Increased neuronal production, enlarged forebrains and cytoarchitectural distortions in beta-catenin overexpressing transgenic mice

Chenn, A.

doi:10.1093/cercor/13.6.599

Cited by 253Neurogenesis and neuroplasticity mechanismsFetal and Pediatric Neurological DisordersDevelopmental Biology and Gene Regulation

Increased neuronal production, enlarged forebrains and cytoarchitectural distortions in beta-catenin overexpressing transgenic mice

Chenn, A.·2003·Cerebral Cortex

DOI 10.1093/cercor/13.6.599

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Abstract

beta-Catenin can function in the decision of neural precursors to proliferate or differentiate during mammalian neuronal development and may regulate cerebral cortical size by controlling the generation of neural precursor cells. Mice expressing high levels of a stabilized beta-catenin transgene in neural precursors develop enlarged brains with expanded precursor populations, increased cerebral cortical surface area, and folds resembling sulci and gyri of higher mammals present at birth. Here we report the effects in adult mice expressing lower levels of the same stabilized beta-catenin transgene in neural precursors. Adult transgenic animals develop enlarged forebrains with thin cerebral cortices with increased surface area, expanded subventricular zones with subcortical aggregations of neurons and enlarged, distorted hippocampi. The brains from transgenic mice also show apparent arrest of neuronal migration and dramatic disorganization of the layering of the cerebral cortex. These findings suggest that beta-catenin can cause expansion of the precursor pool resulting in increased neuronal production and greater brain size and suggest a crucial role for beta-catenin in neuronal migration and cortical lamination.

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Authors: Chenn, A.
Affiliations: Northwestern University (US)
Corresponding author: Chenn, A.
Venue: Cerebral Cortex
Publisher: Oxford University Press (OUP)
Published: 2003-06-01
Volume: 13
Issue: 6
Pages: 599-606
ISSN: 1047-3211 (ISSN-L)
1460-2199
DOI: 10.1093/cercor/13.6.599
OpenAlex: W2170813394
Cited by: 253
References: 33
Citations by year: 2026: 5 · 2025: 2 · 2024: 5 · 2023: 5 · 2022: 2 · 2021: 6 · 2020: 5 · 2019: 17 · 2018: 9 · 2017: 11 · 2016: 7 · 2015: 5 · 2014: 17 · 2013: 10 · 2012: 14
FWCI: 4.31
Type: journal article
Language: en
Open access: closed
Locations: Cerebral Cortex (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Neurological Disorders and Stroke (R01-NS 32457, R01NS032457)
Topics: Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Fetal and Pediatric Neurological Disorders
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Keywords: β-catenin, neural precursor proliferation, brain size, cortical lamination, neuronal migration, subventricular zone, hippocampus, cortical surface area, cytoarchitecture
MeSH terms: Animals, Animals, Newborn, Cell Division, Cell Movement, Cerebral Cortex, Cerebral Ventricles, Cytoskeletal Proteins, Mice, Transgenic, Neurons, Trans-Activators, Prosencephalon, Gene Expression Regulation, Developmental, beta Catenin, Mice

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Increased neuronal production, enlarged forebrains and cytoarchitectural distortions in beta-catenin overexpressing transgenic mice

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