The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
Aging and disease: connections to sirtuins
Abstract
Summary: The sirtuins are highly conserved NAD‐dependent deacetylases that were shown to regulate lifespan in lower organisms and affect diseases of aging in mammals, such as diabetes, cancer, and inflammation. Most relevant to the amelioration of disease, the SIR2 ortholog SIRT1 has been shown to deacetylate many important transcription factors to exert an overarching influence on numerous metabolic pathways. Here we discuss several diseases of aging for which SIRT1 has been recently shown to confer protection. These findings suggest that manipulating sirtuin activity pharmacologically may be a fruitful area to improve human health.
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Citations
Cites
Resveratrol improves health and survival of mice on a high-calorie diet
Baur, J. A., Pearson, K. J., Price, N. L., Jamieson, H. A., Lerin, C., Kalra, A., Prabhu, V. V., Allard, J. S., Lopez-Lluch, G., Lewis, K., et al. (2006) · Nature · doi:10.1038/nature05354 · Cited by 4,290
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Self-citationModulation of NF‐κB‐dependent transcription and cell survival by the SIRT1 deacetylase
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“CR was proposed to be mediated by the SIR2 gene family, which were first shown to have antiaging functions in yeast (Kaeberlein et al., 1999), Caenorhabtidis elegans (Tissenbaum & Guarente, 2001) and Drosophila (Rogina & Helfand, 2004; Wood et al., 2004).”
BackgroundSelf-citationSirtuin activators mimic caloric restriction and delay ageing in metazoans
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IKKβ/NF-κB Activation Causes Severe Muscle Wasting in Mice
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SIRT5 deacetylates carbamoyl phosphate synthetase 1 and regulates the urea cycle
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Self-citation
Cited by
Price, N. L., Gomes, A. P., Ling, A. J. Y., Duarte, F. V., Martin-Montalvo, A., North, B. J., Agarwal, B., Ye, L., Ramadori, G., Teodoro, J. S., et al. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.04.003 · Cited by 1,602
Someya, S., Yu, W., Hallows, W. C., Xu, J., Vann, J. M., Leeuwenburgh, C., Tanokura, M., Denu, J. M., & Prolla, T. A. (2010) · Cell · doi:10.1016/j.cell.2010.10.002 · Cited by 1,150
Transcriptional integration of mitochondrial biogenesis
Scarpulla, R. C., Vega, R. B., & Kelly, D. P. (2012) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2012.06.006 · Cited by 798
Regulation of H SF 1 Function in the Heat Stress Response: Implications in Aging and Disease
Anckar, J., & Sistonen, L. (2011) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-060809-095203 · Cited by 773
Amyloid cascade hypothesis: Pathogenesis and therapeutic strategies in Alzheimer's disease
Barage, S. H., & Sonawane, K. D. (2015) · Neuropeptides · doi:10.1016/j.npep.2015.06.008 · Cited by 579
Metadata
- Authors
- Donmez, G., & Guarente, L.
- Venue
- Aging Cell
- Publisher
- Wiley
- Published
- 2010-03-16
- Volume
- 9
- Issue
- 2
- Pages
- 285-290
- ISSN
- 1474-9718 (ISSN-L)
- 1474-9726
- OpenAlex
- W2079569030
- Cited by
- 311
- References
- 22
- FWCI
- 16.19
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
