The DOI matches its Crossref record; 252 of the 252 references it cites were found in a registry or an index.
Epigenetic mechanisms in anti-cancer actions of bioactive food components—the implications in cancer prevention
Open accessAbstract
The hallmarks of carcinogenesis are aberrations in gene expression and protein function caused by both genetic and epigenetic modifications. Epigenetics refers to the changes in gene expression programming that alter the phenotype in the absence of a change in DNA sequence. Epigenetic modifications, which include amongst others DNA methylation, covalent modifications of histone tails and regulation by non‐coding RNAs, play a significant role in normal development and genome stability. The changes are dynamic and serve as an adaptation mechanism to a wide variety of environmental and social factors including diet. A number of studies have provided evidence that some natural bioactive compounds found in food and herbs can modulate gene expression by targeting different elements of the epigenetic machinery. Nutrients that are components of one‐carbon metabolism, such as folate, riboflavin, pyridoxine, cobalamin, choline, betaine and methionine, affect DNA methylation by regulating the levels of S‐adenosyl‐L‐methionine, a methyl group donor, and S‐adenosyl‐L‐homocysteine, which is an inhibitor of enzymes catalyzing the DNA methylation reaction. Other natural compounds target histone modifications and levels of non‐coding RNAs such as vitamin D, which recruits histone acetylases, or resveratrol, which activates the deacetylase sirtuin and regulates oncogenic and tumour suppressor micro‐RNAs. As epigenetic abnormalities have been shown to be both causative and contributing factors in different health conditions including cancer, natural compounds that are direct or indirect regulators of the epigenome constitute an excellent approach in cancer prevention and potentially in anti‐cancer therapy.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“There are many bioactive molecules present in food and herbs, in addition to folate, that are capable of influencing epigenetics and that have been touted as potential chemopreventative agents. Examples include various B vitamins, retinoic acid, vitamin D3, reservatrol, genistein and daidzein, epigallocatechin-3-gallate (EGCG), and curcumin (Gerhauser, 2013; Stefanska et al., 2012).”
From Influence of Metabolism on Epigenetics and Disease (2013) · cites this paper as Stefanska et al., 2012
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
2 retracted
Kikuno, N., Shiina, H., Urakami, S., Kawamoto, K., Hirata, H., Tanaka, Y., Majid, S., Igawa, M., & Dahiya, R. (2008) · International Journal of Cancer · doi:10.1002/ijc.23590 · Cited by 223
RetractedChung, J.-H., Ostrowski, M. C., Romigh, T., Minaguchi, T., Waite, K. A., & Eng, C. (2006) · Human Molecular Genetics · doi:10.1093/hmg/ddl177 · Cited by 111
RetractedPotent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans
Fire, A., Xu, S., Montgomery, M. K., Kostas, S. A., Driver, S. E., & Mello, C. C. (1998) · Nature · doi:10.1038/35888 · Cited by 15,429
Chromatin modifications and their function
Kouzarides, T. (2007) · Cell · doi:10.1016/j.cell.2007.02.005 · Cited by 10,883
Jenuwein, T., & Allis, C. D. (2001) · Science · doi:10.1126/science.1063127 · Cited by 9,756
MicroRNA expression profiles classify human cancers
Lü, J., Getz, G. A., Miska, E. A., Alvarez-Saavedra, E., Lamb, J., Peck, D., Sweet-Cordero, A., Ebert, B. L., Mak, R. H., Ferrando, A. A., et al. (2005) · Nature · doi:10.1038/nature03702 · Cited by 9,637
The language of covalent histone modifications
Strahl, B. D., & Allis, C. D. (2000) · Nature · doi:10.1038/47412 · Cited by 8,679
High-Resolution Profiling of Histone Methylations in the Human Genome
Barski, A., Cuddapah, S., Cui, K., Roh, T.-Y., Schones, D. E., Wang, Z., Wei, G., Chepelev, I., & Zhao, K. (2007) · Cell · doi:10.1016/j.cell.2007.05.009 · Cited by 6,845
Epigenetic programming by maternal behavior
Weaver, I. C. G., Cervoni, N., Champagne, F. A., D'Alessio, A. C., Sharma, S., Seckl, J. R., Dymov, S., Szyf, M., & Meaney, M. J. (2004) · Nature Neuroscience · doi:10.1038/nn1276 · Cited by 6,177
Okano, M., Bell, D. W., Haber, D. A., & Li, E. (1999) · Cell · doi:10.1016/s0092-8674(00)81656-6 · Cited by 6,143
Flagged first, then by citations
Cited by
Sorted by citations
Items 101–200 of 200
The effect of diet on the intestinal epigenome
Johnson, I. T., & Belshaw, N. J. (2014) · Epigenomics · doi:10.2217/epi.14.8 · Cited by 21
Yadav, M., Manoli, N. N., Vimalraj, S., & Madhunapantula, S. V. (2017) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2017.12.070 · Cited by 21
Yang, Y., Li, C., Li, H., Wu, M., Ren, C., Zhen, Y., Ma, X., Diao, Y.-P., Ma, X., Deng, S., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.15041 · Cited by 21
Epigenetic Dietary Interventions for Prevention of Cancer
Pradhan, N., Kar, S., Parbin, S., Sengupta, D., Deb, M., Das, L., & Patra, S. K. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-812494-9.00002-0 · Cited by 20
Martínez-Jiménez, V., Méndez‐Mancilla, A., & Portales‐Pérez, D. P. (2017) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201600994 · Cited by 19
Decoding Cancer through Silencing the Mitochondrial Gatekeeper VDAC1
Arif, T., Shteinfer‐Kuzmine, A., & Shoshan‐Barmatz, V. (2024) · Biomolecules · doi:10.3390/biom14101304 · Cited by 23
“This metabolism–epigenetics connection has been extensively explored in the context of tumorigenesis [142,147].”
BackgroundRecent Advances on Natural and Non-Natural Xanthones as Potential Anticancer Agents: A Review
Gogoi, U., Pathak, K., Saikia, R., Pathak, M. P., Paul, T., Khan, S. A., & Das, A. (2022) · Medicinal Chemistry · doi:10.2174/1573406419666221226093311 · Cited by 18
Khoogar, R., Kim, B.-C., Morris, J., & Wargovich, M. J. (2016) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00201.2015 · Cited by 17
Maternal prenatal intake of one-carbon metabolism nutrients and risk of childhood leukemia
Singer, A. W., Selvin, S., Block, G., Golden, C. E. M., Carmichael, S. L., & Metayer, C. (2016) · Cancer Causes & Control · doi:10.1007/s10552-016-0773-y · Cited by 17
Kaufman‐Szymczyk, A., Majda, K., Szuławska‐Mroczek, A., Fabianowska‐Majewska, K., & Lubecka, K. (2019) · Molecular Medicine Reports · doi:10.3892/mmr.2019.10619 · Cited by 17
“Natural phytochemicals have raised considerable interest not only as chemopreventive agents but also as chemotherapeutic adjuvants because of their anticancer properties demonstrated in a large number of studies (17).”
BackgroundSelf-citationAgaj, A., Peršurić, Ž., & Pavelić, S. K. (2022) · Molecules · doi:10.3390/molecules27248655 · Cited by 18
Tezcan, G., Tunca, B., Demirci, H., Bekâr, A., Taşkapılıoğlu, M. Ö., Kocaelı, H., Egelí, Ü., Çeçener, G., Tolunay, Ş., & Vatan, Ö. (2017) · Nutrition and Cancer · doi:10.1080/01635581.2017.1339810 · Cited by 16
“Thus, medicinal herbs have become a new frontier for the discovery of cancer therapies (17).”
BackgroundBendrihem, K. A., Mouane, A., Azzi, M., Mihoubi, M. A., Atanassova, M., SAWICKA, B. H., Zahnit, W., & Messaoudi, M. (2025) · Phytotherapy Research · doi:10.1002/ptr.8481 · Cited by 16
“According to recent studies, DNMT1 is responsible for maintaining the methylation pattern in newly synthesized DNA, while DNMT3A and DNMT3B establish new methylation marks in cells during development (Stefanska et al. 2012; Sergeeva et al. 2023).”
InfluentialHurtado‐Lorenzo, A., Honig, G., & Heller, C. A. (2020) · Crohn s & Colitis 360 · doi:10.1093/crocol/otaa087 · Cited by 15
Vitamin D Metabolism Gene Polymorphisms and Their Associated Disorders: A Literature Review
Abouzid, M., Główka, F. K., Kagan, L., & Karaźniewicz‐Łada, M. (2022) · Current Drug Metabolism · doi:10.2174/1389200223666220627104139 · Cited by 16
Methyl Group Metabolism in Differentiation, Aging, and Cancer
Erichsen, L., Thimm, C., & Santourlidis, S. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23158378 · Cited by 15
“On the other hand, there are ingredients that regulate histone modifications or the transcription of non-coding RNAs, such as vitamin D [24].”
BackgroundDEVELOPMENT OF A NEW TECHNOLOGY FOR PROTECTIVE BIOFORTIFICATION WITH SELENIUM OF BRASSICA CROPS
Oancea, A., Gaspar‐Pintiliescu, A., Seciu‐Grama, A., STEFAN, L., Crăciunescu, O., Georgescu, F., & Lăcătuşu, R. (2015) · AgroLife Scientific Journal · doi:10.17930/agl2015213 · Cited by 15
“Previous studies have demonstrated that glucosinolates inhibited (deoxy)cytidine methylation by DNA methyl transferase in normal cells, mainly by their hydrolysis compounds (Stefanska et al., 2012; Shankar et al., 2013).”
ResultFan, G.-H., Wang, Z., Yang, X., Xu, L., Qin, Q., Zhang, C., Ma, J.-X., Cheng, H., & Sun, X.-C. (2014) · Asian Pacific Journal of Cancer Prevention · doi:10.7314/apjcp.2014.15.2.677 · Cited by 14
“Previous studies have reported that resveratrol exerted antitumor activities at various stages of tumor initiation, promotion and progression (Cimino et al., 2012; Stefanska et al., 2012; Whitlock et al., 2012), including in esophageal squamous cell carcinoma (Tang et al., 2013).”
BackgroundRetractedAshraf, W., Ahmad, T., Almalki, N. A. R., Krifa, M., Zaayter, L., Pizzi, A., Muller, C. D., Hamiche, A., Mély, Y., Bronner, C., et al. (2021) · Food & Function · doi:10.1039/d1fo01484f · Cited by 13
Nicoletti, C. F., Assmann, T. S., Souza, L. L., & Martínez, J. A. (2024) · Lifestyle Genomics · doi:10.1159/000541000 · Cited by 13
Zhang, Y., Wei, Y., Liu, H., & Guo, Y. (2025) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2025.5587 · Cited by 13
Verma, R., Rao, L., Nagpal, D., Yadav, M. K., Kumar, M., Mittal, V., & Kaushik, D. K. (2023) · Recent Patents on Nanotechnology · doi:10.2174/1872210517666230823155328 · Cited by 8
Curcumin-Loaded Nanoparticles and Their Potential as Anticancer Agents in Breast Cancer
de Silva, L. S., Goh, B. H., Lee, L., & Chuah, L. (2019) · Springer eBooks · doi:10.1007/978-981-13-7205-6_7 · Cited by 9
Review on Natural Agents as Aromatase Inhibitors: Management of Breast Cancer
Singh, S. K. (2023) · Combinatorial Chemistry & High Throughput Screening · doi:10.2174/0113862073269599231009115338 · Cited by 9
Nano-engineered vitamins as a potential epigenetic modifier against environmental air pollutants
Ratre, P., Chauhan, P., Bhargava, A., Tiwari, R. R., Thareja, S., Srivastava, R. K., & Mishra, P. K. (2022) · Reviews on Environmental Health · doi:10.1515/reveh-2022-0027 · Cited by 9
Biotechnology applications in precision food
Siddique, A., Tayyaba, T., Imran, M., & Rahman, A. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-90042-3.00013-x · Cited by 8
Fareed, M. M., Ullah, S., Qasmi, M., & Shityakov, S. (2022) · Current Molecular Medicine · doi:10.2174/1566524023666221004140858 · Cited by 8
Early treatment with metformin induces resistance against tumor growth in adult rats
Trombini, A. B., Franco, C. C. S., Miranda, R. A., de Oliveira, J. C., Barella, L. F., Prates, K. V., de Souza, A. A., Pavanello, A., Malta, A., Almeida, D. L., et al. (2015) · Cancer Biology & Therapy · doi:10.4161/15384047.2014.962968 · Cited by 8
“Various strategies have been reported to prevent cancer and metabolic syndrome, such as exercise training, functional food and metformin treatment, by modulating metabolism.(13,14) These strategies may support the hypothesis that some agents, such as metformin, could display some direct or indirect action on metabolis…”
BackgroundRauhala, L., Hämäläinen, L., Dunlop, T. W., Pehkonen, P., Bart, G., Kokkonen, M., Tammi, M., Tammi, R., & Pasonen‐Seppänen, S. (2015) · Toxicology in Vitro · doi:10.1016/j.tiv.2015.09.015 · Cited by 8
Is estrogen receptor negative breast cancer risk associated with a fast life history strategy?
Hidaka, B. H., & Boddy, A. M. (2016) · Evolution Medicine and Public Health · doi:10.1093/emph/eov034 · Cited by 8
“Food components can influence epigenetic processes multitudinously; for example, several vitamins participate in the methyl cycle, thereby affecting DNA methylation, and several phytochemicals are known to directly modulate histone acetylation processes [13, 14].”
BackgroundRoles of foods and related components: an overview on cancer causatives, and plausible preventions
Mohammed, H. A., Sulaiman, G. M., Al‐Saffar, A. Z., Abomughaid, M. M., Hussein, N. N., Salih, Z. T., Hadi, N. A., Mohsin, M. H., Al-Kuraishy, H. M., Khan, R. A., et al. (2025) · Applied Food Research · doi:10.1016/j.afres.2025.101132 · Cited by 7
Beneficial Effect of Olive Oil and Its Derivates: Focus on Hematological Neoplasm
Campo, C., Gangemi, S., Pioggia, G., & Allegra, A. (2024) · Life · doi:10.3390/life14050583 · Cited by 7
“Numerous studies have demonstrated the crucial role that phenolic compounds play, such as antioxidants, anti-inflammatory agents, and in the control of epigenetic alterations that lead to antiproliferative protection, through miRNA expression, DNA methylation, and histone modifications [7,18,19].”
BackgroundDiet as a Potential Moderator for Genome Stability and Immune Response in Pediatric Leukemia
Wang, S., Maxwell, C. A., & Akella, N. M. (2021) · Cancers · doi:10.3390/cancers13030413 · Cited by 7
“Adequate folic acid and other micronutrient supplementation during pregnancy is associated with lower risk of childhood leukemia, over various populations and backgrounds, possibly through epigenetic modifications that drive oncogenesis [17,20,21].”
BackgroundMishra, P., Beura, S., Ghosh, R., & Modak, R. (2022) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-3-031-07634-3_8 · Cited by 7
Citric Acid Cycle Genes and Nutrigenetics
Vesnina, A. A., Kozlova, O., Ivanova, S. A., & Prosekov, A. Y. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27052360 · Cited by 7
Wang, H., Wang, W.-H., Wang, W. T., Ma, J., Su, X., Zhang, L.-L., Hou, Y.-L., Liu, J., Ren, J., Luo, X., et al. (2023) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2023.109489 · Cited by 6
Epigenetic Impact of Bioactive Dietary Compounds in Cancer Chemoprevention
Šupić, G., Wagner, D. O., & Magić, Z. (2015) · Springer eBooks · doi:10.1007/978-3-319-21461-0_7 · Cited by 6
Anticancer properties of selected plant polyphenols from the group of flavonoids and stilbenes
Majewski, G., Lubecka, K., Kaufman‐Szymczyk, A., & Fabianowska‐Majewska, K. (2012) · Polish Journal of Public Health · doi:10.12923/j.0044-2011/122-4/a.19 · Cited by 6
Self-citationModulation of Apoptosis in Colon Cancer Cells by Bioactive Compounds
Bostan, M., Mihaila, M. A., Hotnog, C. M., Bleoţu, C., Anton, G., Roman, V., & Braşoveanu, L. I. (2016) · InTech eBooks · doi:10.5772/63382 · Cited by 6
Tierno, R., & de Galarreta, J. I. R. (2016) · Australian Journal of Agricultural Research · doi:10.1071/cp16255 · Cited by 6
Epigenetic modifications in vascular inflammation
Tang, L., Li, L., Liu, Y., Zhang, X., Wang, X., Zheng, Z., Yang, P., & Wu, H. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1711579 · Cited by 5
Radhakrishnan, A. K., Rao, J. S. A., Subramaniam, S., & Ramdas, P. (2021) · Current Research in Immunology · doi:10.1016/j.crimmu.2021.10.001 · Cited by 5
Bioactive Natural Products for Breast Cancer Chemoprevention and Treatment
Mokashi, A., & Bhatia, N. M. (2023) · Current Bioactive Compounds · doi:10.2174/1573407219666230529151351 · Cited by 5
Bioactive Food Components as Dietary Intervention for Cystic Fibrosis
Sirinupong, N., & Yang, Z. (2015) · Current Drug Targets · doi:10.2174/1389450115666141122211111 · Cited by 5
An epigenetic perspective on the treatment of solid tumors with vincristine
Ghorbani, Z., Rahimi, Z., & Jalilian, N. (2025) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2025.104902 · Cited by 4
Río, A. D., & Costa, F. B. D. (2014) · Springer eBooks · doi:10.1007/978-3-319-10226-9_5 · Cited by 4
Association between SIRT6 Methylation and Human Longevity in a Chinese Population
Tang, X. A., Wei, Y., Wang, J., Chen, S., Cai, J., Tang, J., Xu, X., Long, B., Yu, G., Zhang, Z., et al. (2020) · Public Health Genomics · doi:10.1159/000508832 · Cited by 4
The Epigenetic Targets of Berry Anthocyanins in Cancer Prevention
El-Ella, D. M. A., & Bishayee, A. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-812494-9.00006-8 · Cited by 5
Tian, X., Zhou, M., Zhang, J., Huang, X., Jiang, D., Liu, J., Zhang, Q., Chen, D., & Hu, Q. (2025) · DNA and Cell Biology · doi:10.1089/dna.2025.0026 · Cited by 3
“Multiple studies have shown that some naturally occurring bioactive compounds present in foods and herbs can inhibit cancer development through epigenetic regulation (Stefanska et al., 2012).”
Epigenetic Nutraceuticals in Cancer Treatment
Šupić, G., Zeljić, K., & Magić, Z. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-811517-6.00015-5 · Cited by 3
Precise Nutrition and Functional Foods
Ivanović, N., Hippe, B., Lilja, S., & Haslberger, A. G. (2022) · Springer eBooks · doi:10.1007/978-3-031-10153-3_10 · Cited by 4
Self-citationBeetch, M., & Stefañska, B. (2019) · Springer eBooks · doi:10.1007/978-3-319-55530-0_104 · Cited by 3
Diet-Epigenome Interactions: Epi-Drugs Modulating the Epigenetic Machinery during Cancer Prevention
Pehlivan, F. E. (2021) · Biochemistry · doi:10.5772/intechopen.95374 · Cited by 3
“Quercetin is reported to have a broad spectrum of cancer-preventive activities: acting as an antioxidant and modulating enzymes and signaling cascades involved in detoxification, inflammation, proliferation, apoptosis, angiogenesis, autophagy, immune defense, and senescence; besides it has been suggested to have poten…”
BackgroundCHEMICAL CLASSIFICATION AND CHEMISTRY OF PHYTOTHERAPEUTICS CONSTITUENTS
Cui, P., & Duke, C. C. (2015) · doi:10.1002/9781119006039.ch10 · Cited by 3
Targeting Cancer Stem Cells by Phytochemicals: a Multimodal Approach to Colorectal Cancer
Mukherjee, S., Saha, S., Manna, A., Mazumdar, M., Chakraborty, S., Paul, S., & Das, T. (2014) · Current Colorectal Cancer Reports · doi:10.1007/s11888-014-0251-4 · Cited by 2
Epigenetic Alterations in Aging and Aging-Associated Diseases: Review
Gunes, S. O., & Bayramov, B. (2016) · Turkiye Klinikleri Journal of Medical Sciences · doi:10.5336/medsci.2016-51843 · Cited by 2
Stilbenoids as dietary regulators of the cancer epigenome
Beetch, M., Harandi‐Zadeh, S., Shen, K., & Stefañska, B. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-816843-1.00021-7 · Cited by 2
Micro- and Macroevolution: A Continuum or Two Distinct Types of Change?Preprint
DeJong, W., & Degens, H. (2024) · Qeios · doi:10.32388/kiejwr.2 · Cited by 2
Liu, R., Hu, J., Zhang, X., Wu, X., Wei, H., Zhao, Y., He, S., Yu, J. X., Qi, X., Pei, Y., et al. (2024) · World Journal of Traditional Chinese Medicine · doi:10.4103/wjtcm.wjtcm_51_23 · Cited by 1
Hayat, S., Ahmad, J., Naeem, S., Yaseen, F., Aamir, S., Guida, F., Luongo, L., & Maione, S. (2026) · Nutrients · doi:10.3390/nu18060881 · Cited by 1
“It is a study concerned with the influence of nutrients and bioactive compounds on gene expression without altering the DNA sequence [161].”
Kozłowska, H., Cichocka, E., Górczyńska-Kosiorz, S. B., & Gumprecht, J. (2026) · Pharmaceuticals · doi:10.3390/ph19060906 · Cited by 1
Araf, Y., Portlock, T., & O'Sullivan, J. M. (2026) · Nutrients · doi:10.3390/nu18152453 · Cited by 1
“Sulforaphane from cruciferous vegetables acts largely through HDAC inhibition, with downstream effects on chromatin accessibility that indirectly influence DNA methylation at associated promoters [49].”
Zastosowanie związków fenolowych i ich pochodnych w przemyśle i medycynie
Golonko, A., Kalinowska, M., Świsłocka, R., Świderski, G., & Lewandowski, W. (2015) · Budownictwo i Inżynieria Środowiska · Cited by 1
Epigenetic Alterations in Stomach Cancer: Implications for Diet and Nutrition
Gigek, C. O., Chen, E., & Smith, M. D. A. C. (2017) · Springer eBooks · doi:10.1007/978-3-319-31143-2_29-1 · Cited by 1
Epigenetic Alterations in Stomach Cancer: Implications for Diet and Nutrition
Gigek, C. O., Chen, E., & Smith, M. D. A. C. (2019) · Springer eBooks · doi:10.1007/978-3-319-55530-0_29 · Cited by 1
How Do Food Compounds Interact with Their Protein Targets? Alternative Modes for Protein Binding
Astigarraga, M., López-Alejandre, V., Sánchez-Ruiz, A., & Colmenarejo, G. (2025) · Journal of Chemical Information and Modeling · doi:10.1021/acs.jcim.5c00828
Chromatin, histones, and histone modifications in health and disease
Shah, S. G., Rashid, M., Verma, T., & Gupta, S. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-817819-5.00008-5 · Cited by 2
Manzoor, A., Jan, B., Mehraj, S., Rizvi, Q. U. E. H., Manzoor, M., & Ahmad, S. (2020) · Springer eBooks · doi:10.1007/978-981-15-7285-2_9 · Cited by 1
Transcriptional Control Leading to Clinical Outcomes in Breast Cancer Cases
Aftab, A., Khan, R., Hameed, U., Abbas, T., & Ahmad, B. (2022) · Springer eBooks · doi:10.1007/978-981-19-0197-3_13 · Cited by 1
Effects of Histone Deacetylase Inhibitors on Vitamin D Activity in Human Breast Cancer Cells
Savage, B. (2023) · ScholarWorks@UMassAmherst (University of Massachusetts Amherst) · doi:10.7275/4442735 · Cited by 1
Nutritional interventions in age‐related genetic and epigenetic instability and cancer
Ong, T. P., & Loureiro, A. P. D. M. (2015) · Wiley eBooks · doi:10.1002/9781118823408.ch4 · Cited by 1
Epigenetically active drugs target metabolic gene-regulation in leukemic cells
Karlic, H., Boltzmann, L., Varga, J., & Varga, F. (2013)
Self-citationRetinoic Acid Receptor-β, From Gene to Clinic
Fazilaty, H., & Mehdipour, P. (2015) · Springer eBooks · doi:10.1007/978-94-017-9639-2_12
Epigenetics of Endocrine Tumors in Women and Dietary Prevention
Romagnolo, D. F., & Selmin, O. I. (2015) · Springer eBooks · doi:10.1007/978-3-319-22431-2_9
Graham, É. A. (2016) · uO Research (University of Ottawa) · doi:10.20381/ruor-5711
“Several natural compounds have been shown to support chemoprevention and therapy in breast cancers including dietary polyphenols from green tea, turmeric, broccoli, and soybeans (31), catechins from green tea (31), folate from spinach, lentils, and almonds (32), vitamin D3”
Epigenetic and Cancer: An Evaluation of the Impact of Dietary Components
Stokes, J. A., III, Kumar, S., Scissum-Gunn, K. D., Singh, U. P., & Mishra, M. K. (2016) · Springer eBooks · doi:10.1007/978-3-319-24951-3_3
Energy Balance, Epigenetics, and Prostate Cancer
Heber, D., Henning, S. M., & Li, Z. (2016) · Energy balance and cancer · doi:10.1007/978-3-319-41610-6_10
Nutritional and Epigenetics Implications in Esophageal Cancer
Calcagno, D. Q., Oliveira, K. C. D. S., & Martins, N. N. F. (2017) · Springer eBooks · doi:10.1007/978-3-319-31143-2_44-1
Defective DNA Methylation/Demethylation Processes Define Aging-Dependent Methylation Patterns
Zampieri, M., Ciccarone, F., & Caiafa, P. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-811060-7.00002-4
Costa, G. R. (2017) · doi:10.11606/t.9.2017.tde-26102017-113658
Marczyński, Z., Skibska, B., Nowak, S., Rychlińska, I., Jambor, J., & Zgoda, M. M. (2018) · Herba Polonica · doi:10.2478/hepo-2018-0012
“cancer and cardiovascular and neurodegenerative diseases [1-3].”
BackgroundGarcia, E., & Winter, C. K. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-385007-2.00023-1
Natural Compounds as New Cancer Treatments
Barrajon, E. (2019) · MDPI eBooks · doi:10.3390/books978-3-03921-366-5
Beetch, M., & Stefañska, B. (2017) · Springer eBooks · doi:10.1007/978-3-319-31143-2_104-1
Dietary Nitrates and Their Anti‐Platelet Effects
Duttaroy, A. K. (2018) · Wiley eBooks · doi:10.1002/9781119375913.ch7
Nutritional and Epigenetics Implications in Esophageal Cancer
Calcagno, D. Q., Oliveira, K. C. D. S., & Martins, N. N. F. (2019) · Springer eBooks · doi:10.1007/978-3-319-55530-0_44
The Scenario of Recurrence of Cervical Cancer by Epigenetics
Gaikwad, S. (2023) · International Journal for Research in Applied Science and Engineering Technology · doi:10.22214/ijraset.2023.57250
Micro- and Macroevolution: A Continuum or Two Distinct Types of Change?Preprint
DeJong, W., & Degens, H. (2024) · Qeios · doi:10.32388/kiejwr
تأثير مكملات فيتامين د على حالة مثيلة الجين SLC30A10 على خطوط خلايا سرطان القولون
غانم, س. ر., & كراجيان, أ. د. م. ا. (2024) · journal of the college of basic education · doi:10.35950/cbej.v30i123.11302
Nair, R. R., & Ramachandran, S. (2024) · Advances in biochemistry in health and disease · doi:10.1007/978-3-031-55489-6_17
Food Bioactives as Natural Anticancer Therapeutic Agents
Lima, T. P. B., Coimbra, P. P. S., Araújo-Lima, C. F., & Teodoro, A. J. (2025) · Springer eBooks · doi:10.1007/978-981-97-9723-3_12
Szilagyi, A., Galiatsatos, P., & Margolese, N. (2026) · Frontiers in Nutrition · doi:10.3389/fnut.2026.1671166
Predominant miRNAs in Animal-Source Foods and Bioinformatic Analysis
Ilori, O. A., Santis, G. D., Cannataro, R., Tucci, P., & Cione, E. (2026) · Current Issues in Molecular Biology · doi:10.3390/cimb48020237
“Indications from recent studies suggest that such foods could offer more by exerting epigenetic regulation and post-transcriptional activities through their composition of bioactive nucleic acids [6,7].”
Interaction mechanisms of epigenetic integrator UHRF1 with TIP60 acetyltransferase
Ashraf, W. (2018) · theses.fr (ABES) · doi:10.70675/aed43e61z7014z400az8077za1bb36217ac4
Inhibition of UHRF1 protein by epigenetic partners and epi-drugs
Ahmad, T. (2019) · theses.fr (ABES) · doi:10.70675/22ce2b88z3f75z4cf2zba46z32f22041638f
Bioactive Food Compounds Against Liver Cancer
Singh, A., Maheshwari, S., Verma, A., Ansari, V. A., & Prajapati, B. G. (2026) · Food bioactive ingredients · doi:10.1007/978-3-032-23814-6_14
Epigenetic Modulators in Cancer Therapy: Mechanisms and Applications
Kumar, R. R., Malik, M. A., Mittal, A., & Sardana, S. (2026) · Springer eBooks · doi:10.1007/978-981-92-0477-9_19
Metadata
- Authors
- Stefanska, B., Karlic, H., Varga, F., Fabianowska‐Majewska, K., & Haslberger, A.
- Affiliations
- Hanusch Hospital (AT)
- Medical University of Lodz (PL)
- Venue
- British Journal of Pharmacology
- Publisher
- Wiley
- Published
- 2012-08-22
- Volume
- 167
- Issue
- 2
- Pages
- 279-297
- ISSN
- 0007-1188 (ISSN-L)
- 1476-5381
- PMC
- PMC3481038
- OpenAlex
- W1753288383
- Cited by
- 200
- References
- 252
- Citations by year
- 2026: 8 · 2025: 11 · 2024: 10 · 2023: 6 · 2022: 16 · 2021: 13 · 2020: 13 · 2019: 22 · 2018: 8 · 2017: 22 · 2016: 18 · 2015: 20 · 2014: 12 · 2013: 13 · 2012: 8
- FWCI
- 1.55
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- British Journal of Pharmacology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Uniwersytet Łódzki
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Nutrition, Genetics, and Disease
- Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
- Keywords
- epigenetics, cancer prevention, dietary bioactive compounds, DNA methylation, histone modifications, non-coding RNA, one-carbon metabolism, S-adenosylmethionine, folic acid, resveratrol, sirtuins, histone acetyltransferase, vitamin D, microRNA, cancer therapy
- MeSH terms
- Antineoplastic Agents, Food Analysis, Humans, Neoplasms, Gene Expression Regulation, Neoplastic, Epigenesis, Genetic
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
