Cited by 457Nicotinic Acetylcholine Receptors StudySmoking Behavior and CessationNeurotransmitter Receptor Influence on Behavior

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The effects of nicotine on locomotor activity in non‐tolerant and tolerant rats

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Clarke, P.B.S., Kumar, R.·1983·British Journal of Pharmacology

DOI 10.1111/j.1476-5381.1983.tb09398.xPMC PMC2044704

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Abstract

1--Rats were tested for locomotor activity in photocell cages, for 80 min starting immediately after subcutaneous injection of (-)-nicotine bitartrate or 0.9% w/v NaCl solution (saline). In non-tolerant subjects, nicotine (0.1 to 0.4 mg/kg base) depressed activity and induced ataxia in the first 20 min, but increased activity later in the session; these actions were dose-dependent. 2--Tolerance was studied by comparing rats given nicotine (0.4 mg/kg s.c.) every day with control rats given saline instead. Each week, every subject was tested once with nicotine (0.4 mg/kg) and once with saline. With daily or even weekly injections of nicotine, the initial depressant action of the drug was replaced by a dose-dependent stimulant action which occurred throughout the session. In these tolerant animals, little ataxia was seen except when a larger dose of 0.8 mg/kg was given. Tolerance to the depressant action of nicotine persisted for at least 3 weeks. 3--In non-tolerant subjects, mecamylamine (0.5, 1.0 mg/kg s.c.) prevented the initial depressant action of nicotine (0.4 mg/kg). In tolerant rats, the locomotor stimulant action of nicotine (0.4 mg/kg) was prevented by mecamylamine (0.1, 0.32, 1.0 mg/kg s.c.) in a dose-related way; the quaternary ganglion blocker, hexamethonium (0.2, 1.0, 5.0 mg/kg s.c.) had little or no such effect. Neither mecamylamine nor hexamethonium altered activity when given alone. 4--It is suggested that a few treatments with nicotine can unmask a stimulant action of the drug, probably of central origin, which possibly reflects a stimulation of nicotine receptors.

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Psychopharmacology: A Generation of Progress
Ananth, J. (1979) · Psychosomatics · doi:10.1016/s0033-3182(79)73729-7 · Cited by 845
Persistent Behavior at High Rates Maintained by Intravenous Self-Administration of Nicotine
Goldberg, S. R., Spealman, R. D., & Goldberg, D. M. (1981) · Science · doi:10.1126/science.7291998 · Cited by 347
Studies on the mechanism of action of acetylcholine antagonists on rat parasympathetic ganglion cells.
Ascher, P., Large, W. A., & Rang, H. P. (1979) · The Journal of Physiology · doi:10.1113/jphysiol.1979.sp012958 · Cited by 296
Acute and chronic tolerance to nicotine measured by activity in rats
Stolerman, I. P., Fink, R. S., & Jarvik, M. E. (1973) · Psychopharmacology · doi:10.1007/bf00429192 · Cited by 246
Paradoxical tranquilizing and emotion-reducing effects of nicotine.
Gilbert, D. G. (1979) · Psychological Bulletin · doi:10.1037/0033-2909.86.4.643 · Cited by 217
Tobacco Alkaloids and Related Compounds
(1967) · Food and Cosmetics Toxicology · doi:10.1016/s0015-6264(67)82893-1 · Cited by 159
Nicotine tolerance in rats; role of dose and dose interval
Stolerman, I. P., Bunker, P., & Jarvik, M. E. (1974) · Psychopharmacology · doi:10.1007/bf00422555 · Cited by 121
The occurrence of tolerance to a central depressant effect of nicotine
Morrison, C. F., & Stephenson, J. A. (1972) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1972.tb06857.x · Cited by 119
GANGLIONIC BLOCKING PROPERTIES OF 3-METHYLAMINOISOCAMPHANE HYDROCHLORIDE (MECAMYLAMINE): A SECONDARY AMINE
Stone, C. A., Torchiana, M. L., Navarro, A., & Beyer, K. H. (1956) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)11667-4 · Cited by 110
Effects of nicotine on the exploratory locomotion patterns of female Roman high- and low-avoidance rats
Bättig, K., Driscoll, P., Schlatter, J., & Uster, H. J. (1976) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(76)90060-5 · Cited by 96

Show all 30 references

Research works printed but not linked: 7

Barthelemy C., 1970, Comparison de divers antagonistes de l'eserine et de la nicotine chez la souris, J. Pharmac., (Paris), 1, 369
Clarke P.B.S., 1981, Effects of nicotine on intracranial self‐stimulation in non‐tolerant rats, Br. J. Pharmac., 74, 212P
Cox D.R., 1958, Planning of Experiments.
Nelson W.T., 1982, Nicotine self‐administration in rat, Pharmac. Biochem. Behav., 15, 833
Rosecrans J.A., 1969, Effects of nicotine on exploratory behaviour of female rats, Pharmacologist, 11, 246
Schlatter J., 1978, Int. Workshop Behav. Effects of Nicotine, 55
StTtzer M., 1970, Effects of nicotine on fixed interval behaviour and modification by cholinergic antagonists, J. Pharmac. exp. Ther., 171, 165

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Bitner, R. S., Bunnelle, W. H., Decker, M. W., Drescher, K. U., Kohlhaas, K. L., Markosyan, S., Marsh, K. C., Nikkel, A. L., Browman, K., Radek, R., et al. (2010) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.110.167213 · Cited by 97
Nicotine abstinence in the mouse
Isola, R., Vogelsberg, V., Wemlinger, T. A., Neff, N. H., & Hadjiconstantinou, M. (1999) · Brain Research · doi:10.1016/s0006-8993(99)02131-9 · Cited by 96
Pharmacology of Nicotine
Grenhoff, J., & Svensson, T. H. (1989) · British Journal of Addiction · doi:10.1111/j.1360-0443.1989.tb00604.x · Cited by 96
Evidence for an involvement of D1 and D2 dopamine receptors in mediating nicotine-induced hyperactivity in rats
O‘Neill, M. F., Dourish, C. T., & Iversen, S. D. (1991) · Psychopharmacology · doi:10.1007/bf02246034 · Cited by 95
Neuropharmacology and potential efficacy of new treatments for tobacco dependence
Fagerström, K. O., & Balfour, D. J. K. (2006) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.15.2.107 · Cited by 95
Health consequences of using smokeless tobacco: summary of the Advisory Committee's report to the Surgeon General.
Cullen, J. W., Blot, W. J., Henningfield, J. E., Boyd, G. M., Mecklenburg, R. E., & Mm, M. (1986) · PubMed · Cited by 95
Measures and models of nicotine dependence: positive reinforcement
Glautier, S. (2004) · Addiction · doi:10.1111/j.1360-0443.2004.00736.x · Cited by 97
Repeated Nicotine Exposure Enhances Reward-Related Learning in the Rat
Olausson, P., Jentsch, J. D., & Taylor, J. R. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300173 · Cited by 94
Motivational properties of ethanol in mice selectively bred for ethanol-induced locomotor differences
Risinger, F. O., Malott, D. H., Prather, L. K., Niehus, D. R., & Cunningham, C. L. (1994) · Psychopharmacology · doi:10.1007/bf02245064 · Cited by 93
Nicotine place preference using the biased method of conditioning
Calcagnetti, D. J., & Schechter, M. (1994) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/0278-5846(94)90108-2 · Cited by 93
What is the nature of mecamylamine's antagonism of the central effects of nicotine?
Martin, B. R., Onaivi, E. S., & Martin, T. J. (1989) · Biochemical Pharmacology · doi:10.1016/0006-2952(89)90106-8 · Cited by 92
Nicotine induced behavioral locomotor sensitization
Domino, E. F. (2001) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/s0278-5846(00)00148-2 · Cited by 91
Tolerance to nicotine's effects in the elevated plus-maze and increased anxiety during withdrawal
Irvine, E. E., Cheeta, S., & File, S. E. (2001) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(00)00449-4 · Cited by 88
Effect of acute administration of nicotine on in vivo release of noradrenaline in the hippocampus of freely moving rats: A dose-response and antagonist study
Brazell, M. P., Mitchell, S. N., & Gray, J. A. (1991) · Neuropharmacology · doi:10.1016/0028-3908(91)90116-s · Cited by 88
An autoradiographic analysis of cholinergic receptors in mouse brain
Pauly, J. R., Stitzel, J. A., Marks, M. J., & Collins, A. C. (1989) · Brain Research Bulletin · doi:10.1016/0361-9230(89)90072-5 · Cited by 86
Antidepressant-like effects of the subtype-selective nicotinic acetylcholine receptor agonist, SIB-1508Y, in the learned helplessness rat model of depression
Ferguson, S. M., Brodkin, J. D., Kenneth Lloyd, G., & Menzaghi, F. (2000) · Psychopharmacology · doi:10.1007/s002130000531 · Cited by 85
Nicotine as a signal for the presence or absence of sucrose reward: a Pavlovian drug appetitive conditioning preparation in rats
Besheer, J., Palmatier, M. I., Metschke, D. M., & Bevins, R. A. (2004) · Psychopharmacology · doi:10.1007/s00213-003-1621-9 · Cited by 89
Behavioral Pharmacology of Cigarette Smoking
Henningfield, J. E. (1984) · Advances in behavioral pharmacology · doi:10.1016/b978-0-12-004704-8.50011-0 · Cited by 85
Differential behavioral effects of nicotine exposure in adolescent and adult rats
Schochet, T. L., Kelley, A. E., & Landry, C. F. (2004) · Psychopharmacology · doi:10.1007/s00213-004-1831-9 · Cited by 85
Rapid delivery of nicotine promotes behavioral sensitization and alters its neurobiological impact
Samaha, A., Yau, W. W., Yang, P., & Robinson, T. E. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.11.040 · Cited by 83
Nicotine self‐administration in rats
Cox, B. M., D, A. G. M., & Nelson, W. T. (1984) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1984.tb10118.x · Cited by 83
Adolescent and adult male rats differ in sensitivity to nicotine's activity effects
Faraday, M. M., Elliott, B. M., Phillips, J. M., & Grunberg, N. E. (2003) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(03)00024-8 · Cited by 83
Mecamylamine Modifies the Pharmacokinetics and Reinforcing Effects of Alcohol
Blomqvist, O., Hernández–Ávila, C. A., Kirk, J. V., Rose, J. E., & Kranzler, H. R. (2002) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2002.tb02541.x · Cited by 82

Authors: Clarke, P. B. S., & Kumar, R.
ORCID: Clarke, P.B.S.
Kumar, R.
Venue: British Journal of Pharmacology
Publisher: Wiley
Published: 1983-02
Volume: 78
Issue: 2
Pages: 329-337
ISSN: 0007-1188 (ISSN-L)
1476-5381
DOI: 10.1111/j.1476-5381.1983.tb09398.x
PMC: PMC2044704
OpenAlex: W2054668681
Cited by: 457
References: 30
Citations by year: 2026: 1 · 2025: 2 · 2024: 2 · 2023: 1 · 2022: 7 · 2021: 1 · 2020: 5 · 2019: 8 · 2018: 4 · 2017: 9 · 2016: 6 · 2015: 11 · 2014: 8 · 2013: 7 · 2012: 12
FWCI: 4.61
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 10761 d)
Locations: British Journal of Pharmacology (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
eScholarship@McGill (McGill) (submittedVersion)
Funders: Medical Research Council
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Smoking Behavior and Cessation
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords: nicotine, locomotor activity, nicotine tolerance, mecamylamine, hexamethonium, nicotinic acetylcholine receptors, dose-dependent effects
MeSH terms: Animals, Dose-Response Relationship, Drug, Drug Tolerance, Hexamethonium Compounds, Humans, Male, Mecamylamine, Motor Activity, Nicotine, Substance Withdrawal Syndrome, Hexamethonium, Rats

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The effects of nicotine on locomotor activity in non‐tolerant and tolerant rats

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