The clinical implications of ageing for rational drug therapy

Oxidants, oxidative stress and the biology of ageing

Finkel, T., & Holbrook, N. J. (2000) · Nature · doi:10.1038/35041687 · Cited by 9,413 · see citing works

Adherence to medication.

Osterberg, L., & Blaschke, T. (2005) · New England Journal of Medicine · doi:10.1056/nejmra050100 · Cited by 7,974 · see citing works

Untangling the concepts of disability, frailty, and comorbidity: Implications for improved targeting and care

Fried, L. P., Ferrucci, L., Darer, J., Williamson, J. D., & Anderson, G. (2004) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/59.3.m255 · Cited by 4,032 · see citing works

Can Treatment Adherence Be Improved by Using Rubin's Four Tendencies Framework to Understand a Patient's Response to Expectations

Kirk, J. M. W., MacDonald, A., Lavender, P., Dean, J. M., & Rubin, G. (2017) · Biomedicine Hub · doi:10.1159/000480347 · Cited by 3,901 · see citing works

Adverse drug reactions as cause of admission to hospital: prospective analysis of 18 820 patients

Pirmohamed, M., James, S., Meakin, S., Green, C. A., SCOTT, A. K., Walley, T. J., Farrar, K., Park, B. K., & Breckenridge, A. M. (2004) · BMJ · doi:10.1136/bmj.329.7456.15 · Cited by 3,236 · see citing works

Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians

Shimada, T., Yamazaki, H., Mimura, M., Inui, Y., & Guengerich, F. P. (1994) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)22379-5 · Cited by 2,785 · see citing works

Updating the Beers Criteria for Potentially Inappropriate Medication Use in Older Adults

Fick, D. M., Cooper, J. W., Wade, W. E., Waller, J. L., Maclean, J. R., & Beers, M. H. (2003) · Archives of Internal Medicine · doi:10.1001/archinte.163.22.2716 · Cited by 2,389 · see citing works

Prevalence, Expenditures, and Complications of Multiple Chronic Conditions in the Elderly

Wolff, J. L., Starfield, B. H., & Anderson, G. F. (2002) · Archives of Internal Medicine · doi:10.1001/archinte.162.20.2269 · Cited by 2,237 · see citing works

Hepatogastroenterology

Liu, Y., Zhou, Z., Chen, K.-L., Zhou, B., Yang, L., Yan, H., & Li, Y. (2012) · Hepatogastroenterology · doi:10.5754/hge12281 · Cited by 2,097 · see citing works

Age‐related changes in pharmacokinetics and pharmacodynamics: basic principles and practical applications

Mangoni, A. A., & Jackson, S. H. (2003) · British Journal of Clinical Pharmacology · doi:10.1046/j.1365-2125.2003.02007.x · Cited by 1,887 · see citing works

Recent Patterns of Medication Use in the Ambulatory Adult Population of the United States: The Slone Survey

Kaufman, D. W., Kelly, J. P., Rosenberg, L., Anderson, T. E., & Mitchell, A. A. (2002) · JAMA · doi:10.1001/jama.287.3.337 · Cited by 1,845 · see citing works

Longitudinal Studies on the Rate of Decline in Renal Function with Age

Lindeman, R. D., Tobin, J., & Shock, N. W. (1985) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1985.tb07117.x · Cited by 1,578 · see citing works

Explicit criteria for determining potentially inappropriate medication use by the elderly. An update

Beers, M. H. (1997) · Archives of Internal Medicine · doi:10.1001/archinte.157.14.1531 · Cited by 1,439 · see citing works

Explicit criteria for determining inappropriate medication use in nursing home residents. UCLA Division of Geriatric Medicine

Beers, M. H. (1991) · Archives of Internal Medicine · doi:10.1001/archinte.151.9.1825 · Cited by 1,325 · see citing works

Long-term persistence in use of statin therapy in elderly patients

Benner, J. S. (2002) · JAMA · doi:10.1001/jama.288.4.455 · Cited by 1,232 · see citing works

Explicit Criteria for Determining Inappropriate Medication Use in Nursing Home Residents

Beers, M. H. (1991) · Archives of Internal Medicine · doi:10.1001/archinte.1991.00400090107019 · Cited by 1,216 · see citing works

The Effect of Age on Creatinine Clearance in Men: A Cross-sectional and Longitudinal Study

Rowe, J. W., Andres, R., Tobin, J. D., Norris, A. H., & Shock, N. W. (1976) · Journal of Gerontology · doi:10.1093/geronj/31.2.155 · Cited by 1,104 · see citing works

Appropriate prescribing in elderly people: how well can it be measured and optimised?

Spinewine, A., Schmader, K. E., Barber, N., Hughes, C. M., Lapane, K. L., Swine, C., & Hanlon, J. T. (2007) · The Lancet · doi:10.1016/s0140-6736(07)61091-5 · Cited by 1,090 · see citing works

Adherence with statin therapy in elderly patients with and without acute coronary syndromes

Jackevicius, C. A. (2002) · JAMA · doi:10.1001/jama.288.4.462 · Cited by 1,077 · see citing works

Explicit Criteria for Determining Potentially Inappropriate Medication Use by the Elderly

Beers, M. H. (1997) · Archives of Internal Medicine · doi:10.1001/archinte.1997.00440350031003 · Cited by 1,068 · see citing works

Frailty and Activation of the Inflammation and Coagulation Systems With and Without Clinical Comorbidities<subtitle>Results From the Cardiovascular Health Study</subtitle>

Walston, J. (2002) · Archives of Internal Medicine · doi:10.1001/archinte.162.20.2333 · Cited by 940 · see citing works

Changes in plasma protein binding have little clinical relevance

Benet, L. Z., & Hoener, B. (2002) · Clinical Pharmacology & Therapeutics · doi:10.1067/mcp.2002.121829 · Cited by 825 · see citing works

Interventions to Enhance Medication Adherence in Chronic Medical Conditions: A Systematic Review

Kripalani, S., Yao, X., & Haynes, R. B. (2007) · Archives of Internal Medicine · doi:10.1001/archinte.167.6.540 · Cited by 810 · see citing works

Noncardiac comorbidity increases preventable hospitalizations and mortality among medicare beneficiaries with chronic heart failure

Braunstein, J. B., Anderson, G. F., Gerstenblith, G., Weller, W. E., Niefeld, M. R., Herbert, R. J., & Wu, A. W. (2003) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(03)00947-1 · Cited by 778 · see citing works

Aging Biology and Geriatric Clinical Pharmacology

McLean, A. J., & Couteur, D. G. L. (2004) · Pharmacological Reviews · doi:10.1124/pr.56.2.4 · Cited by 771 · see citing works

Frailty and Risk of Falls, Fracture, and Mortality in Older Women: The Study of Osteoporotic Fractures

Ensrud, K. E., Ewing, S. K., Taylor, B. C., Fink, H. A., Stone, K. L., Cauley, J. A., Tracy, J. K., Hochberg, M. C., Rodondi, N., & Cawthon, P. M. (2007) · The Journals of Gerontology Series A · doi:10.1093/gerona/62.7.744 · Cited by 760 · see citing works

Drug-Drug Interactions Among Elderly Patients Hospitalized for Drug Toxicity

Juurlink, D. N., Mamdani, M., Kopp, A., Laupacis, A., & Redelmeier, D. A. (2003) · JAMA · doi:10.1001/jama.289.13.1652 · Cited by 759 · see citing works

Association Between Nonsteroidal Anti-inflammatory Drugs and Upper Gastrointestinal Tract Bleeding/Perforation

Hernández–Dı́az, S., & Rodríguez, L. A. G. (2000) · Archives of Internal Medicine · doi:10.1001/archinte.160.14.2093 · Cited by 701 · see citing works

The effects of age and liver disease on the disposition and elimination of diazepam in adult man.

Klotz, U. E., Avant, G. R., Hoyumpa, A. M., Schenker, S., & Wilkinson, G. R. (1975) · Journal of Clinical Investigation · doi:10.1172/jci107938 · Cited by 693 · see citing works

Adult lean body mass declines with age: Some longitudinal observations

Forbes, G. B., & Reina, J. C. (1970) · Metabolism · doi:10.1016/0026-0495(70)90062-4 · Cited by 684 · see citing works

Reduced β‐adrenoceptor sensitivity in the elderly

Vestal, R. E., Wood, A. J. J., & Shand, D. G. (1979) · Clinical Pharmacology & Therapeutics · doi:10.1002/cpt1979262181 · Cited by 620 · see citing works

Optimising drug treatment for elderly people: the prescribing cascade

Rochon, P. A., & Gurwitz, J. H. (1997) · BMJ · doi:10.1136/bmj.315.7115.1096 · Cited by 609 · see citing works

Free Radical Theory of Aging: An Update: Increasing the Functional Life Span

HARMAN, D. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1354.003 · Cited by 601 · see citing works

Polypharmacy in the elderly: A literature review

Fulton, M. M., & Riley Allen, E. (2005) · Journal of the American Academy of Nurse Practitioners · doi:10.1111/j.1041-2972.2005.0020.x · Cited by 540 · see citing works

Polypharmacy as commonly defined is an indicator of limited value in the assessment of drug‐related problems

Viktil, K. K., Blix, H. S., Moger, T. A., & Reikvam, A. (2006) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.2006.02744.x · Cited by 538 · see citing works

The challenge of managing drug interactions in elderly people

Mallet, L., Spinewine, A., & Huang, A. R. (2007) · The Lancet · doi:10.1016/s0140-6736(07)61092-7 · Cited by 536 · see citing works

Potentially inappropriate medications in the elderly: a French consensus panel list

Laroche, M., Charmes, J., & Merle, L. (2007) · European Journal of Clinical Pharmacology · doi:10.1007/s00228-007-0324-2 · Cited by 518 · see citing works

Interventions for enhancing medication adherence

Haynes, R. B., Yao, X., Degani, A., Kripalani, S. B., Garg, A. X., & McDonald, H. (2005) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd000011.pub2 · Cited by 512 · see citing works

Adverse Drug Reactions as Cause of Hospital Admissions: Results from the Italian Group of Pharmacoepidemiology in the Elderly (GIFA)

Onder, G., Pedone, C., Landi, F., Cesari, M., Vedova, C. D., Bernabei, R., & Gambassi, G. (2002) · Journal of the American Geriatrics Society · doi:10.1046/j.1532-5415.2002.50607.x · Cited by 502 · see citing works

Frailty in Older Men: Prevalence, Progression, and Relationship with Mortality

Cawthon, P. M., Marshall, L. M., Michael, Y., Dam, T.-T. L., Ensrud, K. E., Barrett-Connor, E. L., & ORWOLL, E. S. (2007) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2007.01259.x · Cited by 500 · see citing works

Adverse drug reactions in elderly patients

Routledge, P. A., O'Mahony, M. S., & WOODHOUSE, K. W. (2003) · British Journal of Clinical Pharmacology · doi:10.1046/j.1365-2125.2003.01875.x · Cited by 491 · see citing works

Inappropriate prescribing in the elderly

Gallagher, P., Barry, P. J., & O’Mahony, D. (2007) · Journal of Clinical Pharmacy and Therapeutics · doi:10.1111/j.1365-2710.2007.00793.x · Cited by 463 · see citing works

Influence of Sarcopenia on the Development of Physical Disability: The Cardiovascular Health Study

Janssen, I. (2006) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2005.00540.x · Cited by 459 · see citing works

Frailty: An Emerging Geriatric Syndrome

Ahmed, N. N., Mandel, R., & Fain, M. J. (2007) · The American Journal of Medicine · doi:10.1016/j.amjmed.2006.10.018 · Cited by 448 · see citing works

Hospitalization and Death Associated With Potentially Inappropriate Medication Prescriptions Among Elderly Nursing Home Residents

Lau, D. T., Kasper, J. D., Potter, D. E. B., Lyles, A., & Bennett, R. G. (2005) · Archives of Internal Medicine · doi:10.1001/archinte.165.1.68 · Cited by 442 · see citing works

Polypharmacy and falls in the middle age and elderly population

Ziere, G. J., Dieleman, J. P., Albert Hofman, D., Pols, H. A. P., van der Cammen, T. J. M., & Stricker, B. H. C. (2005) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.2005.02543.x · Cited by 422 · see citing works

The effects of gender, age, ethnicity, and liver cirrhosis on cytochrome P450 enzyme activity in human liver microsomes and inducibility in cultured human hepatocytes

Parkinson, A. (2004) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2004.01.010 · Cited by 385 · see citing works

Effect of age on MAC in humans: a meta-analysis

MAPLESON, W. W. (1996) · British Journal of Anaesthesia · doi:10.1093/bja/76.2.179 · Cited by 355 · see citing works

Skeletal muscle apoptosis, sarcopenia and frailty at old age

Marzetti, E., & Leeuwenburgh, C. (2006) · Experimental Gerontology · doi:10.1016/j.exger.2006.08.011 · Cited by 346 · see citing works

Adverse Drug Reactions in an Elderly Hospitalised Population

Passarelli, M. C. G., Filho, W. J., & Figueras, A. (2005) · Drugs & Aging · doi:10.2165/00002512-200522090-00005 · Cited by 343 · see citing works

Medication Non-Adherence in the Elderly

Hughes, C. M. (2004) · Drugs & Aging · doi:10.2165/00002512-200421120-00004 · Cited by 340 · see citing works

Age-related iso-MAC charts for isoflurane, sevoflurane and desflurane in man †

Nickalls, R. W. D., & MAPLESON, W. W. (2003) · British Journal of Anaesthesia · doi:10.1093/bja/aeg132 · Cited by 331 · see citing works

Coagulation and activation of inflammatory pathways in the development of functional decline and mortality in the elderly

Cohen, H. J., Harris, T., & Pieper, C. F. (2003) · The American Journal of Medicine · doi:10.1016/s0002-9343(02)01484-5 · Cited by 327 · cited 1× · see citing works

Antidepressant-Induced Sexual Dysfunction

Gregorian, R. S., Golden, K. A., Bahce, A., Goodman, C., Kwong, W. J., & Khan, Z. M. (2002) · Annals of Pharmacotherapy · doi:10.1345/aph.1a195 · Cited by 320 · see citing works

Is inappropriate medication use a major cause of adverse drug reactions in the elderly?

Laroche, M., Charmes, J., Nouaille, Y., Picard, N., & Merle, L. (2006) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.2006.02831.x · Cited by 317 · see citing works

The Aging Liver

Couteur, D. G. L., & McLean, A. J. (1998) · Clinical Pharmacokinetics · doi:10.2165/00003088-199834050-00003 · Cited by 308 · see citing works

The Association of Inappropriate Drug Use with Hospitalisation and Mortality

Klarin, I., Wimo, A. B., & Fastbom, J. (2005) · Drugs & Aging · doi:10.2165/00002512-200522010-00005 · Cited by 301 · see citing works

Clinical pharmacology in the geriatric patient

Hilmer, S. N., McLachlan, A. J., & Couteur, D. G. L. (2007) · Fundamental and Clinical Pharmacology · doi:10.1111/j.1472-8206.2007.00473.x · Cited by 298 · see citing works

Antidepressants for depressed elderly

Mottram, P. G., Wilson, K., & Strobl, J. (2006) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd003491.pub2 · Cited by 289 · see citing works

World Population Aging

Lubben, J., & Damron‐Rodriguez, J. (2006) · doi:10.1093/acprof:oso/9780195173727.003.0087 · Cited by 274 · see citing works

Renal function in the elderly: Impact of hypertension and cardiac function

Fliser, D., Franek, E., Joest, M., Block, S., Mutschler, E., & Ritz, E. (1997) · Kidney International · doi:10.1038/ki.1997.163 · Cited by 272 · see citing works

Health Outcomes and Polypharmacy in Elderly Individuals

Frazier, S. C. (2005) · Journal of Gerontological Nursing · doi:10.3928/0098-9134-20050901-04 · Cited by 268 · see citing works

Polypharmacy as a risk factor for adverse drug reactions in geriatric nursing home residents

Nguyen, J. K., Fouts, M. M., Kotabe, S. E., & Lo, E. (2006) · The American Journal of Geriatric Pharmacotherapy · doi:10.1016/j.amjopharm.2006.03.002 · Cited by 265 · see citing works

The Current State of Knowledge on Age, Sex, and Their Interactions on Clinical Pharmacology

Schwartz, J. B. (2007) · Clinical Pharmacology & Therapeutics · doi:10.1038/sj.clpt.6100226 · Cited by 256 · see citing works

Multiple Versus Single Antipsychotic Agents for Hospitalized Psychiatric Patients: Case-Control Study of Risks Versus Benefits

Centorrino, F., Gören, J. L., Hennen, J. A., Salvatore, P., Kelleher, J. P., & Baldessarini, R. J. (2004) · American Journal of Psychiatry · doi:10.1176/appi.ajp.161.4.700 · Cited by 253 · see citing works

Liver Function and Phase I Drug Metabolism in the Elderly

Schmucker, D. L. (2001) · Drugs & Aging · doi:10.2165/00002512-200118110-00005 · Cited by 248 · see citing works

A Prescribing Cascade Involving Cholinesterase Inhibitors and Anticholinergic Drugs

Gill, S. S., Mamdani, M., Naglie, G., Streiner, D. L., Bronskill, S. E., Kopp, A., Shulman, K. I., Lee, P. E., & Rochon, P. A. (2005) · Archives of Internal Medicine · doi:10.1001/archinte.165.7.808 · Cited by 234 · see citing works

Factors contributing to frailty: literature review

Levers, M. J., Estabrooks, C. A., & Kerr, J. C. (2006) · Journal of Advanced Nursing · doi:10.1111/j.1365-2648.2006.04021.x · Cited by 231 · see citing works

Drug metabolism and ageing

Kinirons, M. T., & O'Mahony, M. S. (2004) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.2004.02096.x · Cited by 224 · see citing works

Incidence and Predictors of All and Preventable Adverse Drug Reactions in Frail Elderly Persons After Hospital Stay

Hanlon, J. T., Pieper, C. F., Hajjar, E. R., Sloane, R. J., Lindblad, C. I., Ruby, C. M., & Schmader, K. E. (2006) · The Journals of Gerontology Series A · doi:10.1093/gerona/61.5.511 · Cited by 223 · see citing works

Postural Instability and Consequent Falls and Hip Fractures Associated with Use of Hypnotics in the Elderly: A Comparative Review

Allain, H., Bentu??-Ferrer, D., Polard, E., Akwa, Y., & Patat, A. (2005) · Drugs & Aging · doi:10.2165/00002512-200522090-00004 · Cited by 214 · see citing works

Clinical multimorbidity and physical function in older adults: a record and health status linkage study in general practice

Kadam, U. T., & Croft, P. R. (2007) · Family Practice · doi:10.1093/fampra/cmm049 · Cited by 209 · see citing works

Principles of Drug Therapy for the Elderly Patient

BRESSLER, R. C., & Bahl, J. J. (2003) · Mayo Clinic Proceedings · doi:10.4065/78.12.1564 · Cited by 205 · see citing works

Hepatic Drug Metabolism and Aging

Durnas, C., Loi, C., & Cusack, B. J. (1990) · Clinical Pharmacokinetics · doi:10.2165/00003088-199019050-00002 · Cited by 202 · see citing works

Aging Liver

Anantharaju, A., Feller, A., & Chedid, A. (2002) · Gerontology · doi:10.1159/000065506 · Cited by 201 · see citing works

Effect of Alzheimer caregiving stress and age on frailty markers interleukin-6, c-reactive protein, and d-dimer

von Känel, R., Dimsdale, J. E., Mills, P. J., Ancoli-Israel, S., Patterson, T. L., Mausbach, B. T., & Grant, I. (2006) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/61.9.963 · Cited by 196 · see citing works

Concealed Renal Insufficiency and Adverse Drug Reactions in Elderly Hospitalized Patients

Corsonello, A. (2005) · Archives of Internal Medicine · doi:10.1001/archinte.165.7.790 · Cited by 193 · see citing works

Vulnerability in the Elderly: Frailty

Slaets, J. P. J. (2006) · Medical Clinics of North America · doi:10.1016/j.mcna.2006.05.008 · Cited by 191 · see citing works

Report of the National Institute on Aging Task Force on Comorbidity

Yancik, R., Ershler, W. B., Satariano, W. A., Hazzard, W. R., Cohen, H. J., & Ferrucci, L. (2007) · The Journals of Gerontology Series A · doi:10.1093/gerona/62.3.275 · Cited by 191 · see citing works

Effect of age on functional P-glycoprotein in the blood-brain barrier measured by use of (R)-[11C]verapamil and positron emission tomography

Toornvliet, R., vanBerckel, B. N., Luurtsema, G., Lubberink, M., Geldof, A. A., Bosch, T. M., Oerlemans, R., Lammertsma, A. A., & Franssen, E. J. F. (2006) · Clinical Pharmacology & Therapeutics · doi:10.1016/j.clpt.2006.02.004 · Cited by 190 · see citing works

Aging and the Liver: An Update

Schmucker, D. L. (1998) · The Journals of Gerontology Series A · doi:10.1093/gerona/53a.5.b315 · Cited by 190 · see citing works

Drug‐Drug Interactions Related to Hospital Admissions in Older Adults: A Prospective Study of 1000 Patients

Doucet, J., Chassagne, P., Trivalle, C., Landrin, I., Pauty, M. D., Kadri, N., Ménard, J.-F., & Bercoff, E. (1996) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1996.tb01865.x · Cited by 189 · see citing works

Understanding frailty

Lally, F., & Crome, P. (2007) · Postgraduate Medical Journal · doi:10.1136/pgmj.2006.048587 · Cited by 189 · see citing works

Adverse Drug Reaction-Related Hospitalisations

van der Hooft, C. S., Sturkenboom, M., van Grootheest, K., Kingma, H. J., & Stricker, B. H. C. (2006) · Drug Safety · doi:10.2165/00002018-200629020-00006 · Cited by 187 · see citing works

Aging, Frailty, and Chemotherapy

Balducci, L. (2007) · Cancer Control · doi:10.1177/107327480701400102 · Cited by 184 · see citing works

Comorbidity and Physical Function: Results from the Aging and Longevity Study in the Sirente Geographic Area (ilSIRENTE Study)

Cesari, M., Onder, G., Russo, A., Zamboni, V., Barillaro, C., Ferrucci, L., Pahor, M., Bernabei, R., & Landi, F. (2006) · Gerontology · doi:10.1159/000089822 · Cited by 178 · see citing works

The risk of adverse drug events and hospital-related morbidity and mortality among older adults with potentially inappropriate medication use

Page, R. L., II, & Ruscin, J. M. (2006) · The American Journal of Geriatric Pharmacotherapy · doi:10.1016/j.amjopharm.2006.12.008 · Cited by 177 · see citing works

Renal function in the elderly (>70 years old) measured by means of iohexol clearance, serum creatinine, serum urea and estimated clearance

Fehrman‐Ekholm, I., & Skeppholm, L. (2004) · Scandinavian Journal of Urology and Nephrology · doi:10.1080/00365590310015750 · Cited by 175 · see citing works

Clinical Pharmacokinetic Considerations in the Elderly

Dawling, S., & Crome, P. (1989) · Clinical Pharmacokinetics · doi:10.2165/00003088-198917040-00003 · Cited by 173 · see citing works

The Hepatic Sinusoid in Aging and Cirrhosis

Couteur, D. L., Fraser, R., Hilmer, S., Rivory, L., & Mclean, A. (2005) · Clinical Pharmacokinetics · doi:10.2165/00003088-200544020-00004 · Cited by 172 · see citing works

Differential Pharmacokinetics of Lithium in Elderly Patients

Sproule, B. A., Hardy, B. G., & Shulman, K. I. (2000) · Drugs & Aging · doi:10.2165/00002512-200016030-00002 · Cited by 168 · see citing works

Potentially Inappropriate Medication Use and Healthcare Expenditures in the US Community-Dwelling Elderly

Fu, A. Z., Jiang, J., Reeves, J. H., Fincham, J. E., Liu, G. G., & Perri, M. (2007) · Medical Care · doi:10.1097/01.mlr.0000254571.05722.34 · Cited by 163 · see citing works

Comorbidity in Older Adults: Nosology of Impairment, Diseases, and Conditions

Karlamangla, A. S., Tinetti, M. E., Guralnik, J. M., Studenski, S. A., Wetle, T. T., & Reuben, D. B. (2007) · The Journals of Gerontology Series A · doi:10.1093/gerona/62.3.296 · Cited by 157 · see citing works

Effect of age and Helicobacter pylori infection on gastric acid secretion

Haruma, K., Kamada, T., Kawaguchi, H., Okamoto, S., Yoshihara, M., Sumii, K., Inoue, M., Kishimoto, S., Kajiyama, G., & Miyoshi, A. (2000) · Journal of Gastroenterology and Hepatology · doi:10.1046/j.1440-1746.2000.02131.x · Cited by 151 · see citing works

The Association of Age and Frailty with Paracetamol Conjugation in Man

Wynne, H., Cope, L., Herd, B., Rawlins, M. D., James, O., & WOODHOUSE, K. W. (1990) · Age and Ageing · doi:10.1093/ageing/19.6.419 · Cited by 149 · see citing works

Physiological Features of Aging Persons

Aalami, O. (2003) · Archives of Surgery · doi:10.1001/archsurg.138.10.1068 · Cited by 143 · see citing works

Changes in Renal Function with Aging

Beck, L. H. (1998) · Clinics in Geriatric Medicine · doi:10.1016/s0749-0690(18)30113-7 · Cited by 143 · see citing works

Clinical Pharmacokinetic Considerations in the Elderly

Kinirons, M. T., & Crome, P. (1997) · Clinical Pharmacokinetics · doi:10.2165/00003088-199733040-00005 · Cited by 142 · see citing works

The effect of age on the pharmacokinetics and pharmacodynamics of midazolam

Albrecht, S., Ihmsen, H., Hering, W., Geißlinger, G., Dingemanse, J., Schwilden, H., & Schüttler, J. (1999) · Clinical Pharmacology & Therapeutics · doi:10.1016/s0009-9236(99)90084-x · Cited by 141 · see citing works

The Aging Liver

Zeeh, J., & Platt, D. (2002) · Gerontology · doi:10.1159/000052829 · Cited by 141 · see citing works

Clinically important drug-disease interactions and their prevalence in older adults

Lindblad, C. I., Hanlon, J. T., Gross, C. R., Sloane, R. J., Pieper, C. F., Hajjar, E. R., Ruby, C. M., Schmader, K. E., & Panel, M. C. (2006) · Clinical Therapeutics · doi:10.1016/j.clinthera.2006.08.006 · Cited by 136 · see citing works

Inappropriate prescribing in the elderly: a comparison of the Beers criteria and the improved prescribing in the elderly tool (IPET) in acutely ill elderly hospitalized patients

Barry, P., O'Keefe, N. L., O’Connor, K. A., & O’Mahony, D. (2006) · Journal of Clinical Pharmacy and Therapeutics · doi:10.1111/j.1365-2710.2006.00783.x · Cited by 131 · see citing works

Clinical Pharmacokinetics of New-Generation Antiepileptic Drugs at the Extremes of Age

Perucca, E. (2006) · Clinical Pharmacokinetics · doi:10.2165/00003088-200645040-00002 · Cited by 127 · see citing works

Adverse drug reactions in older Australians, 1981–2002

Burgess, C. L., Holman, C. D. J., & Satti, A. G. (2005) · The Medical Journal of Australia · doi:10.5694/j.1326-5377.2005.tb06698.x · Cited by 126 · see citing works

Falls in the elderly: what can be done?

Akyol, A. D. (2007) · International Nursing Review · doi:10.1111/j.1466-7657.2007.00505.x · Cited by 126 · see citing works

Epidemiology of Adverse Drug Reactions in the Elderly by Drug Class

Beyth, R. J., & Shorr, R. I. (1999) · Drugs & Aging · doi:10.2165/00002512-199914030-00005 · Cited by 122 · see citing works

Inappropriate Drug Use in the Elderly: a Nationwide Register-Based Study

Johnell, K., Fastbom, J., Rosén, M., & Leimanis, A. (2007) · Annals of Pharmacotherapy · doi:10.1345/aph.1k154 · Cited by 120 · see citing works

Potential Interactions between Herbal Medicines and Conventional Drug Therapies Used by Older Adults Attending a Memory Clinic

Dergal, J. M., Gold, J., Laxer, D. A., Lee, M. S. W., Binns, M. A., t, K. L. L., Freedman, M., & Rochon, P. A. (2002) · Drugs & Aging · doi:10.2165/00002512-200219110-00005 · Cited by 118 · see citing works

Methodology, Design, and Analytic Techniques to Address Measurement of Comorbid Disease

Lash, T. L., Mor, V., Wieland, D., Ferrucci, L., Satariano, W. A., & Silliman, R. A. (2007) · The Journals of Gerontology Series A · doi:10.1093/gerona/62.3.281 · Cited by 118 · see citing works

Potential for Alcohol and Prescription Drug Interactions in Older People

Pringle, K. E., Ahern, F. M., Heller, D. A., Gold, C. H., & Brown, T. V. (2005) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2005.00474.x · Cited by 117 · see citing works

Estimation of glomerular filtration rate in the elderly: a comparison of creatinine‐based formulae with serum cystatin C

Wasén, E., Isoaho, R. E., Mattila, K. S., Vahlberg, T. J., Kivelä, S., & Irjala, K. M. A. (2004) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2004.01340.x · Cited by 116 · see citing works

An overview of the clinical pharmacology of enalapril.

Davies, R., Gomez, H., Irvin, J. D., & Walker, J. F. (1984) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.1984.tb02601.x · Cited by 115 · see citing works

Drug metabolism and drug interactions in the elderly

Herrlinger, C., & Klotz, U. E. (2001) · Best Practice & Research Clinical Gastroenterology · doi:10.1053/bega.2001.0249 · Cited by 113 · see citing works

Functional interactions between P-glycoprotein and CYP3A in drug metabolism

Christians, U., Schmitz, V., & Haschke, M. (2005) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1517/17425255.1.4.641 · Cited by 112 · see citing works

Repeat adverse drug reactions causing hospitalization in older Australians: a population‐based longitudinal study 1980–2003

Zhang, M., Holman, C. D. J., Preen, D. B., & Brameld, K. (2006) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.2006.02839.x · Cited by 111 · see citing works

IV. Clinical and physiological aspects of gastrointestinal motility and aging

Orr, W. C., & Chen, C. L. (2002) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00276.2002 · Cited by 108 · see citing works

Aging and Clinical Pharmacology: Implications for Antidepressants

Lotrich, F. E., & Pollock, B. G. (2005) · The Journal of Clinical Pharmacology · doi:10.1177/0091270005280297 · Cited by 106 · see citing works

Pharmacodynamics in the elderly

Vuyk, J. (2003) · Best practice & research. Clinical anaesthesiology · doi:10.1016/s1521-6896(03)00008-9 · Cited by 106 · see citing works

The Effect of Ageing on Cytochrome P450 Enzymes: Consequences for Drug Biotransformation in the Elderly

Wauthier, V., Verbeeck, R. K., & Calderón, P. B. (2007) · Current Medicinal Chemistry · doi:10.2174/092986707780090981 · Cited by 103 · see citing works

Pharmacokinetics and the pharmacodynamic action of midazolam in young and elderly patients undergoing tooth extraction*

Platten, H.-P., Schweizer, E., Dilger, K., Mikus, G., & Klotz, U. E. (1998) · Clinical Pharmacology & Therapeutics · doi:10.1016/s0009-9236(98)90106-0 · Cited by 102 · see citing works

Assessing Potentially Inappropriate Prescribing in the Elderly Veterans Affairs Population Using the HEDIS 2006 Quality Measure

Pugh, M. J., Hanlon, J. T., Zeber, J. E., Bierman, A. S., Cornell, J. E., & Berlowitz, D. R. (2006) · Journal of Managed Care Pharmacy · doi:10.18553/jmcp.2006.12.7.537 · Cited by 101 · see citing works

Hepatic drug metabolism and ageing

Woodhouse, K. W., & James, O. F. W. (1990) · British Medical Bulletin · doi:10.1093/oxfordjournals.bmb.a072387 · Cited by 100 · see citing works

Changes in Small‐Intestine Permeability with Aging

Saltzman, J., Kowdley, K., Perrone, G., & Russell, R. M. (1995) · Journal of The American Geriatrics Society · doi:10.1111/j.1532-5415.1995.tb06382.x · Cited by 99 · see citing works

Risk factors for nephrotoxicity in elderly patients receiving once-daily aminoglycosides

Raveh, D. (2002) · QJM · doi:10.1093/qjmed/95.5.291 · Cited by 99 · see citing works

Suboptimal Prescribing in Elderly Outpatients: Potentially Harmful Drug‐Drug and Drug‐Disease Combinations

Zhan, C., Correa‐de‐Araujo, R., Bierman, A. S., Sangl, J., Miller, M. R., Wickizer, S. W., & Stryer, D. B. (2005) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2005.53112.x · Cited by 98 · see citing works

Medication Nonadherence and Subsequent Risk of Hospitalisation and Mortality among Older Adults

Vik, S., Hogan, D. B., Patten, S. B., Johnson, J. A., Romonko, L., & Maxwell, C. J. (2006) · Drugs & Aging · doi:10.2165/00002512-200623040-00007 · Cited by 98 · see citing works

Effect of Age and Comedication on Levetiracetam Pharmacokinetics and Tolerability

Hirsch, L. J., Haider, H. A., Buchsbaum, R., Weintraub, D. B., Lee, J., Chang, J. T., Resor, S. R., & Bazil, C. W. (2007) · Epilepsia · doi:10.1111/j.1528-1167.2007.01043.x · Cited by 97 · see citing works

Impaired Bronchodilator Response to Albuterol in Healthy Elderly Men and Women

Connolly, M. J., Crowley, J. J., Charan, N. B., Nielson, C., & Vestal, R. E. (1995) · CHEST Journal · doi:10.1378/chest.108.2.401 · Cited by 97 · see citing works

The Relations of Body Composition and Adiposity Measures to Ill Health and Physical Disability in Elderly Men

Ramsay, S. E., Whincup, P. H., Shaper, A. G., & Wannamethee, S. G. (2006) · American Journal of Epidemiology · doi:10.1093/aje/kwj217 · Cited by 94 · see citing works

Drug metabolism and ageing

Wynne, H. (2005) · The Journal of the British Menopause Society · doi:10.1258/136218005775544589 · Cited by 89 · see citing works

Effects of Age and Gender on Single‐Dose Pharmacokinetics of Gabapentin

Boyd, R. A., Türck, D., Abel, R. B., Sedman, A. J., & Bockbrader, H. N. (1999) · Epilepsia · doi:10.1111/j.1528-1157.1999.tb00743.x · Cited by 88 · see citing works

Compliance to Treatment for Hypertension in Elderly Patients: The Shep Pilot Study

Black, D. M., Brand, R., Greenlick, M. R., Hughes, G., & Smith, J. J. B. (1987) · Journal of Gerontology · doi:10.1093/geronj/42.5.552 · Cited by 87 · see citing works

Drug development and use in the elderly: search for the right dose and dosing regimen

Shah, R. R. (2004) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.2004.02228.x · Cited by 87 · see citing works

Framework for Evaluating Disease Severity Measures in Older Adults With Comorbidity

Boyd, C. M., Weiss, C. O., Halter, J., Han, K. C., Ershler, W. B., & Fried, L. P. (2007) · The Journals of Gerontology Series A · doi:10.1093/gerona/62.3.286 · Cited by 85 · see citing works

Differential Pharmacokinetics of Digoxin in Elderly Patients

Hanratty, C. G., McGlinchey, P. G., Johnston, G., & Passmore, A. P. (2000) · Drugs & Aging · doi:10.2165/00002512-200017050-00003 · Cited by 84 · see citing works

Systolic Hypertension in the Elderly Program (SHEP)

Hulley, S. B., Feigal, D. W., Ireland, C., Kuller, L. H., & Smith, W. M. (1986) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1986.tb05476.x · Cited by 83 · see citing works

Influence of Age and Cytochrome P450 2C9 Genotype on the Steady-State Disposition of Diclofenac and Celecoxib

Brenner, S. S., Herrlinger, C., Dilger, K., Mürdter, T. E., Hofmann, U., Marx, C., & Klotz, U. E. (2003) · Clinical Pharmacokinetics · doi:10.2165/00003088-200342030-00003 · Cited by 83 · see citing works

Grapefruit juice–felodipine interaction in the elderly

Dresser, G. K. (2000) · Clinical Pharmacology & Therapeutics · doi:10.1067/mcp.2000.107524 · Cited by 82 · see citing works

Regional Anaesthesia in the Elderly

Tsui, B. C. H., Wagner, A. M., & Finucane, B. T. (2004) · Drugs & Aging · doi:10.2165/00002512-200421140-00001 · Cited by 81 · see citing works

Plasma Aspirin Esterase: the Influence of Old Age and Frailty

Williams, F. M., Wynne, H., WOODHOUSE, K. W., & Rawlins, M. D. (1989) · Age and Ageing · doi:10.1093/ageing/18.1.39 · Cited by 78 · see citing works

Renal handling of drugs in the healthy elderly

Fliser, D., Bischoff, I., Hanses, A., Block, S., Joest, M., Ritz, E., & Mutschler, E. (1999) · European Journal of Clinical Pharmacology · doi:10.1007/s002280050619 · Cited by 77 · see citing works

The Association of Age and Frailty with the Pharmacokinetics and Pharmacodynamics of Metoclopramide

Wynne, H., Yelland, C. E., Cope, L., Boddy, A. V., WOODHOUSE, K. W., & Bateman, D. N. (1993) · Age and Ageing · doi:10.1093/ageing/22.5.354 · Cited by 77 · see citing works

Is There an Antiaging Medicine?

Butler, R. N., Fossel, M., Harman, S. M., Heward, C. B., Olshansky, S. J., Perls, T. T., Rothman, D. J., Rothman, S. M., Warner, H. R., West, M. D., et al. (2002) · The Journals of Gerontology Series A · doi:10.1093/gerona/57.9.b333 · Cited by 76 · see citing works

The erythromycin breath test reflects P-glycoprotein function independently of cytochrome P450 3A activity

Kurnik, D., Wood, A., & Wilkinson, G. R. (2006) · Clinical Pharmacology & Therapeutics · doi:10.1016/j.clpt.2006.06.002 · Cited by 75 · see citing works

The effects of antidepressant medication adherence as well as psychosocial and clinical factors on depression outcome among older adults

Bosworth, H. B., Voils, C. I., Potter, G. G., & Steffens, D. C. (2007) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.1852 · Cited by 74 · see citing works

Inappropriate Prevention of NSAID-Induced Gastrointestinal Events Among Long-Term Users in the Elderly

Lanas, Á., & Ferrández, Á. (2007) · Drugs & Aging · doi:10.2165/00002512-200724020-00004 · Cited by 74 · see citing works

Transdermal Treatment Options for Neurological Disorders

Priano, L., Gasco, M. R., & Mauro, A. (2006) · Drugs & Aging · doi:10.2165/00002512-200623050-00001 · Cited by 71 · see citing works

Frailty in Older Adults

Torpy, J. M., Lynm, C., & Glass, R. M. (2006) · JAMA · doi:10.1001/jama.296.18.2280 · Cited by 71 · see citing works

Human variability in polymorphic CYP2D6 metabolism: is the kinetic default uncertainty factor adequate?

Dorne, J. L. C. M., Walton, K., Slob, W., & RENWICK, A. G. (2002) · Food and Chemical Toxicology · doi:10.1016/s0278-6915(02)00117-5 · Cited by 70 · see citing works

Impact of inappropriate drug use on physical performance among a frail elderly population living in the community

Landi, F., Russo, A., Liperoti, R., Barillaro, C., Danese, P., Pahor, M., Bernabei, R., & Onder, G. (2007) · European Journal of Clinical Pharmacology · doi:10.1007/s00228-007-0321-5 · Cited by 68 · see citing works

Falls in German in‐patients and residents over 65 years of age

Heinze, C., Halfens, R. J. G., & Dassen, T. W. N. (2007) · Journal of Clinical Nursing · doi:10.1111/j.1365-2702.2006.01578.x · Cited by 66 · see citing works

Enzyme induction in the elderly: Effect of rifampin on the pharmacokinetics and pharmacodynamics of propafenone

Dilger, K. (2000) · Clinical Pharmacology & Therapeutics · doi:10.1067/mcp.2000.106872 · Cited by 66 · see citing works

Small Bowel Enterocyte Apoptosis and Proliferation Are Increased in the Elderly

Ciccocioppo, R., Sabatino, A. D., Luinetti, O., Rossi, M., Cifone, M., & Corazza, G. (2002) · Gerontology · doi:10.1159/000058351 · Cited by 64 · see citing works

Age-Related Differences in the Prevalence of Potential Drug-Drug Interactions in Ambulatory Dyslipidaemic Patients Treated with Statins

Egger, S. S., Bravo, A. E. R., Hess, L., Schlienger, R. G., & hl, S. K. H. (2007) · Drugs & Aging · doi:10.2165/00002512-200724050-00006 · Cited by 64 · see citing works

Inappropriate Drug Use and Risk of Transition to Nursing Homes Among Community-Dwelling Older Adults

Zuckerman, I. H., LANGENBERG, P. W., Baumgarten, M., Orwig, D., Byrns, P. J., Simoni, J. M., & Magaziner, J. S. (2006) · Medical Care · doi:10.1097/01.mlr.0000215849.15769.be · Cited by 60 · see citing works

Sarcopenia: Age-Related Skeletal Muscle Changes from Determinants to Physical Disability

Iorio, A. D., Abate, M., Renzo, D. D., Russolillo, A., Battaglini, C. L., Ripari, P., Saggini, R., Paganelli, R., & Abate, G. (2006) · International Journal of Immunopathology and Pharmacology · doi:10.1177/039463200601900401 · Cited by 57 · see citing works

Medication use as a risk factor for falls among hospitalized elderly patients

Walker, P. C., Alrawi, A., Mitchell, J. F., Regal, R. E., & Khanderia, U. (2005) · American Journal of Health-System Pharmacy · doi:10.2146/ajhp050116 · Cited by 56 · see citing works

Frailty and ageing

WOODHOUSE, K. W., & O'Mahony, M. S. (1997) · Age and Ageing · doi:10.1093/ageing/26.4.245 · Cited by 56 · see citing works

P-glycoprotein function in the elderly

Brenner, S. S., & Klotz, U. E. (2004) · European Journal of Clinical Pharmacology · doi:10.1007/s00228-004-0733-4 · Cited by 55 · see citing works

Renal function in the elderly-is the dogma of an inexorable decline of renal function correct?

Fliser, D., Franek, E., & Ritz, E. (1997) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/12.8.1553 · Cited by 55 · see citing works

Transport Proteins and Intestinal Metabolism

Christians, U. (2004) · Therapeutic Drug Monitoring · doi:10.1097/00007691-200404000-00002 · Cited by 54 · see citing works

Glomerular filtration rate as measured by serum cystatin C is an important determinant of plasma homocysteine and serum methylmalonic acid in the elderly

Lewerin, C., Ljungman, S., & Nilsson‐Ehle, H. (2007) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2006.01732.x · Cited by 53 · see citing works

Adverse drug reactions result in 250 000 UK admissions a year

Hitchen, L. (2006) · BMJ · doi:10.1136/bmj.332.7550.1109 · Cited by 53 · see citing works

Effects of Uptake and Efflux Transporter Inhibition on Erythromycin Breath Test Results

Frassetto, L. A., Poon, S., Tsourounis, C., Valera, C., & Benet, L. Z. (2007) · Clinical Pharmacology & Therapeutics · doi:10.1038/sj.clpt.6100148 · Cited by 53 · see citing works

Risk and Predictability of Drug Interactions in the Elderly

Levy, R. H., & Collins, C. J. (2007) · International review of neurobiology · doi:10.1016/s0074-7742(06)81015-9 · Cited by 52 · see citing works

Nonselective Nonaspirin Nonsteroidal Anti-Inflammatory Drugs and Gastrointestinal Bleeding: Relative and Absolute Risk Estimates From Recent Epidemiologic Studies

Tarone, R. E., Blot, W. J., & McLaughlin, J. K. (2004) · American Journal of Therapeutics · doi:10.1097/00045391-200401000-00007 · Cited by 51 · see citing works

Potential Drug—Disease Interactions in Frail, Hospitalized Elderly Veterans

Lindblad, C. I., Artz, M. B., Pieper, C. F., Sloane, R. J., Hajjar, E. R., Ruby, C. M., Schmader, K. E., & Hanlon, J. T. (2005) · Annals of Pharmacotherapy · doi:10.1345/aph.1e467 · Cited by 50 · see citing works

Preventing falls among elderly people in the hospital environment

Kannus, P., Khan, K. M., & Lord, S. R. (2006) · The Medical Journal of Australia · doi:10.5694/j.1326-5377.2006.tb00283.x · Cited by 49 · see citing works

Use of Inappropriate Medications and Their Prognostic Significance Among In-Hospital and Nursing Home Patients with and without Dementia in Finland

Raivio, M., Laurila, J., Strandberg, T. E., Tilvis, R. S., & l, K. H. P. (2006) · Drugs & Aging · doi:10.2165/00002512-200623040-00006 · Cited by 49 · see citing works

Polypharmacy and potential inappropriateness of pharmaco-logical treatment among commuinity-dwellling elderly patients

Rajska-Neumann, A., & Wieczorowska–Tobis, K. (2007) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2007.01.040 · Cited by 48 · see citing works

Non-Cardiovascular Co-Morbidity in Elderly Patients with Heart Failure Outnumbers Cardiovascular Co-Morbidity

van der Wel, M. C., Jansen, R. W. M. M., Bakx, J. C., Bor, H. H. J., Olde-Rikkert, M. G. M., & van Weel, C. (2007) · European Journal of Heart Failure · doi:10.1016/j.ejheart.2007.02.004 · Cited by 47 · see citing works

Herbal, Prescribed, and Over-the-Counter Drug Use in Older Women: Prevalence of Drug Interactions

Yoon, S. L., & Schaffer, S. D. (2006) · Geriatric Nursing · doi:10.1016/j.gerinurse.2006.02.014 · Cited by 46 · see citing works

Multimedikation, Compliance und Zusatzmedikation bei Patienten mit kardiovaskulären Erkrankungen

Rottlaender, D., Scherner, M. P., Schneider, T., & Erdmann, E. (2007) · DMW - Deutsche Medizinische Wochenschrift · doi:10.1055/s-2007-959300 · Cited by 45 · see citing works

DRUG‐RELATED HOSPITAL ADMISSIONS IN A GENERIC PHARMACEUTICAL SYSTEM

Zargarzadeh, A., Emami, M. H., & Hosseini, F. (2007) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.2007.04600.x · Cited by 45 · see citing works

Changes in drug treatment in the elderly between 1971 and 2000

Lernfelt, B., Samúelsson, Ó., Skoog, I. G., & Landahl, S. (2003) · European Journal of Clinical Pharmacology · doi:10.1007/s00228-003-0647-6 · Cited by 43 · see citing works

III. Senescent enteric nervous system: lessons from extraintestinal sites and nonmammalian species

Wiley, J. W. (2002) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00224.2002 · Cited by 42 · see citing works

Erythromycin breath test results in elderly, very elderly, and frail elderly persons

Schwartz, J. B. (2006) · Clinical Pharmacology & Therapeutics · doi:10.1016/j.clpt.2006.01.006 · Cited by 41 · see citing works

Cardiovascular Drug Therapy in the Elderly

Aronow, W. S., Frishman, W. H., & Cheng-Lai, A. (2007) · Cardiology in Review · doi:10.1097/crd.0b013e3180301b69 · Cited by 41 · see citing works

Effect of age on the pharmacokinetics of solifenacin in men and women

Krauwinkel, W. J. J., Smulders, R. A., Mulder, H., Swart, P. J., & Taekema-Roelvink, M. E. J. (2005) · International Journal of Clinical Pharmacology and Therapeutics · doi:10.5414/cpp43227 · Cited by 39 · see citing works

Psychotropic drug use, falls and hip fracture in the elderly

Schwab, M. G., Röder, F., Aleker, T., Ammon, S., Thon, K.-P., Eichelbaum, M. F., & Klotz, U. E. (2000) · Aging Clinical and Experimental Research · doi:10.1007/bf03339841 · Cited by 38 · see citing works

Editorial: Antiaging Medicine: The Good, the Bad, and the Ugly

Fisher, A., & Morley, J. E. (2002) · The Journals of Gerontology Series A · doi:10.1093/gerona/57.10.m636 · Cited by 38 · see citing works

Parenchymal liver disease in the elderly

James, O. (1997) · Gut · doi:10.1136/gut.41.4.430 · Cited by 37 · see citing works

Falls and medications in the elderly.

Daal, J. O., & LIESHOUT, J. J. V. (2005) · PubMed · Cited by 36 · see citing works

Use of Aminoglycosides in Elderly Patients

Mörike, K., Schwab, M. G., & Klotz, U. E. (1997) · Drugs & Aging · doi:10.2165/00002512-199710040-00003 · Cited by 36 · see citing works

Age‐Related Changes in Pharmacokinetics: Predictability and Assessment Methods

Perucca, E. (2007) · International review of neurobiology · doi:10.1016/s0074-7742(06)81011-1 · Cited by 35 · see citing works

Evidence based medicine for older people: available, accessible, acceptable, adaptable?

Nair, B. (2002) · Australasian Journal on Ageing · doi:10.1111/j.1741-6612.2002.tb00418.x · Cited by 32 · see citing works

Optimal Management of Asthma in Elderly Patients

Goeman, D., & Douglass, J. A. (2007) · Drugs & Aging · doi:10.2165/00002512-200724050-00003 · Cited by 31 · see citing works

Bridging the gap: ageing, pharmacokinetics and pharmacodynamics

Burton, D. G. A., Allen, M. C., Bird, J., & Faragher, R. (2005) · Journal of Pharmacy and Pharmacology · doi:10.1211/0022357056163 · Cited by 31 · see citing works

Fragiele ouderen: De identificatie van een risicovolle populatie

Gobbens, R. J. J., Luijkx, K. G., Wijnen-Sponselee, M. T., & Schols, J. M. G. A. (2007) · Tijdschrift voor Gerontologie en Geriatrie · doi:10.1007/bf03074829 · Cited by 30 · see citing works

Choosing nonselective NSAIDs and selective COX-2 inhibitors in the elderly. A clinical use pathway.

Stillman, M. J., & Stillman, M. T. (2007) · PubMed · Cited by 27 · see citing works

Estimation of Glomerular Filtration Rate in the Elderly: Cockcroft‐Gault Formula versus Modification of Diet in Renal Disease Formula

Laroche, M., Charmes, J., Marcheix, A., Bouthier, F., & Merle, L. (2006) · Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy · doi:10.1592/phco.26.7.1041 · Cited by 26 · see citing works

Anaesthesia for the Elderly Patient

Sophie, S. (2017) · European Journal of Anaesthesiology · doi:10.1097/eja.0000000000000645 · Cited by 26 · see citing works

The Mature Stomach

Feldman, M. L. (1997) · JAMA · doi:10.1001/jama.1997.03550080091047 · Cited by 25 · see citing works

The impact of advancing age on P-glycoprotein expression and activity: current knowledge and future directions

Mangoni, A. A. (2007) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1517/17425255.3.3.315 · Cited by 24 · see citing works

The Kinetics of Plasma Aspirin Esterase in Relation to Old Age and Frailty

Summerbell, J., Yelland, C. E., & WOODHOUSE, K. W. (1990) · Age and Ageing · doi:10.1093/ageing/19.2.128 · Cited by 23 · see citing works

Population analyses of amlodipine in patients living in the community and patients living in nursing homes

KANG, D., Verotta, D., & Schwartz, J. B. (2006) · Clinical Pharmacology & Therapeutics · doi:10.1016/j.clpt.2005.09.007 · Cited by 23 · see citing works

Effect of Conjugated Equine Estrogens on Oxidative Metabolism in Middle‐aged and Elderly Postmenopausal Women

O’Connell, M. B., Frye, R. F., Matzke, G. R., Peter, J. V. S., Willhite, L. A., Welch, M. R., Kowal, P. R., & Valleur, J. L. (2006) · The Journal of Clinical Pharmacology · doi:10.1177/0091270006292249 · Cited by 23 · see citing works

Body composition and fat distribution pattern of urban elderly females, Delhi, India.

Tyagi, R., Kapoor, S., & Kapoor, A. K. (2005) · PubMed · Cited by 22 · see citing works

Influence of aging, gastric mucosal atrophy and dietary habits on gastric secretion.

Nakamura, K., Ogoshi, K., & Makuuchi, H. (2006) · PubMed · Cited by 21 · see citing works

Update of the Stroke Therapy Academic Industry Roundtable Preclinical Recommendations

Fisher, M., Feuerstein, G., Howells, D. W., Hurn, P. D., Kent, T. A., Savitz, S. I., & Lo, E. H. (2009) · Stroke · doi:10.1161/strokeaha.108.541128 · Cited by 1,352 · see citing works

Pharmacokinetics and drug metabolism in the elderly

Klotz, U. (2009) · Drug Metabolism Reviews · doi:10.1080/03602530902722679 · Cited by 826 · see citing works

Potentially Inappropriate Medications in the Elderly

Holt-Noreiks, S., Schmiedl, S., & Thürmann, P. (2010) · Deutsches Ärzteblatt international · doi:10.3238/arztebl.2010.0543 · Cited by 795 · see citing works

Age-Related Pharmacokinetic and Pharmacodynamic Changes and Related Risk of Adverse Drug Reactions

Corsonello, A., Pedone, C., & Incalzi, R. A. (2010) · Current Medicinal Chemistry · doi:10.2174/092986710790416326 · Cited by 393 · see citing works

The epidemiology of polypharmacy in older adults: register-based prospective cohort study

Morin, L., Johnell, K., Laroche, M., Fastbom, J., & Wastesson, J. W. (2018) · Clinical Epidemiology · doi:10.2147/clep.s153458 · Cited by 390 · see citing works

Hospitalisation rates and predictors in people with dementia: a systematic review and meta-analysis

Shepherd, H., Livingston, G., Chan, J., & Sommerlad, A. (2019) · BMC Medicine · doi:10.1186/s12916-019-1369-7 · Cited by 232 · see citing works

Polypharmacy and frailty: prevalence, relationship, and impact on mortality in a French sample of 2350 old people

Herr, M., Robine, J., Pinot, J., Arvieu, J., & Ankri, J. (2015) · Pharmacoepidemiology and Drug Safety · doi:10.1002/pds.3772 · Cited by 216 · see citing works

Comparison of Prescribing Criteria to Evaluate the Appropriateness of Drug Treatment in Individuals Aged 65 and Older: A Systematic Review

Dimitrow, M. S., Airaksinen, M. S. A., Kivelä, S., Lyles, A., & Leikola, S. N. S. (2011) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2011.03497.x · Cited by 203 · see citing works

Pharmacokinetics and Pharmacodynamic Changes Associated with Aging and Implications for Drug Therapy

Sera, L., & McPherson, M. L. (2012) · Clinics in Geriatric Medicine · doi:10.1016/j.cger.2012.01.007 · Cited by 166 · see citing works

Drug Burden Index and physical function in older Australian men

Gnjidic, D., Cumming, R. G., Couteur, D. G. L., Handelsman, D. J., Naganathan, V., Abernethy, D. R., & Hilmer, S. N. (2009) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.2009.03411.x · Cited by 166 · see citing works

Review on Pharmacokinetics and Pharmacodynamics and the Aging Kidney

Aymanns, C., Keller, F., Maus, S., Hartmann, B., & Czock, D. (2010) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.03960609 · Cited by 159 · see citing works

Improving the Quality of Pharmacotherapy in Elderly Primary Care Patients Through Medication Reviews: A Randomised Controlled Study

Nymberg, V. M., Rekman, E., Bondesson, Å., Eriksson, T., Jakobsson, U., Westerlund, T., & Midlöv, P. (2013) · Drugs & Aging · doi:10.1007/s40266-013-0057-0 · Cited by 153 · see citing works

Drug Interactions with Herbal Medicines

Shi, S., & Klotz, U. E. (2012) · Clinical Pharmacokinetics · doi:10.2165/11597910-000000000-00000 · Cited by 143 · see citing works

The Economic Burden of Inappropriate Drug Prescribing, Lack of Adherence and Compliance, Adverse Drug Events in Older People

Chiatti, C., Bustacchini, S., Furneri, G., Mantovani, L. G., Cristiani, M., Misuraca, C., & Lattanzio, F. (2012) · Drug Safety · doi:10.1007/bf03319105 · Cited by 143 · see citing works

Psychotropic drugs and the risk of fall injuries, hospitalisations and mortality among older adults

Johnell, K., Jonasdottir Bergman, G., Fastbom, J., Danielsson, B., Borg, N., & Salmi, P. (2017) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.4483 · Cited by 130 · see citing works

Underprescription of Beneficial Medicines in Older People

Cherubini, A., Corsonello, A., & Lattanzio, F. (2012) · Drugs & Aging · doi:10.2165/11631750-000000000-00000 · Cited by 121 · see citing works

Association Between Potentially Inappropriate Medications From the Beers Criteria and the Risk of Unplanned Hospitalization in Elderly Patients

Price, S. D., Holman, C. D. J., Sanfilippo, F. M., & Emery, J. D. (2014) · Annals of Pharmacotherapy · doi:10.1177/1060028013504904 · Cited by 120 · see citing works

Potentially inadequate medications in the elderly: PRISCUS 2.0—first update of the PRISCUS list

Mann, N., Mathes, T., Sönnichsen, A. C., Pieper, D., Klager, E., Moussa, M., & Thürmann, P. (2023) · Deutsches Ärzteblatt international · doi:10.3238/arztebl.m2022.0377 · Cited by 125 · see citing works

Effect of Medication Reconciliation at Hospital Admission on Medication Discrepancies During Hospitalization and at Discharge for Geriatric Patients

Cornu, P., Steurbaut, S., Leysen, T., Baere, E. D., Ligneel, C., Mets, T. F., & Dupont, A. G. (2012) · Annals of Pharmacotherapy · doi:10.1345/aph.1q594 · Cited by 119 · see citing works

Alterations in drug disposition in older adults

Reeve, E., Wiese, M. D., & Mangoni, A. A. (2015) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1517/17425255.2015.1004310 · Cited by 115 · see citing works

Adverse drug reactions leading to urgent hospital admission in an elderly population: prevalence and main features

Pedrós, C., Formiga, F., Corbella, X., & Arnau, J. M. (2015) · European Journal of Clinical Pharmacology · doi:10.1007/s00228-015-1974-0 · Cited by 112 · see citing works

Medication History Reconciliation by Clinical Pharmacists in Elderly Inpatients Admitted from Home or a Nursing Home

Steurbaut, S., Leemans, L., Leysen, T., Baere, E. D., Cornu, P., Mets, T. F., & Dupont, A. G. (2010) · Annals of Pharmacotherapy · doi:10.1345/aph.1p192 · Cited by 108 · see citing works

The “iatrogenic triad”: polypharmacy, drug–drug interactions, and potentially inappropriate medications in older adults

Novaes, P. H., da Cruz, D. T., Lucchetti, A. L. G., Leite, I. C. G., & Lucchetti, G. (2017) · International Journal of Clinical Pharmacy · doi:10.1007/s11096-017-0470-2 · Cited by 97 · see citing works

Polypharmacy and Potentially Inappropriate Medication in People with Dementia: A Nationwide Study

Kristensen, R. U., Nørgaard, A., Jensen‐Dahm, C., Gasse, C., Wimberley, T., & Waldemar, G. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-170905 · Cited by 94 · see citing works

Prescribing Optimization Method for Improving Prescribing in Elderly Patients Receiving Polypharmacy

Maanen, A. C. D., van Marum, R. J., Knol, W., van der Linden, C. M. J., & Jansen, P. A. F. (2009) · Drugs & Aging · doi:10.2165/11316400-000000000-00000 · Cited by 94 · see citing works

Impact of Inappropriate Drug Use on Hospitalizations, Mortality, and Costs in Older Persons and Persons with Dementia: Findings from the SNAC Study

Sköldunger, A., Fastbom, J., Wimo, A. B., Fratiglioni, L., & Johnell, K. (2015) · Drugs & Aging · doi:10.1007/s40266-015-0287-4 · Cited by 91 · see citing works

Inappropriate Drug Use in People with Cognitive Impairment and Dementia: A Systematic Review

Johnell, K. (2015) · Current Clinical Pharmacology · doi:10.2174/1574884710666150609154741 · Cited by 88 · see citing works

Computerized Decision Support Improves Medication Review Effectiveness: An Experiment Evaluating the STRIP Assistant’s Usability

Meulendijk, M. C., Spruit, M. R., Maanen, A. C. D., Numans, M. E., Brinkkemper, S., Jansen, P. A. F., & Knol, W. (2015) · Drugs & Aging · doi:10.1007/s40266-015-0270-0 · Cited by 84 · see citing works

Using explicit criteria to evaluate the quality of prescribing in elderly Italian outpatients: a cohort study

Maio, V., Canale, S. D., Abouzaid, S., & GAP Investigators (2009) · Journal of Clinical Pharmacy and Therapeutics · doi:10.1111/j.1365-2710.2009.01094.x · Cited by 82 · see citing works

The composition of polypharmacy: A register-based study of Swedes aged 75 years and older

Wastesson, J. W., Cedazo-Mı́nguez, Á., Fastbom, J., Maioli, S., & Johnell, K. (2018) · PLoS ONE · doi:10.1371/journal.pone.0194892 · Cited by 81 · see citing works

Safety and Tolerability of Antimicrobial Agents in the Older Patient

Soraci, L., Cherubini, A., Paoletti, L., Filippelli, G., Luciani, F., Laganà, P., Gambuzza, M. E., Filicetti, E., Corsonello, A., & Lattanzio, F. (2023) · Drugs & Aging · doi:10.1007/s40266-023-01019-3 · Cited by 85 · see citing works

Older adults' satisfaction with a medication dispensing device in home care

Reeder, B., Demiris, G., & Marek, K. D. (2013) · Informatics for Health and Social Care · doi:10.3109/17538157.2012.741084 · Cited by 75 · see citing works

Comparison of Prescription Drug Use between Community-Dwelling and Institutionalized Elderly in Sweden

Johnell, K., & Fastbom, J. (2012) · Drugs & Aging · doi:10.1007/s40266-012-0002-7 · Cited by 74 · see citing works

Immunotherapy in Elderly Transplant Recipients

Kuypers, D. R. J. (2009) · Drugs & Aging · doi:10.2165/11316480-000000000-00000 · Cited by 74 · see citing works

Factors Associated with Multiple Medication Use in Different Age Groups

Moen, J., Antonov, K., Larsson, C., Lindblad, U., Nilsson, J. L. G., Råstam, L., & Ring, L. (2009) · Annals of Pharmacotherapy · doi:10.1345/aph.1m354 · Cited by 72 · see citing works

Polypharmacy and potentially inappropriate medications: a cross-sectional analysis among 451 nursing homes in France

Herr, M., Grondin, H., Sanchez, S., Armaingaud, D., Blochet, C., Vial, A., Denormandie, P., & Ankri, J. (2017) · European Journal of Clinical Pharmacology · doi:10.1007/s00228-016-2193-z · Cited by 72 · see citing works

Safety and pharmacokinetics of oral delta-9-tetrahydrocannabinol in healthy older subjects: A randomized controlled trial

Ahmed, A. I. A., van den Elsen, G. A. H., Colbers, A. P. H., van der Marck, M. A., Burger, D. M., Feuth, T. B., Rikkert, M. G. M. O., & Kramers, C. (2014) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2014.06.007 · Cited by 71 · see citing works

Drug use in centenarians compared with nonagenarians and octogenarians in Sweden: a nationwide register-based study

Wastesson, J. W., Parker, M. G., Fastbom, J., Thorslund, M., & Johnell, K. (2011) · Age and Ageing · doi:10.1093/ageing/afr144 · Cited by 68 · see citing works

Trends in Use of Paracetamol in the Nordic Countries

Wastesson, J. W., Martikainen, J. E., Zoëga, H., Schmidt, M., Karlstad, Ø., & Pottegård, A. (2018) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/bcpt.13003 · Cited by 63 · see citing works

The impact of drug interactions and polypharmacy on antimicrobial therapy in the elderly

Corsonello, A., Abbatecola, A. M., Fusco, S., Luciani, F., Marino, A., Catalano, S., Maggio, M. G., & Lattanzio, F. (2014) · Clinical Microbiology and Infection · doi:10.1016/j.cmi.2014.09.011 · Cited by 64 · see citing works

Effects of medication reviews on use of potentially inappropriate medications in elderly patients; a cross-sectional study in Swedish primary care

Lenander, C., Bondesson, Å., Viberg, N., Beckman, A., & Midlöv, P. (2018) · BMC Health Services Research · doi:10.1186/s12913-018-3425-y · Cited by 63 · see citing works

Institutionalization as a Risk Factor for Inappropriate Drug Use in the Elderly: A Swedish Nationwide Register-Based Study

Haasum, Y., Fastbom, J., & Johnell, K. (2012) · Annals of Pharmacotherapy · doi:10.1345/aph.1q597 · Cited by 62 · see citing works

Prospective randomized double-blind trial of racecadotril compared with loperamide in elderly people with gastroenteritis living in nursing homes

Gallelli, L., Colosimo, M., Tolotta, G. A., Falcone, D., Luberto, L., Curto, L. S., Rende, P., Mazzei, F. A., Marigliano, N. M., Sarro, G. D., et al. (2009) · European Journal of Clinical Pharmacology · doi:10.1007/s00228-009-0751-3 · Cited by 58 · see citing works

Potential drug interactions in elderly cancer patients

Girre, V., Arkoub, H., Puts, M. T. E., Vantelon, C., Blanchard, F., Droz, J., & Mignot, L. (2010) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2010.05.004 · Cited by 57 · see citing works

Clinical implications of ageing for the management of IBD

Ha, C. Y., & Katz, S. (2013) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2013.241 · Cited by 57 · see citing works

The impact of pharmaceutical care interventions for medication underuse in older people: a systematic review and meta‐analysis

Meid, A. D., Lampert, A., Burnett, A., Seidling, H. M., & Haefeli, W. E. (2015) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.12657 · Cited by 56 · see citing works

Potentially inappropriate medication and attitudes of older adults towards deprescribing

Achterhof, A. B., Rozsnyai, Z., Reeve, E., Jungo, K. T., Floriani, C., Poortvliet, R. K. E., Rodondi, N., Gussekloo, J., & Streit, S. (2020) · PLoS ONE · doi:10.1371/journal.pone.0240463 · Cited by 56 · see citing works

Potentially inappropriate medication use in older people with cancer: Prevalence and correlates

Saarelainen, L., Turner, J. P., Shakib, S., Singhal, N., Hogan-Doran, J., Prowse, R. J., Johns, S., Lees, J., & Bell, J. S. (2014) · Journal of Geriatric Oncology · doi:10.1016/j.jgo.2014.07.001 · Cited by 55 · see citing works

Global prevalence of polypharmacy and potentially inappropriate medication in older patients with dementia: a systematic review and meta-analysis

Zhao, M., Chen, Z., Xu, T., Fan, P., & Tian, F. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1221069 · Cited by 54 · see citing works

Pharmacokinetic and Pharmacodynamic Properties of Cholinesterase Inhibitors Donepezil, Tacrine, and Galantamine in Aged and Young Lister Hooded Rats

Goh, C. W., Aw, C. C., Lee, J. H., Chen, C., & Browne, E. R. (2010) · Drug Metabolism and Disposition · doi:10.1124/dmd.110.035964 · Cited by 53 · see citing works

Use of potentially inappropriate medication and polypharmacy in older adults: a repeated cross-sectional study

Thorell, K., Midlöv, P., Fastbom, J., & Halling, A. (2020) · BMC Geriatrics · doi:10.1186/s12877-020-1476-5 · Cited by 57 · see citing works

Impact of the Collaborative Pharmaceutical Care at Tallaght Hospital (PACT) model on medication appropriateness of older patients

Tallon, M., Barragry, J., Allen, A., Breslin, N. P., Deasy, E., Moloney, E. D., Delaney, T., Wall, C. A. M., O'Byrne, J., & Grimes, T. (2015) · European Journal of Hospital Pharmacy · doi:10.1136/ejhpharm-2014-000511 · Cited by 52 · see citing works

Glucagon-like peptide-1 receptor agonists as neuroprotective agents for ischemic stroke: a systematic scoping review

Maskery, M. P., Holscher, C., Jones, S. P., Price, C. I., Strain, W. D., Watkins, C. L., Werring, D. J., & Emsley, H. C. (2021) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x20952011 · Cited by 51 · see citing works

Prevalence Of Potentially Inappropriate Medication In The Older Adult Population Within Primary Care In Portugal: A Nationwide Cross-Sectional Study

Simões, P. A., Santiago, L. M., Maurício, K., & Simões, J. A. (2019) · Patient Preference and Adherence · doi:10.2147/ppa.s219346 · Cited by 62 · see citing works

Elimination of Intravenous Oxycodone in the Elderly

Liukas, A., Kuusniemi, K., Aantaa, R., Virolainen, P., Neuvonen, M., Neuvonen, P. J., & Olkkola, K. T. (2010) · Drugs & Aging · doi:10.2165/11586140-000000000-00000 · Cited by 50 · see citing works

Polypharmacy in a Belgian cohort of community-dwelling oldest old (80+)

Wauters, M., Elseviers, M. M., Vaes, B., Degryse, J., Dalleur, O., Stichele, R. V., Bortel, L. M. V., & Azermai, M. (2016) · Acta Clinica Belgica · doi:10.1080/17843286.2016.1148298 · Cited by 50 · see citing works

Microscopic Colitis and Medication Use

Pascua, M. F., Kedia, P. S., Weiner, M. G., Holmes, J. H., Ellenberg, J. H., & Lewis, J. D. (2010) · Clinical Medicine Insights Gastroenterology · doi:10.4137/cgast.s4469 · Cited by 49 · see citing works

Potentially Inappropriate Medication in Elderly Hospitalized Patients

Corsonello, A., Pranno, L., Garasto, S., Fabbietti, P., Bustacchini, S., & Lattanzio, F. (2009) · Drugs & Aging · doi:10.2165/11534640-000000000-00000 · Cited by 48 · see citing works

Discrepancies in Medication Information for the Primary Care Physician and the Geriatric Patient at Discharge

Cornu, P., Steurbaut, S., Leysen, T., Baere, E. D., Ligneel, C., Mets, T. F., & Dupont, A. G. (2012) · Annals of Pharmacotherapy · doi:10.1345/aph.1r022 · Cited by 46 · see citing works

In Vivo Animal Stroke Models

Tajiri, N., Dailey, T., Metcalf, C., Mosley, Y. I., Lau, T., Staples, M., van Loveren, H., Kim, S. U., Yamashima, T., Yasuhara, T., et al. (2013) · Translational Stroke Research · doi:10.1007/s12975-012-0241-2 · Cited by 45 · see citing works

The prevalence and preventability of potentially relevant drug-drug interactions in patients admitted for cardiovascular diseases: A cross-sectional study

Kovačević, M., Kovačević, S. V., Miljković, B., Radovanović, S., & Stevanovic, P. D. (2017) · International Journal of Clinical Practice · doi:10.1111/ijcp.13005 · Cited by 44 · see citing works

Danish register-based study on the association between specific cardiovascular drugs and fragility fractures

Torstensson, M., Hansen, A. H., Leth-Møller, K., Jørgensen, T. S. H., Sahlberg, M., Andersson, C., Nelveg-Kristensen, K. E., Ryg, J., Weeke, P. E., Torp-Pedersen, C. T., et al. (2015) · BMJ Open · doi:10.1136/bmjopen-2015-009522 · Cited by 43 · see citing works

Drug related problems in older adults living with dementia

Ruangritchankul, S., Peel, N. M., Hanjani, L. S., & Gray, L. (2020) · PLoS ONE · doi:10.1371/journal.pone.0236830 · Cited by 47 · see citing works

Remaining Life Expectancy With and Without Polypharmacy: A Register-Based Study of Swedes Aged 65 Years and Older

Wastesson, J. W., Canudas‐Romo, V., Lindahl‐Jacobsen, R., & Johnell, K. (2015) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2015.07.015 · Cited by 42 · see citing works

Clinical implications of aging

King, M., & Lipsky, M. S. (2015) · Disease-a-Month · doi:10.1016/j.disamonth.2015.09.006 · Cited by 41 · see citing works

Utility of the Edmonton Frail Scale in identifying frail elderly patients during treatment of colorectal cancer

Meyers, B. M., Al-Shamsi, H. O., Rask, S., Yelamanchili, R., Phillips, C., Παπαϊωάννου, Α., Pond, G. R., Jeyabalan, N., Zbuk, K. M., & Dhesy‐Thind, S. (2017) · Journal of Gastrointestinal Oncology · doi:10.21037/jgo.2016.11.12 · Cited by 39 · see citing works

Effects of an interprofessional deprescribing intervention in Swiss nursing homes: the Individual Deprescribing Intervention (IDeI) randomised controlled trial

Cateau, D., Ballabeni, P., & Niquille, A. (2021) · BMC Geriatrics · doi:10.1186/s12877-021-02465-7 · Cited by 39 · see citing works

Geriatric Conditions and the Risk of Adverse Drug Reactions in Older Adults

Lattanzio, F., Landi, F., Bustacchini, S., Abbatecola, A. M., Corica, F., Pranno, L., & Corsonello, A. (2012) · Drug Safety · doi:10.1007/bf03319103 · Cited by 39 · see citing works

Interpretation in Cross-Language Research: Tongues-Tied in the Health Care Interview?

Ballantyne, P. J., Yang, M., & Boon, H. S. (2013) · Journal of Cross-Cultural Gerontology · doi:10.1007/s10823-013-9210-9 · Cited by 38 · see citing works

Gender and Polypharmacotherapy in the Elderly: A Clinical Challenge

Hofer-Dückelmann, C. (2012) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-30726-3_9 · Cited by 38 · see citing works

Does Acute Whole-Body Vibration Training Improve the Physical Performance of People with Knee Osteoarthritis?

Salmon, J. R., Roper, J. A., & Tillman, M. D. (2011) · The Journal of Strength and Conditioning Research · doi:10.1519/jsc.0b013e318242a4be · Cited by 37 · see citing works

Time trends in 20 years of medication use in older adults: Findings from three elderly cohorts in Stockholm, Sweden

Craftman, Å. G., Johnell, K., Fastbom, J., Westerbotn, M., & Strauss, E. I. V. (2015) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2015.11.010 · Cited by 37 · see citing works

Clinical pharmacology of oncology agents in older adults: A comprehensive review of how chronologic and functional age can influence treatment-related effects

Nightingale, G., Schwartz, R. N., Kachur, E., Dixon, B. N., Cote, C., Barlow, A., Barlow, B., & Medina, P. J. (2018) · Journal of Geriatric Oncology · doi:10.1016/j.jgo.2018.06.008 · Cited by 36 · see citing works

Geriatric pain management, pharmacological and nonpharmacological considerations.

Kaye, A. D., Baluch, A., Kaye, R. J., Niaz, R. S., Kaye, A. J., Liu, H., & Fox, C. J. (2014) · Psychology & Neuroscience · doi:10.3922/j.psns.2014.1.04 · Cited by 34 · see citing works

General practitioners’ attitudes towards decision-supported prescribing: An analysis of the Dutch primary care sector

Meulendijk, M. C., Spruit, M. R., Maanen, A. C. D., Numans, M. E., Brinkkemper, S., & Jansen, P. A. F. (2013) · Health Informatics Journal · doi:10.1177/1460458212472333 · Cited by 34 · see citing works

Prescribing pattern of medicines in chronic kidney disease with emphasis on phosphate binders

Bajait, C., Pimpalkhute, S., Sontakke, S. D., Jaiswal, K., & Dawri, A. (2014) · Indian Journal of Pharmacology · doi:10.4103/0253-7613.125163 · Cited by 33 · see citing works

Mortality, hospitalisation, institutionalisation in community-dwelling oldest old: The impact of medication

Wauters, M., Elseviers, M. M., Vaes, B., Degryse, J., Stichele, R. V., Christiaens, T., & Azermai, M. (2016) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2016.02.009 · Cited by 33 · see citing works

Pharmacokinetics and pharmacodynamics of immunosuppressive drugs in elderly kidney transplant recipients

Shi, Y., Hesselink, D. A., & van Gelder, T. (2015) · Transplantation Reviews · doi:10.1016/j.trre.2015.04.007 · Cited by 31 · see citing works

Potentially inappropriate medications in elderly ambulatory and institutionalized patients: an observational study

Primejdie, D. P., Bojita, M. T., & Popa, A. (2016) · BMC Pharmacology and Toxicology · doi:10.1186/s40360-016-0081-x · Cited by 31 · see citing works

Uso de medicamentos potencialmente inapropriados em idosos institucionalizados: prevalência e fatores associados

Moreira, F. S. M., Jerez‐Roig, J., Ferreira, L. M. D. B. M., Dantas, A. P. D. Q. M., de Lima, K. C., & Ferreira, M. Â. F. (2020) · Ciência & Saúde Coletiva · doi:10.1590/1413-81232020256.26752018 · Cited by 43 · see citing works

Antimuscarinics for the treatment of overactive bladder: understanding the role of muscarinic subtype selectivity

Glavind, K., & Chancellor, M. B. (2011) · International Urogynecology Journal · doi:10.1007/s00192-011-1411-6 · Cited by 29 · see citing works

Managing medical and psychiatric multimorbidity in older patients

Carlson, D. M., & Yarns, B. C. (2023) · Therapeutic Advances in Psychopharmacology · doi:10.1177/20451253231195274 · Cited by 28 · see citing works

Polypharmacy and Excessive Polypharmacy Among Persons Living with Chronic Pain: A Cross-Sectional Study on the Prevalence and Associated Factors

Zahlan, G., Clifford‐Faugère, G. D., Nguefack, H. L. N., Guénette, L., Pagé, M. G., Blais, L., & Lacasse, A. (2023) · Journal of Pain Research · doi:10.2147/jpr.s411451 · Cited by 29 · see citing works

Glomerular filtration rate in patients with atrial fibrillation on warfarin treatment: A subgroup analysis from the AURICULA registry in Sweden

Jönsson, K. M., Wieloch, M., Sterner, G., Nyman, U., Elmståhl, S., Engström, G., & Svensson, P. J. (2011) · Thrombosis Research · doi:10.1016/j.thromres.2011.04.022 · Cited by 28 · see citing works

Loss of response after switching from brand name to generic formulations: three cases and a discussion of key clinical considerations when switching

Margolese, H. C., Wolf, Y., Desmarais, J. E., & Beauclair, L. (2010) · International Clinical Psychopharmacology · doi:10.1097/yic.0b013e328337910b · Cited by 28 · see citing works

Polypharmacy and Kidney Function in Community-Dwelling Adults Age 60 Years and Older: A Prospective Observational Study.

Ernst, R., Fischer, K., Molino, C. D. G. R. C., Orav, E., Theiler, R., Meyer, U., Fischler, M., Gagesch, M., Ambühl, P., Freystätter, G., et al. (2020) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2019.07.007 · Cited by 23 · see citing works

To what extent does the indicator “concurrent use of three or more psychotropic drugs” capture use of potentially inappropriate psychotropics among the elderly?

Lesén, E., Petzold, M., Sundell, K. A., & Carlsten, A. (2009) · European Journal of Clinical Pharmacology · doi:10.1007/s00228-009-0623-x · Cited by 28 · see citing works

Do We Need Different Treatments for Very Elderly COPD Patients?

Valente, S., Pasciuto, G., Bernabei, R., & Corbo, G. M. (2010) · Respiration · doi:10.1159/000320221 · Cited by 27 · see citing works

Longitudinal patterns of potentially inappropriate medication use following incident dementia diagnosis

Ramsey, C. M., Gnjidic, D., Agogo, G. O., Allore, H. G., & Moga, D. C. (2017) · Alzheimer s & Dementia Translational Research & Clinical Interventions · doi:10.1016/j.trci.2017.10.008 · Cited by 28 · see citing works

Polypharmacy in Chronic Neurological Diseases: Multiple Sclerosis, Dementia and Parkinson’s Disease

Frahm, N., Hecker, M., & Zettl, U. K. (2021) · Current Pharmaceutical Design · doi:10.2174/1381612827666210728102832 · Cited by 25 · see citing works

Severity and Management of Drug–Drug Interactions in Acute Geriatric Patients

Lea, M., Rognan, S. E., Koristovic, R., Wyller, T. B., & Molden, E. (2013) · Drugs & Aging · doi:10.1007/s40266-013-0091-y · Cited by 25 · see citing works

Heart failure in the elderly: ten peculiar management considerations

Bader, F. M., Atallah, B., Brennan, L., Rimawi, R., & Khalil, M. E. (2017) · Heart Failure Reviews · doi:10.1007/s10741-017-9598-3 · Cited by 26 · see citing works

Importance of potentially inappropriate medications, number of chronic conditions and medications for the risk of hospitalisation in elderly in Sweden: a case–control study

Thorell, K., Midlöv, P., Fastbom, J., & Halling, A. (2019) · BMJ Open · doi:10.1136/bmjopen-2019-029477 · Cited by 24 · see citing works

Perceived medication adverse effects and coping strategies reported by chronic heart failure patients

Smedt, R. H. E. D., Denig, P., Haaijer‐Ruskamp, F. M., & Jaarsma, T. (2009) · International Journal of Clinical Practice · doi:10.1111/j.1742-1241.2008.01954.x · Cited by 24 · see citing works

Potentially inappropriate medication use among older adult patients on follow-up at the chronic care clinic of a specialized teaching hospital in Ethiopia. A cross-sectional study

Tesfaye, B. T., Tessema, M. T., Yizengaw, M. A., & Bosho, D. D. (2021) · BMC Geriatrics · doi:10.1186/s12877-021-02463-9 · Cited by 23 · see citing works

Exercise training in older adults, what effects on muscle oxygenation? A systematic review

Fiogbé, E., Vassimon‐Barroso, V., & Takahashi, A. C. D. M. (2017) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2017.03.001 · Cited by 23 · see citing works

Stakeholders' views on the use of psychotropic medication in older people: a systematic review

Bednarczyk, E., Cook, S., Brauer, R., & Garfield, S. (2022) · Age and Ageing · doi:10.1093/ageing/afac060 · Cited by 22 · see citing works

Rational use of medicines: prescribing indicators at different levels of health care

Ferreira, M. B. C., Heineck, I., Flores, L. M., Camargo, A. L., Pizzol, T. D. S. D., Torres, I. L. D. S., Köenig, Á., Trevisol, D. J., de Melo, A. M. M. F., Cardoso, T. F. M., et al. (2013) · Brazilian Journal of Pharmaceutical Sciences · doi:10.1590/s1984-82502013000200015 · Cited by 22 · see citing works

Evidence, Ethics and Medication Management in Older People

Couteur, D. G. L., Ford, G. A., & McLachlan, A. J. (2010) · Journal of Pharmacy Practice and Research · doi:10.1002/j.2055-2335.2010.tb00523.x · Cited by 22 · see citing works

Medication‐related problems in older people in Catalonia: A real‐world data study

Troncoso‐Mariño, A., López‐Jiménez, T., Roso‐Llorach, A., Villén, N., Amado, E., Guisado‐Clavero, M., Fernández‐Bertolín, S., Pons‐Vigués, M., Boreu, Q. F., & Violán, C. (2020) · Pharmacoepidemiology and Drug Safety · doi:10.1002/pds.5149 · Cited by 19 · see citing works

Pharmacotherapy of older and senile patients. Review

Kuprash, L., Panteleymonova, T., & Kuprash, O. (2024) · Ageing & Longevity · doi:10.47855/jal9020-2024-3-5

Aging Changes and Pharmacotherapy Principles

Miller, M. D., & Solai, L. K. (2013) · Oxford University Press eBooks · doi:10.1093/med/9780199765782.003.0004

Impact of ageing on the pharmacokinetics and pharmacodynamics of the drugs

Polaka, S., Tella, J. D., Tekade, M., Sharma, M. C., & Tekade, R. K. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-98367-9.00008-1 · Cited by 6 · see citing works

Pharmacokinetics and Pharmacodynamic Changes Associated with Aging and Implications for Drug Therapy

Sera, L., & McPherson, M. L. (2012) · Clinics in Geriatric Medicine · doi:10.1016/j.cger.2012.01.007 · Cited by 166 · see citing works

Drug therapy

Rochon, P. A., & Gurwitz, J. H. (1995) · The Lancet · doi:10.1016/s0140-6736(95)92656-9 · Cited by 123 · see citing works