Cited by 235Parkinson's Disease Mechanisms and TreatmentsNeuroinflammation and Neurodegeneration MechanismsNuclear Receptors and Signaling

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The lipopolysaccharide Parkinson’s disease animal model: mechanistic studies and drug discovery

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Dutta, Garima, Zhang, Ping, Liu, Bin·2008·Fundamental & Clinical Pharmacology

DOI 10.1111/j.1472-8206.2008.00616.xPMC PMC2632601

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Abstract

Research in the last two decades has unveiled an important role for neuroinflammation in the degeneration of the nigrostriatal dopaminergic (DA) pathway that constitutes the pathological basis of the prevailing movement disorder, Parkinson’s disease (PD). Neuroinflammation is characterized by the activation of brain glial cells, primarily microglia and astrocytes that release various soluble factors that include free radicals (reactive oxygen and nitrogen species), cytokines, and lipid metabolites. The majority of these glia‐derived factors are proinflammatory and neurotoxic and are particularly deleterious to oxidative damage‐vulnerable nigral DA neurons. As a proof of concept, various immunologic stimuli have been employed to directly induce glial activation to model DA neurodegeneration in PD. The bacterial endotoxin, lipopolysaccharide (LPS), has been the most extensively utilized glial activator for the induction of inflammatory DA neurodegeneration. In this review, we will summarize the various in vitro and in vivo LPS PD models. Furthermore, we will highlight the contribution of the LPS PD models to the mechanistic studies of PD pathogenesis and the search for neuroprotective agents for the treatment of PD.

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See all 235

Authors: Dutta, G., Zhang, P., & Liu, B.
Affiliations: University of Florida (US)
Corresponding author: Liu, Bin
ORCID: Liu, Bin
Venue: Fundamental & Clinical Pharmacology
Publisher: Wiley
Published: 2008-09-21
Volume: 22
Issue: 5
Pages: 453-464
ISSN: 0767-3981 (ISSN-L)
1472-8206
DOI: 10.1111/j.1472-8206.2008.00616.x
PMC: PMC2632601
OpenAlex: W2057913943
Cited by: 235
References: 106
Citations by year: 2026: 2 · 2025: 11 · 2024: 14 · 2023: 10 · 2022: 15 · 2021: 19 · 2020: 15 · 2019: 10 · 2018: 13 · 2017: 14 · 2016: 14 · 2015: 13 · 2014: 14 · 2013: 16 · 2012: 22
FWCI: 1.63
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Fundamental and Clinical Pharmacology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Environmental Health Sciences (ES013265, R01ES013265)
Topics: Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Receptors and Signaling
Keywords: Parkinson's disease, lipopolysaccharide, neuroinflammation, nigrostriatal pathway, dopaminergic neuron loss, microglial activation, astrocytes, glial activation, neuroprotection, drug discovery, oxidative stress, cytokines, Parkinson's disease model
MeSH terms: Animals, Antiparkinson Agents, Disease Models, Animal, Humans, Lipopolysaccharides, Parkinson Disease, Drug Discovery

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The lipopolysaccharide Parkinson’s disease animal model: mechanistic studies and drug discovery

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