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Cited by 457Nicotinic Acetylcholine Receptors StudySmoking Behavior and CessationNeurotransmitter Receptor Influence on Behavior

The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.

The effects of nicotine on locomotor activity in non‐tolerant and tolerant rats

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Clarke, P.B.S., Kumar, R.·1983·British Journal of Pharmacology
DOI 10.1111/j.1476-5381.1983.tb09398.xPMC PMC2044704
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Abstract

1--Rats were tested for locomotor activity in photocell cages, for 80 min starting immediately after subcutaneous injection of (-)-nicotine bitartrate or 0.9% w/v NaCl solution (saline). In non-tolerant subjects, nicotine (0.1 to 0.4 mg/kg base) depressed activity and induced ataxia in the first 20 min, but increased activity later in the session; these actions were dose-dependent. 2--Tolerance was studied by comparing rats given nicotine (0.4 mg/kg s.c.) every day with control rats given saline instead. Each week, every subject was tested once with nicotine (0.4 mg/kg) and once with saline. With daily or even weekly injections of nicotine, the initial depressant action of the drug was replaced by a dose-dependent stimulant action which occurred throughout the session. In these tolerant animals, little ataxia was seen except when a larger dose of 0.8 mg/kg was given. Tolerance to the depressant action of nicotine persisted for at least 3 weeks. 3--In non-tolerant subjects, mecamylamine (0.5, 1.0 mg/kg s.c.) prevented the initial depressant action of nicotine (0.4 mg/kg). In tolerant rats, the locomotor stimulant action of nicotine (0.4 mg/kg) was prevented by mecamylamine (0.1, 0.32, 1.0 mg/kg s.c.) in a dose-related way; the quaternary ganglion blocker, hexamethonium (0.2, 1.0, 5.0 mg/kg s.c.) had little or no such effect. Neither mecamylamine nor hexamethonium altered activity when given alone. 4--It is suggested that a few treatments with nicotine can unmask a stimulant action of the drug, probably of central origin, which possibly reflects a stimulation of nicotine receptors.

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Research works printed but not linked: 7

  1. Barthelemy C., 1970, Comparison de divers antagonistes de l'eserine et de la nicotine chez la souris, J. Pharmac., (Paris), 1, 369
  2. Clarke P.B.S., 1981, Effects of nicotine on intracranial self‐stimulation in non‐tolerant rats, Br. J. Pharmac., 74, 212P
  3. Cox D.R., 1958, Planning of Experiments.
  4. Nelson W.T., 1982, Nicotine self‐administration in rat, Pharmac. Biochem. Behav., 15, 833
  5. Rosecrans J.A., 1969, Effects of nicotine on exploratory behaviour of female rats, Pharmacologist, 11, 246
  6. Schlatter J., 1978, Int. Workshop Behav. Effects of Nicotine, 55
  7. StTtzer M., 1970, Effects of nicotine on fixed interval behaviour and modification by cholinergic antagonists, J. Pharmac. exp. Ther., 171, 165

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Metadata

Authors
Clarke, P. B. S., & Kumar, R.
ORCID
Venue
British Journal of Pharmacology
Publisher
Wiley
Published
1983-02
Volume
78
Issue
2
Pages
329-337
ISSN
  • 0007-1188 (ISSN-L)
  • 1476-5381
DOI
10.1111/j.1476-5381.1983.tb09398.x
PMC
PMC2044704
OpenAlex
W2054668681
Cited by
457
References
30
Citations by year
2026: 1 · 2025: 2 · 2024: 2 · 2023: 1 · 2022: 7 · 2021: 1 · 2020: 5 · 2019: 8 · 2018: 4 · 2017: 9 · 2016: 6 · 2015: 11 · 2014: 8 · 2013: 7 · 2012: 12
FWCI
4.61
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 10761 d)
Locations
  • British Journal of Pharmacology (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • eScholarship@McGill (McGill) (submittedVersion)
Funders
Medical Research Council
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Smoking Behavior and Cessation
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords
nicotine, locomotor activity, nicotine tolerance, mecamylamine, hexamethonium, nicotinic acetylcholine receptors, dose-dependent effects
MeSH terms
Animals, Dose-Response Relationship, Drug, Drug Tolerance, Hexamethonium Compounds, Humans, Male, Mecamylamine, Motor Activity, Nicotine, Substance Withdrawal Syndrome, Hexamethonium, Rats

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