The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
Aminoguanidine selectively inhibits inducible nitric oxide synthase
Open accessAbstract
1. Endotoxin induces nitric oxide synthase in vascular tissue, including rat main pulmonary artery. Currently available agents that cause inhibition of nitric oxide synthase are relatively non-selective between the constitutive and inducible forms of the enzyme. 2. Aminoguanidine caused a dose-dependent increase in phenylephrine-induced tension in intact and endothelium-denuded pulmonary artery rings from endotoxin-treated rats, but had no effect on sham-treated controls. 3. Contraction caused by aminoguanidine in endothelium-denuded vessels from endotoxin-treated rats was unaffected by indomethacin (10 microM), and by cimetidine and mepyramine (both 10 microM), excluding an effect of aminoguanidine mediated by arachidonic acid metabolites or histamine. 4. Contraction caused by aminoguanidine in endothelium-denuded vessels from endotoxin-treated rats was abolished by L-arginine (2 mM) and L-NG-monomethyl arginine (300 microM), but unaffected by D-arginine and D-NG-monomethyl arginine, suggesting that its action is mediated by the L-arginine/nitric oxide pathway. 5. Aminoguanidine had no effect on acetylcholine-induced relaxation of intact vessels from shamtreated rats. However, relaxation of artery rings from endotoxin-treated rats by L-arginine was competitively inhibited by aminoguanidine.6. These results in isolated main pulmonary arteries of the rat confirm previous reports that aminoguanidine is a selective inhibitor of inducible nitric oxide synthase.
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Cites
Vascular endothelial cells synthesize nitric oxide from L-arginine
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The Cardiovascular Response of Normal Humans to the Administration of Endotoxin
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Pulmonary Hypertension in Severe Acute Respiratory Failure
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Aminoguanidine, a Novel Inhibitor of Nitric Oxide Formation, Prevents Diabetic Vascular Dysfunction
Corbett, J. A., Tilton, R. G., Chang, K., Hasan, K. S., Ido, Y., Wang, J. L., Sweetland, M. A., Lancaster, J. R., Williamson, J. R., & McDaniel, M. L. (1992) · Diabetes · doi:10.2337/diab.41.4.552 · Cited by 628
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Loss of vascular responsiveness induced by endotoxin involves L-arginine pathway
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Cited by
Nitric oxide: a key mediator in the early and late phase of carrageenan‐induced rat paw inflammation
Salvemini, D., Wang, Z., Wyatt, P. S., Bourdon, D. M., Marino, M. H., Manning, P. T., & Currie, M. G. (1996) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1996.tb15475.x · Cited by 668
Titheradge, M. A. (1999) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(99)00031-6 · Cited by 457
Cerebral Blood Flow Regulation by Nitric Oxide: Recent Advances
Toda, N., Ayajiki, K., & Okamura, T. (2009) · Pharmacological Reviews · doi:10.1124/pr.108.000547 · Cited by 386
Modulation of Prostaglandin Biosynthesis by Nitric Oxide and Nitric Oxide Donors
Mollace, V., Muscoli, C., Masini, E., Cuzzocrea, S., & Salvemini, D. (2005) · Pharmacological Reviews · doi:10.1124/pr.57.2.1 · Cited by 357
Bolli, R., Manchikalapudi, S., Tang, X.-L., Takano, H., Qiu, Y., Guo, Y., Zhang, Q., & Jadoon, A. K. (1997) · Circulation Research · doi:10.1161/01.res.81.6.1094 · Cited by 313
Metadata
- Authors
- Griffiths, M. J. D., Messent, M., MacAllister, R. J., & Evans, T. W.
- Venue
- British Journal of Pharmacology
- Publisher
- Wiley
- Published
- 1993-11
- Volume
- 110
- Issue
- 3
- Pages
- 963-968
- ISSN
- 0007-1188 (ISSN-L)
- 1476-5381
- OpenAlex
- W2037597903
- Cited by
- 397
- References
- 17
- FWCI
- 16.02
- Type
- journal article
- Language
- en
- Open access
- bronze
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