The DOI matches its Crossref record; 105 of the 106 references it cites were found in a registry or an index.
The lipopolysaccharide Parkinson’s disease animal model: mechanistic studies and drug discovery
Open accessAbstract
Research in the last two decades has unveiled an important role for neuroinflammation in the degeneration of the nigrostriatal dopaminergic (DA) pathway that constitutes the pathological basis of the prevailing movement disorder, Parkinson’s disease (PD). Neuroinflammation is characterized by the activation of brain glial cells, primarily microglia and astrocytes that release various soluble factors that include free radicals (reactive oxygen and nitrogen species), cytokines, and lipid metabolites. The majority of these glia‐derived factors are proinflammatory and neurotoxic and are particularly deleterious to oxidative damage‐vulnerable nigral DA neurons. As a proof of concept, various immunologic stimuli have been employed to directly induce glial activation to model DA neurodegeneration in PD. The bacterial endotoxin, lipopolysaccharide (LPS), has been the most extensively utilized glial activator for the induction of inflammatory DA neurodegeneration. In this review, we will summarize the various in vitro and in vivo LPS PD models. Furthermore, we will highlight the contribution of the LPS PD models to the mechanistic studies of PD pathogenesis and the search for neuroprotective agents for the treatment of PD.
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“Neuroinflammation is characterised by the activation of microglia and astrocytes [29].”
From Neuroprotective Effect of Ceftriaxone on MPTP‐Induced Parkinson’s Disease Mouse Model by Regulating Inflammation and Intestinal Microbiota (2021) · cites this paper as [29]
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Microglial cell origin and phenotypes in health and disease
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“Conversely, activation of microglia by LPS is sufficient to induce the death of dopaminergic neurons: injection of LPS into the intraperitoneal cavities of animals or the substantia nigra in the brain induces drastic microglial cell inflammatory responses followed by the death of dopaminergic neuron”
BackgroundTansey, M. G., & Goldberg, M. S. (2010) · Neurobiology of Disease · doi:10.1016/j.nbd.2009.11.004 · Cited by 1,045
“…Author M anuscript peripheral macrophage populations and study their role in degeneration of the nigrostriatal pathway (for a detailed review see (Dutta et al., 2008)) and depending on the route, dose, and frequency of administration may be modeling very different inflammatory responses in the…”
BackgroundA Comprehensive Review on the Role of the Gut Microbiome in Human Neurological Disorders
Sorboni, S. G., Moghaddam, H. S., Esfehani, R. J., & Soleimanpour, S. (2022) · Clinical Microbiology Reviews · doi:10.1128/cmr.00338-20 · Cited by 586
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“Additional supporting evidence is that oral administration of LPS is able to induce intestinal PD pathology in rodents [31, 32].”
BackgroundTargeting Microglial Activation States as a Therapeutic Avenue in Parkinson’s Disease
Subramaniam, S., & Federoff, H. J. (2017) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2017.00176 · Cited by 353
Metadata
- Authors
- Dutta, G., Zhang, P., & Liu, B.
- Affiliations
- University of Florida (US)
- Corresponding author
- Liu, Bin
- ORCID
- Liu, Bin
- Venue
- Fundamental & Clinical Pharmacology
- Publisher
- Wiley
- Published
- 2008-09-21
- Volume
- 22
- Issue
- 5
- Pages
- 453-464
- ISSN
- 0767-3981 (ISSN-L)
- 1472-8206
- PMC
- PMC2632601
- OpenAlex
- W2057913943
- Cited by
- 235
- References
- 106
- Citations by year
- 2026: 2 · 2025: 11 · 2024: 14 · 2023: 10 · 2022: 15 · 2021: 19 · 2020: 15 · 2019: 10 · 2018: 13 · 2017: 14 · 2016: 14 · 2015: 13 · 2014: 14 · 2013: 16 · 2012: 22
- FWCI
- 1.63
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Fundamental and Clinical Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Environmental Health Sciences (ES013265, R01ES013265)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Receptors and Signaling
- Keywords
- Parkinson's disease, lipopolysaccharide, neuroinflammation, nigrostriatal pathway, dopaminergic neuron loss, microglial activation, astrocytes, glial activation, neuroprotection, drug discovery, oxidative stress, cytokines, Parkinson's disease model
- MeSH terms
- Animals, Antiparkinson Agents, Disease Models, Animal, Humans, Lipopolysaccharides, Parkinson Disease, Drug Discovery
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