Replication and protection of telomeres

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Mammalian Telomeres End in a Large Duplex Loop

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Telomere Shortening and Tumor Formation by Mouse Cells Lacking Telomerase RNA

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Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity.

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Untitled work

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TRF2 Protects Human Telomeres from End-to-End Fusions

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Origin of Concatemeric T7DNA

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DNA Damage Foci at Dysfunctional Telomeres

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Essential role of mouse telomerase in highly proliferative organs

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Reverse Transcriptase Motifs in the Catalytic Subunit of Telomerase

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Control of telomere length by the human telomeric protein TRF1

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Cellular Senescence in Aging Primates

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Pot1, the Putative Telomere End-Binding Protein in Fission Yeast and Humans

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Protection of mammalian telomeres

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Senescence Induced by Altered Telomere State, Not Telomere Loss

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Loss of a yeast telomere: Arrest, recovery, and chromosome loss

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Control of Human Telomere Length by TRF1 and TRF2

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Hayflick, his limit, and cellular ageing

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<i>TLC1</i> : Template RNA Component of <i>Saccharomyces cerevisiae</i> Telomerase

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POT1 as a terminal transducer of TRF1 telomere length control

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Single-Stranded DNA Arising at Telomeres in cdc13 Mutants May Constitute a Specific Signal for the RAD9 Checkpoint

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DNA processing is not required for ATM-mediated telomere damage response after TRF2 deletion

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Defective Telomere Lagging Strand Synthesis in Cells Lacking WRN Helicase Activity

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Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres

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Partners and pathways

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Telomere Length Homeostasis Is Achieved via a Switch between Telomerase- Extendible and -Nonextendible States

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Homologous Recombination Generates T-Loop-Sized Deletions at Human Telomeres

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Senescence Mutants of Saccharomyces cerevisiae With a Defect in Telomere Replication Identify Three Additional EST Genes

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The Mre11 complex is required for ATM activation and the G2/M checkpoint

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Different telomere damage signaling pathways in human and mouse cells

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Essential role of limiting telomeres in the pathogenesis of Werner syndrome

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T-loops and the origin of telomeres

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Pot1 Deficiency Initiates DNA Damage Checkpoint Activation and Aberrant Homologous Recombination at Telomeres

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Cdc13 Delivers Separate Complexes to the Telomere for End Protection and Replication

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Recent Expansion of the Telomeric Complex in Rodents: Two Distinct POT1 Proteins Protect Mouse Telomeres

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ATM‐dependent telomere loss in aging human diploid fibroblasts and DNA damage lead to the post‐translational activation of p53 protein involving poly(ADP‐ribose) polymerase

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Telomerase-Mediated Telomere Addition In Vivo Requires DNA Primase and DNA Polymerases α and δ

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DNA Ligase IV-Dependent NHEJ of Deprotected Mammalian Telomeres in G1 and G2

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Telomere maintenance is dependent on activities required for end repair of double-strand breaks

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Telomeric DNA in ALT Cells Is Characterized by Free Telomeric Circles and Heterogeneous t-Loops

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The DNA Damage Machinery and Homologous Recombination Pathway Act Consecutively to Protect Human Telomeres

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A critical role for telomeres in suppressing and facilitating carcinogenesis

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The Saccharomyces CDC 13 protein is a single-strand TG 1–3 telomeric DNA-binding protein in vitro that affects telomere behavior in vivo

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Telomere length homeostasis requires that telomerase levels are limiting

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POT1 protects telomeres from a transient DNA damage response and determines how human chromosomes end

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Break-Induced Replication and Recombinational Telomere Elongation in Yeast

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Evidence for a New Step in Telomere Maintenance

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Telomere proteins: Specific recognition and protection of the natural termini of Oxytricha macronuclear DNA

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Semi-conservative DNA replication through telomeres requires Taz1

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Stn1, a new Saccharomyces cerevisiae protein, is implicated in telomere size regulation in association with Cdc13.Preprint

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Crystal Structure of the Oxytricha nova Telomere End Binding Protein Complexed with Single Strand DNA

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Stn1, a new Saccharomyces cerevisiae protein, is implicated in telomere size regulation in association with Cdc13.

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Ten1 functions in telomere end protection and length regulation in association with Stn1 and Cdc13

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The telomerase reverse transcriptase is limiting and necessary for telomerase function in vivo

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Cdc13 both positively and negatively regulates telomere replicationPreprint

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Telomere-End Processing

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Variability at the Telomeres of the Human X/Y Pseudoautosomal Region

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Cell cycle-dependent regulation of yeast telomerase by Ku

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Frequent recombination in telomeric DNA may extend the proliferative life of telomerase-negative cells

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Human POT1 Facilitates Telomere Elongation by Telomerase

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Telomere maintenance without telomerase

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Targeted Deletion Reveals an Essential Function for the Telomere Length Regulator Trf1

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The Fission Yeast Taz1 Protein Protects Chromosomes from Ku-Dependent End-to-End Fusions

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Telomerase and ATM/Tel1p Protect Telomeres from Nonhomologous End Joining

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Transformation of normal human cells in the absence of telomerase activation

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Ku: A multifunctional protein involved in telomere maintenance

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Pol12, the B subunit of DNA polymerase α, functions in both telomere capping and length regulationPreprint

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Molecular characterization of inter-telomere and intra-telomere mutations in human ALT cells

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Long lifespan in worms with long telomeric DNA

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Delivery of Yeast Telomerase to a DNA Break Depends on the Recruitment Functions of Cdc13 and Est1

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Telomere Binding of Checkpoint Sensor and DNA Repair Proteins Contributes to Maintenance of Functional Fission Yeast Telomeres

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Quantitative amplification of single-stranded DNA (QAOS) demonstrates that cdc13-1 mutants generate ssDNA in a telomere to centromere direction

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For Better or Worse? Telomerase Inhibition and Cancer

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Rescue of a telomere length defect of Nijmegen breakage syndrome cells requires NBS and telomerase catalytic subunit

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Altering telomere structure allows telomerase to act in yeast lacking ATM kinases

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Human Telomeres Have Different Overhang Sizes at Leading versus Lagging Strands

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Reciprocal Association of the Budding Yeast ATM-Related Proteins Tel1 and Mec1 with Telomeres In Vivo

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