Hepple, Russell T.

Exercise Promotes Healthy Aging of Skeletal Muscle

Cartee, G. D., Hepple, R. T., Bamman, M. M., & Zierath, J. R. (2016) · Cell Metabolism

Muscle Physiology and DisordersNutrition and Health in Aging

Cited by 483

Mitochondrial functional impairment with aging is exaggerated in isolated mitochondria compared to permeabilized myofibers

Picard, M., Ritchie, D., Wright, K. J., Romestaing, C., Thomas, M. M., Rowan, S. L., Taivassalo, T., & Hepple, R. T. (2010) · Aging Cell

Mitochondrial Function and PathologyMuscle Physiology and Disorders

Cited by 238

Increased sensitivity to mitochondrial permeability transition and myonuclear translocation of endonuclease G in atrophied muscle of physically active older humans

Gouspillou, G., Sgarioto, N., Kapchinsky, S., Purves‐Smith, F., Norris, B., Pion, C. H., Barbat‐Artigas, S., Lemieux, F., Taivassalo, T., Morais, J. A., et al. (2014) · The FASEB Journal

Mitochondrial Function and PathologyMuscle Physiology and Disorders

Cited by 217

Mitochondrial functional specialization in glycolytic and oxidative muscle fibers: tailoring the organelle for optimal function

Picard, M., Hepple, R. T., & Burelle, Y. (2012) · American Journal of Physiology-Cell Physiology

Mitochondrial Function and PathologyMuscle Physiology and Disorders

Cited by 214

Resistance and aerobic training in older men: effects onV˙ o 2 peak and the capillary supply to skeletal muscle

Hepple, R. T., Mackinnon, S. L. M., Goodman, J. M., Thomas, S. G., & Plyley, M. J. (1997) · Journal of Applied Physiology

Cardiovascular and exercise physiologySports Performance and Training

Cited by 203

The impact of ageing, physical activity, and pre‐frailty on skeletal muscle phenotype, mitochondrial content, and intramyocellular lipids in men

St‐Jean‐Pelletier, F., Pion, C. H., Leduc‐Gaudet, J., Sgarioto, N., Zovilé, I., Barbat‐Artigas, S., Reynaud, O., Alkaterji, F., Lemieux, F. C., Grenon, A., et al. (2017) · Journal of Cachexia, Sarcopenia and Muscle

Muscle Physiology and DisordersNutrition and Health in Aging

Cited by 156

Protective role of Parkin in skeletal muscle contractile and mitochondrial function

Gouspillou, G., Godin, R., Piquereau, J., Picard, M., Mofarrahi, M., Mathew, J., Purves‐Smith, F. M., Sgarioto, N., Hepple, R. T., Burelle, Y., et al. (2018) · The Journal of Physiology

Muscle Physiology and DisordersMitochondrial Function and Pathology

Cited by 115

Caloric restriction protects mitochondrial function with aging in skeletal and cardiac muscles

Hepple, R. T., Baker, D. J., McConkey, M., Murynka, T., & Norris, R. (2006) · Rejuvenation Research

Genetics, Aging, and Longevity in Model OrganismsMitochondrial Function and Pathology

Cited by 94

No decline in skeletal muscle oxidative capacity with aging in long-term calorically restricted rats: Effects are independent of mitochondrial DNA integrity

Baker, D. J., Betik, A. C., Krause, D. J., & Hepple, R. T. (2006) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences

Mitochondrial Function and PathologyGenetics, Aging, and Longevity in Model Organisms

Cited by 89

Long-term caloric restriction abrogates the age-related decline in skeletal muscle aerobic function

Hepple, R. T., Baker, D. J., Kaczor, J. J., & Krause, D. J. (2005) · The FASEB Journal

Genetics, Aging, and Longevity in Model OrganismsCardiovascular and exercise physiology

Cited by 80

Failed Upregulation of TFAM Protein and Mitochondrial DNA in Oxidatively Deficient Fibers of Chronic Obstructive Pulmonary Disease Locomotor Muscle

Konokhova, Y., Spendiff, S., Jagoe, R. T., Aare, S., Kapchinsky, S., MacMillan, N. J., Rozakis, P., Picard, M., Aubertin-Leheudre, M., Pion, C. H., et al. (2016) · Skeletal Muscle

Mitochondrial Function and PathologyMuscle Physiology and Disorders

Cited by 46

Facts and controversies in our understanding of how caloric restriction impacts the mitochondrion

Gouspillou, G., & Hepple, R. T. (2013) · Experimental Gerontology

Genetics, Aging, and Longevity in Model OrganismsMitochondrial Function and Pathology

Cited by 42

Increased capillarity in leg muscle of finches living at altitude

Hepple, R. T., Agey, P. J., Hazelwood, L., Szewczak, J. M., MacMillen, R. E., & Mathieu-Costello, O. (1998) · Journal of Applied Physiology

High Altitude and HypoxiaPhysiological and biochemical adaptations

Cited by 34

Signatures of cysteine oxidation on muscle structural and contractile proteins are associated with physical performance and muscle function in older adults: Study of Muscle, Mobility and Aging (SOMMA)

Day, N. J., Kelly, S. S., Lui, L., Mansfield, T. A., Gaffrey, M. J., Trejo, J. B., Sagendorf, T. J., Attah, I. K., Moore, R. J., Douglas, C. M., et al. (2024) · Aging Cell

Muscle Physiology and DisordersRedox biology and oxidative stress

Cited by 31

Autophagy gene expression in skeletal muscle of older individuals is associated with physical performance, muscle volume and mitochondrial function in the study of muscle, mobility and aging ( SOMMA )

Coen, P. M., Huo, Z., Tranah, G. J., Barnes, H. N., Zhang, X., Wolff, C. A., Wu, K., Cawthon, P. M., Hepple, R. T., Toledo, F. G. S., et al. (2024) · Aging Cell

Autophagy in Disease and TherapyMuscle Physiology and Disorders

Cited by 17

Expression of mitochondrial oxidative stress response genes in muscle is associated with mitochondrial respiration, physical performance, and muscle mass in the Study of Muscle, Mobility and Aging (SOMMA)

Tranah, G. J., Barnes, H. N., Cawthon, P. M., Coen, P. M., Esser, K. A., Hepple, R. T., Huo, Z., Kramer, P. A., Toledo, F. G. S., Evans, D. S., et al. (2023) · Aging Cell

Exercise and Physiological ResponsesMitochondrial Function and Pathology

Cited by 16

Energetics and clinical factors for the time required to walk 400 m: The Study of Muscle, Mobility and Aging ( SOMMA )

Cummings, S. R., Lui, L., Glynn, N. W., Mau, T., Cawthon, P. M., Kritchevsky, S. B., Coen, P. M., Goodpaster, B., Marcinek, D. J., Hepple, R. T., et al. (2024) · Journal of the American Geriatrics Society

Cardiovascular and exercise physiologyBalance, Gait, and Falls Prevention

Cited by 12

Skeletal Muscle Energetics Explain the Sex Disparity in Mobility Impairment in the Study of Muscle, Mobility and Aging

Kramer, P. A., Coen, P. M., Cawthon, P. M., Distefano, G., Cummings, S. R., Goodpaster, B. H., Hepple, R. T., Kritchevsky, S. B., Shankland, E. G., Marcinek, D. J., et al. (2024) · The Journals of Gerontology, Series A: Biological Sciences and Medical Sciences

Nutrition and Health in AgingMitochondrial Function and Pathology

Cited by 8

Skeletal muscle energetics explain the sex disparity in mobility impairment in the Study of Muscle, Mobility and Aging (SOMMA)

Kramer, P. A., Coen, P. M., Cawthon, P. M., Distefano, G., Cummings, S. R., Goodpaster, B. H., Hepple, R. T., Kritchevsky, S. B., Shankland, E. G., Marcinek, D. J., et al. (2023) · The Journals of Gerontology Series A

Nutrition and Health in AgingMitochondrial Function and Pathology

Cited by 8