The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Clinical pharmacology in the geriatric patient
Open accessAbstract
Geriatric patients are a subset of older people with multiple comorbidities that usually have significant functional implications. Geriatric patients have impaired homeostasis and wide inter‐individual variability. Comprehensive geriatric assessment captures the complexity of the problems that characterize frail older patients and can be used to guide management, including prescribing. Prescribing for geriatric patients requires an understanding of the efficacy of the medication in frail older people, assessment of the risk of adverse drug events, discussion of the harm:benefit ratio with the patient, a decision about the dose regime and careful monitoring of the patient's response. This requires evaluation of evidence from clinical trials, application of the evidence to frail older people through an understanding of changes in pharmacokinetics and pharmacodynamics, and attention to medication management issues. Given that most disease occurs in older people, and that older people are the major recipients of drug therapy in the Western world, increased research and a better evidence base is essential to guide clinicians who manage geriatric patients.
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Cites
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Cited by
Pharmacokinetics and drug metabolism in the elderly
Klotz, U. (2009) · Drug Metabolism Reviews · doi:10.1080/03602530902722679 · Cited by 826
Carrière, I., Fourrier-Reglat, A., Dartigues, J.-F., Rouaud, O., Pasquier, F., Ritchie, K., & Ancelin, M.-L. (2009) · Archives of Internal Medicine · doi:10.1001/archinternmed.2009.229 · Cited by 374
Systematic review of anticholinergic risk scales in older adults
Durán, C. E., Azermai, M., & Vander Stichele, R. H. (2013) · European Journal of Clinical Pharmacology · doi:10.1007/s00228-013-1499-3 · Cited by 369
The clinical implications of ageing for rational drug therapy
Shi, S., Mörike, K., & Klotz, U. (2008) · European Journal of Clinical Pharmacology · doi:10.1007/s00228-007-0422-1 · Cited by 244
Drug Metabolism in Older People--A Key Consideration in Achieving Optimal Outcomes With Medicines
McLachlan, A. J., & Pont, L. G. (2012) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/glr118 · Cited by 172
Self-citation
Metadata
- Authors
- Hilmer, S. N., McLachlan, A. J., & Le Couteur, D. G.
- Venue
- Fundamental & Clinical Pharmacology
- Publisher
- Wiley
- Published
- 2007-04-05
- Volume
- 21
- Issue
- 3
- Pages
- 217-230
- ISSN
- 0767-3981 (ISSN-L)
- 1472-8206
- OpenAlex
- W2051350612
- Cited by
- 296
- References
- 11
- FWCI
- 5.75
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Hilmer, S. N., McLachlan, A. J., & Le Couteur, D. G. (2007). Clinical pharmacology in the geriatric patient. Fundamental & Clinical Pharmacology. https://doi.org/10.1111/j.1472-8206.2007.00473.x
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
