The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
The aging neurogenic subventricular zone
Open accessAbstract
Summary: In the adult mouse brain, the subventricular zone (SVZ) is a neurogenic stem cell niche only 4–5 cell diameters thick. Within this narrow zone, a unique microenvironment supports stem cell self‐renewal, gliogenesis or neurogenesis lineage decisions and tangential migration of newly generated neurons out of the SVZ and into the olfactory bulb. However, with aging, SVZ neurogenesis declines. Here, we examine the dynamic interplay between SVZ cytoarchitecture and neurogenesis through aging. Assembly of high‐resolution electron microscopy images of corresponding coronal sections from 2‐, 10‐ and 22‐month‐old mice into photomontages reveal a thinning of the SVZ with age. Following a 2‐h BrdU pulse, we detect a significant decrease in cell proliferation from 2 to 22 months. Neuroblast numbers decrease with age, as do transitory amplifying progenitor cells, while both SVZ astrocytes and adjacent ependymal cells remain relatively constant. At 22 months, only residual pockets of neurogenesis remain and neuroblasts become restricted to the anterior dorsolateral horn of the SVZ. Within this dorsolateral zone many key components of the younger neurogenic niche are maintained; however, in the aged SVZ, increased numbers of SVZ astrocytes are found interposed within the ependyma. These astrocytes co‐label with markers to ependymal cells and astrocytes, form intercellular adherens junctions with neighboring ependymal cells, and some possess multiple basal bodies of cilia within their cytoplasm. Together, these data reveal an age‐related, progressive restriction of SVZ neurogenesis to the dorsolateral aspect of the lateral ventricle with increased numbers of SVZ astrocytes interpolated within the ependyma.
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Cites
Gage, F. H. (2000) · Science · doi:10.1126/science.287.5457.1433 · Cited by 4,786
Subventricular zone astrocytes are neural stem cells in the adult mammalian brain
Doetsch, F., Caillé, I., Lim, D. A., García-Verdugo, J. M., & Alvarez-Buylla, A. (1999) · Cell · doi:10.1016/s0092-8674(00)80783-7 · Cited by 3,898
Kuhn, H., Dickinson-Anson, H., & Gage, F. (1996) · The Journal of Neuroscience · doi:10.1523/jneurosci.16-06-02027.1996 · Cited by 3,139
Morshead, C. M., Reynolds, B. A., Craig, C. G., McBurney, M. W., Staines, W. A., Morassutti, D., Weiss, S., & van der Kooy, D. (1994) · Neuron · doi:10.1016/0896-6273(94)90046-9 · Cited by 1,403
The glial identity of neural stem cells
Doetsch, F. (2003) · Nature Neuroscience · doi:10.1038/nn1144 · Cited by 724
Restoring production of hippocampal neurons in old age
Cameron, H. A., & McKay, R. D. G. (1999) · Nature Neuroscience · doi:10.1038/13197 · Cited by 710
Conditional telomerase induction causes proliferation of hair follicle stem cells
Sarin, K. Y., Cheung, P., Gilison, D., Lee, E., Tennen, R. I., Wang, E., Artandi, M. K., Oro, A. E., & Artandi, S. E. (2005) · Nature · doi:10.1038/nature03836 · Cited by 425
Jin, K., Sun, Y., Xie, L., Batteur, S., Mao, X. O., Smelick, C., Logvinova, A., & Greenberg, D. A. (2003) · Aging Cell · doi:10.1046/j.1474-9728.2003.00046.x · Cited by 396 · cited 6×
“However, it is unclear which cells are targeted by the growth factors and it is unknown if this level of neurogenesis can be sustained past the 1-week observation period reported (Jin et al., 2003).”
BackgroundInfluentialChenn, A. (2003) · Cerebral Cortex · doi:10.1093/cercor/13.6.599 · Cited by 253
Cited by
Vascular and Neurogenic Rejuvenation of the Aging Mouse Brain by Young Systemic Factors
Katsimpardi, L., Litterman, N. K., Schein, P. A., Miller, C. M., Loffredo, F. S., Wojtkiewicz, G. R., Chen, J. W., Lee, R. T., Wagers, A. J., & Rubin, L. L. (2014) · Science · doi:10.1126/science.1251141 · Cited by 1,037
A specialized vascular niche for adult neural stem cells
Tavazoie, M., Van der Veken, L., Silva-Vargas, V., Louissaint, M., Colonna, L., Zaidi, B., Garcia-Verdugo, J. M., & Doetsch, F. (2008) · Cell stem cell · doi:10.1016/j.stem.2008.07.025 · Cited by 1,033
Single-cell analysis reveals T cell infiltration in old neurogenic niches
Dulken, B. W., Buckley, M. T., Navarro Negredo, P., Saligrama, N., Cayrol, R., Leeman, D. S., George, B. M., Boutet, S. C., Hebestreit, K., Pluvinage, J. V., et al. (2019) · Nature · doi:10.1038/s41586-019-1362-5 · Cited by 521
Adult Neural Stem Cells Bridge Their Niche
Fuentealba, L. C., Obernier, K., & Alvarez-Buylla, A. (2012) · Cell Stem Cell · doi:10.1016/j.stem.2012.05.012 · Cited by 364
Nithianantharajah, J., & Hannan, A. J. (2009) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2009.10.001 · Cited by 320
Metadata
- Authors
- Luo, J., Daniels, S. B., Lennington, J. B., Notti, R. Q., & Conover, J. C.
- Venue
- Aging Cell
- Publisher
- Wiley
- Published
- 2006-02-22
- Volume
- 5
- Issue
- 2
- Pages
- 139-152
- ISSN
- 1474-9718 (ISSN-L)
- 1474-9726
- OpenAlex
- W2070439522
- Cited by
- 286
- References
- 9
- FWCI
- 3.93
- Type
- journal article
- Language
- en
- Open access
- bronze
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