Mitochondrial function and apoptotic susceptibility in aging skeletal muscle
Open accessAbstract
During aging, skeletal muscle undergoes sarcopenia, a condition characterized by a loss of muscle cell mass and alterations in contractile function. The origin of these decrements is unknown, but evidence suggests that they can be partly attributed to mitochondrial dysfunction. To characterize the nature of this dysfunction, we investigated skeletal muscle contractile properties, subsarcolemmal (SS) and intermyofibrillar (IMF) mitochondrial biogenesis and function, as well as apoptotic susceptibility in young (6 months old) and senescent (36 months old) Fischer 344 Brown Norway rats. Muscle mass and maximal force production were significantly lower in the 36-month group, which is indicative of a sarcopenic phenotype. Furthermore, contractile activity in situ revealed greater fatigability in the 36-month compared to the 6-month animals. This decrement could be partially accounted for by a 30% lower mitochondrial content in fast-twitch muscle from 36-month animals, as well as lower protein levels of the transcriptional coactivator peroxisome proliferator-activated receptor gamma coactivator-1alpha. Enzyme activities and glutamate-induced oxygen consumption rates in isolated SS and IMF mitochondria were similar between age groups. However, mitochondrial reactive oxygen species (ROS) production during state 3 respiration was approximately 1.7-fold greater in mitochondria isolated from 36-month compared to 6-month animals, and was accompanied by a 1.8-fold increase in the DNA repair enzyme 8-oxoguanine glycosylase 1 in fast-twitch muscle. Basal rates of release of cytochrome c and endonuclease G in SS mitochondria were 3.5- to 7-fold higher from senescent animals. These data suggest that the age-related sarcopenia and muscle fatigability are associated with enhanced ROS production, increased mitochondrial apoptotic susceptibility and reduced transcriptional drive for mitochondrial biogenesis.
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Apoptosis increases with ageing and contributes to sarcopenia.
“Apoptosis is well known to increase with ageing and contribute to sarcopenia (Dirks & Leeuwenburgh, 2004; Leeuwenburgh et al. 2005; Chabi et al. 2008; Gouspillou et al. 2014b).”
From Parkin overexpression protects from ageing‐related loss of muscle mass and strength (2019) · cites this paper as Chabi et al. 2008
The Introduction reports increased apoptosis in aged skeletal muscle. The Discussion proposes apoptosis as a contributor to sarcopenia, but the study’s conclusion establishes an association with increased mitochondrial apoptotic susceptibility, not that apoptosis causes sarcopenia. The citing sentence states that contribution more definitively than this paper supports. (LLM, conf=0.85)
Experimental — accuracy not yet measuredNormal ageing is associated with a trend for a decrease in PGC-1α expression.
“We found that normal ageing is associated with a trend for a decrease in PGC‐1α expression, which is a finding consistent with previous studies (Baker et al. 2006; Chabi et al. 2008; Joseph et al. 2012).”
From Parkin overexpression protects from ageing‐related loss of muscle mass and strength (2019) · cites this paper as Chabi et al. 2008
Mitochondrial Ca2+ overload is partly responsible for the increased incidence of apoptosis in aged skeletal muscle cells.
“This is partly responsible for the increased incidence of apoptosis in aged skeletal muscle cells (50).”
From From mitochondria to sarcopenia: role of 17β-estradiol and testosterone (2023) · cites this paper as [50]
The mitochondrial permeability transition pore (mPTP) becomes dysfunctional in old rodents and humans.
“Several studies have also shown that the mitochondrial permeability transition pore (mPTP) becomes dysfunctional in old rodents and humans [9,12,13,14].”
From Mitochondrial Dynamics and Mitophagy in Skeletal Muscle Health and Aging (2021) · cites this paper as [13]
Opening the mPTP releases mitochondrial contents into the cytosol and initiates apoptotic signaling.
“Opening the mPTP induces a further loss of mitochondrial membrane potential, and releases the mitochondrial contents to the cytosol to initiate apoptotic signaling (24, 77, 89).”
From Mitochondria initiate and regulate sarcopenia (2017) · cites this paper as [24]
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Cites
Bradford, M. M. (1976) · Analytical Biochemistry · doi:10.1016/0003-2697(76)90527-3 · Cited by 255,302 · see citing works
Green, D. R., & Reed, J. C. (1998) · Science · doi:10.1126/science.281.5381.1309 · Cited by 8,998 · see citing works
Decline in skeletal muscle mitochondrial respiratory chain function: possible factor in ageing
Trounce, I., Byrne, E., & Marzuki, S. (1989) · The Lancet · doi:10.1016/s0140-6736(89)92143-0 · Cited by 730 · see citing works
Growth Curves and Survival Characteristics of the Animals Used in the Biomarkers of Aging Program
Turturro, A., Witt, W. W., Lewis, S. M., Hass, B. S., Lipman, R. D., & Hart, R. W. (1999) · The Journals of Gerontology Series A · doi:10.1093/gerona/54.11.b492 · Cited by 668 · see citing works
Oxidative capacity and ageing in human muscle
Conley, K. E., Jubrias, S. A., & Esselman, P. C. (2000) · The Journal of Physiology · doi:10.1111/j.1469-7793.2000.t01-1-00203.x · Cited by 651 · see citing works
WANAGAT, J., CAO, Z., PATHARE, P., & AIKEN, J. M. (2001) · The FASEB Journal · doi:10.1096/fj.00-0320com · Cited by 378 · see citing works
Apoptosis in skeletal muscle with aging
Dirks, A., & Leeuwenburgh, C. (2002) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00458.2001 · Cited by 377 · see citing works
Judge, S., Jang, Y. M., SMITH, A. R. W., Hagen, T. M., & Leeuwenburgh, C. (2005) · The FASEB Journal · doi:10.1096/fj.04-2622fje · Cited by 328 · see citing works
Drew, B., Phaneuf, S., Dirks, A. J., Selman, C., Gredilla, R., Lezza, A. M. S., Barja, G., & Leeuwenburgh, C. (2003) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00455.2002 · Cited by 287 · see citing works
Cogswell, A. M., Stevens, R. J., & Hood, D. A. (1993) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1993.264.2.c383 · Cited by 286 · see citing works
Self-citationAging Selectively Decreases Oxidative Capacity in Rat Heart Interfibrillar Mitochondria
Fannin, S. W., Lesnefsky, E. J., Slabe, T. J., Hassan, M. O., & Hoppel, C. L. (1999) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1999.1508 · Cited by 262 · see citing works
Effect of denervation on mitochondrially mediated apoptosis in skeletal muscle.
Adhihetty, P. J., O'Leary, M. F. N., Chabi, B., Wicks, K. L., & Hood, D. A. (2007) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00768.2006 · Cited by 240 · see citing works
Self-citationMitochondrial abnormalities are more frequent in muscles undergoing sarcopenia
Bua, E. A., McKiernan, S. H., Wanagat, J., McKenzie, D., & Aiken, J. M. (2002) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01102.2001 · Cited by 223 · see citing works
Mitochondria-associated apoptotic signalling in denervated rat skeletal muscle
Siu, P. M., & Alway, S. E. (2005) · The Journal of Physiology · doi:10.1113/jphysiol.2004.081083 · Cited by 216 · see citing works
Regulation of Mitochondrial Biogenesis in Muscle by Endurance Exercise
Irrcher, I., Adhihetty, P. J., Joseph, A.-M., Ljubicic, V., & Hood, D. A. (2003) · Sports Medicine · doi:10.2165/00007256-200333110-00001 · Cited by 210 · see citing works
Self-citationDirks, A. J., & Leeuwenburgh, C. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2003.10.003 · Cited by 190 · see citing works
Koves, T. R., Noland, R. C., Bates, A. L., Henes, S. T., Muoio, D. M., & Cortright, R. N. (2005) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00391.2004 · Cited by 178 · see citing works
Apoptotic responses to hindlimb suspension in gastrocnemius muscles from young adult and aged rats
Siu, P. M., Pistilli, E. E., & Alway, S. E. (2005) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00198.2005 · Cited by 170 · see citing works
Mitochondrial DNA mutations, energy metabolism and apoptosis in aging muscle
Dirks, A. J., Hofer, T., Marzetti, E., Pahor, M., & Leeuwenburgh, C. (2006) · Ageing Research Reviews · doi:10.1016/j.arr.2006.03.002 · Cited by 169 · see citing works
Adhihetty, P. J., Ljubicic, V., Menzies, K. J., & Hood, D. A. (2005) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00031.2005 · Cited by 161 · see citing works
Self-citationGordon, J. W., Rungi, A. A., Inagaki, H., & Hood, D. A. (2001) · Journal of Applied Physiology · doi:10.1152/jappl.2001.90.1.389 · Cited by 160 · see citing works
Self-citationReduced oxidative power but unchanged antioxidative capacity in skeletal muscle from aged humans
Tonkonogi, M., Fernström, M., Walsh, B., Ji, L. L., Rooyackers, O., Hammarqvist, F., Wernerman, J., & Sahlin, K. (2003) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-003-1044-9 · Cited by 159 · see citing works
Protein Import into Subsarcolemmal and Intermyofibrillar Skeletal Muscle Mitochondria
Takahashi, M. T., & Hood, D. A. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.44.27285 · Cited by 132 · see citing works
Self-citationHagen, J. L., Krause, D. J., Baker, D. J., Fu, M. H., Tarnopolsky, M. A., & Hepple, R. T. (2004) · The Journals of Gerontology Series A · doi:10.1093/gerona/59.11.1099 · Cited by 113 · see citing works
Chung, L. H., & Ng, Y.-C. (2005) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2005.08.003 · Cited by 112 · see citing works
Nakabeppu, Y., Tsuchimoto, D., Furuichi, M., & Sakumi, K. (2004) · Free Radical Research · doi:10.1080/10715760410001688348 · Cited by 104 · see citing works
Differential responses to endurance training in subsarcolemmal and intermyofibrillar mitochondria
Bizeau, M. E., Willis, W. T., & Hazel, J. R. (1998) · Journal of Applied Physiology · doi:10.1152/jappl.1998.85.4.1279 · Cited by 104 · see citing works
Barrientos, A., Casademont, J., Rötig, A., Miró, Ò., Urbano-Márquez, Á., Rustin, P., & Cardellach, F. (1996) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1996.1839 · Cited by 95 · see citing works
Mo, J., Xia, Y., Wade, T. J., Schmitt, M., Le, X. C., Dang, R., & Mumford, J. L. (2006) · Environmental Health Perspectives · doi:10.1289/ehp.8723 · Cited by 95 · see citing works
Chronic stimulation-induced changes in mitochondria and performance in rat skeletal muscle
Takahashi, M., & Hood, D. A. (1993) · Journal of Applied Physiology · doi:10.1152/jappl.1993.74.2.934 · Cited by 86 · see citing works
Self-citationRasmussen, U. F., Krustrup, P., Kjær, M., & Rasmussen, H. (2003) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-003-1022-2 · Cited by 82 · see citing works
Risom, L., Möller, P., Kristjansen, P. E. G., Loft, S. H., & Vogel, U. B. (2003) · Free Radical Research · doi:10.1080/1071576031000150788 · Cited by 80 · see citing works
Ipsi- and contralateral fibre transformations by cross-reinnervation. A principle of symmetry
Reichmann, H., Srihari, T., & Pette, D. (1983) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/bf00584358 · Cited by 77 · see citing works
Lezza, A. M. S., Pesce, V., Cormio, A., Fracasso, F., Vecchiet, J., Felzani, G., Cantatore, P., & Gadaleta, M. N. (2001) · FEBS Letters · doi:10.1016/s0014-5793(01)02628-x · Cited by 75 · see citing works
Real-time flow cytometry analysis of permeability transition in isolated mitochondria
Lecoeur, H., Langonné, A., Baux, L., et al. (2003) · Experimental Cell Research · doi:10.1016/j.yexcr.2003.10.030 · Cited by 75 · see citing works
Adhihetty, P. J., Ljubicic, V., & Hood, D. A. (2006) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00311.2006 · Cited by 67 · see citing works
Self-citationMosoni, L., Malmezat, T., VALLUY, M.-C., Houlier, M. L., Attaix, D., & Mirand, P. P. (1999) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1999.277.4.e608 · Cited by 55 · see citing works
Rice, K. M., & Blough, E. R. (2006) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2006.03.005 · Cited by 52 · see citing works
Bézaire, V., Heigenhauser, G. J. F., & Spriet, L. L. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00237.2003 · Cited by 51 · see citing works
The Interaction of Aging and Endurance Exercise Upon the Mitochondrial Function of Skeletal Muscle
Farrar, R. P., Martin, T. P., & Ardies, C. M. (1981) · Journal of Gerontology · doi:10.1093/geronj/36.6.642 · Cited by 50 · see citing works
Martin, C., Dubouchaud, H., Mosoni, L., Chardigny, J., Oudot, A., Fontaine, E. M., Vergely, C., Kériel, C., Rochette, L., Leverve, X. M., et al. (2007) · Aging Cell · doi:10.1111/j.1474-9726.2007.00271.x · Cited by 49 · see citing works
Role of UCP3 in state 4 respiration during contractile activity-induced mitochondrial biogenesis
Ljubicic, V., Adhihetty, P. J., & Hood, D. A. (2004) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00336.2004 · Cited by 45 · see citing works
Self-citationCortina, M. S., Gordon, W. C., Lukiw, W. J., & Bazan, N. G. (2005) · Experimental Eye Research · doi:10.1016/j.exer.2005.04.017 · Cited by 32 · see citing works
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Sarcopenia: Aging-Related Loss of Muscle Mass and Function
Larsson, L., Degens, H., Li, M., Salviati, L., Lee, Y. I., Thompson, W., Kirkland, J. L., & Sandri, M. (2019) · Physiological Reviews · doi:10.1152/physrev.00061.2017 · Cited by 1,797 · see citing works
Metabolic Control of Longevity
López-Otín, C., Galluzzi, L., Freije, J. M. P., Madeo, F., & Kroemer, G. (2016) · Cell · doi:10.1016/j.cell.2016.07.031 · Cited by 753 · see citing works
Oxidative Stress, Molecular Inflammation and Sarcopenia
Meng, S.-J., & Yu, L.-J. (2010) · International Journal of Molecular Sciences · doi:10.3390/ijms11041509 · Cited by 637 · see citing works
Mitochondrial dysfunction and sarcopenia of aging: from signaling pathways to clinical trials
Marzetti, E., Calvani, R., Cesari, M., Buford, T. W., Lorenzi, M., Behnke, B. J., & Leeuwenburgh, C. (2013) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2013.06.024 · Cited by 627 · see citing works
Maintenance of Skeletal Muscle Mitochondria in Health, Exercise, and Aging
Hood, D. A., Memme, J. M., Oliveira, A. N., & Triolo, M. (2019) · Annual Review of Physiology · doi:10.1146/annurev-physiol-020518-114310 · Cited by 567 · see citing works
Self-citationExercise Promotes Healthy Aging of Skeletal Muscle
Cartee, G. D., Hepple, R. T., Bamman, M. M., & Zierath, J. R. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.05.007 · Cited by 483 · see citing works
Mitochondrial quality control and muscle mass maintenance.
Romanello, V., & Sandri, M. (2016) · Frontiers in Physiology · doi:10.3389/fphys.2015.00422 · Cited by 434 · see citing works
Mitochondria and ageing: Role in heart, skeletal muscle and adipose tissue
Boengler, K., Kosiol, M., Mayr, M., Schulz, R., & Rohrbach, S. (2017) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12178 · Cited by 421 · see citing works
Autophagy Impairment in Muscle Induces Neuromuscular Junction Degeneration and Precocious Aging
Carnio, S., LoVerso, F., Baraibar, M. A., Longa, E., Khan, M. M., Maffei, M., Reischl, M., Canepari, M., Loefler, S., Kern, H., et al. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.07.061 · Cited by 423 · see citing works
Exercise and mitochondrial health
Memme, J. M., Erlich, A. T., Phukan, G., & Hood, D. A. (2021) · The Journal of Physiology · doi:10.1113/jp278853 · Cited by 343 · see citing works
Self-citationMitochondrial dysfunction in aging: Much progress but many unresolved questions
Payne, B. A. I., & Chinnery, P. F. (2015) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2015.05.022 · Cited by 335 · see citing works
Mitochondrial pathways in sarcopenia of aging and disuse muscle atrophy
Calvani, R., Joseph, A.-M., Adhihetty, P. J., Miccheli, A., Bossola, M., Leeuwenburgh, C., Bernabei, R., & Marzetti, E. (2013) · bchm · doi:10.1515/hsz-2012-0247 · Cited by 328 · see citing works
Mitochondrial morphology is altered in atrophied skeletal muscle of aged mice
Leduc-Gaudet, J.-P., Picard, M., Pelletier, F. S.-J., Sgarioto, N., Auger, M.-J., Vallée, J., Robitaille, R., St-Pierre, D. H., & Gouspillou, G. (2015) · Oncotarget · doi:10.18632/oncotarget.4235 · Cited by 273 · see citing works
Mitochondrial Dynamics and Mitophagy in Skeletal Muscle Health and Aging
Leduc-Gaudet, J.-P., Hussain, S. N. A., Barreiro, E., & Gouspillou, G. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22158179 · Cited by 268 · see citing works
The Effect of Aging on Human Skeletal Muscle Mitochondrial and Intramyocellular Lipid Ultrastructure
Crane, J. D., Devries, M. C., Safdar, A., Hamadeh, M. J., & Tarnopolsky, M. A. (2010) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/glp179 · Cited by 262 · see citing works
Picard, M., Ritchie, D., Wright, K. J., Romestaing, C., Thomas, M. M., Rowan, S. L., Taivassalo, T., & Hepple, R. T. (2010) · Aging Cell · doi:10.1111/j.1474-9726.2010.00628.x · Cited by 238 · see citing works
Hood, D. A. (2009) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/h09-045 · Cited by 242 · see citing works
Self-citationSkeletal muscle aging and the mitochondrion
Johnson, M. L., Robinson, M. M., & Nair, K. S. (2013) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2012.12.003 · Cited by 233 · see citing works
Gouspillou, G., Sgarioto, N., Kapchinsky, S., Purves‐Smith, F., Norris, B., Pion, C. H., Barbat‐Artigas, S., Lemieux, F., Taivassalo, T., Morais, J. A., et al. (2014) · The FASEB Journal · doi:10.1096/fj.13-242750 · Cited by 217 · see citing works
Picard, M., Hepple, R. T., & Burelle, Y. (2012) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00368.2011 · Cited by 214 · see citing works
Thirupathi, A., & de Souza, C. T. (2017) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-017-0576-y · Cited by 198 · see citing works
Joseph, A., Adhihetty, P. J., & Leeuwenburgh, C. (2016) · The Journal of Physiology · doi:10.1113/jp270659 · Cited by 186 · see citing works
Mitochondria, Muscle Health, and Exercise with Advancing Age
Carter, H. N., Chen, C. C. W., & Hood, D. A. (2015) · Physiology · doi:10.1152/physiol.00039.2014 · Cited by 191 · see citing works
Self-citationLuo, L., Lu, A.-M., Wang, Y., Hong, A., Chen, Y., Hu, J., Li, X., & Qin, Z.-H. (2013) · Experimental Gerontology · doi:10.1016/j.exger.2013.02.009 · Cited by 192 · see citing works
Chen, M., Wang, Y., Deng, S., Lian, Z., & Yu, K. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.964130 · Cited by 187 · see citing works
Mitochondrial death effectors: Relevance to sarcopenia and disuse muscle atrophy
Marzetti, E., Hwang, J. C. Y., Lees, H. A., Wohlgemuth, S. E., Dupont-Versteegden, E. E., Carter, C. S., Bernabei, R., & Leeuwenburgh, C. (2010) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2009.05.007 · Cited by 174 · see citing works
Marzetti, E., Wohlgemuth, S. E., Lees, H. A., Chung, H.-Y., Giovannini, S., & Leeuwenburgh, C. (2008) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2008.05.005 · Cited by 172 · see citing works
Iqbal, S., Ostojic, O., Singh, K., Joseph, A., & Hood, D. A. (2013) · Muscle & Nerve · doi:10.1002/mus.23838 · Cited by 169 · see citing works
Ljubicic, V., Joseph, A.-M., Saleem, A., Uguccioni, G., Collu-Marchese, M., Lai, R. Y. J., Nguyen, L. M.-D., & Hood, D. A. (2010) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2009.07.031 · Cited by 167 · see citing works
Self-citationAdaptive plasticity of autophagic proteins to denervation in aging skeletal muscle
O'Leary, M. F., Vainshtein, A., Iqbal, S., Ostojic, O., & Hood, D. A. (2013) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00240.2012 · Cited by 165 · see citing works
Self-citationUnravelling the mechanisms regulating muscle mitochondrial biogenesis
Hood, D. A., Tryon, L. D., Carter, H. N., Kim, Y., & Chen, C. C. W. (2016) · Biochemical Journal · doi:10.1042/bcj20160009 · Cited by 159 · see citing works
St‐Jean‐Pelletier, F., Pion, C. H., Leduc‐Gaudet, J., Sgarioto, N., Zovilé, I., Barbat‐Artigas, S., Reynaud, O., Alkaterji, F., Lemieux, F. C., Grenon, A., et al. (2017) · Journal of Cachexia, Sarcopenia and Muscle · doi:10.1002/jcsm.12139 · Cited by 156 · see citing works
Mitochondria initiate and regulate sarcopenia
Alway, S. E., Mohamed, J. S., & Myers, M. J. (2017) · Exercise and Sport Sciences Reviews · doi:10.1249/jes.0000000000000101 · Cited by 153 · see citing works
“Opening the mPTP induces a further loss of mitochondrial membrane potential and releases the mitochondrial contents to the cytosol to initiate apoptotic signaling (24,77,89).”
BackgroundMitochondrial energetics is impaired <i>in vivo</i> in aged skeletal muscle
Gouspillou, G., Bourdel‐Marchasson, I., Rouland, R., Calmettes, G., Biran, M., Deschodt‐Arsac, V., Miraux, S., Thiaudiere, E., Pasdois, P., Detaille, D., et al. (2014) · Aging Cell · doi:10.1111/acel.12147 · Cited by 147 · see citing works
Carter, H. N., Kim, Y., Erlich, A. T., Zarrin‐khat, D., & Hood, D. A. (2018) · The Journal of Physiology · doi:10.1113/jp275998 · Cited by 136 · see citing works
Self-citationMuscle wasting and aging: Experimental models, fatty infiltrations, and prevention
Brioche, T., Pagano, A. F., Py, G., & Chopard, A. (2016) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2016.04.006 · Cited by 129 · see citing works
Mitochondrial ROS regulate oxidative damage and mitophagy but not age-related muscle fiber atrophy
Sakellariou, G. K., Pearson, T., Lightfoot, A. P., Nye, G. A., Wells, N., Giakoumaki, I. I., Vasilaki, A., Griffiths, R. D., Jackson, M. J., & McArdle, A. (2016) · Scientific Reports · doi:10.1038/srep33944 · Cited by 133 · see citing works
Tian, G., Sawashita, J., Kubo, H., Nishio, S.-Y., Hashimoto, S., Suzuki, N., Yoshimura, H., Tsuruoka, M., Wang, Y., Liu, Y., et al. (2014) · Antioxidants & Redox Signaling · doi:10.1089/ars.2013.5406 · Cited by 123 · see citing works
Hao, Y., Jackson, J. R., Wang, Y., Edens, N., Pereira, S. L., & Alway, S. E. (2011) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00840.2010 · Cited by 124 · see citing works
Christian, C. J., & Benian, G. M. (2020) · Aging Cell · doi:10.1111/acel.13223 · Cited by 113 · see citing works
Parkin overexpression protects from ageing‐related loss of muscle mass and strength
Leduc‐Gaudet, J., Reynaud, O., Hussain, S. N., & Gouspillou, G. (2019) · The Journal of Physiology · doi:10.1113/jp277157 · Cited by 119 · see citing works
Olesen, J., Gliemann, L., Biensø, R., Schmidt, J., Hellsten, Y., & Pilegaard, H. (2014) · The Journal of Physiology · doi:10.1113/jphysiol.2013.270256 · Cited by 119 · see citing works
Update on mitochondria and muscle aging: All wrong roads lead to sarcopenia
Picca, A., Calvani, R., Bossola, M., Allocca, E., Menghi, A., Pesce, V., Lezza, A. M. S., Bernabei, R., Landi, F., & Marzetti, E. (2018) · Biological Chemistry · doi:10.1515/hsz-2017-0331 · Cited by 116 · see citing works
Protective role of Parkin in skeletal muscle contractile and mitochondrial function
Gouspillou, G., Godin, R., Piquereau, J., Picard, M., Mofarrahi, M., Mathew, J., Purves‐Smith, F. M., Sgarioto, N., Hepple, R. T., Burelle, Y., et al. (2018) · The Journal of Physiology · doi:10.1113/jp275604 · Cited by 115 · see citing works
Cellular and molecular mechanisms of sarcopenia: The S100B perspective
Riuzzi, F., Sorci, G., Arcuri, C., Giambanco, I., Bellezza, I., Minelli, A., & Donato, R. (2018) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12363 · Cited by 114 · see citing works
Parkin is required for exercise-induced mitophagy in muscle: Impact of aging
Chen, C. C. W., Erlich, A. T., Crilly, M. J., & Hood, D. A. (2018) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00391.2017 · Cited by 108 · see citing works
Self-citationCheema, N., Herbst, A., McKenzie, D., & Aiken, J. M. (2015) · Aging Cell · doi:10.1111/acel.12399 · Cited by 107 · see citing works
Ascensão, A., Lumini-Oliveira, J., Machado, N. G., Ferreira, R. M., Gonçalves, I. O., Moreira, A. C., Marques, F., Sardão, V. A., Oliveira, P. J., & Magalhães, J. (2011) · Clinical Science · doi:10.1042/cs20100254 · Cited by 103 · see citing works
Gheller, B. J. F., Riddle, E. S., Lem, M. R., & Thalacker-Mercer, A. E. (2016) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-071715-050901 · Cited by 98 · see citing works
Molecular basis for an attenuated mitochondrial adaptive plasticity in aged skeletal muscle
Ljubicic, V., Joseph, A.-M., Adhihetty, P. J., Huang, J. H., Saleem, A., Uguccioni, G., & Hood, D. A. (2009) · Aging · doi:10.18632/aging.100083 · Cited by 98 · see citing works
Self-citationThe Interplay between Mitochondrial Morphology and Myomitokines in Aging Sarcopenia
Romanello, V. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms22010091 · Cited by 101 · see citing works
Effects of Nrf2 deficiency on mitochondrial oxidative stress in aged skeletal muscle
Kitaoka, Y., Tamura, Y., Takahashi, K., Takeda, K., Takemasa, T., & Hatta, H. (2019) · Physiological Reports · doi:10.14814/phy2.13998 · Cited by 94 · see citing works
Mitochondrial Dysfunction in Skeletal Muscle Pathologies
Abrigo, J., Simon, F., Cabrera, D., Vilos, C., & Cabello-Verrugio, C. (2019) · Current Protein & Peptide Science · doi:10.2174/1389203720666190402100902 · Cited by 88 · see citing works
Goljanek‐Whysall, K., Soriano‐Arroquia, A., McCormick, R., Chinda, C., & McDonagh, B. (2020) · Aging Cell · doi:10.1111/acel.13140 · Cited by 81 · see citing works
“This is consistent with previously reported data showing mitochondrial content decrease in muscle during aging (Chabi et al., 2008; Hepple, 2014; Smith, Soriano-Arroquia, Goljanek-Whysall, Jackson, & McDonagh, 2018).”
BackgroundResultRole of PGC-1α in sarcopenia: Etiology and potential intervention—A mini-review
Ji, L. L., & Kang, C. (2015) · Gerontology · doi:10.1159/000365947 · Cited by 77 · see citing works
Contribution of muscle satellite cells to sarcopenia
Huo, F., Liu, Q., & Liu, H. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.892749 · Cited by 74 · see citing works
Gannon, J., Doran, P., Kirwan, A., & Ohlendieck, K. (2009) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2009.06.004 · Cited by 74 · see citing works
Faitg, J., Leduc-Gaudet, J.-P., Reynaud, O., Ferland, G., Gaudreau, P., & Gouspillou, G. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.00420 · Cited by 72 · see citing works
“The impact of aging on muscle mitochondrial content remains a controversial topic, with some studies showing reduced mitochondrial content in aged skeletal muscle (Conley et al., 2000;Chabi et al., 2008;Lanza and Nair, 2009;Crane et al., 2010) and others reporting no effect of aging (Russ and Kent-Braun, 2004;Gouspill…”
BackgroundVignaud, J., Loiseau, C., Hérault, J., Mayer, C., Côme, M., Martin, I., & Ulmann, L. (2023) · Antioxidants · doi:10.3390/antiox12051050 · Cited by 72 · see citing works
Lippi, L., de Sire, A., Mezian, K., Curci, C., Perrero, L., Turco, A., Andaloro, S., Ammendolia, A., Fusco, N., & Invernizzi, M. (2022) · Aging Clinical and Experimental Research · doi:10.1007/s40520-021-02073-w · Cited by 65 · see citing works
Lumini-Oliveira, J., Magalhães, J., Pereira, C. V., Moreira, A. C., Oliveira, P. J., & Ascensão, A. (2011) · Mitochondrion · doi:10.1016/j.mito.2010.07.005 · Cited by 66 · see citing works
Gouspillou, G., Bourdel-Marchasson, I., Rouland, R., Calmettes, G., Franconi, J.-M., Deschodt-Arsac, V., & Diolez, P. (2010) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2009.09.004 · Cited by 62 · see citing works
Russ, D. W., Grandy, J. S., Toma, K., & Ward, C. W. (2011) · Acta Physiologica · doi:10.1111/j.1748-1716.2010.02191.x · Cited by 61 · see citing works
Tarnopolsky, M. A. (2009) · Applied Physiology Nutrition and Metabolism · doi:10.1139/h09-022 · Cited by 59 · see citing works
From mitochondria to sarcopenia: role of 17β-estradiol and testosterone
Tian, X., Lou, S., & Shi, R. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1156583 · Cited by 54 · see citing works
“This is partly responsible for the increased incidence of apoptosis in aged skeletal muscle cells (50).”
BackgroundRegulation of muscle and mitochondrial health by the mitochondrial fission protein Drp1 in aged mice
Dulac, M., Leduc‐Gaudet, J., Cefis, M., Ayoub, M., Reynaud, O., Shams, A., Moamer, A., Nery Ferreira, M. F., Hussain, S. N., & Gouspillou, G. (2021) · The Journal of Physiology · doi:10.1113/jp281752 · Cited by 51 · see citing works
Facts and controversies in our understanding of how caloric restriction impacts the mitochondrion
Gouspillou, G., & Hepple, R. T. (2013) · Experimental Gerontology · doi:10.1016/j.exger.2013.03.004 · Cited by 42 · see citing works
Andreani, C., Bartolacci, C., Guescini, M., Battistelli, M., Stocchi, V., Orlando, F., Provinciali, M., Amici, A., Marchini, C., Tiano, L., et al. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/8936251 · Cited by 37 · see citing works
Huang, J. H., Joseph, A.-M., Ljubicic, V., Iqbal, S., & Hood, D. A. (2010) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/glp201 · Cited by 35 · see citing works
Self-citation"Sr stress" in mixed hindlimb muscles of aging Male rats
Russ, D. W., Krause, J., Wills, A., & Arreguin, R. (2012) · Biogerontology · doi:10.1007/s10522-012-9399-y · Cited by 32 · see citing works
Exercise is muscle mitochondrial medicine
Oliveira, A. N., Richards, B. J., Slavin, M., & Hood, D. A. (2021) · Exercise and Sport Sciences Reviews · doi:10.1249/jes.0000000000000250 · Cited by 26 · see citing works
Self-citationLong-Term PGC1β Overexpression Leads to Apoptosis, Autophagy and Muscle Wasting
Sopariwala, D. H., Yadav, V., Badin, P.-M., Likhite, N., Sheth, M., Lorca, S., Vila, I. K., Kim, E. R., Tong, Q., Song, M. S., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-10238-9 · Cited by 14 · see citing works
- Authors
- Chabi, B., Ljubicic, V., Menzies, K. J., Huang, J. H., Saleem, A., & Hood, D. A.
- Affiliations
- York University (CA)
- Corresponding author
- Hood, David A.
- ORCID
- Venue
- Aging Cell
- Publisher
- Wiley
- Published
- 2007-10-11
- Volume
- 7
- Issue
- 1
- Pages
- 2-12
- ISSN
- 1474-9718 (ISSN-L)
- 1474-9726
- OpenAlex
- W2061335198
- Cited by
- 437
- References
- 43
- Citations by year
- 2026: 10 · 2025: 24 · 2024: 23 · 2023: 20 · 2022: 23 · 2021: 30 · 2020: 29 · 2019: 29 · 2018: 27 · 2017: 25 · 2016: 26 · 2015: 19 · 2014: 20 · 2013: 22 · 2012: 21
- FWCI
- 8.83
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Aging Cell (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion, cc-by)
- Funders
- Heart and Stroke Foundation of Canada
- Canadian Institutes of Health Research
- Natural Sciences and Engineering Research Council of Canada
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Keywords
- sarcopenia, skeletal muscle aging, mitochondrial dysfunction, mitochondrial biogenesis, apoptosis, reactive oxygen species, muscle fatigue, PGC-1α, cytochrome c release, endonuclease G, fast-twitch muscle, subsarcolemmal mitochondria, interfibrillar mitochondria, muscle contractile properties
- MeSH terms
- Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha, Mitochondrial Permeability Transition Pore, Aging, Animals, Citrate (si)-Synthase, Electron Transport Complex IV, Endodeoxyribonucleases, Kinetics, Male, Mitochondria, Muscle, Myofibrils, Oxygen Consumption, Rats, Inbred F344, Sarcolemma, Transcription Factors, RNA-Binding Proteins, Apoptosis, Reactive Oxygen Species, Muscle, Skeletal, Mitochondrial Proteins, Mitochondrial Membrane Transport Proteins, Cytochromes c, Rats, Membrane Potential, Mitochondrial
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