Long-term caloric restriction ameliorates the decline in diastolic function in humans
Open accessAbstract
Objectives We determined whether caloric restriction (CR) has cardiac-specific effects that attenuate the established aging-associated impairments in diastolic function (DF).Background Caloric restriction retards the aging process in small mammals; however, no information is available on the effects of long-term CR on human aging. In healthy individuals, Doppler echocardiography has established the pattern of aging-associated DF impairment, whereas little change is observed in systolic function (SF).Methods Diastolic function was assessed in 25 subjects (age 53 +/- 12 years) practicing CR for 6.5 +/- 4.6 years and 25 age- and gender-matched control subjects consuming Western diets. Diastolic function was quantified by transmitral flow, Doppler tissue imaging, and model-based image processing (MBIP) of E waves. C-reactive protein (CRP), tumor necrosis factor-alpha (TNF-alpha), and transforming growth factor-beta1 (TGF-beta1) were also measured.Results No difference in SF was observed between groups; however, standard transmitral Doppler flow DF indexes of the CR group were similar to those of younger individuals, and MBIP-based, flow-derived DF indexes, reflecting chamber viscoelasticity and stiffness, were significantly lower than in control subjects. Blood pressure, serum CRP, TNF-alpha, and TGF-beta(1) levels were significantly lower in the CR group (102 +/- 10/61 +/- 7 mm Hg, 0.3 +/- 0.3 mg/l, 0.8 +/- 0.5 pg/ml, 29.4 +/- 6.9 ng/ml, respectively) compared with the Western diet group (131 +/- 11/83 +/- 6 mm Hg, 1.9 +/- 2.8 mg/l, 1.5 +/- 1.0 pg/ml, 35.4 +/- 7.1 ng/ml, respectively).Conclusions Caloric restriction has cardiac-specific effects that ameliorate aging-associated changes in DF. These beneficial effects on cardiac function might be mediated by the effect of CR on blood pressure, systemic inflammation, and myocardial fibrosis.
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This calorie-restricted diet was associated with improvements in oxidative stress, inflammation, glucose, insulin sensitivity, blood pressure, lipids, and cardiac function.
“This diet was associated with improvements in oxidative stress, inflammation, glucose, insulin sensitivity, blood pressure, lipids, and cardiac function (34,35).”
From Dietary Strategies for Improving Post-Prandial Glucose, Lipids, Inflammation, and Cardiovascular Health (2008) · cites this paper as [35]
The Results passage reports better diastolic function and lower blood pressure and inflammatory markers in the calorie-restricted group; Blood analyses likewise reports lower CRP, TNF-α, and TGF-β1. The paper’s cross-sectional design supports an association, but our copy does not substantiate the claimed improvements in oxidative stress, glucose, insulin sensitivity, or lipids. Page numbers are not available in the indexed copy. (LLM, conf=0.88)
Experimental — accuracy not yet measuredA similar degree of calorie restriction in humans has been achieved by diets low in processed foods and high in vegetables, fruits, nuts, low-fat dairy, egg whites, soy protein, whole wheat, and lean meat that provide more than 100% of the daily value for all essential nutrients.
“A similar degree of calorie restriction in humans has been achieved by diets low in processed foods and high in vegetables, fruits, nuts, low-fat dairy, egg whites, soy protein, whole wheat, and lean meat that provides Ͼ100% of the daily value for all of the essential nutrients (34,35).”
From Dietary Strategies for Improving Post-Prandial Glucose, Lipids, Inflammation, and Cardiovascular Health (2008) · cites this paper as [35]
The Study participants section (page unavailable) reports that the calorie-restriction group consumed fewer calories than the Western-diet group and met at least 100% of the recommended intake for each nutrient. It does not identify the listed foods or say the diet was low in processed foods; it also says “at least 100%,” not “more than 100%.” (LLM, conf=0.86)
Experimental — accuracy not yet measuredIn the Calorie Restriction Society study, those on the calorie-restricted diet demonstrated metabolic improvements including body fat, lower blood pressure, improved insulin sensitivity, and lipid profile.
“Those on the calorie-restricted diet demonstrated a number of metabolic improvements including body fat, lower blood pressure, and improved insulin sensitivity, and lipid profile (210–212).”
From A Critical Review of the Evidence That Metformin Is a Putative Anti-Aging Drug That Enhances Healthspan and Extends Lifespan (2021) · cites this paper as [212]
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- Doppler mitral inflow patterns in a typical young individual (left panel), age-matched comparison subject (middle panel), and representative caloric restriction (CR) subject (right panel). WD ϭ Western diet. 401 JACC Vol. 47, No. 2, 2006 Meyer et al. January 17, 2006:398-402 Caloric Restriction and Diastolic Function
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- Authors
- Meyer, T. E., Kovács, S. J., Ehsani, A. A., Klein, S., Holloszy, J. O., & Fontana, L.
- Affiliations
- Washington University in St. Louis (US)
- Corresponding author
- Fontana, Luigi
- Venue
- Journal of the American College of Cardiology
- Publisher
- Elsevier BV
- Published
- 2006-01
- Volume
- 47
- Issue
- 2
- Pages
- 398-402
- ISSN
- 0735-1097 (ISSN-L)
- OpenAlex
- W2083860193
- Cited by
- 383
- References
- 21
- Citations by year
- 2026: 4 · 2025: 13 · 2024: 6 · 2023: 7 · 2022: 9 · 2021: 18 · 2020: 17 · 2019: 17 · 2018: 18 · 2017: 14 · 2016: 19 · 2015: 24 · 2014: 17 · 2013: 33 · 2012: 23
- FWCI
- 22.98
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of the American College of Cardiology (publishedVersion)
- PubMed (publishedVersion)
- Institutional Research Information System (Università degli Studi di Brescia) (submittedVersion)
- Funders
- American Heart Association
- National Institutes of Health (DK56351, DK20579, RR‐00036)
- National Institute on Aging (AG 00078)
- National Heart, Lung, and Blood Institute (K24HL004023, HL-04023, HL 54179, R01HL054179)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK 56351, DK20579, P30DK056341)
- National Center for Research Resources (RR.00036)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Keywords
- caloric restriction, diastolic function, cardiac aging, systolic function, myocardial stiffness, transmitral flow, tissue Doppler imaging, model-based image processing, E-wave, C-reactive protein, TNF-α, TGF-β1, systemic inflammation, blood pressure, myocardial fibrosis, Western diet
- MeSH terms
- Adult, Aged, Aged, 80 and over, Aging, C-Reactive Protein, Cross-Sectional Studies, Diastole, Female, Humans, Image Processing, Computer-Assisted, Male, Middle Aged, Systole, Tumor Necrosis Factor-alpha, Echocardiography, Doppler, Transforming Growth Factor beta, Caloric Restriction, Transforming Growth Factor beta1
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