Inconsistencies and Controversies Surrounding the Amyloid Hypothesis of Alzheimer's Disease

Amyloid oligomers exacerbate tau pathology in a mouse model of tauopathy

Selenica, M.-L. B., Brownlow, M., Jimenez, J. P., Lee, D. C., Pena, G., Dickey, C. A., Gordon, M. N., & Morgan, D. (2013) · Neurodegenerative Diseases · doi:10.1159/000337230 · Cited by 10,359 · see citing works

Gene Dose of Apolipoprotein E Type 4 Allele and the Risk of Alzheimer's Disease in Late Onset Families

Corder, E. H., Saunders, A. M., Strittmatter, W. J., Schmechel, D. E., Gaskell, P. C., Small, G. W., Roses, A. D., Haines, J. L., & Pericak-Vance, M. A. (1993) · Science · doi:10.1126/science.8346443 · Cited by 9,429 · see citing works

Copper-Zinc Superoxide Dismutase (SOD1) Is Released by Microglial Cells and Confers Neuroprotection against 6-OHDA Neurotoxicity

Polazzi, E., Mengoni, I., Caprini, M., Peña‐Altamira, E., Kurtys, E., & Monti, B. (2012) · Neurosignals · doi:10.1159/000337115 · Cited by 9,023 · see citing works

Power failure: why small sample size undermines the reliability of neuroscience

Button, K. S., Ioannidis, J. P. A., Mokrysz, C., Nosek, B. A., Flint, J., Robinson, E. S. J., & Munafò, M. R. (2013) · Nature Reviews Neuroscience · doi:10.1038/nrn3475 · Cited by 7,641 · cited 1× · see citing works

Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

Glenner, G. G., & Wong, C. W. (1984) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(84)80190-4 · Cited by 5,404 · see citing works

The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

Kang, J., Lemaire, H.-G., Unterbeck, A., Salbaum, J. M., Masters, C. L., Grzeschik, K.-H., Multhaup, G., Beyreuther, K., & Müller-Hill, B. (1987) · Nature · doi:10.1038/325733a0 · Cited by 4,619 · see citing works

Inflammation and Alzheimer’s disease

Akiyama, H. (2000) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)00124-x · Cited by 4,514 · see citing works

Amyloid plaque core protein in Alzheimer disease and Down syndrome.

Masters, C. L., Simms, G., Weinman, N. A., Multhaup, G., McDonald, B. L., & Beyreuther, K. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.12.4245 · Cited by 4,431 · see citing works

Alzheimer's Disease Is a Synaptic Failure

Selkoe, D. J. (2002) · Science · doi:10.1126/science.1074069 · Cited by 4,420 · see citing works

Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment

Terry, R. D., Masliah, E., Salmon, D. P., Butters, N., DeTeresa, R., Hill, R., Hansen, L. A., & Katzman, R. (1991) · Annals of Neurology · doi:10.1002/ana.410300410 · Cited by 4,397 · see citing works

Meta-Analysis of 74,046 Individuals Identifies 11 New Susceptibility Loci for Alzheimer’s Disease

(EADI), E. A. D. I., Lambert, J.-C., (GERAD), G. A. E. R. I. A. D., Alzheimer's Disease Genetic Consortium (ADGC), (CHARGE), C. F. H. A. A. R. I. G. E., Ibrahim-Verbaas, C. A., Harold, D., Naj, A. C., Sims, R., Bellenguez, C., et al. (2013) · Nature Genetics · doi:10.1038/ng.2802 · Cited by 4,336 · see citing works

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

Sherrington, R., Rogaev, E. I., Liang, Y., Rogaeva, E. A., Levesque, G., Ikeda, M., Chi, H., Lin, C., Li, G., Holman, K., et al. (1995) · Nature · doi:10.1038/375754a0 · Cited by 4,051 · see citing works

Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

Shankar, G. M., Li, S., Mehta, T. H., Garcia-Munoz, A., Shepardson, N. E., Smith, I., Brett, F. M., Farrell, M. A., Rowan, M. J., Lemere, C. A., et al. (2008) · Nature Medicine · doi:10.1038/nm1782 · Cited by 3,685 · see citing works

Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology.

Grundke-Iqbal, I., Iqbal, K., Tung, Y. C., Quinlan, M., Wisniewski, H. M., & Binder, L. I. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.13.4913 · Cited by 3,676 · see citing works

Cognitive reserve in ageing and Alzheimer's disease

Stern, Y. (2012) · The Lancet Neurology · doi:10.1016/s1474-4422(12)70191-6 · Cited by 3,557 · cited 1× · see citing works

Phases of Aβ-deposition in the human brain and its relevance for the development of AD

Thal, D. R., Rüb, U., Orantes, M., & Braak, H. (2002) · Neurology · doi:10.1212/wnl.58.12.1791 · Cited by 3,490 · see citing works

2013 Alzheimer's disease facts and figures

Thies, W. H., & Bleiler, L. (2013) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2013.02.003 · Cited by 3,331 · see citing works

Immunization with amyloid-β attenuates Alzheimer-disease-like pathology in the PDAPP mouse

Schenk, D., Barbour, R., Dunn, W., Gordon, G., Grajeda, H., Guido, T., Hu, K., Huang, J., Johnson-Wood, K., Khan, K., et al. (1999) · Nature · doi:10.1038/22124 · Cited by 3,160 · see citing works

Microglia promote learning-dependent synapse formation through brain-derived neurotrophic factor

Parkhurst, C. N., Yang, G., Ninan, I., Savas, J. N., Yates, J. R., Lafaille, J. J., Hempstead, B. L., Littman, D. R., & Gan, W.-B. (2013) · Cell · doi:10.1016/j.cell.2013.11.030 · Cited by 2,599 · see citing works

Secreted amyloid β–protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

Scheuner, D., Eckman, C., Jensen, M., Song, X., Citron, M., Suzuki, N., Bird, T. D., Hardy, J., Hutton, M., Kukull, W., et al. (1996) · Nature Medicine · doi:10.1038/nm0896-864 · Cited by 2,599 · see citing works

Candidate gene for the chromosome 1 familial Alzheimer’s disease locus

Levy-Lahad, E., Wasco, W., Poorkaj, P., Romano, D. M., Oshima, J., Pettingell, W. H., Yu, C.-E., Jondro, P. D., Schmidt, S. D., Wang, K., et al. (1995) · Science · doi:10.1126/science.7638622 · Cited by 2,577 · see citing works

Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein

Games, D., Adams, D., Alessandrini, R., Barbour, R., Borthelette, P., Blackwell, C., Carr, T., Clemens, J., Donaldson, T., Gillespie, F., et al. (1995) · Nature · doi:10.1038/373523a0 · Cited by 2,516 · see citing works

The toxic Aβ oligomer and Alzheimer's disease: an emperor in need of clothes

Benilova, I., Karran, E., & De Strooper, B. (2012) · Nature Neuroscience · doi:10.1038/nn.3028 · Cited by 1,962 · see citing works

Two Phase 3 Trials of Bapineuzumab in Mild-to-Moderate Alzheimer's Disease

Salloway, S., Sperling, R., Fox, N. C., Blennow, K., Klunk, W., Raskind, M., Sabbagh, M., Honig, L. S., Porsteinsson, A. P., Ferris, S., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1304839 · Cited by 1,960 · see citing works

Demonstrated brain insulin resistance in Alzheimer’s disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline

Talbot, K., Wang, H.-Y., Kazi, H., Han, L.-Y., Bakshi, K. P., Stucky, A., Fuino, R. L., Kawaguchi, K. R., Samoyedny, A. J., Wilson, R. S., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci59903 · Cited by 1,871 · see citing works

Twenty years of the Alzheimer's disease amyloid hypothesis: a genetic perspective

Tanzi, R. E., & Bertram, L. (2005) · Cell · doi:10.1016/j.cell.2005.02.008 · Cited by 1,849 · see citing works

Tripartite synapses: astrocytes process and control synaptic information

Perea, G., Navarrete, M., & Araque, A. (2009) · Trends in Neurosciences · doi:10.1016/j.tins.2009.05.001 · Cited by 1,820 · see citing works

A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline

Jonsson, T., Atwal, J. K., Steinberg, S., Snaedal, J., Jonsson, P. V., Bjornsson, S., Stefansson, H., Sulem, P., Gudbjartsson, D., Maloney, J., et al. (2012) · Nature · doi:10.1038/nature11283 · Cited by 1,738 · see citing works

Phase 3 Trials of Solanezumab for Mild-to-Moderate Alzheimer's Disease

Doody, R. S., Thomas, R. G., Farlow, M., Iwatsubo, T., Vellas, B., Joffe, S., Kieburtz, K., Raman, R., Sun, X., Aisen, P. S., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1312889 · Cited by 1,668 · see citing works

Resting Microglia Directly Monitor the Functional State of Synapses <i>In Vivo</i> and Determine the Fate of Ischemic Terminals

Wake, H., Moorhouse, A. J., Jinno, S., Kohsaka, S., & Nabekura, J. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.4363-08.2009 · Cited by 1,619 · see citing works

Natural Oligomers of the Alzheimer Amyloid-β Protein Induce Reversible Synapse Loss by Modulating an NMDA-Type Glutamate Receptor-Dependent Signaling Pathway

Shankar, G. M., Bloodgood, B. L., Townsend, M., Walsh, D. M., Selkoe, D. J., & Sabatini, B. L. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.4970-06.2007 · Cited by 1,592 · see citing works

Microglial interactions with synapses are modulated by visual experience

Tremblay, M.-È., Lowery, R. L., & Majewska, A. K. (2010) · PLoS Biology · doi:10.1371/journal.pbio.1000527 · Cited by 1,542 · see citing works

Uber eine eigenartige Erkrankung der Hirnrinde

Alzheimer, A. (1907) · Medical Entomology and Zoology · Cited by 1,503 · see citing works

Familial Alzheimer's Disease–Linked Presenilin 1 Variants Elevate Aβ1–42/1–40 Ratio In Vitro and In Vivo

Borchelt, D. R., Thinakaran, G., Eckman, C. B., Lee, M. K., Davenport, F., Ratovitsky, T., Prada, C.-M., Kim, G., Seekins, S., Yager, D., et al. (1996) · Neuron · doi:10.1016/s0896-6273(00)80230-5 · Cited by 1,478 · see citing works

Single App knock-in mouse models of Alzheimer’s disease

Saito, T., Matsuba, Y., Mihira, N., Takano, J., Nilsson, P., Itohara, S., Iwata, N., & Saido, T. C. (2014) · Nature Neuroscience · doi:10.1038/nn.3697 · Cited by 1,447 · see citing works

Neurodegeneration induced by beta-amyloid peptides in vitro: the role of peptide assembly state

Pike, C., Burdick, D., Walencewicz, A., Glabe, C., & Cotman, C. (1993) · The Journal of Neuroscience · doi:10.1523/jneurosci.13-04-01676.1993 · Cited by 1,417 · see citing works

Neuropathology of human Alzheimer disease after immunization with amyloid-β peptide: a case report

Nicoll, J. A. R., Wilkinson, D., Holmes, C., Steart, P., Markham, H., & Weller, R. O. (2003) · Nature Medicine · doi:10.1038/nm840 · Cited by 1,397 · see citing works

Mutation of the Alzheimer's Disease Amyloid Gene in Hereditary Cerebral Hemorrhage, Dutch Type

Levy, E., Carman, M. D., Fernandez-Madrid, I. J., Power, M. D., Lieberburg, I. M., van Duinen, S. G., Bots, G. T. A. M., Luyendijk, W., & Frangione, B. (1990) · Science · doi:10.1126/science.2111584 · Cited by 1,380 · see citing works

Astrocytes mediate synapse elimination through MEGF10 and MERTK pathways

Chung, W.-S., Clarke, L. E., Wang, G. X., Stafford, B. K., Sher, A., Chakraborty, C., Joung, J., Foo, L. C., Thompson, A., Chen, C., et al. (2013) · Nature · doi:10.1038/nature12776 · Cited by 1,377 · cited 1× · see citing works

Amyloid-β and tau — a toxic pas de deux in Alzheimer's disease

Ittner, L. M., & Götz, J. (2010) · Nature reviews. Neuroscience · doi:10.1038/nrn2967 · Cited by 1,357 · see citing works

Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid β-protein in both transfected cells and transgenic mice

Citron, M., Westaway, D., Xia, W., Carlson, G., Diehl, T., Levesque, G., Johnson-wood, K., Lee, M., Seubert, P., Davis, A., et al. (1997) · Nature Medicine · doi:10.1038/nm0197-67 · Cited by 1,271 · see citing works

APP locus duplication causes autosomal dominant early-onset Alzheimer disease with cerebral amyloid angiopathy

Rovelet‐Lecrux, A., Hannequin, D., Raux, G., Meur, N. L., Laquerrière, A., Vital, A., Dumanchin‐Njock, C., Feuillette, S., Brice, A., Vercelletto, M., et al. (2005) · Nature Genetics · doi:10.1038/ng1718 · Cited by 1,249 · see citing works

Human ApoE isoforms differentially regulate brain amyloid-β peptide clearance

Castellano, J. M., Kim, J., Stewart, F. R., Jiang, H., DeMattos, R. B., Patterson, B. W., Fagan, A. M., Morris, J. C., Mawuenyega, K. G., Cruchaga, C., et al. (2011) · Science Translational Medicine · doi:10.1126/scitranslmed.3002156 · Cited by 1,227 · see citing works

A Phase 3 Trial of Semagacestat for Treatment of Alzheimer's Disease

Doody, R. S., Raman, R., Farlow, M., Iwatsubo, T., Vellas, B., Joffe, S., Kieburtz, K., He, F., Sun, X., Thomas, R. G., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1210951 · Cited by 1,224 · see citing works

Aβ Oligomer-Induced Aberrations in Synapse Composition, Shape, and Density Provide a Molecular Basis for Loss of Connectivity in Alzheimer's Disease

Lacor, P. N., Buniel, M. C., Furlow, P. W., Sanz Clemente, A., Velasco, P. T., Wood, M., Viola, K. L., & Klein, W. L. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.3501-06.2007 · Cited by 1,188 · see citing works

Microglia: new roles for the synaptic stripper

Kettenmann, H., Kirchhoff, F., & Verkhratsky, A. (2013) · Neuron · doi:10.1016/j.neuron.2012.12.023 · Cited by 1,173 · see citing works

Scrapie prions aggregate to form amyloid-like birefringent rods

Prusiner, S. B., McKinley, M. P., Bowman, K. A., Bolton, D. C., Bendheim, P. E., Groth, D., & Glenner, G. G. (1983) · Cell · doi:10.1016/0092-8674(83)90168-x · Cited by 1,043 · see citing works

2011 Alzheimer's disease facts and figures

Alzheimer's Association (2011) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2011.02.004 · Cited by 914 · see citing works

Neurotoxicity of a Fragment of the Amyloid Precursor Associated with Alzheimer's Disease

Yankner, B. A., Dawes, L. R., Fisher, S., Villa-Komaroff, L., Oster-Granite, M. L., & Neve, R. L. (1989) · Science · doi:10.1126/science.2474201 · Cited by 907 · see citing works

An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer’s disease–associated Aβ oligomers

Bomfim, T. R., Forny‐Germano, L., Sathler, L. B., Brito‐Moreira, J., Houzel, J., Decker, H., Silverman, M. A., Kazi, H., Melo, H. M., McClean, P. L., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci57256 · Cited by 830 · see citing works

Fibrillar amyloid-β burden in cognitively normal people at 3 levels of genetic risk for Alzheimer's disease

Reiman, E. M., Chen, K., Liu, X., Bandy, D., Yu, M., Lee, W., Ayutyanont, N., Keppler, J., Reeder, S. A., Langbaum, J. B. S., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0900345106 · Cited by 785 · see citing works

The Genetics of Alzheimer's Disease

Bertram, L., & Tanzi, R. E. (2012) · Progress in molecular biology and translational science · doi:10.1016/b978-0-12-385883-2.00008-4 · Cited by 784 · see citing works

Aβ Immunotherapy Leads to Clearance of Early, but Not Late, Hyperphosphorylated Tau Aggregates via the Proteasome

Oddo, S., Billings, L., Kesslak, J. P., Cribbs, D. H., & LaFerla, F. M. (2004) · Neuron · doi:10.1016/j.neuron.2004.07.003 · Cited by 780 · see citing works

Methods of Behavior Analysis in Neuroscience

(2008) · CRC Press eBooks · doi:10.1201/9780367802622 · Cited by 777 · see citing works

apoE isoform–specific disruption of amyloid β peptide clearance from mouse brain

Deane, R., Sagare, A., Hamm, K., Parisi, M., Lane, S., Finn, M. B., Holtzman, D. M., & Zlokovic, B. V. (2008) · Journal of Clinical Investigation · doi:10.1172/jci36663 · Cited by 771 · see citing works

The A4 Study: Stopping AD Before Symptoms Begin?

Sperling, R. A., Rentz, D. M., Johnson, K. A., Karlawish, J. H., Donohue, M., Salmon, D. P., & Aisen, P. S. S. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3007941 · Cited by 756 · see citing works

Roles of amyloid precursor protein and its fragments in regulating neural activity, plasticity and memory

Turner, P. R., O’Connor, K., Tate, W. P., & Abraham, W. C. (2003) · Progress in Neurobiology · doi:10.1016/s0301-0082(03)00089-3 · Cited by 751 · see citing works

The genetics of Alzheimer disease

Tanzi, R. E. (2012) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a006296 · Cited by 727 · see citing works

Altered expression of synaptic proteins occurs early during progression of Alzheimer's disease

Masliah, E., Mallory, M., Alford, M., DeTeresa, R., Hansen, L. A., McKeel, D. W., & Morris, J. C. (2001) · Neurology · doi:10.1212/wnl.56.1.127 · Cited by 720 · see citing works

The Relationship between Aβ and Memory in the Tg2576 Mouse Model of Alzheimer's Disease

Westerman, M. A., Cooper-Blacketer, D., Mariash, A., Kotilinek, L., Kawarabayashi, T., Younkin, L. H., Carlson, G. A., Younkin, S. G., & Ashe, K. H. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-05-01858.2002 · Cited by 714 · see citing works

SYMPOSIUM: Clearance of Aβ from the Brain in Alzheimer's Disease: Perivascular Drainage of Amyloid‐β Peptides from the Brain and Its Failure in Cerebral Amyloid Angiopathy and Alzheimer's Disease

Weller, R. O., Subash, M., Preston, S., Mazanti, I., & Carare, R. O. (2008) · Brain Pathology · doi:10.1111/j.1750-3639.2008.00133.x · Cited by 682 · see citing works

Early Aβ accumulation and progressive synaptic loss, gliosis, and tangle formation in AD brain

Ingelsson, M., Fukumoto, H., Newell, K. L., Growdon, J. H., Hedley–Whyte, E. T., Frosch, M. P., Albert, M. S., Hyman, B. T., & Irizarry, M. C. (2004) · Neurology · doi:10.1212/01.wnl.0000115115.98960.37 · Cited by 666 · see citing works

Neuropathology of nondemented aging: presumptive evidence for preclinical Alzheimer disease

Price, J. L., McKeel, D. W., Buckles, V. D., Roe, C. M., Xiong, C., Grundman, M., Hansen, L. A., Petersen, R. C., Parisi, J. E., Dickson, D. W., et al. (2009) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2009.04.002 · Cited by 661 · see citing works

Effect of Tarenflurbil on Cognitive Decline and Activities of Daily Living in Patients With Mild Alzheimer Disease&lt;subtitle&gt;A Randomized Controlled Trial&lt;/subtitle&gt;

Green, R. C. (2009) · JAMA · doi:10.1001/jama.2009.1866 · Cited by 643 · see citing works

A quantitative morphometric analysis of the neuronal and synaptic content of the frontal and temporal cortex in patients with Alzheimer's disease

Davies, C. A., Mann, D. M. A., Sumpter, P. Q., & Yates, P. O. (1987) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(87)90057-8 · Cited by 628 · see citing works

ADAM10 is the physiologically relevant, constitutive α‐secretase of the amyloid precursor protein in primary neurons

Kuhn, P., Wang, H., Dislich, B., Colombo, A., Zeitschel, U., Ellwart, J. W., Kremmer, E., Roßner, S., & Lichtenthaler, S. F. (2010) · The EMBO Journal · doi:10.1038/emboj.2010.167 · Cited by 621 · cited 1× · see citing works

Two-year follow-up of amyloid deposition in patients with Alzheimer's disease

Engler, H., Forsberg, A., Almkvist, O., Blomquist, G., Larsson, E., Savitcheva, I., Wall, A. E., Ringheim, A., Långström, B., & Nordberg, A. K. (2006) · Brain · doi:10.1093/brain/awl178 · Cited by 614 · see citing works

Interleukin 1 regulates synthesis of amyloid beta-protein precursor mRNA in human endothelial cells.

Goldgaber, D., Harris, H. W., Hla, T., Maciag, T., DONNELLY, R. J., Jacobsen, J. S., Vitek, M. P., & Gajdusek, D. C. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.19.7606 · Cited by 591 · see citing works

Fibrillar amyloid deposition leads to local synaptic abnormalities and breakage of neuronal branches

Tsai, J., Grutzendler, J., Duff, K., & Gan, W.-B. (2004) · Nature Neuroscience · doi:10.1038/nn1335 · Cited by 561 · see citing works

Dendritic Spine Abnormalities in Amyloid Precursor Protein Transgenic Mice Demonstrated by Gene Transfer and Intravital Multiphoton Microscopy

Spires, T. L., Meyer-Luehmann, M., Stern, E. A., McLean, P. J., Skoch, J., Nguyen, P. T., Bacskai, B. J., & Hyman, B. T. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.1879-05.2005 · Cited by 550 · cited 1× · see citing works

The stress of dieting

Hutchinson, E. (2011) · Nature reviews. Neuroscience · doi:10.1038/nrn2985 · Cited by 534 · see citing works

Alzheimer neuropathologic alterations in aged cognitively normal subjects

Davis, D. G., Schmitt, F. A., Wekstein, D. R., & Markesbery, W. R. (1999) · Journal of Neuropathology and Experimental Neurology · doi:10.1097/00005072-199904000-00008 · Cited by 516 · cited 1× · see citing works

Deficient brain insulin signalling pathway in Alzheimer's disease and diabetes

Liu, Y. M., Liu, F., Grundke, I., Iqbal, K., & Gong, C. (2011) · The Journal of Pathology · doi:10.1002/path.2912 · Cited by 505 · see citing works

Resolving controversies on the path to Alzheimer's therapeutics

Selkoe, D. J. (2011) · Nature Medicine · doi:10.1038/nm.2460 · Cited by 494 · see citing works

The presenilin hypothesis of Alzheimer’s disease: Evidence for a loss-of-function pathogenic mechanism.

Shen, J., & Kelleher, R. J. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0608332104 · Cited by 485 · see citing works

Pittsburgh compound B imaging and prediction of progression from cognitive normality to symptomatic Alzheimer disease

Morris, J. C., Roe, C. M., Grant, E. A., Head, D., Storandt, M., Goate, A. M., Fagan, A. M., Holtzman, D. M., & Mintun, M. A. (2009) · Archives of Neurology · doi:10.1001/archneurol.2009.269 · Cited by 476 · see citing works

Early-Versus Late-Onset Alzheimer's Disease: More than Age Alone

Koedam, E. L. G. E., Lauffer, V., van der Vlies, A. E., van der Flier, W. M., Scheltens, P., & Pijnenburg, Y. A. L. (2010) · Journal of Alzheimer's Disease · doi:10.3233/jad-2010-1337 · Cited by 452 · see citing works

The Aβ oligomer hypothesis for synapse failure and memory loss in Alzheimer’s disease

Ferreira, S. T., & Klein, W. L. (2011) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2011.08.003 · Cited by 442 · cited 1× · see citing works

Mechanism of amyloid removal in patients with Alzheimer disease treated with gantenerumab

Ostrowitzki, S. (2012) · Archives of Neurology · doi:10.1001/archneurol.2011.1538 · Cited by 431 · cited 1× · see citing works

Tumor Necrosis Factor α Produces Insulin Resistance in Skeletal Muscle by Activation of Inhibitor κB Kinase in a p38 MAPK-dependent Manner

de Álvaro, C., Teruel, T., Hernández, R., & Lorenzo, M. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m312021200 · Cited by 430 · see citing works

Environmental standardization: cure or cause of poor reproducibility in animal experiments?

Richter, S. H., Garner, J. P., & Würbel, H. (2009) · Nature Methods · doi:10.1038/nmeth.1312 · Cited by 425 · see citing works

Animal Models of Alzheimer Disease

LaFerla, F. M., & Green, K. N. (2012) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a006320 · Cited by 419 · see citing works

TNF-α Mediates PKR-Dependent Memory Impairment and Brain IRS-1 Inhibition Induced by Alzheimer’s β-Amyloid Oligomers in Mice and Monkeys

Lourenco, M. V., Clarke, J. R., Frozza, R. L., Bomfim, T. R., Forny‐Germano, L., Batista, A. F., Sathler, L. B., Brito‐Moreira, J., Amaral, O. B., Silva, C. A., et al. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.11.002 · Cited by 415 · see citing works

Presenilin clinical mutations can affect γ‐secretase activity by different mechanisms

Bentahir, M., Nyabi, O., Verhamme, J., Tolia, A., Horré, K., Wiltfang, J., Esselmann, H., & Strooper, B. D. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03578.x · Cited by 412 · see citing works

APP duplication is sufficient to cause early onset Alzheimer's dementia with cerebral amyloid angiopathy

Sleegers, K., Brouwers, N., Gijselinck, I., Theuns, J., Goossens, D., Wauters, J., Del‐Favero, J., Cruts, M., van Duijn, C. M., & Broeckhoven, C. V. (2006) · Brain · doi:10.1093/brain/awl203 · Cited by 406 · see citing works

Systemic immune challenges trigger and drive Alzheimer-like neuropathology in mice

Krstic, D., Madhusudan, A., Doehner, J., Vogel, P., Notter, T., Imhof, C., Manalastas, A., Hilfiker, M., Pfister, S., Schwerdel, C., et al. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-151 · Cited by 400 · see citing works

Cognition, reserve, and amyloid deposition in normal aging

Rentz, D. M., Locascio, J. J., Becker, J. A., Moran, E. K., Eng, E., Buckner, R. L., Sperling, R. A., & Johnson, K. A. (2009) · Annals of Neurology · doi:10.1002/ana.21904 · Cited by 395 · see citing works

Safety and Tolerability of the γ-Secretase Inhibitor Avagacestat in a Phase 2 Study of Mild to Moderate Alzheimer Disease

Coric, V., van Dyck, C. H., Salloway, S., Andreasen, N., Brody, M., RICHTER, R. W., Soininen, H. S., Thein, S., Shiovitz, T. M., Pilcher, G. D., et al. (2012) · Archives of Neurology · doi:10.1001/archneurol.2012.2194 · Cited by 374 · see citing works

Reassessing the amyloid cascade hypothesis of Alzheimer's disease

Pimplikar, S. W. (2008) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2008.12.015 · Cited by 373 · see citing works

APOE genotype-specific differences in the innate immune response

Vitek, M. P., Brown, C. M., & Colton, C. A. (2009) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.11.014 · Cited by 362 · see citing works

Liraglutide can reverse memory impairment, synaptic loss and reduce plaque load in aged APP/PS1 mice, a model of Alzheimer's disease

McClean, P. L., & Hölscher, C. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.08.005 · Cited by 359 · see citing works

Amyloid beta from axons and dendrites reduces local spine number and plasticity

Wei, W., Nguyen, L. N., Kessels, H. W., Hagiwara, H., Sisodia, S., & Malinow, R. (2010) · Nature Neuroscience · doi:10.1038/nn.2476 · Cited by 357 · see citing works

Reversible paired helical filament-like phosphorylation of tau is an adaptive process associated with neuronal plasticity in hibernating animals

Arendt, T., Stieler, J., Strijkstra, A. M., Hut, R. A., Rüdiger, J., Van der Zee, E. A., Harkany, T., Holzer, M., & Härtig, W. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-18-06972.2003 · Cited by 357 · see citing works

Reduced neprilysin in high plaque areas of Alzheimer brain: a possible relationship to deficient degradation of β-amyloid peptide

Yasojima, K., Akiyama, H., McGeer, E. G., & McGeer, P. L. (2001) · Neuroscience Letters · doi:10.1016/s0304-3940(00)01675-x · Cited by 357 · see citing works

Soluble Aβ oligomer production and toxicity

Larson, M. E., & Lesné, S. E. (2012) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2011.07478.x · Cited by 356 · see citing works

Amyloid imaging in cognitively normal individuals, at-risk populations and preclinical Alzheimer's disease

Chételat, G., Joie, R. L., Villain, N., Perrotin, A., Sayette, V. D. L., Eustache, F., & Vandenberghe, R. R. (2013) · NeuroImage Clinical · doi:10.1016/j.nicl.2013.02.006 · Cited by 353 · see citing works

Cerebrospinal fluid tau and ptau181 increase with cortical amyloid deposition in cognitively normal individuals: Implications for future clinical trials of Alzheimer's disease

Fagan, A. M., Mintun, M. A., Shah, A. R., Aldea, P., Roe, C. M., Mach, R. H., Marcus, D., Morris, J. C., & Holtzman, D. M. (2009) · EMBO Molecular Medicine · doi:10.1002/emmm.200900048 · Cited by 353 · see citing works

Insulin resistance syndrome and Alzheimer's disease: Age- and obesity-related effects on memory, amyloid, and inflammation

Craft, S. (2005) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.08.021 · Cited by 347 · see citing works

Methods of Behavior Analysis in Neuroscience

(2000) · CRC Press eBooks · doi:10.1201/9781420041811 · Cited by 345 · see citing works

Alzheimer's Prevention Initiative: A Plan to Accelerate the Evaluation of Presymptomatic Treatments

Reiman, E. M., Langbaum, J. B. S., Fleisher, A., Caselli, R. J., Chen, K., Ayutyanont, N., Quiroz, Y. T., Kosik, K. S., Lopera, F. J., & Tariot, P. N. (2011) · Journal of Alzheimer s Disease · doi:10.3233/jad-2011-0059 · Cited by 340 · see citing works

Reduced Hippocampal Insulin-Degrading Enzyme in Late-Onset Alzheimer's Disease Is Associated with the Apolipoprotein E-ε4 Allele

Cook, D. G., Leverenz, J. B., McMillan, P. J., Kulstad, J. J., Ericksen, S., Roth, R. A., Schellenberg, G. D., Jin, L., Kovacina, K. S., & Craft, S. (2003) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63822-9 · Cited by 329 · see citing works

Meta-analysis of amyloid-cognition relations in cognitively normal older adults

Hedden, T., Oh, H., Younger, A. P., & Patel, T. A. (2013) · Neurology · doi:10.1212/wnl.0b013e31828ab35d · Cited by 320 · see citing works

Lipids revert inert Aβ amyloid fibrils to neurotoxic protofibrils that affect learning in mice

Martins, I. C., Kuperstein, I., Wilkinson, H. R., Maes, E., Vanbrabant, M., Jonckheere, W., Gelder, P. V., Hartmann, D., D’Hooge, R., Strooper, B. D., et al. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601953 · Cited by 311 · see citing works

Safety, tolerability, and antibody response of active Aβ immunotherapy with CAD106 in patients with Alzheimer's disease: randomised, double-blind, placebo-controlled, first-in-human study

Winblad, B. G., Andreasen, N., Minthon, L., Floesser, A., Imbert, G., Dumortier, T., Maguire, R. P., Blennow, K., Lundmark, J., Staufenbiel, M., et al. (2012) · The Lancet Neurology · doi:10.1016/s1474-4422(12)70140-0 · Cited by 311 · see citing works

Neuroinflammation and Neuronal Loss Precede Aβ Plaque Deposition in the hAPP-J20 Mouse Model of Alzheimer’s Disease

Wright, A. L., Zinn, R., Hohensinn, B., Konen, L. M., Beynon, S. B., Tan, R. P., Clark, I. A., Abdipranoto, A., & Vissel, B. (2013) · PLoS ONE · doi:10.1371/journal.pone.0059586 · Cited by 310 · see citing works

Amyloid‐beta oligomerization in Alzheimer dementia versus high‐pathology controls

Esparza, T. J., Zhao, H., Cirrito, J. R., Cairns, N. J., Bateman, R. J., Holtzman, D. M., & Brody, D. L. (2012) · Annals of Neurology · doi:10.1002/ana.23748 · Cited by 304 · see citing works

Evaluation of excess significance bias in animal studies of neurological diseases

Tsilidis, K. K., Panagiotou, O. A., Sena, E. S., Aretouli, E., Evangelou, E., Howells, D. W., Salman, R. A.-S., Macleod, M. R., & Ioannidis, J. P. A. (2013) · PLoS Biology · doi:10.1371/journal.pbio.1001609 · Cited by 295 · see citing works

The morphological phenotype of β-amyloid plaques and associated neuritic changes in Alzheimer’s disease

Dickson, T. C., & Vickers, J. C. (2001) · Neuroscience · doi:10.1016/s0306-4522(01)00169-5 · Cited by 294 · see citing works

Potent amyloidogenicity and pathogenicity of Aβ43

Saito, T., Suemoto, T., Brouwers, N., Sleegers, K., Funamoto, S., Mihira, N., Matsuba, Y., Yamada, K., Nilsson, P., Takano, J., et al. (2011) · Nature Neuroscience · doi:10.1038/nn.2858 · Cited by 280 · see citing works

Alzheimer-like neurodegeneration in aged antinerve growth factor transgenic mice

Capsoni, S., Ugolini, G., Comparini, A., Ruberti, F., Berardi, N., & Cattaneo, A. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.12.6826 · Cited by 279 · see citing works

Developing β‐secretase inhibitors for treatment of Alzheimer’s disease

Ghosh, A. K., Brindisi, M., & Tang, J. (2011) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2011.07476.x · Cited by 272 · see citing works

Neuroinflammation and Synaptic Loss

Rao, J. S., Kellom, M., Kim, H., Rapoport, S. I., & Reese, E. A. (2012) · Neurochemical Research · doi:10.1007/s11064-012-0708-2 · Cited by 262 · see citing works

Neuronal changes in normal human aging and Alzheimer's disease.

Uylings, H., & de Brabander, J. D. (2002) · Brain and Cognition · doi:10.1006/brcg.2001.1500 · Cited by 260 · see citing works

Epigenetic mechanisms in Alzheimer's disease

Mastroeni, D., Grover, A., Delvaux, E., Whiteside, C. M., Coleman, P. D., & Rogers, J. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2010.08.017 · Cited by 258 · see citing works

The presence of sodium dodecyl sulphate-stable Aβ dimers is strongly associated with Alzheimer-type dementia

Donald, J. M. M., Savva, G. M., Brayne, C., Welzel, A. T., Forster, G., Shankar, G. M., Selkoe, D. J., Ince, P. G., & Walsh, D. M. (2010) · Brain · doi:10.1093/brain/awq065 · Cited by 251 · see citing works

Comparative Analysis of Amyloid-β Chemical Structure and Amyloid Plaque Morphology of Transgenic Mouse and Alzheimer's Disease Brains

Kuo, Y., Kokjohn, T. A., Beach, T. G., Sue, L. I., Brune, D. C., Lopez, J. C., Kalback, W. M., Abramowski, D., Sturchler, C., Staufenbiel, M., et al. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m007859200 · Cited by 245 · see citing works

Alzheimer's disease-like pathological features in transgenic mice expressing the APP intracellular domain

Ghosal, K., Vogt, D. L., Liang, M., Shen, Y., Lamb, B. T., & Pimplikar, S. W. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0907652106 · Cited by 245 · see citing works

Astrocyte-induced Synaptogenesis Is Mediated by Transforming Growth Factor β Signaling through Modulation of d-Serine Levels in Cerebral Cortex Neurons

Diniz, L. P., Almeida, J. C., Tortelli, V., Lopes, C. V., Setti-Perdigão, P., Stipursky, J., Kahn, S. A., Romão, L. F., Miranda, J. D., Alves‐Leon, S. V., et al. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.380824 · Cited by 237 · see citing works

THE FAMILIAL OCCURRENCE OF CREUTZFELDT-JAKOB DISEASE AND ALZHEIMER'S DISEASE

Masters, C. L., Gajdusek, D. C., & Gibbs, C. J. (1981) · Brain · doi:10.1093/brain/104.3.535 · Cited by 237 · see citing works

Microglia: A new frontier for synaptic plasticity, learning and memory, and neurodegenerative disease research

Morris, G. P., Clark, I. A., Zinn, R., & Vissel, B. (2013) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2013.07.002 · Cited by 236 · see citing works

Dendritic spine loss in the hippocampus of young PDAPP and Tg2576 mice and its prevention by the ApoE2 genotype

Lanz, T. A., Carter, D. B., & Merchant, K. M. (2003) · Neurobiology of Disease · doi:10.1016/s0969-9961(03)00079-2 · Cited by 227 · see citing works

A novel presenilin 1 mutation associated with Pick's disease but not β‐amyloid plaques

Dermaut, B., Kumar‐Singh, S., Engelborghs, S., Theuns, J., Rademakers, R., Saerens, J., Pickut, B. A., Peeters, K., den Broeck, M. V., Vennekens, K., et al. (2004) · Annals of Neurology · doi:10.1002/ana.20083 · Cited by 212 · see citing works

Alzheimer's therapeutics: Continued clinical failures question the validity of the amyloid hypothesis—but what lies beyond?

Mullane, K., & Williams, M. J. (2012) · Biochemical Pharmacology · doi:10.1016/j.bcp.2012.11.014 · Cited by 212 · see citing works

Developing an international network for Alzheimer’s research: the Dominantly Inherited Alzheimer Network

Morris, J. C., Aisen, P. S. S., Bateman, R. J., Benzinger, T. L. S., Cairns, N. J., Fagan, A. M., Ghetti, B. F., Goate, A., Holtzman, D. M., Klunk, W. E., et al. (2012) · Clinical Investigation · doi:10.4155/cli.12.93 · Cited by 205 · see citing works

Tumor necrosis factor-α synthesis inhibitor 3,6′-dithiothalidomide attenuates markers of inflammation, Alzheimer pathology and behavioral deficits in animal models of neuroinflammation and Alzheimer’s disease

Tweedie, D., Ferguson, R. A., Fishman, K., Frankola, K. A., van Praag, H., Holloway, H. W., Luo, W., Li, Y., Caracciolo, L., Russo, I., et al. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-106 · Cited by 204 · see citing works

Aβ-independent processes—rethinking preclinical AD

Chételat, G. (2013) · Nature Reviews Neurology · doi:10.1038/nrneurol.2013.21 · Cited by 184 · see citing works

Presenilin 2 familial Alzheimer's disease mutations result in partial loss of function and dramatic changes in Aβ 42/40 ratios

Walker, E. S., Martínez, M., Brunkan, A. L., & Goate, A. (2004) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02858.x · Cited by 178 · see citing works

Tau protein and neurodegeneration

Goedert, M. (2004) · Seminars in Cell &amp; Developmental Biology · doi:10.1016/j.semcdb.2003.12.015 · Cited by 177 · see citing works

Apolipoprotein E suppresses glial cell secretion of TNFα

Laskowitz, D. T., Goel, S., Bennett, E. R., & Matthew, W. D. (1997) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(97)00021-0 · Cited by 175 · see citing works

Neurotoxicity and Memory Deficits Induced by Soluble Low-Molecular-Weight Amyloid- 1-42 Oligomers Are Revealed In Vivo by Using a Novel Animal Model

Brouillette, J., Caillierez, R., Zommer, N., Pires, C. A., Benilova, I., Blum, D. L., Strooper, B. D., & Buée, L. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.5901-11.2012 · Cited by 173 · see citing works

High Striatal Amyloid β-Peptide Deposition Across Different Autosomal Alzheimer Disease Mutation Types

Villemagne, V. L., Ataka, S., Mizuno, T., Brooks, W. S., Wada, Y., Kondo, M., Jones, G. R., Watanabe, Y., Mulligan, R. S., Nakagawa, M., et al. (2009) · Archives of Neurology · doi:10.1001/archneurol.2009.285 · Cited by 171 · see citing works

Alzheimer disease pathology as a host response

Castellani, R. J., Lee, H.-G., Zhu, X., Perry, G., & Smith, M. A. (2008) · Journal of Neuropathology &amp; Experimental Neurology · doi:10.1097/nen.0b013e318177eaf4 · Cited by 171 · see citing works

Neural Stem Cells Improve Memory in an Inducible Mouse Model of Neuronal Loss

Yamasaki, T. R., Blurton-Jones, M. M., Morrissette, D. A., Kitazawa, M., Oddo, S., & LaFerla, F. M. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.1627-07.2007 · Cited by 158 · see citing works

Reduced β-Amyloid Production and Increased Inflammatory Responses in Presenilin Conditional Knock-out Mice

Beglopoulos, V., Sun, X., Saura, C. A., Lemere, C. A., Kim, R. D., & Shen, J. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m409544200 · Cited by 154 · see citing works

Neuronal death: where does the end begin?

Conforti, L., Adalbert, R., & Coleman, M. P. (2007) · Trends in Neurosciences · doi:10.1016/j.tins.2007.02.004 · Cited by 148 · see citing works

APP Transgenic Mice Tg2576 Accumulate Aβ Peptides That Are Distinct from the Chemically Modified and Insoluble Peptides Deposited in Alzheimer's Disease Senile Plaques

Kalback, W. M., Watson, M. D., Kokjohn, T. A., Kuo, Y., Weiss, N., Luehrs, D. C., Lopez, J. C., Brune, D. C., Sisodia, S. S., Staufenbiel, M., et al. (2001) · Biochemistry · doi:10.1021/bi015685+ · Cited by 146 · see citing works

Synaptic gene dysregulation within hippocampal CA1 pyramidal neurons in mild cognitive impairment

Counts, S., Alldred, M. J., Che, S., Ginsberg, S. D., & Mufson, E. J. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.10.018 · Cited by 139 · see citing works

Senile plaque composition and posttranslational modification of amyloid-β peptide and associated proteins

Atwood, C., Martins, R. N., Smith, M. A., & Perry, G. L. (2002) · Peptides · doi:10.1016/s0196-9781(02)00070-0 · Cited by 137 · see citing works

Variability in cognitive presentation of Alzheimer's disease

Stopford, C. L., Snowden, J. S., Thompson, J. C., & Neary, D. (2007) · Cortex · doi:10.1016/j.cortex.2005.11.002 · Cited by 133 · see citing works

A plasticity-based theory of the pathogenesis of Alzheimer's disease.

MESULAM, M. ‐. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb05559.x · Cited by 130 · see citing works

Variations in the neuropathology of familial Alzheimer’s disease

Shepherd, C. E., McCann, H., & Halliday, G. M. (2009) · Acta Neuropathologica · doi:10.1007/s00401-009-0521-4 · Cited by 129 · see citing works

Brain Oligomeric β-Amyloid but Not Total Amyloid Plaque Burden Correlates With Neuronal Loss and Astrocyte Inflammatory Response in Amyloid Precursor Protein/Tau Transgenic Mice

Rocha-Souto, B. D., Scotton, T. C., Coma, M., Serrano‐Pozo, A., Hashimoto, T., Serenó, L., Rodríguez, M., Sánchez, B., Hyman, B. T., & Gómez‐Isla, T. (2011) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e318217a118 · Cited by 128 · see citing works

The impact of different presenilin 1 andpresenilin 2 mutations on amyloid deposition, neurofibrillary changes and neuronal loss in the familial Alzheimer's disease brain

Gómez‐Isla, T., Growdon, W. B., McNamara, M. J., Nochlin, D., Bird, T. D., Arango, J. C., Lopera, F., Kosik, K. S., Lantos, P. L., Cairns, N. J., et al. (1999) · Brain · doi:10.1093/brain/122.9.1709 · Cited by 128 · see citing works

Transmission and age‐at‐onset patterns in familial Alzheimer's disease

Farrer, L. A., Myers, R. H., Cupples, L. A., George‐Hyslop, P. S., Bird, T. D., Rossor, M. N., MULLAN, M. J., Polinsky, R. J., Nee, L. E., Heston, L. L., et al. (1990) · Neurology · doi:10.1212/wnl.40.3_part_1.395 · Cited by 125 · see citing works

The isolation and amino acid composition of senile plaque core protein

Allsop, D., Landon, M., & Kidd, M. (1983) · Brain Research · doi:10.1016/0006-8993(83)91273-8 · Cited by 124 · see citing works

Rapid, concurrent alterations in pre- and postsynaptic structure induced by naturally-secreted amyloid-β protein

Calabrese, B., Shaked, G. M., Tabarean, I. V., Braga, J., Koo, E. H., & Halpain, S. (2007) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2007.02.006 · Cited by 123 · see citing works

Amyloid-β Peptide: Dr. Jekyll or Mr. Hyde?

Puzzo, D., & Arancio, O. (2012) · Journal of Alzheimer s Disease · doi:10.3233/jad-2012-129033 · Cited by 122 · see citing works

Compounding artefacts with uncertainty, and an amyloid cascade hypothesis that is ‘too big to fail’

Castellani, R. J., & Smith, M. A. (2011) · The Journal of Pathology · doi:10.1002/path.2885 · Cited by 121 · see citing works

Standards for the publication of mouse mutant studies

Crusio, W. E., Goldowitz, D., Holmes, A., & Wolfer, D. P. (2008) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2008.00438.x · Cited by 118 · see citing works

Frontotemporal dementia and parkinsonism associated with the IVS1+1G->A mutation in progranulin: a clinicopathologic study

Boeve, B. F., Baker, M., Dickson, D. W., Parisi, J. E., Giannini, C., Josephs, K. A., Hutton, M., Pickering-Brown, S. M., Rademakers, R., Tang‐Wai, D. F., et al. (2006) · Brain · doi:10.1093/brain/awl268 · Cited by 110 · see citing works

The role of amyloid β in the pathogenesis of Alzheimer's disease

Gilbert, B. J. (2013) · Journal of Clinical Pathology · doi:10.1136/jclinpath-2013-201515 · Cited by 107 · see citing works

Amyloid β peptide adversely affects spine number and motility in hippocampal neurons

Shrestha, B. R., Vitolo, O. V., Joshi, P., Lordkipanidze, T. G., Shelanski, M. L., & Dunaevsky, A. (2006) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2006.07.011 · Cited by 103 · see citing works

Chapter 4 Alzheimer's Disease in Adults with Down Syndrome

Zigman, W. B., Devenny, D. A., Krinsky‐McHale, S. J., Jenkins, E. C., Urv, T. K., Węgiel, J., Schupf, N., & Silverman, W. P. (2008) · International review of research in mental retardation · doi:10.1016/s0074-7750(08)00004-9 · Cited by 99 · see citing works

Mutations in progranulin explain atypical phenotypes with variants in MAPT

Pickering-Brown, S. M., Baker, M., Gass, J. M., Boeve, B. F., Loy, C. T., Brooks, W. S., Mackenzie, I. R., Martins, R. N., Kwok, J. B., Halliday, G. M., et al. (2006) · Brain · doi:10.1093/brain/awl289 · Cited by 98 · see citing works

Structural Basis of C-terminal β-Amyloid Peptide Binding by the Antibody Ponezumab for the Treatment of Alzheimer's Disease

LaPorte, S. L., Bollini, S. S., Lanz, T. A., Abdiche, Y. N., Rusnak, A. S., Ho, W.-H., Kobayashi, D. T., Harrabi, O., Pappas, D. C., Mina, E. W., et al. (2011) · Journal of Molecular Biology · doi:10.1016/j.jmb.2011.11.047 · Cited by 96 · see citing works

Amyloid plaque formation precedes dendritic spine loss

Bittner, T., Burgold, S., Dorostkar, M. M., Fuhrmann, M., Wegenast‐Braun, B. M., Schmidt, B., Kretzschmar, H. A., & Herms, J. W. (2012) · Acta Neuropathologica · doi:10.1007/s00401-012-1047-8 · Cited by 92 · see citing works

High Degree of Heterogeneity in Alzheimer's Disease Progression Patterns

Komarova, N. L., & Thalhauser, C. J. (2011) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1002251 · Cited by 92 · see citing works

Alzheimer’s disease mutations in APP but not γ-secretase modulators affect epsilon-cleavage-dependent AICD production

Dimitrov, M. I., Alattia, J., Lemmin, T., Lehal, R., Fligier, A., Houacine, J., Hussain, I., Radtke, F., Peraro, M. D., Beher, D., et al. (2013) · Nature Communications · doi:10.1038/ncomms3246 · Cited by 92 · see citing works

A mutant PSEN1 causes dementia with lewy bodies and variant Alzheimer's disease

Ishikawa, A., Piao, Y., Miyashita, A., Kuwano, R., Onodera, O., Ohtake, H., Suzuki, M., Nishizawa, M., & Takahashi, H. (2005) · Annals of Neurology · doi:10.1002/ana.20393 · Cited by 92 · see citing works

Transgenic mice for the amyloid precursor protein 695 isoform have impaired spatial memory

Yamaguchi, F., Richards, S. J., Beyreuther, K., Salbaum, M., Carlson, G. A., & Dunnett, S. B. (1991) · Neuroreport · doi:10.1097/00001756-199112000-00013 · Cited by 90 · see citing works

Targeting Beta Amyloid: A Clinical Review of Immunotherapeutic Approaches in Alzheimer's Disease

Lobello, K., Ryan, J. M., Liu, E., Rippon, G. A., & Black, R. S. (2012) · International Journal of Alzheimer s Disease · doi:10.1155/2012/628070 · Cited by 86 · see citing works

Cognitive trajectories associated with β-amyloid deposition in the oldest-old without dementia

Snitz, B. E., Weissfeld, L. A., López, O. L., Kuller, L. H., Saxton, J. A., Singhabahu, D., Klunk, W. E., Mathis, C. A., Price, J. C., Ives, D. G., et al. (2013) · Neurology · doi:10.1212/wnl.0b013e31828c2fc8 · Cited by 86 · see citing works

Oligomers, fact or artefact? SDS-PAGE induces dimerization of β-amyloid in human brain samples

Watt, A. D., Perez, K. A., Rembach, A., Sherratt, N. A., Hung, L. W., Johanssen, T., McLean, C., Kok, W. M., Hutton, C. A., Fodero‐Tavoletti, M. T., et al. (2013) · Acta Neuropathologica · doi:10.1007/s00401-013-1083-z · Cited by 85 · see citing works

Progressive cognitive impairment and anxiety induction in the absence of plaque deposition in C57BL/6 inbred mice expressing transgenic amyloid precursor protein

Lee, K., Lee, S. H., Kim, H., Song, J.-S., Yang, S., Paik, S. G., & Han, P. (2004) · Journal of Neuroscience Research · doi:10.1002/jnr.20127 · Cited by 85 · see citing works

Type 2 Diabetic and Alzheimer's Disease Mice Present Similar Behavioral, Cognitive, and Vascular Anomalies

Carvalho, C., Machado, N. J., Mota, P. C., Correia, S. C., Cardoso, S., Santos, R. X., Santos, M. S., Oliveira, C. R., & Moreira, P. I. (2013) · Journal of Alzheimer s Disease · doi:10.3233/jad-130005 · Cited by 85 · see citing works

Reduction of aggregated Tau in neuronal processes but not in the cell bodies after Aβ42 immunisation in Alzheimer’s disease

Boche, D., Donald, J., Love, S., Harris, S., Neal, J. W., Holmes, C., & Nicoll, J. A. R. (2010) · Acta Neuropathologica · doi:10.1007/s00401-010-0705-y · Cited by 85 · see citing works

Normal cognitive behavior in two distinct congenic lines of transgenic mice hyperexpressing mutant APPSWE

Savonenko, A. V., Xu, G. M., Price, D. L., Borchelt, D., & Markowska, A. L. (2003) · Neurobiology of Disease · doi:10.1016/s0969-9961(02)00012-8 · Cited by 82 · see citing works

APOE-Mimetic Peptides Reduce Behavioral Deficits, Plaques and Tangles in Alzheimer’s Disease Transgenics

Vitek, M. P., Christensen, D. J., Wilcock, D. M., Davis, J., Nostrand, W. E. V., Li, F. Q., & Colton, C. A. (2012) · Neurodegenerative Diseases · doi:10.1159/000334914 · Cited by 82 · see citing works

Stopping a thief and killer: Alzheimer's disease crisis demands greater commitment to research

Thies, W. H. (2011) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2011.02.002 · Cited by 80 · see citing works

CHF5074 Reduces Biomarkers of Neuroinflammation in Patients with Mild Cognitive Impairment: A 12-Week, Double-Blind, Placebo- Controlled Study

Ross, J., Sharma, S., Winston, J., Nunez, M., Bottini, G., Franceschi, M., Scarpini, E. A., Frigerio, E., Fiorentini, F., Fernández, M., et al. (2013) · Current Alzheimer Research · doi:10.2174/13892037113149990144 · Cited by 78 · see citing works

FAD mutants unable to increase neurotoxic Aβ 42 suggest that mutation effects on neurodegeneration may be independent of effects on Aβ

Shioi, J., Georgakopoulos, A., Mehta, P. D., Kouchi, Z., Litterst, C. M., Baki, L., & Robakis, N. K. R. K. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.04391.x · Cited by 78 · see citing works

Blocking ADAM10 synaptic trafficking generates a model of sporadic Alzheimer’s disease

Epis, R., Marcello, E. E., Gardoni, F., Vastagh, C., Malinverno, M., Balducci, C., Colombo, A. V., Borroni, B., Vara, H., Dell’Agli, M., et al. (2010) · Brain · doi:10.1093/brain/awq217 · Cited by 76 · see citing works

Molecular Insights into the Pathogenesis of Alzheimer's Disease and Its Relationship to Normal Aging

Podtelezhnikov, A. A., Tanis, K. Q., Nebozhyn, M., Ray, W. J., Stone, D. J., & Loboda, A. P. (2011) · PLoS ONE · doi:10.1371/journal.pone.0029610 · Cited by 75 · see citing works

Tumor Necrosis Factor-Induced Cerebral Insulin Resistance in Alzheimer's Disease Links Numerous Treatment Rationales

Clark, I. A., Atwood, C., Bowen, R. L., Paz-Filho, G., & Vissel, B. (2012) · Pharmacological Reviews · doi:10.1124/pr.112.005850 · Cited by 75 · see citing works

The use of SELDI-TOF MS in the search for biological markers of Alzheimer’s disease

Watt, A. D. (2013) · Minerva Access (University of Melbourne) · Cited by 75 · see citing works

Modulation of γ-secretase by EVP-0015962 reduces amyloid deposition and behavioral deficits in Tg2576 mice

Rogers, K., Felsenstein, K. M., Hrdlicka, L., Tu, Z., Albayya, F., Lee, W., Hopp, S., Miller, M.-J., Spaulding, D., Yang, Z., et al. (2012) · Molecular Neurodegeneration · doi:10.1186/1750-1326-7-61 · Cited by 75 · see citing works

Dementia-free centenarians

Perls, T. T. (2004) · Experimental Gerontology · doi:10.1016/j.exger.2004.08.015 · Cited by 74 · see citing works

Mechanisms of AD neurodegeneration may be independent of Aβ and its derivatives

Robakis, N. K. R. K. (2010) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2010.05.022 · Cited by 71 · see citing works

Peripheral administration of an anti-TNF-α receptor fusion protein counteracts the amyloid induced elevation of hippocampal TNF-α levels and memory deficits in mice

Detrait, E., Danis, B., Lamberty, Y., & Foerch, P. (2014) · Neurochemistry International · doi:10.1016/j.neuint.2014.04.001 · Cited by 69 · see citing works

Neocortical synaptic bouton number is maintained despite robust amyloid deposition in APP23 transgenic mice

Boncristiano, S., Calhoun, M. E., Howard, V., Bondolfi, L., Kaeser, S. A., Wiederhold, K.-H., Staufenbiel, M., & Jucker, M. (2005) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2004.06.010 · Cited by 68 · see citing works

3,6′‐Dithiothalidomide, a new TNF‐α synthesis inhibitor, attenuates the effect of Aβ1–42intracerebroventricular injection on hippocampal neurogenesis and memory deficit

Russo, I., Caracciolo, L., Tweedie, D., Choi, S., Greig, N. H., Barlati, S., & Bosetti, F. (2012) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2012.07846.x · Cited by 65 · see citing works

Transgenic Mouse Models of Alzheimer’s Disease: Behavioral Testing and Considerations

Bryan, K. J., Lee, H., Perry, G. L., Smith, M. A., & Casadesús, G. (2009) · Europe PMC (PubMed Central) · Cited by 64 · see citing works

Cerebrovascular requirement for sealant, anti-coagulant and remodeling molecules that allow for the maintenance of vascular integrity and blood supply

Atwood, C., Bowen, R. L., Smith, M. A., & Perry, G. L. (2003) · Brain Research Reviews · doi:10.1016/s0165-0173(03)00206-6 · Cited by 64 · see citing works

What’s hAPPening at synapses? The role of amyloid β-protein precursor and β-amyloid in neurological disorders

Westmark, C. J. (2012) · Molecular Psychiatry · doi:10.1038/mp.2012.122 · Cited by 63 · see citing works

Novel PSEN1 and PGRN mutations in early-onset familial frontotemporal dementia

Bernardi, L., Tomaino, C., Anfossi, M., Gallo, M., Geracitano, S., Costanzo, A., Colao, R., Puccio, G., Frangipane, F., Curcio, S. A. M., et al. (2008) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2008.01.005 · Cited by 61 · see citing works

Do current therapeutic anti-Aβ antibodies for Alzheimer’s disease engage the target?

Watt, A. D., Crespi, G. A. N., Down, R. A., Ascher, D. B., Gunn, A. P., Perez, K. A., McLean, C., Villemagne, V. L., Parker, M. W., Barnham, K. J., et al. (2014) · Acta Neuropathologica · doi:10.1007/s00401-014-1290-2 · Cited by 60 · see citing works

Consequences of Inhibiting Amyloid Precursor Protein Processing Enzymes on Synaptic Function and Plasticity

Wang, H., Megill, A., He, K., Kirkwood, A., & Lee, H. (2012) · Neural Plasticity · doi:10.1155/2012/272374 · Cited by 59 · see citing works

Understanding Dementia Prevalence Among Centenarians

Poon, L. W., Woodard, J. L., Miller, L. S., Green, R. C., Gearing, M., Davey, A., Arnold, J., Martin, P., Siegler, I. C., Nahapetyan, L., et al. (2012) · The Journals of Gerontology Series A · doi:10.1093/gerona/glr250 · Cited by 59 · see citing works

Spatial learning deficit in mice expressing human 751-amino acid β-amyloid precursor protein

D’Hooge, R., Nagels, G., Westland, C. E., Mucke, L., & Deyn, P. P. D. (1996) · Neuroreport · doi:10.1097/00001756-199611040-00080 · Cited by 58 · see citing works

Aβ1–42 reduces synapse number and inhibits neurite outgrowth in primary cortical and hippocampal neurons: A quantitative analysis

Evans, N. A., Facci, L., OWEN, D. E., Soden, P. E., Burbidge, S. A., Prinjha, R. K., Richardson, J. C., & Skaper, S. D. (2008) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2008.08.001 · Cited by 53 · see citing works

COG1410 Improves Cognitive Performance and Reduces Cortical Neuronal Loss in the Traumatically Injured Brain

Hoane, M., Kaufman, N. A., Vitek, M., & McKenna, S. (2009) · Journal of Neurotrauma · doi:10.1089/neu.2008.0565 · Cited by 53 · see citing works

Atypical dementia associated with a novel presenilin‐2 mutation

Binetti, G. G., Signorini, S. G., Squitti, R., Alberici, A., Benussi, L., Cassetta, E., Frisoni, G. B., Barbiero, L., Feudatari, E., Nicosia, F. M., et al. (2003) · Annals of Neurology · doi:10.1002/ana.10760 · Cited by 52 · see citing works

APP heterozygosity averts memory deficit in knockin mice expressing the Danish dementia BRI2 mutant

Tamayev, R., Matsuda, S., Giliberto, L., Arancio, O., & D'adamio, L. (2011) · The EMBO Journal · doi:10.1038/emboj.2011.161 · Cited by 51 · see citing works

Attenuated Hippocampus-Dependent Learning and Memory Decline in Transgenic TgAPPswe Fischer-344 Rats

Ruiz‐Opazo, N., Kosik, K. S., Lopez, L. V., Bagamasbad, P., Ponce, L. R. B., & Herrera, V. L. M. (2004) · Molecular Medicine · doi:10.2119/2003-00044.herrera · Cited by 51 · see citing works

Synaptic Plasticity Defect Following Visual Deprivation in Alzheimer's Disease Model Transgenic Mice

William, C. M., Andermann, M. L., Goldey, G. J., Roumis, D. K., Reid, R. C., Shatz, C. J., Albers, M. W., Frosch, M. P., & Hyman, B. T. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.5369-11.2012 · Cited by 50 · see citing works

Predicting the failure of amyloid-β vaccine

Smith, M. A., Atwood, C., Joseph, J. A., & Perry, G. L. (2002) · The Lancet · doi:10.1016/s0140-6736(02)08695-6 · Cited by 49 · see citing works

Increases in the Risk of Cognitive Impairment and Alterations of Cerebral β-amyloid Metabolism in Mouse Model of Heart Failure

Hong, X., Bu, L., Wang, Y., Xu, J., Wu, J., Huang, Y., Liu, J., Suo, H., Yang, L., Shi, Y., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0063829 · Cited by 48 · see citing works

P4‐196: The novel BACE inhibitor MK‐8931 dramatically lowers cerebrospinal fluid Aβ peptides in healthy subjects following single‐ and multiple‐dose administration

Forman, M. S., Palcza, J. S., Tseng, J., Leempoels, J., Ramael, S., Han, D., Jhee, S. S., Ereshefsky, L., Tanen, M. R. L., Laterza, O., et al. (2012) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2012.05.1900 · Cited by 45 · see citing works

COG1410, a novel apolipoprotein‐E mimetic, improves functional and morphological recovery in a rat model of focal brain ischemia

Tukhovskaya, E. A., Yukin, A. Y., Khokhlova, O. N., Murashev, A. N., & Vitek, M. P. (2008) · Journal of Neuroscience Research · doi:10.1002/jnr.21874 · Cited by 44 · see citing works

Chapter 38: The involvement of astrocytes and an acute phase response in the amyloid deposition of Alzheimer's disease

Potter, H. (1992) · Progress in brain research · doi:10.1016/s0079-6123(08)61772-0 · Cited by 38 · see citing works

Inflammation as a central mechanism in Alzheimer's disease

Kinney, J. W., Bemiller, S. M., Murtishaw, A. S., Leisgang, A. M., Salazar, A. M., & Lamb, B. T. (2018) · Alzheimer's &amp; Dementia: Translational Research &amp; Clinical Interventions · doi:10.1016/j.trci.2018.06.014 · Cited by 2,253 · see citing works

A critical appraisal of amyloid-β-targeting therapies for Alzheimer disease

Panza, F., Lozupone, M., Logroscino, G., & Imbimbo, B. P. (2019) · Nature Reviews Neurology · doi:10.1038/s41582-018-0116-6 · Cited by 965 · see citing works

The Amyloid-β Oligomer Hypothesis: Beginning of the Third Decade

Cline, E. N., Bicca, M. A., Viola, K. L., & Klein, W. L. (2018) · Journal of Alzheimer's Disease · doi:10.3233/jad-179941 · Cited by 870 · see citing works

TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy

Yuan, P., Condello, C., Keene, C. D., Wang, Y., Bird, T. D., Paul, S. M., Luo, W., Colonna, M., Baddeley, D., & Grutzendler, J. (2016) · Neuron · doi:10.1016/j.neuron.2016.05.003 · Cited by 817 · see citing works

Molecular genetics of early-onset Alzheimer’s disease revisited

Cacace, R., Sleegers, K., & Van Broeckhoven, C. (2016) · Alzheimer's &amp; Dementia · doi:10.1016/j.jalz.2016.01.012 · Cited by 617 · see citing works

Iron neurochemistry in Alzheimer's disease and Parkinson's disease: targets for therapeutics

Belaidi, A. A., & Bush, A. I. (2015) · Journal of Neurochemistry · doi:10.1111/jnc.13425 · Cited by 580 · see citing works

Glucose transporters in brain in health and disease

Koepsell, H. (2020) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-020-02441-x · Cited by 558 · see citing works

Spatial navigation deficits — overlooked cognitive marker for preclinical Alzheimer disease?

Coughlan, G., Laczó, J., Hort, J., Minihane, A.-M., & Hornberger, M. (2018) · Nature Reviews Neurology · doi:10.1038/s41582-018-0031-x · Cited by 500 · see citing works

Activation of microglia and astrocytes: a roadway to neuroinflammation and Alzheimer’s disease

Kaur, D., Sharma, V., & Deshmukh, R. R. (2019) · Inflammopharmacology · doi:10.1007/s10787-019-00580-x · Cited by 493 · see citing works

Striking while the iron is hot: Iron metabolism and ferroptosis in neurodegeneration

Masaldan, S., Bush, A. I., Devos, D., Rolland, A., & Moreau, C. (2018) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.09.033 · Cited by 485 · see citing works

The contribution of neuroinflammation to amyloid toxicity in Alzheimer's disease

Minter, M. R., Taylor, J. M., & Crack, P. J. (2016) · Journal of Neurochemistry · doi:10.1111/jnc.13411 · Cited by 451 · see citing works

Synaptic Impairment in Alzheimer’s Disease: A Dysregulated Symphony

Forner, S., Baglietto-Vargas, D., Martini, A. C., Trujillo-Estrada, L., & LaFerla, F. M. (2017) · Trends in Neurosciences · doi:10.1016/j.tins.2017.04.002 · Cited by 430 · see citing works

Glucose Transporters at the Blood-Brain Barrier: Function, Regulation and Gateways for Drug Delivery

Patching, S. (2017) · Molecular Neurobiology · doi:10.1007/s12035-015-9672-6 · Cited by 315 · see citing works

Practical recommendations for timely, accurate diagnosis of symptomatic Alzheimer’s disease (MCI and dementia) in primary care: a review and synthesis

Liss, J. L., Seleri Assunção, S., Cummings, J., Atri, A., Geldmacher, D. S., Candela, S. F., Devanand, D. P., Fillit, H. M., Susman, J., Mintzer, J., et al. (2021) · Journal of Internal Medicine · doi:10.1111/joim.13244 · Cited by 312 · see citing works

A novel Alzheimer disease locus located near the gene encoding tau protein

Jun, G., Ibrahim-Verbaas, C. A., Vronskaya, M., Lambert, J.-C., Chung, J., Naj, A. C., Kunkle, B. W., Wang, L.-S., Bis, J. C., Bellenguez, C., et al. (2016) · Molecular Psychiatry · doi:10.1038/mp.2015.23 · Cited by 297 · see citing works

Genes associated with Alzheimer&amp;#39;s disease: an overview and current status

Giri, M., Lü, Y., & Zhang, M. (2016) · Clinical Interventions in Aging · doi:10.2147/cia.s105769 · Cited by 311 · see citing works

GFAP as a Potential Biomarker for Alzheimer’s Disease: A Systematic Review and Meta-Analysis

Kim, K. Y., Shin, K. Y., & Chang, K.-A. (2023) · Cells · doi:10.3390/cells12091309 · Cited by 309 · see citing works

Antibiotic-induced perturbations in microbial diversity during post-natal development alters amyloid pathology in an aged APPSWE/PS1ΔE9 murine model of Alzheimer’s disease

Minter, M. R., Hinterleitner, R., Meisel, M., Zhang, C., Leone, V., Zhang, X., Oyler-Castrillo, P., Zhang, X., Musch, M. W., Shen, X., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-11047-w · Cited by 292 · see citing works

The amyloid cascade hypothesis: an updated critical review

Kepp, K. P., Robakis, N. K. R. K., Høilund‐Carlsen, P. F., Sensi, S. L., & Vissel, B. (2023) · Brain · doi:10.1093/brain/awad159 · Cited by 294 · see citing works

Clearance of cerebral Aβ in Alzheimer’s disease: reassessing the role of microglia and monocytes

Zuroff, L. R., Daley, D. A., Black, K. L., & Koronyo‐Hamaoui, M. (2017) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-017-2463-7 · Cited by 275 · see citing works

Plasma neuronal exosomes serve as biomarkers of cognitive impairment in HIV infection and Alzheimer’s disease

Pulliam, L., Sun, B., Mustapić, M., Chawla, S., & Kapogiannis, D. (2019) · Journal of NeuroVirology · doi:10.1007/s13365-018-0695-4 · Cited by 246 · see citing works

A key role for MAM in mediating mitochondrial dysfunction in Alzheimer disease

Area-Gomez, E., de Groof, A., Bonilla, E., Montesinos, J., Tanji, K., Boldogh, I., Pon, L., & Schon, E. A. (2018) · Cell Death &amp; Disease · doi:10.1038/s41419-017-0215-0 · Cited by 235 · see citing works

Questions concerning the role of amyloid-β in the definition, aetiology and diagnosis of Alzheimer’s disease

Morris, G. P., Clark, I. A., & Vissel, B. (2018) · Acta Neuropathologica · doi:10.1007/s00401-018-1918-8 · Cited by 212 · see citing works

Trem2 Deletion Reduces Late-Stage Amyloid Plaque Accumulation, Elevates the Aβ42:Aβ40 Ratio, and Exacerbates Axonal Dystrophy and Dendritic Spine Loss in the PS2APP Alzheimer's Mouse Model

Meilandt, W. J., Ngu, H., Gogineni, A., Lalehzadeh, G., Lee, S.-H., Srinivasan, K., Imperio, J., Wu, T., Weber, M., Kruse, A. J., et al. (2020) · The Journal of Neuroscience · doi:10.1523/jneurosci.1871-19.2019 · Cited by 210 · see citing works

Drug repositioning and repurposing for Alzheimer disease

Ballard, C., Aarsland, D., Cummings, J., O’Brien, J., Mills, R., Molinuevo, J. L., Fladby, T., Williams, G., Doherty, P., Corbett, A., et al. (2020) · Nature Reviews Neurology · doi:10.1038/s41582-020-0397-4 · Cited by 201 · see citing works

GABAergic Inhibitory Interneuron Deficits in Alzheimer’s Disease: Implications for Treatment

Xu, Y., Zhao, M., Han, Y., & Zhang, H. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.00660 · Cited by 203 · see citing works

Novel dual GLP-1/GIP receptor agonists show neuroprotective effects in Alzheimer's and Parkinson's disease models

Hölscher, C. (2018) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.01.040 · Cited by 201 · see citing works

Tumor necrosis factor α Inhibition for Alzheimer’s Disease

Chang, R., Yee, K.-L., & Sumbria, R. K. (2017) · Journal of Central Nervous System Disease · doi:10.1177/1179573517709278 · Cited by 195 · see citing works

Understanding the Amyloid Hypothesis in Alzheimer’s Disease

Paroni, G., Bisceglia, P., & Seripa, D. (2019) · Journal of Alzheimer s Disease · doi:10.3233/jad-180802 · Cited by 186 · see citing works

Mitochondrial dysfunction: the missing link between aging and sporadic Alzheimer’s disease

Grimm, A., Friedland, K., & Eckert, A. (2015) · Biogerontology · doi:10.1007/s10522-015-9618-4 · Cited by 182 · see citing works

Insulin-Degrading Enzyme in the Fight against Alzheimer's Disease

Kurochkin, I. V., Guarnera, E., & Berezovsky, I. N. (2018) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2017.10.008 · Cited by 185 · see citing works

Amyloid‐β immunotherapy for alzheimer disease: Is it now a long shot?

Panza, F., Lozupone, M., Seripa, D., & Imbimbo, B. P. (2019) · Annals of Neurology · doi:10.1002/ana.25410 · Cited by 178 · see citing works

Computer Aided Drug Design and its Application to the Development of Potential Drugs for Neurodegenerative Disorders

Baig, M. H., Ahmad, K., Rabbani, G., Danishuddin, M., & Choi, I. (2017) · Current Neuropharmacology · doi:10.2174/1570159x15666171016163510 · Cited by 176 · see citing works

A Systematic Review of Glucose Transport Alterations in Alzheimer's Disease

Kyrtata, N., Emsley, H. C. A., Sparasci, O., Parkes, L. M., & Dickie, B. R. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.626636 · Cited by 171 · see citing works

Hippocampal plasticity during the progression of Alzheimer’s disease

Mufson, E. J., Mahady, L. J., Waters, D., Counts, S., Perez, S. E., DeKosky, S. T., Ginsberg, S. D., Ikonomović, M. D., Scheff, S. W., & Binder, L. I. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.03.006 · Cited by 172 · see citing works

Evidence of demyelination in mild cognitive impairment and dementia using a direct and specific magnetic resonance imaging measure of myelin content

Bouhrara, M., Reiter, D. A., Bergeron, C. M., Zukley, L. M., Ferrucci, L., Resnick, S. M., & Spencer, R. G. S. (2018) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2018.03.007 · Cited by 164 · see citing works

Extrasynaptic NMDA receptors in acute and chronic excitotoxicity: implications for preventive treatments of ischemic stroke and late-onset Alzheimer’s disease

Yu, S. P., Jiang, M. Q., Shim, S. S., Pourkhodadad, S., & Wei, L. (2023) · Molecular Neurodegeneration · doi:10.1186/s13024-023-00636-1 · Cited by 165 · see citing works

Protective Effect of Amyloid-β Peptides Against Herpes Simplex Virus-1 Infection in a Neuronal Cell Culture Model

Bourgade, K., Le Page, A., Bocti, C., Witkowski, J. M., Dupuis, G., Frost, E. H., & Fülöp, T. (2016) · Journal of Alzheimer’s Disease · doi:10.3233/jad-150652 · Cited by 161 · see citing works

Nuclear factor‐kappa β as a therapeutic target for Alzheimer's disease

Jha, N. K., Jha, S. K., Kar, R., Nand, P., Swati, K., & Goswami, V. K. (2019) · Journal of Neurochemistry · doi:10.1111/jnc.14687 · Cited by 160 · see citing works

Synaptic dysfunction in Alzheimer's disease: the effects of amyloid beta on synaptic vesicle dynamics as a novel target for therapeutic intervention

Alifragis, P., & Marsh, J. (2018) · Neural Regeneration Research · doi:10.4103/1673-5374.230276 · Cited by 151 · see citing works

Soluble pre-fibrillar tau and β-amyloid species emerge in early human Alzheimer’s disease and track disease progression and cognitive decline

Koss, D. J., Jones, G., Cranston, A., Gardner, H., Kanaan, N. M., & Platt, B. (2016) · Acta Neuropathologica · doi:10.1007/s00401-016-1632-3 · Cited by 149 · see citing works

Alzheimer’s disease: How metal ions define β-amyloid function

Kepp, K. P. (2017) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2017.05.007 · Cited by 151 · see citing works

Stem cell therapy for Alzheimer's disease

Liu, X., Yang, L.-P., & Zhao, L. (2020) · World Journal of Stem Cells · doi:10.4252/wjsc.v12.i8.787 · Cited by 157 · see citing works

Amyloid β oligomers (AβOs) in Alzheimer’s disease

Mroczko, B., Groblewska, M., Litman‐Zawadzka, A., Kornhuber, J., & Lewczuk, P. (2017) · Journal of Neural Transmission · doi:10.1007/s00702-017-1820-x · Cited by 146 · see citing works

The Vascular Hypothesis of Alzheimer’s Disease: A Key to Preclinical Prediction of Dementia Using Neuroimaging

de la Torre, J. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-180004 · Cited by 150 · see citing works

Peptide based therapeutics and their use for the treatment of neurodegenerative and other diseases

Baig, M. H., Ahmad, K., Saeed, M., Alharbi, A. M., Barreto, G. E., Ashraf, G. M., & Choi, I. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.04.025 · Cited by 146 · see citing works

Liver Dysfunction as a Novel Player in Alzheimer’s Progression: Looking Outside the Brain

Estrada, L. D., Ahumada, P., Cabrera, D., & Arab, J. P. (2019) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2019.00174 · Cited by 144 · see citing works

Copper Toxicity Links to Pathogenesis of Alzheimer’s Disease and Therapeutics Approaches

Ijaz, H. W., Wang, W., & Lang, M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21207660 · Cited by 146 · see citing works

Dystrophic microglia in late‐onset Alzheimer's disease

Streit, W. J., Khoshbouei, H., & Bechmann, I. (2020) · Glia · doi:10.1002/glia.23782 · Cited by 152 · see citing works

Metabolism-Centric Overview of the Pathogenesis of Alzheimer's Disease

Kang, S., Lee, Y., & Lee, J. E. (2017) · Yonsei Medical Journal · doi:10.3349/ymj.2017.58.3.479 · Cited by 143 · see citing works

Astroglial atrophy in Alzheimer’s disease

Verkhratsky, A., Rodriguez, J. J., Pivoriūnas, A., Zorec, R., & Semyanov, A. V. (2019) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-019-02310-2 · Cited by 140 · see citing works

Intracerebral Injection of Extracellular Vesicles from Mesenchymal Stem Cells Exerts Reduced Aβ Plaque Burden in Early Stages of a Preclinical Model of Alzheimer’s Disease

Elia, C. A., Tamborini, M., Rasile, M., Desiato, G., Marchetti, S., Swuec, P., Mazzitelli, S., Clemente, F., Anselmo, A., Matteoli, M., et al. (2019) · Cells · doi:10.3390/cells8091059 · Cited by 142 · see citing works

The emerging role of exosomes in Alzheimer’s disease

Zhang, T., Ma, S., Lv, J., Wang, X., Afewerky, H. K., Li, H. R., & Lu, Y. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101321 · Cited by 139 · see citing works

Role of the metabolism of branched-chain amino acids in the development of Alzheimer's disease and other metabolic disorders

Polis, B., & Samson, A. O. (2020) · Neural Regeneration Research · doi:10.4103/1673-5374.274328 · Cited by 136 · see citing works

Fisetin Reduces the Impact of Aging on Behavior and Physiology in the Rapidly Aging SAMP8 Mouse

Currais, A. J. M., Farrokhi, C. B., Dargusch, R., Armando, A. M., Quehenberger, O., Schubert, D. A., & Maher, P. A. (2017) · The Journals of Gerontology Series A · doi:10.1093/gerona/glx104 · Cited by 134 · see citing works

The Coming of Age of the Angiotensin Hypothesis in Alzheimer’s Disease: Progress Toward Disease Prevention and Treatment?

Kehoe, P. G. (2018) · Journal of Alzheimer’s Disease · doi:10.3233/jad-171119 · Cited by 133 · see citing works

BACE-1 Inhibitors: From Recent Single-Target Molecules to Multitarget Compounds for Alzheimer’s Disease

Prati, F., Bottegoni, G., Bolognesi, M. L., & Cavalli, A. (2017) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.7b00393 · Cited by 132 · see citing works

Microglia-Mediated Neuroprotection, TREM2, and Alzheimer’s Disease: Evidence From Optical Imaging

Condello, C., Yuan, P., & Grutzendler, J. (2018) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.10.007 · Cited by 131 · see citing works

Role of metals in Alzheimer’s disease

Das, N., Raymick, J. B., & Sarkar, S. (2021) · Metabolic Brain Disease · doi:10.1007/s11011-021-00765-w · Cited by 131 · see citing works

Clinical Pharmacokinetics and Safety of ALZ-801, a Novel Prodrug of Tramiprosate in Development for the Treatment of Alzheimer’s Disease

Hey, J. A., Yu, Y., Versavel, M., Abushakra, S. R., Kočiš, P., Power, A., Kaplan, P. L., Amedio, J. C., & Tolar, M. (2017) · Clinical Pharmacokinetics · doi:10.1007/s40262-017-0608-3 · Cited by 130 · see citing works

Alzheimer’s disease due to loss of function: A new synthesis of the available data

Kepp, K. P. (2016) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2016.06.004 · Cited by 123 · see citing works

Amyloid-β, tau, and the cholinergic system in Alzheimer’s disease: seeking direction in a tangle of clues

Majdi, A., Sadigh‐Eteghad, S., Aghsan, S. R., Farajdokht, F., Vatandoust, S. M., Abbas-Abad, A. N., & Mahmoudi, J. (2020) · Reviews in the Neurosciences · doi:10.1515/revneuro-2019-0089 · Cited by 124 · see citing works

Temporal Dynamics of β-Amyloid Accumulation in Aging and Alzheimer Disease

Jagust, W. J., Landau, S. M., & Jack, C. R. (2021) · Neurology · doi:10.1212/wnl.0000000000011524 · Cited by 120 · see citing works

Excess cerebral TNF causing glutamate excitotoxicity rationalizes treatment of neurodegenerative diseases and neurogenic pain by anti-TNF agents

Clark, I. A., & Vissel, B. (2016) · Journal of Neuroinflammation · doi:10.1186/s12974-016-0708-2 · Cited by 123 · see citing works

Brain metabolic stress and neuroinflammation at the basis of cognitive impairment in Alzheimer’s disease

Felice, F. G. D., & Lourenco, M. V. (2015) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2015.00094 · Cited by 120 · see citing works

Insulin Resistance Exacerbates Alzheimer Disease via Multiple Mechanisms

Wei, Z.-H., Koya, J., & Reznik, S. E. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.687157 · Cited by 121 · see citing works

Circadian Rhythm and Alzheimer’s Disease

Homolak, J., Mudrovčić, M., Vukić, B., & Toljan, K. (2018) · Medical Sciences · doi:10.3390/medsci6030052 · Cited by 115 · see citing works

Intraneuronal protein aggregation as a trigger for inflammation and neurodegeneration in the aging brain

Currais, A., Fischer, W. H., Maher, P., & Schubert, D. (2017) · The FASEB Journal · doi:10.1096/fj.201601184 · Cited by 110 · see citing works

A cell therapy approach to restore microglial Trem2 function in a mouse model of Alzheimer’s disease

Yoo, Y., Neumayer, G., Shibuya, Y., Mader, M. M.-D., & Wernig, M. (2023) · Cell Stem Cell · doi:10.1016/j.stem.2023.07.006 · Cited by 109 · see citing works

The ratio of phosphatidylcholines to lysophosphatidylcholines in plasma differentiates healthy controls from patients with Alzheimer's disease and mild cognitive impairment

Klavins, K., Koal, T., Dallmann, G., Marksteiner, J., Kemmler, G., & Humpel, C. (2015) · Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring · doi:10.1016/j.dadm.2015.05.003 · Cited by 110 · see citing works

Menopause, obesity and inflammation: interactive risk factors for Alzheimer’s disease

Christensen, A., & Pike, C. J. (2015) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2015.00130 · Cited by 108 · see citing works

The Role of Mitochondrial Calcium Homeostasis in Alzheimer’s and Related Diseases

Ryan, K. C., Ashkavand, Z., & Norman, K. R. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21239153 · Cited by 107 · see citing works

Linking the Amyloid, Tau, and Mitochondrial Hypotheses of Alzheimer’s Disease and Identifying Promising Drug Targets

Fišar, Z. (2022) · Biomolecules · doi:10.3390/biom12111676 · Cited by 110 · see citing works

Dysregulation of Intracellular Calcium Signaling in Alzheimer's Disease

Александровна, П. Е., Pchitskaya, E. I., & Борисович, Б. И. (2018) · Antioxidants and Redox Signaling · doi:10.1089/ars.2018.7506 · Cited by 102 · see citing works

Infection Augments Expression of Mechanosensing Piezo1 Channels in Amyloid Plaque-Reactive Astrocytes

Velasco‐Estevez, M., Mampay, M., Boutin, H., Chaney, A. M., Warn, P. A., Sharp, J., Burgess, E., Moeendarbary, E., Dev, K. K., & Sheridan, G. K. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00332 · Cited by 105 · see citing works

Alzheimer’s disease beyond amyloid: Can the repetitive failures of amyloid-targeted therapeutics inform future approaches to dementia drug discovery?

Mullane, K., & Williams, M. J. (2020) · Biochemical Pharmacology · doi:10.1016/j.bcp.2020.113945 · Cited by 106 · see citing works

Vascular Hypothesis of Alzheimer Disease

Scheffer, S., Hermkens, D. M. A., van der Weerd, L., de Vries, H. E., & Daemen, M. J. A. P. (2021) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.120.311911 · Cited by 103 · see citing works

Amyloid-β induces lipid droplet-mediated microglial dysfunction via the enzyme DGAT2 in Alzheimer’s disease

Prakash, P., Manchanda, P., Paouri, E., Bisht, K., Sharma, K., Rajpoot, J., Wendt, V., Hossain, A., Wijewardhane, P. R., Randolph, C. E., et al. (2025) · Immunity · doi:10.1016/j.immuni.2025.04.029 · Cited by 104 · see citing works

Effects of neural stem cell transplantation in Alzheimer’s disease models

Hayashi, Y., Lin, H.-T., Lee, C.-C., & Tsai, K. (2020) · Journal of Biomedical Science · doi:10.1186/s12929-020-0622-x · Cited by 105 · see citing works

Interactions between inflammation, sex steroids, and Alzheimer’s disease risk factors

Uchoa, M. F., Moser, V., & Pike, C. J. (2016) · Frontiers in neuroendocrinology (Print) · doi:10.1016/j.yfrne.2016.09.001 · Cited by 95 · see citing works

Cellular Senescence and Iron Dyshomeostasis in Alzheimer’s Disease

Masaldan, S., Belaidi, A. A., Ayton, S., & Bush, A. I. (2019) · Pharmaceuticals · doi:10.3390/ph12020093 · Cited by 103 · see citing works

Ferroptosis regulation through Nrf2 and implications for neurodegenerative diseases

Xiang, Y., Song, X., & Long, D. (2024) · Archives of Toxicology · doi:10.1007/s00204-023-03660-8 · Cited by 109 · see citing works

Amphiphilic Distyrylbenzene Derivatives as Potential Therapeutic and Imaging Agents for Soluble and Insoluble Amyloid β Aggregates in Alzheimer’s Disease

Sun, L., Cho, H.-J., Sen, S., Arango, A. S., Huynh, T. T., Huang, Y., Bandara, N., Rogers, B. E., Tajkhorshid, E., & Mirica, L. M. (2021) · Journal of the American Chemical Society · doi:10.1021/jacs.1c05470 · Cited by 100 · see citing works

Alzheimer’s disease (AD) therapeutics – 1: Repeated clinical failures continue to question the amyloid hypothesis of AD and the current understanding of AD causality

Mullane, K., & Williams, M. (2018) · Biochemical Pharmacology · doi:10.1016/j.bcp.2018.09.026 · Cited by 98 · see citing works

Anti-Viral Properties of Amyloid-β Peptides

Bourgade, K., Dupuis, G., Frost, E. H., & Fülöp, T. (2016) · Journal of Alzheimer s Disease · doi:10.3233/jad-160517 · Cited by 96 · see citing works

Understanding the roles of mutations in the amyloid precursor protein in Alzheimer disease

Hunter, S., & Brayne, C. (2018) · Molecular Psychiatry · doi:10.1038/mp.2017.218 · Cited by 94 · see citing works

Human iPSC-Derived Hippocampal Spheroids: An Innovative Tool for Stratifying Alzheimer Disease Patient-Specific Cellular Phenotypes and Developing Therapies

Pomeshchik, Y., Klementieva, O., Gil, J., Martinsson, I., Hansen, M. G., de Vries, T., Sancho-Balsells, A., Russ, K., Savchenko, E., Collin, A., et al. (2020) · Stem Cell Reports · doi:10.1016/j.stemcr.2020.06.001 · Cited by 95 · see citing works

Neurotoxic amyloidogenic peptides in the proteome of SARS-COV2: potential implications for neurological symptoms in COVID-19

Charnley, M., Islam, S., Bindra, G. K., Engwirda, J., Ratcliffe, J., Zhou, J., Mezzenga, R., Hulett, M. D., Han, K., Berryman, J. T., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-30932-1 · Cited by 94 · see citing works

Dual-target compounds for Alzheimer's disease: Natural and synthetic AChE and BACE-1 dual-inhibitors and their structure-activity relationship (SAR)

Ferreira, J. P. S., Albuquerque, H. M. T., Cardoso, S. M., Silva, A. M. S., & Silva, V. L. M. (2021) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2021.113492 · Cited by 96 · see citing works

Early Changes in Hippocampal Neurogenesis in Transgenic Mouse Models for Alzheimer’s Disease

Unger, M. S., Marschallinger, J., Kaindl, J., Höfling, C., Roßner, S., Heneka, M. T., der Linden, A. V., & Aigner, L. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-0018-9 · Cited by 91 · see citing works

The protective effects of polyphenols on Alzheimer's disease: A systematic review

Colizzi, C. (2018) · Alzheimer s & Dementia Translational Research & Clinical Interventions · doi:10.1016/j.trci.2018.09.002 · Cited by 93 · see citing works

Obesity and sex interact in the regulation of Alzheimer's disease

Moser, V. A., & Pike, C. J. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.08.021 · Cited by 89 · see citing works

The expanding phenotypes of cohesinopathies: one ring to rule them all!

Piché, J., Vliet, P. P. V., Pucéat, M., & Andelfinger, G. (2019) · Cell Cycle · doi:10.1080/15384101.2019.1658476 · Cited by 89 · see citing works

Alzheimer’s disease – the journey of a healthy brain into organ failure

Golde, T. E. (2022) · Molecular Neurodegeneration · doi:10.1186/s13024-022-00523-1 · Cited by 90 · see citing works

Detection of Alzheimer's disease at mild cognitive impairment and disease progression using autoantibodies as blood‐based biomarkers

DeMarshall, C. A., Nagele, E. P., Sarkar, A., Acharya, N. K., Godsey, G. A., Goldwaser, E. L., Kosciuk, M. C., Thayasivam, U., Han, M. C., Belinka, B. A., et al. (2016) · Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring · doi:10.1016/j.dadm.2016.03.002 · Cited by 86 · see citing works

TREM2-Dependent Effects on Microglia in Alzheimer’s Disease

Zhou, Y., Ulland, T. K., & Colonna, M. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00202 · Cited by 88 · see citing works

The role of Bcl-2 proteins in modulating neuronal Ca2+ signaling in health and in Alzheimer's disease

Callens, M., Kraskovskaya, N., Derevtsova, K. Z., Annaert, W. G., Bultynck, G., Борисович, Б. И., & Vervliet, T. (2021) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2021.118997 · Cited by 86 · see citing works

Molecular Recognition with Macrocyclic Receptors for Application in Precision Medicine

Pan, Y., Tian, J., & Guo, D. (2023) · Accounts of Chemical Research · doi:10.1021/acs.accounts.3c00585 · Cited by 84 · see citing works

Amyloid β: one of three danger‐associated molecules that are secondary inducers of the proinflammatory cytokines that mediate <scp>A</scp>lzheimer's disease

Clark, I. A., & Vissel, B. (2015) · British Journal of Pharmacology · doi:10.1111/bph.13181 · Cited by 84 · see citing works

Does neuroinflammation drive the relationship between tau hyperphosphorylation and dementia development following traumatic brain injury?

Collins-Praino, L. E., & Corrigan, F. (2017) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2016.09.027 · Cited by 95 · see citing works

The toxic Aβ oligomer and Alzheimer's disease: an emperor in need of clothes

Benilova, I., Karran, E., & De Strooper, B. (2012) · Nature Neuroscience · doi:10.1038/nn.3028 · Cited by 1,962 · see citing works

Reconsideration of Amyloid Hypothesis and Tau Hypothesis in Alzheimer's Disease

Kametani, F., & Hasegawa, M. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00025 · Cited by 836 · see citing works

What evidence would prove the amyloid hypothesis? Towards rational drug treatments for Alzheimer's disease

Morgan, D., & Keller, R. K. (2002) · Journal of Alzheimer s Disease · doi:10.3233/jad-2002-4317 · Cited by 3 · see citing works

Beyond Amyloid: Rethinking the Foundations of Alzheimer’s Disease Pathogenesis and Therapy

Jin, K., Yang, S., & Forster, M. J. (2025) · Aging and Disease · doi:10.14336/ad.2025.01119

Reassessing the amyloid cascade hypothesis of Alzheimer's disease

Pimplikar, S. W. (2008) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2008.12.015 · Cited by 373 · see citing works