Antifungal effects of Allium sativum (garlic) extract against the Aspergillus species involved in otomycosis
Abstract
Otomycosis due to saprophytic keratolytic fungi represents a small percentage of clinical external otitis. Although there are certain antibacterial and antifungal agents available, they usually are very caustic, potentially ototoxic and cannot be used if the ear drum is perforated. Garlic is utilized as a folk medicine in many countries for its antimicrobial and other beneficial properties. In response to a lack of otic preparations, the authors studied the efficacy of garlic extracts against the fungi belonging to the genus Aspergillus which are the most common cause of this infection. Aqueous garlic extract (AGE) and concentrated garlic oil (CGO) along with various commercial garlic supplements and pharmaceutical prescriptions were used in an in-vitro study. AGE and especially CGO were found to have antifungal activity. These agents showed similar or better inhibitory effects than the pharmaceutical preparations and demonstrated similar minimum inhibitory concentrations.
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Allicin and garlic oil showed potent antifungal effects against Candida albicans, Ascosphaera apisin, and A. niger and acted by penetrating the cellular membrane and organelle membranes like mitochondria, leading to organelle destruction and cell death.
“Moreover, allicin and garlic oil showed potent antifungal effects against Candida albicans, Ascosphaera apisin, and A. niger [44] and they acted by penetrating the cellular membrane as well as organelles membranes like the mitochondria and leading to organelles destruction and cell death [57].”
From Chemical Constituents and Pharmacological Activities of Garlic (Allium sativum L.): A Review (2020) · cites this paper as [57]
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Chemical Constituents and Pharmacological Activities of Garlic (Allium sativum L.): A Review
El-Saber Batiha, G., Magdy Beshbishy, A., G. Wasef, L., Elewa, Y. H. A., A. Al-Sagan, A., Abd El-Hack, M. E., Taha, A. E., M. Abd-Elhakim, Y., & Prasad Devkota, H. (2020) · Nutrients · doi:10.3390/nu12030872 · Cited by 931 · see citing works
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- Authors
- Pai, S. T., & Platt, M. W.
- Affiliations
- University of New Mexico (US)
- Venue
- Letters in Applied Microbiology
- Publisher
- Oxford University Press (OUP)
- Published
- 1995-01
- Volume
- 20
- Issue
- 1
- Pages
- 14-18
- ISSN
- 0266-8254 (ISSN-L)
- 1472-765X
- OpenAlex
- W1972706314
- Cited by
- 109
- References
- 17
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 6 · 2023: 5 · 2022: 5 · 2021: 6 · 2020: 5 · 2019: 2 · 2018: 1 · 2017: 5 · 2016: 2 · 2015: 3 · 2014: 11 · 2013: 2 · 2012: 3
- FWCI
- 2.05
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Letters in Applied Microbiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Garlic and Onion Studies
- Life Sciences › Agricultural and Biological Sciences › Food Science › Essential Oils and Antimicrobial Activity
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Keywords
- garlic extract, garlic, Aspergillus, otomycosis, antifungal activity, garlic oil, otitis externa, minimum inhibitory concentration, folk medicine
- MeSH terms
- Aspergillus fumigatus, Aspergillus nidulans, Aspergillus niger, Clotrimazole, Garlic, Ketoconazole, Microbial Sensitivity Tests, Mycoses, Otitis Externa, Plant Extracts, Plant Oils, Plants, Medicinal
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