Mitochondrial functional impairment with aging is exaggerated in isolated mitochondria compared to permeabilized myofibers

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Inhibiting Mitochondrial Fission Protects the Heart Against Ischemia/Reperfusion Injury

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Analysis of mitochondrial function in situ in permeabilized muscle fibers, tissues and cells

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Mitochondrial Dysfunction in Aging and Longevity: A Causal or Protective Role?

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Mitochondrial structure and function are not different between nonfailing donor and end‐stage failing human hearts

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Comprehensive Metabolic Profiling of Age-Related Mitochondrial Dysfunction in the High-Fat-Fed ob/ob Mouse Heart

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Mitochondrial Function in Permeabilized Cardiomyocytes Is Largely Preserved in the Senescent Rat Myocardium

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Skeletal muscle mitochondrial function: is it quality or quantity that makes the difference in insulin resistance?

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Reliability of maximal mitochondrial oxidative phosphorylation in permeabilized fibers from thevastus lateralisemploying high-resolution respirometry

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Preserved skeletal muscle oxidative capacity in older adults despite decreased cardiorespiratory fitness with ageing

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Time course of liver mitochondrial function and intrinsic changes in oxidative phosphorylation in a rat model of sepsis

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Modulating Oxidant Levels to Promote Healthy Aging

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MFN2 overexpression in skeletal muscles of young and old mice causes a mild hypertrophy without altering mitochondrial respiration and H2O2 emission

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Isolation of Intact Mitochondria from Skeletal Muscle by Differential Centrifugation for High-resolution Respirometry Measurements

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Impact of physical activity on physical function, mitochondrial energetics, ROS production, and Ca2+ handling across the adult lifespan in men

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Lifelong Ulk1-Mediated Autophagy Deficiency in Muscle Induces Mitochondrial Dysfunction and Contractile Weakness

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Lower citrate synthase activity, mitochondrial complex expression, and fewer oxidative myofibers characterize skeletal muscle from growth restricted fetal sheep.

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Analysis of Mitochondrial Function, Structure, and Intracellular Organization In Situ in Cardiomyocytes and Skeletal Muscles

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Crosstalk between Adipose Tissue and Hepatic Mitochondria in the Development of the Inflammation and Liver Injury during Ageing in High-Fat Diet Fed Rats

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Genetic deletion of soluble epoxide hydrolase provides cardioprotective responses following myocardial infarction in aged mice

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Changes in the mitochondrial function and in the efficiency of energy transfer pathways during cardiomyocyte aging

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Impact of capillary and sarcolemmal proximity on mitochondrial structure and energetic function in skeletal muscle

Parry, H. A., Willingham, T. B., Giordano, K. A., Kim, Y., Qazi, S., Knutson, J. R., Combs, C. A., & Glancy, B. C. (2024) · The Journal of Physiology · doi:10.1113/jp286246 · Cited by 27

Impaired Muscle Efficiency but Preserved Peripheral Hemodynamics and Mitochondrial Function With Advancing Age: Evidence From Exercise in the Young, Old, and Oldest-Old

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Mitochondrial function in peripheral blood cells across the human lifespan

Ehinger, J. K., Westerlund, E., Frostner, E. Å., Karlsson, M., Paul, G., Sjövall, F., & Elmér, E. (2024) · npj Aging · doi:10.1038/s41514-023-00130-4 · Cited by 22

Heterochronic Parabiosis: Old Blood Induces Changes in Mitochondrial Structure and Function of Young Mice

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Mitochondrial function in heart failure: The impact of ischemic and non-ischemic etiology

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Serum from Calorie-Restricted Rats Activates Vascular Cell eNOS through Enhanced Insulin Signaling Mediated by Adiponectin

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Bioenergetics of the aging heart and skeletal muscles: Modern concepts and controversies

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Reduced adenosine diphosphate sensitivity in skeletal muscle mitochondria increases reactive oxygen species production in mouse models of aging and oxidative stress but not denervation

Pharaoh, G. A., Brown, J. L., Ranjit, R., Ungvari, Z. I., & Remmen, H. V. (2020) · JCSM Rapid Communications · doi:10.1002/rco2.29 · Cited by 21

Mitochondrial respiration atlas reveals differential changes in mitochondrial function across sex and age

Sarver, D. C., Saqib, M., Chen, F., & Wong, G. W. (2024) · eLife · doi:10.7554/elife.96926.4 · Cited by 43

Vascular mitochondrial respiratory function: the impact of advancing age

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Transgenic expression of SOD1 specifically in neurons of Sod1 deficient mice prevents defects in muscle mitochondrial function and calcium handling

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Effect of age on in vivo oxidative capacity in two locomotory muscles of the leg

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The role of attenuated redox and heat shock protein responses in the age-related decline in skeletal muscle mass and function

McArdle, A., & Jackson, M. J. (2017) · Essays in Biochemistry · doi:10.1042/ebc20160088 · Cited by 19

Dysfonctions mitochondriales et vieillissement musculaire

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A microfluidic device for immuno-affinity-based separation of mitochondria from cell culture

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Assessing the function of mitochondria in cytosolic context in human skeletal muscle: Adopting high-resolution respirometry to homogenate of needle biopsy tissue samples

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Physiological adaptations to reproduction II. Mitochondrial adjustments in livers of lactating mice

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Rapid isolation and purification of functional platelet mitochondria using a discontinuous Percoll gradient

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Age‐related changes of skeletal muscle metabolic response to contraction are also sex‐dependent

Campbell, M. D., Djukovic, D., Raftery, D., & Marcinek, D. J. (2023) · The Journal of Physiology · doi:10.1113/jp285124 · Cited by 17

Deletion of Neuronal CuZnSOD Accelerates Age-Associated Muscle Mitochondria and Calcium Handling Dysfunction That Is Independent of Denervation and Precedes Sarcopenia

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Skeletal Muscle Mitochondrial Respiration Is Elevated in Female Cynomolgus Macaques Fed a Western Compared with a Mediterranean Diet

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High-intensity exercise training — too much of a good thing?

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How does mitochondrial function relate to thermogenic capacity and basal metabolic rate in small birds?

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Delineating the contribution of ageing and physical activity to changes in mitochondrial characteristics across the lifespan

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Aging Exacerbates Ischemia-Reperfusion-Induced Mitochondrial Respiration Impairment in Skeletal Muscle

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Pharynx mitochondrial [Ca2+] dynamics in live C. elegans worms during aging

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Rapid and transient oxygen consumption increase following acute HDAC/KDAC inhibition in Drosophila tissue

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Declined expressions of vast mitochondria-related genes represented by CYCS and transcription factor ESRRA in skeletal muscle aging

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Skeletal muscle from aged American Quarter Horses shows impairments in mitochondrial biogenesis and expression of autophagy markers

Li, C., White-Springer, S. H., Warren, L. K., & Wohlgemuth, S. E. (2017) · Experimental Gerontology · doi:10.1016/j.exger.2017.11.022 · Cited by 16

Analysis of respiratory capacity in brain tissue preparations: high-resolution respirometry for intact hippocampal slices

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Considerations for using isolated cell systems to understand cardiac metabolism and biology

McNally, L. A., Altamimi, T., Fulghum, K., & Hill, B. G. (2020) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2020.12.007 · Cited by 16

Early septic shock induces loss of oxidative phosphorylation yield plasticity in liver mitochondria

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High-resolution respirometry of fine-needle muscle biopsies in pre-manifest Huntington’s disease expansion mutation carriers shows normal mitochondrial respiratory function

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Review: Using isolated mitochondria to investigate mitochondrial hydrogen peroxide metabolism

Treberg, J. R. (2021) · Comparative Biochemistry and Physiology Part B Biochemistry and Molecular Biology · doi:10.1016/j.cbpb.2021.110614 · Cited by 13

Revisiting the contribution of mitochondrial biology to the pathophysiology of skeletal muscle insulin resistance

Frangos, S. M., Bishop, D. J., & Holloway, G. P. (2021) · Biochemical Journal · doi:10.1042/bcj20210145 · Cited by 14

Mitochondrial metabolism in aging: Effect of dietary interventions

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Dietary management and physical exercise can improve climbing defects and mitochondrial activity inDrosophila melanogaster parkinnull mutants

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BAM15 Relieves Neurodegeneration in Aged Caenorhabditis elegans and Extends Lifespan

Cho, I., Song, H., Ji, H. E., Yang, S., & Cho, J. H. (2022) · Metabolites · doi:10.3390/metabo12111129 · Cited by 13

Low protein to carbohydrate ratio diet delays onset of Parkinsonism like phenotype in Drosophila melanogaster parkin null mutants

Bajracharya, R., & Ballard, J. W. O. (2016) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2016.10.003 · Cited by 13

Integrating sex and gender in mitochondrial science

Junker, A., Juster, R., & Picard, M. A. (2022) · Current Opinion in Physiology · doi:10.1016/j.cophys.2022.100536 · Cited by 13

Reduced oxidative capacity of skeletal muscle IS NOT an inevitable consequence of adult ageing

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Mitochondrial respiration analysis in permeabilized porcine left ventricular and human right atrial specimens with ischemia-reperfusion

Eickelmann, C., Lieder, H. R., Shehada, S.-E., Thielmann, M., Heusch, G., & Kleinbongard, P. (2023) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00172.2023 · Cited by 12

microRNA-1 regulates metabolic flexibility by programming adult skeletal muscle pyruvate metabolism

Ismaeel, A., Peck, B. D., Montgomery, M. M., Burke, B. I., Goh, J. Z., Kang, G., Burrows-Franco, A., Xia, Q., Goljanek‐Whysall, K., McDonagh, B., et al. (2025) · Molecular Metabolism · doi:10.1016/j.molmet.2025.102182 · Cited by 13

Redox Homeostasis in Age-Related Muscle Atrophy

Sakellariou, G. K., & McDonagh, B. (2018) · Advances in experimental medicine and biology · doi:10.1007/978-981-13-1435-3_13 · Cited by 11

Diet-induced obesity augments ischemic myopathy and functional decline in a murine model of peripheral artery disease

Fletcher, E., Miserlis, D., Sorokolet, K., Wilburn, D. T., Bradley, C., Papoutsi, E., Wilkinson, T. C. I., Ring, A., Ferrer, L. M., Haynatzki, G. R., et al. (2023) · Translational research · doi:10.1016/j.trsl.2023.05.002 · Cited by 11

Mitochondrial Targeted Interventions for AgingPreprint

Liu, S. Z., Chiao, Y. A., Rabinovitch, P. S., & Marcinek, D. J. (2023) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a041199 · Cited by 11

Resistance-based training improves mitochondrial capacity and redox balance in aging adults, independent of polyphenol supplementation

Flensted-Jensen, M., Weinreich, C. M., Kleis-Olsen, A.-S., Hansen, F., Skyggelund, N. S., Pii, J. R., Whitlock, R., Karlsen, A., Ingersen, A., Reihmane, D., et al. (2025) · Redox Biology · doi:10.1016/j.redox.2025.103972 · Cited by 13

Measuring Mitochondrial Function: From Organelle to Organism

Lewis, M. T., Levitsky, Y., Bazil, J. N., & Wiseman, R. W. (2022) · Methods in molecular biology · doi:10.1007/978-1-0716-2309-1_10 · Cited by 9

Revisiting the Mitochondrial Function and Communication in Neurodegenerative Diseases

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Development of a high‐throughput method for real‐time assessment of cellular metabolism in intact long skeletal muscle fibre bundles

Li, R., Steyn, F. J., Stout, M. B., Lee, K., Cully, T. R., Calderón, J. C., & Ngo, S. T. (2016) · The Journal of Physiology · doi:10.1113/jp272988 · Cited by 10

Mitochondrial Function in Oxidative and Glycolytic Bovine Skeletal Muscle Postmortem

Ramos, P. M., Bell, L. C., Wohlgemuth, S. E., & Scheffler, T. L. (2020) · Meat and Muscle Biology · doi:10.22175/mmb.11698 · Cited by 9

Muscling in on mitochondrial sexual dimorphism; role of mitochondrial dimorphism in skeletal muscle health and disease

Nye, G., Sakellariou, G. K., Degens, H., & Lightfoot, A. P. (2017) · Clinical Science · doi:10.1042/cs20160940 · Cited by 8

Texas Sour Orange Juice Used in Scaffolds for Tissue Engineering

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Combined changes in temperature and pH mimicking exercise result in decreased efficiency in muscle mitochondria

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Dietary nitrate supplementation mitigates age‐related changes at the neuromuscular junction in mice

Rossi, M., Zuccarelli, L., Brocca, L., Sazzi, C., Gissi, C., Rossi, P., Grassi, B., Porcelli, S., Bottinelli, R., & Pellegrino, M. A. (2025) · The Journal of Physiology · doi:10.1113/jp287592 · Cited by 7

Quantitative fluorescence imaging of mitochondria in body wall muscles of Caenorhabditis elegans under hyperglycemic conditions using a microfluidic chip

Sofela, S., Sahloul, S., Bhattacharjee, S., Bose, A., Usman, U., & Song, Y. (2020) · Integrative Biology · doi:10.1093/intbio/zyaa011 · Cited by 7

Uremic Myopathy and Mitochondrial Dysfunction in Kidney Disease

Serrano, E., Whitaker‐Menezes, D., Zhao, L., Roche, M. E., & Cantarin, M. P. M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232113515 · Cited by 9

Mechanical ventilation preserves diaphragm mitochondrial function in a rat sepsis model

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Effects of chronic alcohol intoxication on aerobic exercise-induced adaptations in female mice

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Behavioral Factors of Longevity

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Does Adipose Tissue Thermogenesis Play a Role in Metabolic Health?

Porter, C. C., Børsheim, E., & Sidossis, L. S. (2013) · Journal of Obesity · doi:10.1155/2013/204094 · Cited by 5

Antioxidants and Polyphenols Mediate Mitochondrial Mediated Muscle Death Signaling in Sarcopenia

Alway, S. E. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-810422-4.00026-9 · Cited by 6

Mitochondrial haplotype and sex modulate responses to endurance exercise training

Ahn, B., Wei, T., Pettit‐Mee, R. J., Kim, E., Musci, R. V., Wanagat, J., Nguyen, H. V. M., Richardson, A. G., & Kim, H. (2025) · The Journal of Physiology · doi:10.1113/jp288330 · Cited by 4

The Impact of Seasonal Fluctuations on Rat Liver Mitochondria Response to Tested Compounds— A Comparison between Autumn and Spring. New Insight into Collecting and Interpretation of Experimental Data Originating from Different Seasons

Łabieniec-Watała, M., & Siewiera, K. (2013) · CellBio · doi:10.4236/cellbio.2013.21003 · Cited by 4

Alteration of mitochondrial function in the livers of mice with glycogen branching enzyme deficiency

Malińska, D., Testoni, G., Bejtka, M., Durán, J., Guinovart, J. J., & Duszyński, J. (2021) · Biochimie · doi:10.1016/j.biochi.2021.04.001 · Cited by 4

From mitochondria to cells to humans: Targeting bioenergetics in aging and disease

Berry, B. J., Pharaoh, G. A., & Marcinek, D. J. (2023) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2023.106391 · Cited by 3

Diving into cancer OXPHOS – The application of metabolic control analysis to cell and tissue research

Puurand, M., Tepp, K., & Käämbre, T. (2023) · Biosystems · doi:10.1016/j.biosystems.2023.105032 · Cited by 4

Blocking the mineralocorticoid receptor prevents cardiac and mitochondrial dysfunction through the activation of NOX‐4 in female hormone deprivation rats

Rodrigues, S. M. L., Ximenes, C. F., Rodrigues, N. D. C., Ronconi, K. S., Costa, A. K. N., Vieira, L. B., da Silva, M. L. Y., FERREIRA, K. K. S., Eliezeck, M., Scalzo, S., et al. (2025) · Acta Physiologica · doi:10.1111/apha.70007 · Cited by 3

Measuring and Interpreting Oxygen Consumption Rates in Whole Fly Head Segments

Dietz, L. J., Venkatasubramani, A. V., Müller-Eigner, A., de Angelis, M. H., Imhof, A., Becker, L., & Peleg, S. (2019) · Journal of Visualized Experiments · doi:10.3791/58601 · Cited by 3

Conserved spinal cord bioenergetics in experimental autoimmune encephalomyelitis in C57BL6 mice, measured using phosphorescence oxygen analyzer

Shamsi, M. A., Shahin, A., Kamyan, D., Alnaqbi, A., Shaban, S. F., & Souid, A. (2021) · Heliyon · doi:10.1016/j.heliyon.2021.e08111 · Cited by 3

Feeding effects on liver mitochondrial bioenergetics of Boa constrictor (Serpentes: Boidae)

Araujo, H. R. D. M., Sartori, M. R., Navarro, C. D. C., de Carvalho, J. E., & da Cruz, A. L. (2021) · Journal of Experimental Biology · doi:10.1242/jeb.243142 · Cited by 3

Protonophore treatment augments energy expenditure in mice housed at thermoneutrality

Sadler, D. G., Landes, R. D., Treas, L. D., Sikes, J. D., & Porter, C. C. (2024) · Frontiers in Physiology · doi:10.3389/fphys.2024.1452986 · Cited by 3

Novel Insights to Mitochondrial Impact in Aging Skeletal Muscle

Semel, M. G., Lukasiewicz, C. J., & Hepple, R. T. (2025) · Exercise and Sport Sciences Reviews · doi:10.1249/jes.0000000000000364 · Cited by 5

A needle in a haystack:focus on “Proteomic alterations of distinct mitochondrial subpopulations in the type 1 diabetic heart”

Davidson, S. M. (2010) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00751.2010 · Cited by 3

Doping for sex: Bad for mitochondrial performances? Case of testosterone supplemented Hyla arborea during the courtship period

Desprat, J. L., Teulier, L., Puijalon, S., Dumet, A., Romestaing, C., Tattersall, G. J., Lengagne, T., & Mondy, N. (2017) · Comparative Biochemistry and Physiology Part A Molecular & Integrative Physiology · doi:10.1016/j.cbpa.2017.04.021 · Cited by 3

Roles of DRP1 and the fission protein interactome as regulators of cellular stability and sarcopenia in skeletal muscle aging

Nivedya, C., Venkhatesh, P., Rodriguez, B. I., Le, H., Afolabi, J., Marshall, A., Neikirk, K., Masenga, S. K., Aftab, M., Kazma, L. J., et al. (2025) · Aging advances. · doi:10.4103/agingadv.agingadv-d-25-00013 · Cited by 2

Tissue-specific mitochondrial toxicity of cigarette smoke concentrate: consequence to oxidative phosphorylation

Decker, S. T., Matias, A. A., Cuadra, A. E., Bannon, S. T., Madden, J. P., Erol, M. E., Serviente, C. F., Fénelon, K., & Layec, G. (2023) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00199.2023 · Cited by 4

Comparing whole body and red muscle mitochondrial respiration in an active teleost fish, brook trout (Salvelinus fontinalis)

Durhack, T. C., Aminot, M., Treberg, J. R., & Enders, E. C. (2023) · Canadian Journal of Zoology · doi:10.1139/cjz-2023-0045 · Cited by 2

The impact of physical activity on physical performance, mitochondrial bioenergetics, ROS production and calcium handling across the human adult lifespanPreprint

Cefis, M., Marcangeli, V., Hammad, R., Granet, J., Leduc‐Gaudet, J., Gaudreau, P., Trumpff, C., Huang, H., Picard, M. A., Aubertin‐Leheudre, M., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.07.09.602758 · Cited by 2

Role of Mitochondria in the Skeletal Muscle Metabolism in Obesity and Type 2 Diabetes

Miotto, P. M., & Holloway, G. P. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-811752-1.00006-7 · Cited by 1

High-Resolution Respirometry Methodology for Bioenergetic and Metabolic Studies in Intact Brain Slices

Dias, C., Lourenço, C. F., Laranjinha, J. A. N., & Ledo, A. (2024) · Methods in molecular biology · doi:10.1007/978-1-0716-4264-1_2 · Cited by 1

Novel Interacting Partners of MGP-40, a Chitinase-Like Protein in Buffalo Mammary Epithelial Cells

Anand, J. V., Jaswal, S., Jena, M. K., Kumar, S., Kaushik, J. K., & Mohanty, A. K. (2024) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-024-01623-z · Cited by 1

Isolated Mitochondria from Skeletal Muscle Show Exaggerated Impairments with Aging Compared to Mitochondria from Permeabilized Myofibers

Picard, M. A., Ritchie, D., Wright, K., Thomas, M. M., Rowan, S. L., Taivassalo, T., & Hepple, R. T. (2010) · Medicine & Science in Sports & Exercise · doi:10.1249/01.mss.0000389385.10676.54

Changes In Mitochondrial Function With Aging Do Not Translate To Degree Of Atrophy In Senescent Sol And Edl Muscle

Ritchie, D., Picard, M. A., Wright, K. J., Thomas, M. M., Rowan, S. L., Taivassalo, T., & Hepple, R. T. (2010) · Medicine & Science in Sports & Exercise · doi:10.1249/01.mss.0000389364.21871.3c

Alterations in intrinsic mitochondrial function with aging are fiber type‐specific and do not explain differential atrophy between muscles

Picard, M. A., Ritchie, D., Thomas, M. M., Wright, K. J., & Hepple, R. T. (2011) · Aging Cell · doi:10.1111/j.1474-9726.2011.00745.x · Cited by 154

Mitochondrial function and apoptotic susceptibility in aging skeletal muscle

Chabi, B., Ljubicic, V., Menzies, K. J., Huang, J. H., Saleem, A., & Hood, D. A. (2008) · Aging Cell · doi:10.1111/j.1474-9726.2007.00347.x · Cited by 437

Experimental evidence against the mitochondrial theory of aging A study of isolated human skeletal muscle mitochondria

Rasmussen, U. F., Krustrup, P., Kjær, M., & Rasmussen, H. (2003) · Experimental Gerontology · doi:10.1016/s0531-5565(03)00092-5 · Cited by 136