The DOI matches its Crossref record; 252 of the 252 references it cites were found in a registry or an index.
Epigenetic mechanisms in anti-cancer actions of bioactive food components—the implications in cancer prevention
Open accessAbstract
The hallmarks of carcinogenesis are aberrations in gene expression and protein function caused by both genetic and epigenetic modifications. Epigenetics refers to the changes in gene expression programming that alter the phenotype in the absence of a change in DNA sequence. Epigenetic modifications, which include amongst others DNA methylation, covalent modifications of histone tails and regulation by non‐coding RNAs, play a significant role in normal development and genome stability. The changes are dynamic and serve as an adaptation mechanism to a wide variety of environmental and social factors including diet. A number of studies have provided evidence that some natural bioactive compounds found in food and herbs can modulate gene expression by targeting different elements of the epigenetic machinery. Nutrients that are components of one‐carbon metabolism, such as folate, riboflavin, pyridoxine, cobalamin, choline, betaine and methionine, affect DNA methylation by regulating the levels of S‐adenosyl‐L‐methionine, a methyl group donor, and S‐adenosyl‐L‐homocysteine, which is an inhibitor of enzymes catalyzing the DNA methylation reaction. Other natural compounds target histone modifications and levels of non‐coding RNAs such as vitamin D, which recruits histone acetylases, or resveratrol, which activates the deacetylase sirtuin and regulates oncogenic and tumour suppressor micro‐RNAs. As epigenetic abnormalities have been shown to be both causative and contributing factors in different health conditions including cancer, natural compounds that are direct or indirect regulators of the epigenome constitute an excellent approach in cancer prevention and potentially in anti‐cancer therapy.
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“There are many bioactive molecules present in food and herbs, in addition to folate, that are capable of influencing epigenetics and that have been touted as potential chemopreventative agents. Examples include various B vitamins, retinoic acid, vitamin D3, reservatrol, genistein and daidzein, epigallocatechin-3-gallate (EGCG), and curcumin (Gerhauser, 2013; Stefanska et al., 2012).”
From Influence of Metabolism on Epigenetics and Disease (2013) · cites this paper as Stefanska et al., 2012
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2 retracted
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RetractedChung, J.-H., Ostrowski, M. C., Romigh, T., Minaguchi, T., Waite, K. A., & Eng, C. (2006) · Human Molecular Genetics · doi:10.1093/hmg/ddl177 · Cited by 111
RetractedPotent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans
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Chromatin modifications and their function
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MicroRNA expression profiles classify human cancers
Lü, J., Getz, G. A., Miska, E. A., Alvarez-Saavedra, E., Lamb, J., Peck, D., Sweet-Cordero, A., Ebert, B. L., Mak, R. H., Ferrando, A. A., et al. (2005) · Nature · doi:10.1038/nature03702 · Cited by 9,637
The language of covalent histone modifications
Strahl, B. D., & Allis, C. D. (2000) · Nature · doi:10.1038/47412 · Cited by 8,679
High-Resolution Profiling of Histone Methylations in the Human Genome
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Epigenetic programming by maternal behavior
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Vitamin D for health: a global perspective
Hossein-nezhad, A., & Holick, M. F. (2013) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2013.05.011 · Cited by 1,298
“Epigenetic modification refers to heritable changes in gene expression that are not mediated by alterations in DNA sequence.(52) This hypothesis, first articulated by Barker et al,(53) postulated that in utero epigenetic fetal programming (as a result of environmental events during pregnancy) induced specific genes an…”
Influence of Metabolism on Epigenetics and Disease
Kaelin, W. G., & McKnight, S. L. (2013) · Cell · doi:10.1016/j.cell.2013.03.004 · Cited by 920
“Examples include various B vitamins, retinoic acid, vitamin D3, reservatrol, genistein and daidzein, epigallocatechin-3-gallate (EGCG), and curcumin (Gerhauser, 2013; Stefanska et al., 2012).”
Potential Health Benefits of Olive Oil and Plant Polyphenols
Gorzynik-Debicka, M., Przychodzeń, P., Cappello, F., Kuban‐Jankowska, A., Marino, A., Knap, N., Woźniak, M., & Górska‐Ponikowska, M. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19030686 · Cited by 656
“There are many studies pointing out an essential role of polyphenolic compounds as derived from vegetables, fruits, or herbs in the regulation of epigenetic modifications, resulting in the antiproliferative protection [61].”
BackgroundSeven sirtuins for seven deadly diseases ofaging
Morris, B. J. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.10.525 · Cited by 386
“L-homocysteine, an inhibitor of DNA methylation enzymes [587].”
BackgroundGene methylation in gastric cancer
Qu, Y., Dang, S., & Hou, P. (2013) · Clinica Chimica Acta · doi:10.1016/j.cca.2013.05.002 · Cited by 376
Metadata
- Authors
- Stefanska, B., Karlic, H., Varga, F., Fabianowska‐Majewska, K., & Haslberger, A.
- Affiliations
- Hanusch Hospital (AT)
- Medical University of Lodz (PL)
- Venue
- British Journal of Pharmacology
- Publisher
- Wiley
- Published
- 2012-08-22
- Volume
- 167
- Issue
- 2
- Pages
- 279-297
- ISSN
- 0007-1188 (ISSN-L)
- 1476-5381
- PMC
- PMC3481038
- OpenAlex
- W1753288383
- Cited by
- 200
- References
- 252
- Citations by year
- 2026: 8 · 2025: 11 · 2024: 10 · 2023: 6 · 2022: 16 · 2021: 13 · 2020: 13 · 2019: 22 · 2018: 8 · 2017: 22 · 2016: 18 · 2015: 20 · 2014: 12 · 2013: 13 · 2012: 8
- FWCI
- 1.55
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- British Journal of Pharmacology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Uniwersytet Łódzki
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Nutrition, Genetics, and Disease
- Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
- Keywords
- epigenetics, cancer prevention, dietary bioactive compounds, DNA methylation, histone modifications, non-coding RNA, one-carbon metabolism, S-adenosylmethionine, folic acid, resveratrol, sirtuins, histone acetyltransferase, vitamin D, microRNA, cancer therapy
- MeSH terms
- Antineoplastic Agents, Food Analysis, Humans, Neoplasms, Gene Expression Regulation, Neoplastic, Epigenesis, Genetic
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