., & Frisén, J. (2014) · Cell · doi:10.1016/j.cell.2014.01.044 · Cited by 937 · see citing works
Butovsky, O., Ziv, Y., Schwartz, A., Landa, G., Talpalar, A. E., Pluchino, S., Martino, G., & Schwartz, M. (2006) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2005.10.006 · Cited by 923 · see citing works
IL-1β is an essential mediator of the antineurogenic and anhedonic effects of stress
Koo, J. W., & Duman, R. S. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0708092105 · Cited by 862 · see citing works
Goshen, I., Kreisel, T., Ben-Menachem-Zidon, O., Licht, T., Weidenfeld, J., Ben-Hur, T., & Yirmiya, R. (2008) · Molecular Psychiatry · doi:10.1038/sj.mp.4002055 · Cited by 762 · see citing works
Evidence for a cytokine model of cognitive function
McAfoose, J., & Baune, B. T. (2009) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2008.10.005 · Cited by 760 · see citing works
The therapeutic potential of neural stem cells
Martino, G., & Pluchino, S. (2006) · Nature reviews. Neuroscience · doi:10.1038/nrn1908 · Cited by 738 · see citing works
Antidepressants increase neural progenitor cells in the human hippocampus
Boldrini, M., Underwood, M. D., Hen, R., Rosoklija, G. B., Dwork, A. J., John Mann, J., & Arango, V. (2009) · Neuropsychopharmacology · doi:10.1038/npp.2009.75 · Cited by 686 · see citing works
Cheng, B., Christakos, S., & Mattson, M. P. (1994) · Neuron · doi:10.1016/0896-6273(94)90159-7 · Cited by 660 · see citing works
Cytokines and cognition–the case for a head-to-toe inflammatory paradigm.
Wilson, C. J., Finch, C. E., & Cohen, H. J. (2002) · Journal of the American Geriatrics Society · doi:10.1046/j.1532-5415.2002.50619.x · Cited by 637 · see citing works
Functional significance of adult neurogenesis
Kempermann, G., Wiskott, L., & Gage, F. H. (2004) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2004.03.001 · Cited by 630 · see citing works
Interleukin-1 Expression in Different Plaque Types in Alzheimerʼs Disease
Griffin, W. S. T., Sheng, J. G., Roberts, G. W., & Mrak, R. E. (1995) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199503000-00014 · Cited by 546 · see citing works
“Inflammatory” Cytokines: Neuromodulators in Normal Brain?
Vitkovic, L., Bockaert, J., & Jacque, C. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.740457.x · Cited by 506 · see citing works
Biebl, M., Cooper, C., Winkler, J., & Kuhn, H. G. (2000) · Neuroscience Letters · doi:10.1016/s0304-3940(00)01368-9 · Cited by 504 · see citing works
Microglia Enhance Neurogenesis and Oligodendrogenesis in the Early Postnatal Subventricular Zone
Shigemoto‐Mogami, Y., Hoshikawa, K., Goldman, J. E., Sekino, Y., & Sato, K. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.1619-13.2014 · Cited by 499 · see citing works
Antidepressants increase human hippocampal neurogenesis by activating the glucocorticoid receptor
Anacker, C., Zunszain, P. A., Cattaneo, A., Carvalho, L. A., Garabedian, M. J., Thuret, S., Price, J., & Pariante, C. M. (2011) · Molecular Psychiatry · doi:10.1038/mp.2011.26 · Cited by 435 · see citing works
Doublecortin expression in the adult rat telencephalon
Nácher, J., Crespo, C., & McEwen, B. S. (2001) · European Journal of Neuroscience · doi:10.1046/j.0953-816x.2001.01683.x · Cited by 424 · see citing works
Interferons and viral infections
Fensterl, V., & Sen, G. C. (2009) · BioFactors · doi:10.1002/biof.6 · Cited by 396 · see citing works
Interleukin-1β: A New Regulator of the Kynurenine Pathway Affecting Human Hippocampal Neurogenesis
Zunszain, P. A., Anacker, C., Cattaneo, A., Choudhury, S., Musaelyan, K., Myint, A. M., Thuret, S., Price, J., & Pariante, C. M. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2011.277 · Cited by 388 · see citing works
Self-citationWhitney, N. P., Eidem, T. M., Peng, H., Huang, Y., & Zheng, J. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.05886.x · Cited by 371 · see citing works
Butovsky, O., Talpalar, A. E., Ben‐Yaakov, K., & Schwartz, M. (2005) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2005.03.005 · Cited by 368 · see citing works
Evolutionary divergence and functions of the human interleukin (IL) gene family
Brocker, C., Thompson, D., Matsumoto, A., Nebert, D. W., & Vasiliou, V. (2010) · Human Genomics · doi:10.1186/1479-7364-5-1-30 · Cited by 368 · see citing works
Interleukin-1, neuroinflammation, and Alzheimer's disease
Mrak, R. E. (2001) · Neurobiology of Aging · doi:10.1016/s0197-4580(01)00287-1 · Cited by 356 · see citing works
Nestin structure and predicted function in cellular cytoskeletal organisation.
Michalczyk, K., & Ziman, M. R. (2005) · PubMed · doi:10.14670/hh-20.665 · Cited by 334 · see citing works
Nakanishi, M., Niidome, T., Matsuda, S., Akaike, A., Kihara, T., & Sugimoto, H. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05309.x · Cited by 324 · see citing works
Neumann, H., Schweigreiter, R., Yamashita, T., Rosenkranz, K., Wekerle, H., & Barde, Y. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-03-00854.2002 · Cited by 323 · see citing works
Chemokines Regulate the Migration of Neural Progenitors to Sites of Neuroinflammation
Belmadani, A. A., Tran, P. B., Ren, D., & Miller, R. J. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.0156-06.2006 · Cited by 322 · see citing works
Zunszain, P. A., Hepgul, N., & Pariante, C. M. (2012) · Current topics in behavioral neurosciences · doi:10.1007/7854_2012_211 · Cited by 317 · see citing works
The bHLH Gene<i>Hes1</i>as a Repressor of the Neuronal Commitment of CNS Stem Cells
Nakamura, Y., Sakakibara, S.-I., Miyata, T., Ogawa, M., Shimazaki, T., Weiss, S., Kageyama, R., & Okano, H. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-01-00283.2000 · Cited by 316 · cited 2× · see citing works
“Indeed, IL-6 and LIF receptor complex are involved in the activation of the transcription factor hairy-enhancer-of-split 1 (HES-1), which in turns negatively regulates neurogenesis and induces gliogenesis [62].”
Glucocorticoid-Related Molecular Signaling Pathways Regulating Hippocampal Neurogenesis
Anacker, C., Cattaneo, A., Luoni, A., Musaelyan, K., Zunszain, P. A., Milanesi, E., Rybka, J., Berry, A., Cirulli, F., Thuret, S., et al. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2012.253 · Cited by 313 · see citing works
Differentiation of Mesencephalic Progenitor Cells into Dopaminergic Neurons by Cytokines
Ling, Z. D., Potter, E. D., Lipton, J. W., & Carvey, P. M. (1998) · Experimental Neurology · doi:10.1006/exnr.1998.6715 · Cited by 295 · see citing works
Cooper‐Kuhn, C. M., & Kuhn, H. G. (2002) · Developmental Brain Research · doi:10.1016/s0165-3806(01)00243-7 · Cited by 293 · see citing works
Role of Sox2 in the development of the mouse neocortex
Bani‐Yaghoub, M., Tremblay, R. G., Lei, J. X., Zhang, D., Zurakowski, B., Sandhu, J. K., Smith, B., Ribecco‐Lutkiewicz, M., Kennedy, J. A., Walker, P. R., et al. (2006) · Developmental Biology · doi:10.1016/j.ydbio.2006.03.007 · Cited by 271 · see citing works
Pisanu, A., Lecca, D., Mulas, G., Wardas, J., Simbula, G., Spiga, S., & Carta, A. R. (2014) · Neurobiology of Disease · doi:10.1016/j.nbd.2014.08.011 · Cited by 268 · see citing works
Inflammation: A new candidate in modulating adult neurogenesis
Das, S., & Basu, A. (2007) · Journal of Neuroscience Research · doi:10.1002/jnr.21585 · Cited by 226 · see citing works
Neuronal synapse formation induced by microglia and interleukin 10
Lim, S.-H., Park, E., You, B., Jung, Y., Park, A.-R., Park, S. G., & Lee, J.-R. (2013) · PLoS ONE · doi:10.1371/journal.pone.0081218 · Cited by 224 · see citing works
Localization of estrogen receptor ?-immunoreactivity in astrocytes of the adult rat brain
Azcoitia, Í., Sierra, A., & García‐Segura, L. M. (1999) · Glia · doi:10.1002/(sici)1098-1136(199905)26:3 · Cited by 222 · see citing works
Bernardino, L., Agasse, F., Silva, B., Ferreira, R., Grade, S., & Malva, J. O. (2008) · Stem Cells · doi:10.1634/stemcells.2007-0914 · Cited by 220 · see citing works
TGF‐β control of cell proliferation
Huang, S. S., & Huang, J. S. (2005) · Journal of Cellular Biochemistry · doi:10.1002/jcb.20558 · Cited by 219 · see citing works
Pro-inflammatory cytokines and their effects in the dentate gyrus
Pickering, M., & O’Connor, J. J. (2007) · Progress in Brain Research · doi:10.1016/s0079-6123(07)63020-9 · Cited by 217 · see citing works
Tumor necrosis factor α triggers proliferation of adult neural stem cells via IKK/NF-κB signaling
Widera, D., Mikenberg, I., Elvers, M., Kaltschmidt, C., & Kaltschmidt, B. (2006) · BMC Neuroscience · doi:10.1186/1471-2202-7-64 · Cited by 216 · see citing works
Kiyota, T., Dixie, K. L. I., Swan, R. J., Jacobsen, M. T., Andrews, S. J., & Ikezu, T. (2011) · Gene Therapy · doi:10.1038/gt.2011.126 · Cited by 216 · see citing works
Neuroprotective role of IL-4 against activated microglia.
Chao, C., Molitor, T. W., & Hu, S. (1993) · The Journal of Immunology · doi:10.4049/jimmunol.151.3.1473 · Cited by 213 · see citing works
Macrophages and microglia in central nervous system injury: are they helpful or harmful?
Schwartz, M. (2003) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-200304000-00001 · Cited by 207 · see citing works
Interleukin-6 and Neural Stem Cells: More Than Gliogenesis
Islam, O., Gong, X.-D., Rose‐John, S., & Heese, K. (2008) · Molecular Biology of the Cell · doi:10.1091/mbc.e08-05-0463 · Cited by 172 · see citing works
IFN‐γ enhances neurogenesis in wild‐type mice and in a mouse model of Alzheimer's disease
Baron, R., Nemirovsky, A., Harpaz, I., Cohen, H., Owens, T., & Monsonego, A. (2008) · The FASEB Journal · doi:10.1096/fj.08-105866 · Cited by 165 · see citing works
Johansson, S., Price, J., & Modo, M. (2008) · Stem Cells · doi:10.1634/stemcells.2008-0116 · Cited by 148 · see citing works
Role of Neuroinflammation in Adult Neurogenesis and Alzheimer Disease: Therapeutic Approaches
Fuster-Matanzo, A., Llorens-Martı́n, M., Hernández, F., & Ávila, J. (2013) · Mediators of Inflammation · doi:10.1155/2013/260925 · Cited by 146 · see citing works
Wang, X., Fu, S., Wang, Y., Yu, P., Hu, J., Gu, W., Xu, X., & Lu, P. (2007) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2007.07.005 · Cited by 142 · see citing works
Glial cell-specific mechanisms of TGF-β1 induction by IL-1 in cerebral cortex
da Cunha, A., Jefferson, J. A., Jackson, R. W., & Vitković, L. (1993) · Journal of Neuroimmunology · doi:10.1016/0165-5728(93)90214-j · Cited by 141 · see citing works
A New Class of Reverse Signaling Costimulators Belongs to the TNF Family
Sun, M., & Fink, P. J. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.7.4307 · Cited by 141 · see citing works
KRIEGLSTEIN, K. G., Zheng, F., Unsicker, K., & Alzheimer, C. (2011) · Trends in Neurosciences · doi:10.1016/j.tins.2011.06.002 · Cited by 136 · see citing works
Basu, A., Lazović, J., Krady, J. K., Mauger, D. T., Rothstein, R. P., Smith, M. B. H., & Levison, S. W. (2005) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600002 · Cited by 118 · see citing works
Lehner, B., Sandner, B., Marschallinger, J., Lehner, C., Furtner, T., Couillard‐Després, S., Rivera, F. J., Brockhoff, G., Bauer, H., Weidner, N., et al. (2011) · Cell and Tissue Research · doi:10.1007/s00441-011-1213-7 · Cited by 116 · see citing works
Interferon-γ Induced Medulloblastoma in the Developing Cerebellum
Lin, W., Kemper, A., McCarthy, K. D., Pytel, P., Wang, J.-P., Campbell, I. L., Utset, M. F., & Popko, B. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.2604-04.2004 · Cited by 115 · see citing works
Oh, J., McCloskey, M. A., Blong, C. C., Bendickson, L., Nilsen‐Hamilton, M., & Sakaguchi, D. S. (2010) · Journal of Neuroscience Research · doi:10.1002/jnr.22447 · Cited by 97 · see citing works
Interleukin-10 regulates progenitor differentiation and modulates neurogenesis on adult brain
Pérez-Asensio, F. J., Perpiñá, U., Planas, A. M., & Pozas, E. (2013) · Journal of Cell Science · doi:10.1242/jcs.127803 · Cited by 95 · see citing works
Moriyama, M., Fukuhara, T., Britschgi, M., He, Y., Narasimhan, R., Villeda, S., Molina, H. D., Huber, B. T., Holers, M., & Wyss‐Coray, T. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.3617-10.2011 · Cited by 93 · see citing works
Continuous neurogenesis in the adult brain
Imayoshi, I., Sakamoto, M., Ohtsuka, T., & Kageyama, R. (2009) · Development Growth & Differentiation · doi:10.1111/j.1440-169x.2009.01094.x · Cited by 91 · see citing works
Nuclear Factor Kappa B Signaling Initiates Early Differentiation of Neural Stem Cells
Zhang, Y., Liu, J., Yao, S., Li, F., Xin, L., Lai, M., Bracchi-Ricard, V. C., Xu, H., Yen, W., Meng, W., et al. (2011) · Stem Cells · doi:10.1002/stem.1006 · Cited by 91 · see citing works
TNF-α antibody infusion impairs survival of stroke-generated neuroblasts in adult rat brain
Heldmann, U., Thored, P., Claasen, J.-H., Arvidsson, A., Kokaia, Z., & Lindvall, O. (2005) · Experimental Neurology · doi:10.1016/j.expneurol.2005.07.024 · Cited by 88 · see citing works
Pugazhenthi, S., Zhang, Y., Bouchard, R. J., & Mahaffey, G. (2013) · PLoS ONE · doi:10.1371/journal.pone.0069585 · Cited by 85 · see citing works
Chen, E., Xu, D., Lan, X., Jia, B., Sun, L., Zheng, J., & Peng, H. (2013) · Current Molecular Medicine · doi:10.2174/15665240113139990076 · Cited by 85 · see citing works
Wu, J.-P., Kuo, J., Liu, Y.-L., & Tzeng, S. (2000) · Neuroscience Letters · doi:10.1016/s0304-3940(00)01472-5 · Cited by 84 · see citing works
Furlan, R., Poliani, P. L., Marconi, P., Bergami, A., Ruffini, F., Adorini, L., Jc, G., Comı, G., & Martino, G. (2001) · Gene Therapy · doi:10.1038/sj.gt.3301357 · Cited by 83 · see citing works
Hayley, S. P. (2008) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s4476 · Cited by 80 · see citing works
Maródi, L., Goda, K., Palicz, A., & Szabó, G. (2001) · Clinical & Experimental Immunology · doi:10.1046/j.1365-2249.2001.01693.x · Cited by 79 · see citing works
Peng, H., Whitney, N. P., Wu, Y., Tian, C., Dou, H., Zhou, Y., & Zheng, J. (2008) · Glia · doi:10.1002/glia.20665 · Cited by 78 · see citing works
The Rb-CDK4/6 Signaling Pathway Is Critical in Neural Precursor Cell Cycle Regulation
Ferguson, K. L., Callaghan, S. M., O'Hare, M. J., Park, D. S., & Slack, R. S. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m004879200 · Cited by 78 · see citing works
Elevated CNS Inflammation in Patients with Preclinical Alzheimer's Disease
Monson, N. L., Ireland, S. J., Ligocki, A. J., Chen, D., Rounds, W. H., Li, M., Huebinger, R. M., Munro Cullum, C., Greenberg, B. M., Stowe, A. M., et al. (2014) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2013.183 · Cited by 76 · see citing works
The role of inflammatory cytokines on the aetiopathogenesis of depression
Makhija, K., & Karunakaran, S. (2013) · Australian & New Zealand Journal of Psychiatry · doi:10.1177/0004867413488220 · Cited by 76 · see citing works
Crampton, S. J., Collins, L., Toulouse, A., Nolan, Y. M., & O’Keeffe, G. W. (2011) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2011.07634.x · Cited by 75 · see citing works
McPherson, C. A., Aoyama, M., & Harry, G. J. (2010) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2010.09.003 · Cited by 74 · see citing works
Ryan, S. M., O’Keeffe, G. W., O’Connor, C., Keeshan, K., & Nolan, Y. M. (2013) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2013.03.005 · Cited by 74 · see citing works
Intrastriatal implantation of interleukin-1
Wang, J., Bankiewicz, K. S., Plunkett, R. J., & Oldfield, E. H. (1994) · Journal of neurosurgery · doi:10.3171/jns.1994.80.3.0484 · Cited by 69 · see citing works
Muñoz, A., Garrido‐Gil, P., Dominguez‐Meijide, A., & Labandeira-García, J. L. (2014) · Experimental Neurology · doi:10.1016/j.expneurol.2014.08.019 · Cited by 69 · see citing works
Zonis, S., Ljubimov, V. A., Mahgerefteh, M. Y., Pechnick, R. N., Wawrowsky, K., & Chesnokova, V. (2013) · Hippocampus · doi:10.1002/hipo.22192 · Cited by 67 · see citing works
Therapeutic Potential of Adult Neural Stem Cells
Taupin, P. (2006) · Recent Patents on CNS Drug Discovery · doi:10.2174/157488906778773670 · Cited by 67 · see citing works
Mäkelä, J., Koivuniemi, R., Korhonen, L., & Lindholm, D. (2010) · PLoS ONE · doi:10.1371/journal.pone.0011091 · Cited by 61 · see citing works
A new role for interferon gamma in neural stem/precursor cell dysregulation
Walter, J., Honsek, S. D., Illes, S., Wellen, J. M., Hartung, H., Rose, C. R., & Dihné, M. (2011) · Molecular Neurodegeneration · doi:10.1186/1750-1326-6-18 · Cited by 59 · see citing works
Illes, S., Theiss, S., Hartung, H., Siebler, M., & Dihné, M. (2009) · BMC Neuroscience · doi:10.1186/1471-2202-10-93 · Cited by 59 · see citing works
Inflammatory Mediators as Biomarkers in Brain Disorders
Nuzzo, D., Picone, P., Caruana, L., Vasto, S., Barera, A., Caruso, C., & Carlo, M. D. (2013) · Inflammation · doi:10.1007/s10753-013-9780-2 · Cited by 53 · see citing works
Green, H. F., & Nolan, Y. M. (2012) · Translational Psychiatry · doi:10.1038/tp.2012.117 · Cited by 51 · see citing works
Robertson, B., Kong, G., Peng, Z., Bentivoglio, M., & Kristensson, K. (2000) · Brain Research Bulletin · doi:10.1016/s0361-9230(00)00240-9 · Cited by 51 · see citing works
The therapeutic potential of adult neural stem cells.
Taupin, P. (2006) · PubMed · Cited by 48 · see citing works
Lan, X., Chen, Q., Wang, Y., Jia, B., Sun, L., Zheng, J., & Peng, H. (2012) · PLoS ONE · doi:10.1371/journal.pone.0050783 · Cited by 47 · see citing works
Interleukin 18 activates MAPKs and STAT3 but not NF-κB in hippocampal HT-22 cells
Alboni, S., Montanari, C., Benatti, C., Sánchez-Alavez, M., Rigillo, G., Blom, J. M. C., Brunello, N., Conti, B., Pariante, C. M., & Tascedda, F. (2014) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2014.02.015 · Cited by 46 · see citing works
Can adult neurogenesis buffer stress responses and depressive behaviour?
Anacker, C., & Pariante, C. M. (2012) · Molecular Psychiatry · doi:10.1038/mp.2011.133 · Cited by 45 · see citing works
Upregulation of the Transport System for TNFa at the Blood-Brain Barrier
Pan, W., & Kastin, A. J. (2001) · Archives of Physiology and Biochemistry · doi:10.1076/apab.109.4.350.4238 · Cited by 43 · see citing works
IL6 Protects MN9D Cells and Midbrain Dopaminergic Neurons from MPP+-Induced Neurodegeneration
Spittau, B., Zhou, X., Ming, M., & KRIEGLSTEIN, K. G. (2012) · NeuroMolecular Medicine · doi:10.1007/s12017-012-8189-7 · Cited by 41 · see citing works
Zhang, K., Xu, H., Cao, L., Li, K., & Huang, Q. (2012) · Brain Research · doi:10.1016/j.brainres.2012.10.025 · Cited by 36 · see citing works
Impact of indomethacin on neuroinflammation and hippocampal neurogenesis in aged mice
Boehme, M., Guenther, M., Stahr, A., Liebmann, M., Jaenisch, N., Witte, O. W., & Frahm, C. (2014) · Neuroscience Letters · doi:10.1016/j.neulet.2014.04.043 · Cited by 34 · see citing works
Deficient interferon‐γ receptor‐mediated signaling in neonatal macrophages
Maródi, L. (2002) · Acta Paediatrica · doi:10.1111/j.1651-2227.2002.tb02915.x · Cited by 33 · see citing works
Gliotypic Neural Stem Cells Transiently Adopt Tumorigenic Properties During Normal Differentiation
Walton, N. M., Snyder, G. E., Park, D., Kobeissy, F. H., Scheffler, B., & Steindler, D. A. (2008) · Stem Cells · doi:10.1634/stemcells.2008-0842 · Cited by 23 · see citing works
Cellular and molecular mechanisms of neuronal migration in neocortical development
Honda, T., Tabata, H., & Nakajima, K. (2003) · Seminars in Cell and Developmental Biology · doi:10.1016/s1084-9521(03)00008-9 · Cited by 21 · see citing works
Interleukin-11, an IL-6-like cytokine
Hook, C., & Kuprash, D. V. (2011) · Molecular Biology · doi:10.1134/s0026893311010055 · Cited by 11 · see citing works
Walter, J., Hartung, H., & Dihné, M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0043338 · Cited by 10 · see citing works
Cellular distribution of interleukin-1α-immunoreactivity after MPTP intoxication in mice
Hébert, G. A., Mingam, R., Arsaut, J., Dantzer, R., & Demotes‐Mainard, J. (2005) · Molecular Brain Research · doi:10.1016/j.molbrainres.2005.04.019 · Cited by 7 · see citing works
Kent, S. (1983) · PubMed · Cited by 3 · see citing works
Flagged first, then by citations
2 of the 116 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
- 97 Marz, P. et al. (1999) Role of interleukin-6 and soluble IL-6 receptor in region-specific induction of astrocytic differentiation and neurotrophin expression. Glia 26, 191-200 http://refhub.elsevier.com/S0166-2236(1400234-3/sbref0490)
Cited by
Sorted by citations
Enache, D., Pariante, C. M., & Mondelli, V. (2019) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2019.06.015 · Cited by 615 · see citing works
“QUIN is regarded as a neurotoxic end product of the kynurenic pathway, while KYNA is neuroprotective (Borsini et al., 2015; Miller and Raison, 2016).”
BackgroundPathogenesis of depression: Insights from human and rodent studies
Ménard, C., Hodes, G. E., & Russo, S. J. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2015.05.053 · Cited by 593 · see citing works
Calder, P. C., Bosco, N., Bourdet‐Sicard, R., Capuron, L., Delzenne, N. M., Dore, J. M., Franceschi, C., Lehtinen, M. J., Recker, T., Salvioli, S., et al. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2017.09.001 · Cited by 498 · see citing works
NLRP3 inflammasome-driven pathways in depression: clinical and preclinical findings
Kaufmann, F. N., Costa, A. P., Ghisleni, G., Diaz, A. P., Rodrigues, A. L. S., Peluffo, H., & Kaster, M. P. (2017) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2017.03.002 · Cited by 370 · see citing works
Tau and neuroinflammation: what impact for Alzheimer's disease and tauopathies?
Laurent, C., Buée, L., & Blum, D. (2018) · Biomedical Journal · doi:10.1016/j.bj.2018.01.003 · Cited by 348 · see citing works
Depression's Unholy Trinity: Dysregulated Stress, Immunity, and the Microbiome
Cruz-Pereira, J. S., Rea, K., Nolan, Y. M., O'Leary, O. F., Dinan, T. G., & Cryan, J. F. (2020) · Annual Review of Psychology · doi:10.1146/annurev-psych-122216-011613 · Cited by 320 · see citing works
Chronic peripheral inflammation, hippocampal neurogenesis, and behavior
Chesnokova, V., Pechnick, R. N., & Wawrowsky, K. (2016) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2016.01.017 · Cited by 299 · see citing works
Du Preez, A., Onorato, D., Eiben, I., Musaelyan, K., Egeland, M., Zunszain, P. A., Fernandes, C., Thuret, S., & Pariante, C. M. (2021) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2020.07.015 · Cited by 285 · see citing works
Haroon, E., Daguanno, A. W., Woolwine, B. J., Goldsmith, D. R., Baer, W. M., Wommack, E. C., Felger, J. C., & Miller, A. H. (2018) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2018.05.026 · Cited by 291 · see citing works
The dual roles of cytokines in Alzheimer’s disease: update on interleukins, TNF-α, TGF-β and IFN-γ
Zheng, C., Zhou, X.-W., & Wang, J.-Z. (2016) · Translational Neurodegeneration · doi:10.1186/s40035-016-0054-4 · Cited by 292 · see citing works
Amani, H., Habibey, R., Shokri, F., Hajmiresmail, S. J., Akhavan, O., Mashaghi, A., & Pazoki–Toroudi, H. (2019) · Scientific Reports · doi:10.1038/s41598-019-42633-9 · Cited by 273 · see citing works
Innate immunity at the crossroads of healthy brain maturation and neurodevelopmental disorders
Zengeler, K. E., & Lukens, J. R. (2021) · Nature reviews. Immunology · doi:10.1038/s41577-020-00487-7 · Cited by 254 · see citing works
Mast cells in neuroinflammation and brain disorders
Hendriksen, E., van Bergeijk, D. A., Oosting, R. S., & Redegeld, F. A. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.05.001 · Cited by 240 · see citing works
Redondo‐Castro, E., Cunningham, C. J., Miller, J., Martuscelli, L., Sarah, A.-A., Rothwell, N. J., Kielty, C. M., Allan, S. M., & Pinteaux, E. (2017) · Stem Cell Research & Therapy · doi:10.1186/s13287-017-0531-4 · Cited by 239 · see citing works
Adult neurogenesis, glia, and the extracellular matrix
Cope, E. C., & Gould, E. (2019) · Cell Stem Cell · doi:10.1016/j.stem.2019.03.023 · Cited by 236 · see citing works
The Role of BDNF in the Neuroimmune Axis Regulation of Mood Disorders
Jin, Y., Sun, L., Yang, W., Cui, R., & Xu, S. B. (2019) · Frontiers in Neurology · doi:10.3389/fneur.2019.00515 · Cited by 199 · see citing works
Misiak, B., Stańczykiewicz, B., Kotowicz, K., RYBAKOWSKI, J. K., Samochowiec, J., & Frydecka, D. (2017) · Schizophrenia Research · doi:10.1016/j.schres.2017.04.015 · Cited by 198 · see citing works
Amanollahi, M., Jameie, M., Heidari, A., & Rezaei, N. (2022) · Molecular Neurobiology · doi:10.1007/s12035-022-03102-z · Cited by 200 · see citing works
Ryan, S. M., & Nolan, Y. M. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.12.004 · Cited by 191 · see citing works
Role of Adiposity-Driven Inflammation in Depressive Morbidity
Capuron, L., Lasselin, J., & Castanon, N. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2016.123 · Cited by 182 · see citing works
Baumeister, D., Ciufolini, S., & Mondelli, V. (2016) · Psychopharmacology · doi:10.1007/s00213-015-4044-5 · Cited by 183 · see citing works
The role of inflammation in suicidal behaviour
Brundin, L., Erhardt, S., Bryleva, E. Y., Achtyes, E. D., & Postolache, T. T. (2015) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.12458 · Cited by 174 · see citing works
Zheng, J., Li, H., Tian, N., Liu, F., Wang, L., Yin, Y., Yue, L., Ma, L., Wan, Y., & Wang, J. (2020) · Cell stem cell · doi:10.1016/j.stem.2019.12.015 · Cited by 155 · see citing works
Xie, J., Huang, L., Li, X., Li, H., Zhou, Y., Zhu, H., Pan, T., Kendrick, K. M., & Xu, W. (2017) · Oncotarget · doi:10.18632/oncotarget.19326 · Cited by 156 · see citing works
The Relationship Between the Gut Microbiome-Immune System-Brain Axis and Major Depressive Disorder
Foster, J. A., Baker, G. B., & Dursun, S. M. (2021) · Frontiers in Neurology · doi:10.3389/fneur.2021.721126 · Cited by 153 · see citing works
Nielsen, O. H., Gubatan, J. M. B., Juhl, C. B., Streett, S. E., & Maxwell, C. V. (2020) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2020.09.021 · Cited by 144 · see citing works
Cell Death Pathways: a Novel Therapeutic Approach for Neuroscientists
Morris, G., Walker, A. J., Berk, M., Maes, M. H. J., & Puri, B. K. (2017) · Molecular Neurobiology · doi:10.1007/s12035-017-0793-y · Cited by 129 · see citing works
Silva, N. J., Nagashima, M., Li, J., Kakuk‐Atkins, L., Ashrafzadeh, M., Hyde, D. R., & Hitchcock, P. F. (2020) · Glia · doi:10.1002/glia.23792 · Cited by 119 · see citing works
The role of IL-6 in neurodevelopment after prenatal stress
Gumusoglu, S. B., Fine, R. S., Murray, S. J., Bittle, J. L., & Stevens, H. E. (2017) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2017.05.015 · Cited by 129 · see citing works
Sugden, K., Moffitt, T. E., Pinto, L., Poulton, R., Williams, B. S., & Caspi, A. (2016) · PLoS ONE · doi:10.1371/journal.pone.0148435 · Cited by 126 · see citing works
Kandemır, F. M., Yıldırım, S., Küçükler, S., Çağlayan, C., Mahamadu, A., & Dörtbudak, M. B. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.06.048 · Cited by 124 · see citing works
Surget, A., & Belzung, C. (2021) · Molecular Psychiatry · doi:10.1038/s41380-021-01136-8 · Cited by 122 · see citing works
Borsini, A., Cattaneo, A., Malpighi, C., Thuret, S., Harrison, N. A., MRC ImmunoPsychiatry Consortium, Zunszain, P. A., & Pariante, C. M. (2018) · International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyx083 · Cited by 113 · see citing works
Nikolopoulos, D., Manolakou, T., Polissidis, A., Filia, A., Bertsias, G. K., Koutmani, Y., & Boumpas, D. T. (2023) · Annals of the Rheumatic Diseases · doi:10.1136/ard-2022-223506 · Cited by 121 · see citing works
Cognitive impairment after cancer treatment: mechanisms, clinical characterization, and management
Fleming, B., Edison, P., & Kenny, L. M. (2023) · BMJ · doi:10.1136/bmj-2022-071726 · Cited by 120 · see citing works
The birth of new neurons in the maternal brain: Hormonal regulation and functional implications
Leuner, B., & Sabihi, S. (2016) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2016.02.004 · Cited by 110 · see citing works
Khan, A., Shal, B., Naveed, M., Shah, F. A., Atiq, A., Khan, N. U., Kim, Y. S., & Khan, S. (2019) · NeuroToxicology · doi:10.1016/j.neuro.2019.02.002 · Cited by 109 · see citing works
Majidi, J., Kosari-Nasab, M., & Salari, A.-A. (2016) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2015.10.009 · Cited by 109 · see citing works
Mast Cells in Neurodegenerative Disease
Jones, M. K., Nair, A. A., & Gupta, M. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00171 · Cited by 109 · see citing works
Preez, A. D., Law, T., Onorato, D., Lim, Y. M., Eiben, P., Musaelyan, K., Egeland, M. T., Hye, A., Zunszain, P. A., Thuret, S., et al. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-01000-3 · Cited by 111 · see citing works
Han, Y., Zhang, L., Wang, Q., Zhang, D.-D., Zhao, Q., Zhang, J., Xie, L., Liu, G., & You, Z. (2019) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2019.04.021 · Cited by 105 · see citing works
Busquets, O., Ettcheto, M., Pallàs, M., Beas‐Zárate, C., Verdaguer, E., Auladell, C., Folch, J., & Camins, A. (2016) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2016.11.002 · Cited by 104 · see citing works
Medina-Rodriguez, E. M., Lowell, J. A., Worthen, R. J., Syed, S. A., & Beurel, E. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00547 · Cited by 103 · see citing works
The CNS Immune Landscape from the Viewpoint of a T Cell
Mundt, S., Greter, M., Flügel, A., & Becher, B. (2019) · Trends in Neurosciences · doi:10.1016/j.tins.2019.07.008 · Cited by 102 · see citing works
Microglial P2Y12 Receptor Regulates Seizure-Induced Neurogenesis and Immature Neuronal Projections
Mo, M., Eyo, U. B., Xie, M., Peng, J., Bosco, D. B., Umpierre, A. D., Zhu, X., Tian, D., Xu, P., & Wu, L. (2019) · Journal of Neuroscience · doi:10.1523/jneurosci.0487-19.2019 · Cited by 93 · see citing works
Inserra, A., Mastronardi, C. A., Rogers, G. B., Licinio, J., & Wong, M. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-1359-3 · Cited by 95 · see citing works
Dubey, S., Heinen, S., Krantic, S. M., McLaurin, J., Branch, D. R., Hynynen, K., & Aubert, I. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1908658117 · Cited by 91 · see citing works
Pang, Y., & Fan, L. (2017) · Neural Regeneration Research · doi:10.4103/1673-5374.202926 · Cited by 91 · see citing works
Borsini, A., Benedetto, M. G. D., Giacobbe, J., & Pariante, C. M. (2020) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyaa055 · Cited by 86 · see citing works
Role of Inflammation in the Development of Neuropsychiatric Symptom Domains: Evidence and Mechanisms
Capuron, L., & Castanon, N. (2016) · Current topics in behavioral neurosciences · doi:10.1007/7854_2016_14 · Cited by 88 · see citing works
Friend, Foe or Both? Immune Activity in Alzheimer’s Disease
Frost, G. R., Jonas, L. A., & Li, Y. (2019) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2019.00337 · Cited by 86 · see citing works
DNA Methylation Signatures of Mood Stabilizers and Antipsychotics in Bipolar Disorder
Houtepen, L. C., van Bergen, A. H., Vinkers, C. H., & Boks, M. P. (2016) · Epigenomics · doi:10.2217/epi.15.98 · Cited by 87 · see citing works
A survey of neuroimmune changes in pregnant and postpartum female rats
Haim, A., Julian, D. L., Albin-Brooks, C., Brothers, H. M., Lenz, K. M., & Leuner, B. (2016) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2016.09.026 · Cited by 82 · see citing works
Update on the Relationship Between Depression and Neuroendocrine Metabolism
Qiu, W., Cai, X., Zheng, C., Qiu, S., Ke, H., & Huang, Y. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.728810 · Cited by 86 · see citing works
Woods, R. M., Lorusso, J. M., Fletcher, J., ElTaher, H., McEwan, F., Harris, I., Kowash, H. M., D'Souza, S. W., Harte, M., Hager, R., et al. (2023) · Neuronal Signaling · doi:10.1042/ns20220064 · Cited by 84 · see citing works
Ferraris, P., Cochet, M., Hamel, R., Gladwyn-Ng, I. E., Alfano, C., Diop, F., Garcia, D., Talignani, L., Montero‐Menei, C. N., Nougaırède, A., et al. (2019) · Emerging Microbes & Infections · doi:10.1080/22221751.2019.1637283 · Cited by 80 · see citing works
Targeted intervention in nerve–cancer crosstalk enhances pancreatic cancer chemotherapy
Qin, J., Liu, J., Wei, Z., Li, X., Chen, Z., Li, J., Zheng, W., Liu, H., Xu, S., Yong, T., et al. (2024) · Nature Nanotechnology · doi:10.1038/s41565-024-01803-1 · Cited by 83 · see citing works
Horgusluoglu, E., Nho, K. T., Risacher, S. L., Kim, S., Foroud, T., Shaw, L. M. J., Trojanowski, J. Q., Aisen, P. S. S., Petersen, R. C., Jack, C. R., et al. (2017) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2017.08.010 · Cited by 78 · see citing works
Sarubbo, F., Moranta, D., & Pani, G. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.05.011 · Cited by 77 · see citing works
North, H. F., Weissleder, C., Fullerton, J. M., Sager, R., Webster, M. J., & Weickert, C. S. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01742-8 · Cited by 75 · see citing works
Clough, E., Inigo, J., Chandra, D., Chaves, L., Reynolds, J. L., Aalinkeel, R., Schwartz, S. A., Khmaladze, A., & Mahajan, S. D. (2021) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-021-10015-6 · Cited by 75 · see citing works
Gampierakis, I. A., Koutmani, Y., Semitekolou, M., Morianos, I., Polissidis, A., Katsouda, A., Charalampopoulos, I., Xanthou, G., Gravanis, A., & Karalis, K. P. (2020) · Molecular Psychiatry · doi:10.1038/s41380-020-0651-6 · Cited by 75 · see citing works
Beyond the neuron: Role of non-neuronal cells in stress disorders
Cathomas, F., Holt, L. M., Parise, E. M., Liu, J., Murrough, J. W., Casaccia, P., Nestler, E. J., & Russo, S. J. (2022) · Neuron · doi:10.1016/j.neuron.2022.01.033 · Cited by 70 · see citing works
Towards Neuroecosociality: Mental Health in Adversity
Rose, N., Birk, R., & Manning, N. (2021) · Theory, Culture and Society. Explorations in Critical Social Science · doi:10.1177/0263276420981614 · Cited by 51 · see citing works
Microglia and HPA axis in depression: An overview of participation and relationship
Pereira, G. C., Piton, E., dos Santos, B. M., Ramanzini, L. G., Camargo, L. F. M., da Silva, R. M., & Bochi, G. V. (2021) · The World Journal of Biological Psychiatry · doi:10.1080/15622975.2021.1939154 · Cited by 69 · see citing works
Leschik, J., Lutz, B., & Gentile, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22147339 · Cited by 70 · see citing works
Cavaliere, F., Donno, C., & Dâ€TMAmbrosi, N. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00211 · Cited by 67 · see citing works
Cytokines profile and peripheral blood mononuclear cells morphology in Rett and autistic patients
Pecorelli, A., Cervellati, F., Belmonte, G., Montagner, G., Waldon, P., Hayek, J., Gambari, R., & Valacchi, G. (2015) · Cytokine · doi:10.1016/j.cyto.2015.10.002 · Cited by 67 · see citing works
Kovács, D., Eszlári, N., Petschner, P., Pap, D., Vas, S., Kovacs, P. L., Gonda, X., Juhász, G., & Bagdy, G. (2016) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2016.02.012 · Cited by 64 · see citing works
Salles, G. N., Calió, M. L., Hölscher, C., Soares, C. P., Porcionatto, M. A., & Lobo, A. O. (2019) · Neuropharmacology · doi:10.1016/j.neuropharm.2019.107813 · Cited by 65 · see citing works
Impaired constitutive and regenerative neurogenesis in adult hyperglycemic zebrafish
Dorsemans, A.-C., Soulé, S., Weger, M., Bourdon, E., d’Hellencourt, C. L., Meilhac, O., & Diotel, N. (2016) · The Journal of Comparative Neurology · doi:10.1002/cne.24065 · Cited by 64 · see citing works
The choroid plexus as a sex hormone target: Functional implications
Santos, C. R. A., Duarte, A. C., Quintela, T., Tomás, J., Albuquerque, T., Marques, F., Palha, J. A., & Gonçalves, I. (2016) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2016.12.002 · Cited by 66 · see citing works
Brain-immune crosstalk in the treatment of major depressive disorder
Branchi, I., Poggini, S., Capuron, L., Benedetti, F., Poletti, S., Tamouza, R., Drexhage, H. A., Penninx, B. W. J. H., & Pariante, C. M. (2020) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2020.11.016 · Cited by 64 · see citing works
Gender Differences in the Neurobiology of Anxiety: Focus on Adult Hippocampal Neurogenesis
Marques, A. A., Bevilaqua, M. C. D. N., da Fonseca, A. M. P., Nardi, A. E., Thuret, S., & Dias, G. P. (2016) · Neural Plasticity · doi:10.1155/2016/5026713 · Cited by 78 · see citing works
Sensing the world and its dangers: An evolutionary perspective in neuroimmunology
Kraus, A., Buckley, K. M., & Salinas, I. (2021) · eLife · doi:10.7554/elife.66706 · Cited by 63 · see citing works
Augusto‐Oliveira, M., Arrifano, G. D. P., Malva, J. O., & Lopez, M. E. C. (2019) · Cells · doi:10.3390/cells8020125 · Cited by 61 · see citing works
Systemic maternal inflammation promotes ASD via IL-6 and IFN-γ
Majerczyk, D., Ayad, E., Brewton, K. L., Saing, P., & Hart, P. C. (2022) · Bioscience Reports · doi:10.1042/bsr20220713 · Cited by 62 · see citing works
Manzari‐Tavakoli, A., Babajani, A., Farjoo, M. H., Hajinasrollah, M., Bahrami, S., & Niknejad, H. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.827275 · Cited by 62 · see citing works
Yu, D., Li, T., Delpech, J.-C., Zhu, B., Kishore, P., Koshi, T., Luo, R., Pratt, K. J. B., Popova, G., Nowakowski, T. J., et al. (2022) · Science Advances · doi:10.1126/sciadv.abm2545 · Cited by 58 · see citing works
Zuo, Y., Wang, J., Liao, F., Yan, X., Li, J., Huang, L., & Liu, F. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00401 · Cited by 58 · see citing works
Inflammatory and neurodegenerative pathophysiology implicated in postpartum depression
Worthen, R. J., & Beurel, E. (2022) · Neurobiology of Disease · doi:10.1016/j.nbd.2022.105646 · Cited by 58 · see citing works
Imbalance between the anti- and pro-inflammatory milieu in blood leukocytes of autistic children
Ahmad, S. F., Nadeem, A., Ansari, M. A., Bakheet, S. A., Attia, S. M., Zoheir, K. M. A., AL-Ayadhi, L. Y., Alzahrani, M. Z., Alsaad, A. M. S., Alotaibi, M. R., et al. (2016) · Molecular Immunology · doi:10.1016/j.molimm.2016.12.019 · Cited by 58 · see citing works
Peters, S., Zitzelsperger, E., Kuespert, S., Iberl, S., Heydn, R., Johannesen, S. W., Petri, S., Aigner, L., Thal, D. R., Hermann, A., et al. (2017) · Frontiers in Neurology · doi:10.3389/fneur.2017.00669 · Cited by 54 · see citing works
Jiang, N., Lv, J., Wang, H., Lü, C., Wang, Q., Xia, T., Bao, Y., Li, S., & Liu, X. (2019) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2019.09.007 · Cited by 56 · see citing works
Neurogenesis after traumatic brain injury - The complex role of HMGB1 and neuroinflammation
Manivannan, S., Marei, O., Elalfy, O., & Zaben, M. (2020) · Neuropharmacology · doi:10.1016/j.neuropharm.2020.108400 · Cited by 55 · see citing works
Turkin, A., Tuchina, O. P., & Klempin, F. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.665739 · Cited by 53 · see citing works
Developmental roles of microglia: A window into mechanisms of disease
Anderson, S., & Vetter, M. L. (2018) · Developmental Dynamics · doi:10.1002/dvdy.1 · Cited by 50 · see citing works
The chemokine CXCL1 and its receptor CXCR2 contribute to chronic stress‐induced depression in mice
Chai, H., Fu, X., Ma, L., Sun, H., Chen, G., Song, M., Chen, W., Chen, Y., Tan, M., Guo, Y., et al. (2019) · The FASEB Journal · doi:10.1096/fj.201802359rr · Cited by 51 · see citing works
Ma, Y., Matsuwaki, T., Yamanouchi, K., & Nishihara, M. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-9939-6 · Cited by 49 · see citing works
Benedetto, M. G. D., Bottanelli, C., Cattaneo, A., Pariante, C. M., & Borsini, A. (2019) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2019.05.032 · Cited by 49 · see citing works
Li, Y., Liang, W., Guo, C., Chen, X., Huang, Y., Wang, H., Song, L., Zhang, D., Zhan, W., Lin, Z., et al. (2020) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2020.112616 · Cited by 51 · see citing works
Relationships between Inflammation and Age-Related Neurocognitive Changes
Jin, R., Chan, A. K. Y., Wu, J., & Lee, T. M. C. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232012573 · Cited by 50 · see citing works
Regulation of adult neural progenitor cell functions by purinergic signaling
Tang, Y., & Illés, P. (2016) · Glia · doi:10.1002/glia.23056 · Cited by 49 · see citing works
Nuclear deterrents: Intrinsic regulators of IL-1β-induced effects on hippocampal neurogenesis
Ó’Léime, C. S., Cryan, J. F., & Nolan, Y. M. (2017) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2017.07.153 · Cited by 50 · see citing works
Early-life inflammation with LPS delays fear extinction in adult rodents
Doenni, V. M., Song, C. M., Hill, M. N., & Pittman, Q. J. (2016) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2016.11.022 · Cited by 48 · see citing works
Weissleder, C., North, H. F., Bitar, M., Fullerton, J. M., Sager, R., Barry, G., Piper, M., Halliday, G. M., Webster, M. J., & Weickert, C. S. (2021) · Molecular Psychiatry · doi:10.1038/s41380-021-01149-3 · Cited by 46 · see citing works
Malberg, J. E., Hen, R., & Madsen, T. M. (2021) · Biological Psychiatry · doi:10.1016/j.biopsych.2021.01.010 · Cited by 46 · see citing works
Cannabinoid Actions on Neural Stem Cells: Implications for Pathophysiology
Rodrigues, R. S., Lourenço, D. M., Paulo, S. L., Mateus, J. M., Ferreira, M. F., Mouro, F. M., Moreira, J. B., Ribeiro, F. F., Sebastião, A. M., & Xapelli, S. (2019) · Molecules · doi:10.3390/molecules24071350 · Cited by 45 · see citing works
Ahmad, S. F., Nadeem, A., Ansari, M. A., Bakheet, S. A., Alshammari, M. A., & Attia, S. M. (2018) · Neurochemistry International · doi:10.1016/j.neuint.2018.09.006 · Cited by 44 · see citing works
The role of mast cells in the gut and brain
Traina, G. (2021) · Journal of Integrative Neuroscience · doi:10.31083/j.jin.2021.01.313 · Cited by 42 · see citing works
- Authors
- Borsini, A., Zunszain, P. A., Thuret, S., & Pariante, C. M.
- Affiliations
- King's College London (GB)
- Venue
- Trends in Neurosciences
- Publisher
- Elsevier BV
- Published
- 2015-03
- Volume
- 38
- Issue
- 3
- Pages
- 145-157
- ISSN
- 0166-2236 (ISSN-L)
- OpenAlex
- W2055823139
- Cited by
- 381
- References
- 116
- Citations by year
- 2026: 18 · 2025: 23 · 2024: 23 · 2023: 29 · 2022: 47 · 2021: 49 · 2020: 39 · 2019: 43 · 2018: 29 · 2017: 30 · 2016: 32 · 2015: 18 · 2012: 1
- FWCI
- 4.44
- Type
- journal article
- Language
- en
- Open access
- green
- kclpure.kcl.ac.uk
- Licence
- Locations
- Trends in Neurosciences (publishedVersion)
- PubMed (publishedVersion)
- Research Portal (King's College London) (submittedVersion, other-oa)
- Funders
- South London and Maudsley NHS Foundation Trust (MR/J002739/1)
- Psychiatry Research Trust
- Alzheimer's Society
- National Institute for Health and Care Research (MR/J002739/1)
- King's College London
- Medical Research Council (MR/J002739/1)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- neurogenesis, inflammatory cytokines, brain-immune communication, neuronal proliferation, neuronal differentiation, neuroinflammation, neuropsychiatric disorders, cognitive processes
- MeSH terms
- Animals, Brain, Humans, Cytokines, Cell Proliferation, Neurogenesis
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