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Cited by 292Probiotics and Fermented FoodsBacterial Cancer TherapyReproductive tract infections research

The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.

Effects of Lactobacillus strains on cancer cell proliferation and oxidative stress in vitro

Choi, S.S., Kim, Y., Han, K.S., You, S., Oh, S., Kim, S.H.·2006·Letters in Applied Microbiology
DOI 10.1111/j.1472-765x.2006.01913.x
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Abstract

AIMS: The objective of this study was to assess in vitro, whether heat-killed (HK) lactic acid bacteria cells and fractionations of HK cells could suppress the viability of human cancer cells and inhibit the cytotoxicity associated with oxidative stress. METHODS AND RESULTS: Among the strains, the HK cells of Lactobacillus acidophilus 606 and Lactobacillus casei ATCC 393 exhibited the most profound inhibitory activity in all of the tested cell lines. HK cells of L. acidophilus 606 were determined to be less toxic to healthy human embryo fibroblasts (hEF cells) than were HK cells of L. casei ATCC 393. The soluble polysaccharides from L. acidophilus 606 evidenced the most effective anticancer activity, but inhibited hEF cell growth by only 20%. The soluble polysaccharides from L. acidophilus 606 were partly observed to induce apoptosis in the HT-29 cells by DNA fragmentation and propidium iodine staining. Both the HK cells of L. acidophilus 606 and the soluble polysaccharide components of this strain also exhibited potent antioxidative activity. CONCLUSIONS: Our findings suggest that the soluble polysaccharide fraction from L. acidophilus 606 may constitute a novel anticancer agent, which manifests a high degree of selectivity for human cancer cells and antioxidative agent in the food industry. SIGNIFICANCE AND IMPACT OF THE STUDY: These soluble polysaccharide components from Lactobacillus may be applied to various foods, and used as adjuncts for cancer therapy and prevention.

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Crossref · 10.1111/j.1472-765x.2006.01913.x

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Metadata

Authors
Choi, S. S., Kim, Y., Han, K. S., You, S., Oh, S., & Kim, S. H.
Affiliations
  • Korea University (KR)
  • Chonnam National University (KR)
Corresponding author
Kim, Y.
ORCID
Venue
Letters in Applied Microbiology
Publisher
Oxford University Press (OUP)
Published
2006-05
Volume
42
Issue
5
Pages
452-458
ISSN
  • 0266-8254 (ISSN-L)
  • 1365-2673
DOI
10.1111/j.1472-765x.2006.01913.x
OpenAlex
W2027893246
Semantic Scholar
b03391f881507bfb3a1f60aeb52deecdf337161b
Cited by
292
References
20
Citations by year
2026: 7 · 2025: 14 · 2024: 13 · 2023: 22 · 2022: 35 · 2021: 22 · 2020: 25 · 2019: 21 · 2018: 16 · 2017: 20 · 2016: 31 · 2015: 18 · 2014: 13 · 2013: 8 · 2012: 6
FWCI
5.36
Type
journal article
Language
en
Open access
closed
Licence
doi.wiley.com/10.1002/tdm_license_1.1 (tdm, 3410 d)
Locations
  • Letters in Applied Microbiology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Bacterial Cancer Therapy
  • Life Sciences › Immunology and Microbiology › Microbiology › Reproductive tract infections research
Keywords
Lactobacillus acidophilus, Lactobacillus casei, anticancer activity, tumor cell proliferation, oxidative stress, soluble polysaccharides, apoptosis, HT-29 cells, antioxidant activity, cancer prevention
MeSH terms
Antineoplastic Agents, Antioxidants, Cell Survival, Humans, Lactobacillus, Lactobacillus acidophilus, Lacticaseibacillus casei, Microscopy, Fluorescence, Polysaccharides, Bacterial, Propidium, Staining and Labeling, Apoptosis, Oxidative Stress, Cell Line, Tumor, Cell Proliferation, DNA Fragmentation

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