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Cited by 5Muscle metabolism and nutritionMetabolism, Diabetes, and CancerCardiovascular and exercise physiology

The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.

No effect of carbohydrate feeding on glycogen synthase in human muscle during exercise

Yan, Z., Spencer, M. K., Katz, A.·1993·Clinical Physiology
DOI 10.1111/j.1475-097x.1993.tb00326.x
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Abstract

Summary. The effect of carbohydrate (CHO) feedings on exercise‐mediated changes in glycogen synthase fractional (GSF) activity has been investigated. Subjects cycled at ‐70% of maximal oxygen uptake on two occasions: the first to fatigue (135±17 min; meanæ) (control, CON), and the second at the same workload and duration as the first, but with the addition of frequent ingestion of CHO during exercise (0.27 g kg‐1 body weight every 15 min). Biopsies were taken from the quadriceps femoris muscle before and immediately after exercise. Plasma glucose and insulin decreased during CON exercise, but remained elevated throughout CHO exercise (end of exercise: glucose = 4.4±0.2 mM CON vs. 5.8±0.2 CHO, P < 0.01; insulin = 9±l mU ml‐1 CON vs. 19±3 CHO, P < 0.05). Glycogen decreased to ‐ 10% of the basal value during CON and to ‐20% during CHO, and there was no significant difference in net glycogenosis between treatments. GSF activity averaged 0.25±0.03 and 0.22±0.05 at rest, and increased to 0.51 ±0.08 and 0.48±0.09 after exercise in CON and CHO, respectively (P > 0.05 between treatments). It is concluded that under the present conditions CHO feedings do not alter the exercise‐mediated changes in GSF activity. The increase in GSF during exercise is attributed at least in part to the decrease in muscle glycogen (which increases the suitability of GS as substrate for GS phosphatase).

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Crossref · 10.1111/j.1475-097x.1993.tb00326.x

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18 of 18 references verified0 citation errors · 0 not checkable

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  • All but one study extracted the muscle biopsy from the vastus lateralis; the remaining study reported sampling from the quadriceps femoris but did not report the specific muscle.

    “All but one study extracted the muscle biopsy from the vastus lateralis, the remaining study reported sampling from the quadriceps femoris, but did not report the speci fi c muscle (60).”

    From Carbohydrate ingestion during prolonged exercise and net skeletal muscle glycogen utilization: A meta-analysis. (2026) · cites this paper as [60]

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Metadata

Authors
Yan, Z., Spencer, M. K., & Katz, A.
Affiliations
University of Illinois Urbana-Champaign (US)
Corresponding author
Katz, A.
ORCID
Venue
Clinical Physiology
Publisher
Wiley
Published
1993-05
Volume
13
Issue
3
Pages
265-270
ISSN
  • 0144-5979 (ISSN-L)
  • 1365-2281
DOI
10.1111/j.1475-097x.1993.tb00326.x
OpenAlex
W2078803169
Cited by
5
References
18
Citations by year
2025: 1 · 2022: 1
FWCI
0.14
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 5455 d)
Locations
  • Clinical Physiology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
  • Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
Keywords
glycogen synthase, carbohydrate intake, physical activity, muscle glycogen, glycogenolysis, insulin, plasma glucose, quadriceps, exercise fatigue, glycogen synthase phosphatase, skeletal muscle
MeSH terms
Adolescent, Adult, Dietary Carbohydrates, Fatty Acids, Nonesterified, Female, Gluconeogenesis, Glycogen, Glycogen Synthase, Heart Rate, Humans, Male, Middle Aged, Muscles, Physical Endurance, Respiration, Uridine Diphosphate Glucose, Exercise

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