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Epigenetic mechanisms in anti-cancer actions of bioactive food components—the implications in cancer prevention
Open accessAbstract
The hallmarks of carcinogenesis are aberrations in gene expression and protein function caused by both genetic and epigenetic modifications. Epigenetics refers to the changes in gene expression programming that alter the phenotype in the absence of a change in DNA sequence. Epigenetic modifications, which include amongst others DNA methylation, covalent modifications of histone tails and regulation by non‐coding RNAs, play a significant role in normal development and genome stability. The changes are dynamic and serve as an adaptation mechanism to a wide variety of environmental and social factors including diet. A number of studies have provided evidence that some natural bioactive compounds found in food and herbs can modulate gene expression by targeting different elements of the epigenetic machinery. Nutrients that are components of one‐carbon metabolism, such as folate, riboflavin, pyridoxine, cobalamin, choline, betaine and methionine, affect DNA methylation by regulating the levels of S‐adenosyl‐L‐methionine, a methyl group donor, and S‐adenosyl‐L‐homocysteine, which is an inhibitor of enzymes catalyzing the DNA methylation reaction. Other natural compounds target histone modifications and levels of non‐coding RNAs such as vitamin D, which recruits histone acetylases, or resveratrol, which activates the deacetylase sirtuin and regulates oncogenic and tumour suppressor micro‐RNAs. As epigenetic abnormalities have been shown to be both causative and contributing factors in different health conditions including cancer, natural compounds that are direct or indirect regulators of the epigenome constitute an excellent approach in cancer prevention and potentially in anti‐cancer therapy.
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“There are many bioactive molecules present in food and herbs, in addition to folate, that are capable of influencing epigenetics and that have been touted as potential chemopreventative agents. Examples include various B vitamins, retinoic acid, vitamin D3, reservatrol, genistein and daidzein, epigallocatechin-3-gallate (EGCG), and curcumin (Gerhauser, 2013; Stefanska et al., 2012).”
From Influence of Metabolism on Epigenetics and Disease (2013) · cites this paper as Stefanska et al., 2012
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Ahmad, A., Li, Y., Bao, B., Kong, D., & Sarkar, F. H. (2013) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201300528 · Cited by 37
Molecular mechanisms of action of Trehalose in cancer: A comprehensive review
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Calcagno, D. Q., Wisnieski, F., Mota, E. R. D. S., de Sousa, S. B. M., da Silva, J. M. C., Leal, M. F., Gigek, C. O., Santos, L. C., Rasmussen, L. T., de Assumpção, P. P., et al. (2019) · Epigenomics · doi:10.2217/epi-2018-0081 · Cited by 35
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“A number of studies have provided evidence that some natural bioactive components of food and plants can target cancer cells by regulating different elements of the epigenetic machinery, which modulates gene expression and intracellular signaling.(31,32) Diverse tea polyphenols including catechin and its derivatives C…”
BackgroundEpigenetic reprogramming in breast cancer: From new targets to new therapies
Katz, T. A., Huang, Y., Davidson, N. E., & Jankowitz, R. C. (2014) · Annals of Medicine · doi:10.3109/07853890.2014.923740 · Cited by 33
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Resveratrol Inhibits Sodium/Iodide Symporter Gene Expression and Function in Rat Thyroid Cells
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Nutritional Epigenetic Regulators in the Field of Cancer
Schnekenburger, M., & Diederich, M. F. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-800206-3.00018-5 · Cited by 35
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“Apart from catechol compounds that reduce intracellular SAM pools available for DNA and histone methylation, polyphenols lack a direct link with the epigenetic machineries and the mechanisms underlying their epigenetic action are yet to be determined.”
InfluentialCurcumin's prevention of inflammation-driven early gastric cancer and its molecular mechanism
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Dietary macro- and micro-nutrients intake adequacy at 6th and 12th month post-bariatric surgery
Ziadlou, M., Hosseini‐Esfahani, F., Khosravi, H. M., Hosseinpanah, F., Barzin, M., Khalaj, A., & Valizadeh, M. (2020) · BMC Surgery · doi:10.1186/s12893-020-00880-y · Cited by 32
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“It is recognized thatmethyldonor diet can influence methylation status, and therefore cancer risk [33].”
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Sikander, M., Malik, S., Chauhan, N., Κhan, P., Kumari, S., Kashyap, V. K., Khan, S., Ganju, A., Halaweish, F. T., Yallapu, M. M., et al. (2019) · Cancers · doi:10.3390/cancers11030364 · Cited by 30
The Mitochondrial Protein VDAC1 at the Crossroads of Cancer Cell Metabolism: The Epigenetic Link
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Targeting microRNAs with thymoquinone: a new approach for cancer therapy
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“Several investigations have indicated that dietary phytochemicals exhibiting anticancer characteristics are able to target disrupted cellular epigenetic systems and play crucial roles [43].”
BackgroundHistone demethylase GASC1 - a potential prognostic and predictive marker in invasive breast cancer
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“Nowadays epigenetics is making an increasingly important impact in cancer research [2-4].”
BackgroundEpigenomics, Pharmacoepigenomics, and Personalized Medicine in Cervical Cancer
Kabekkodu, S. P., Chakrabarty, S., Ghosh, S., Brand, A. M., & Satyamoorthy, K. (2017) · Public Health Genomics · doi:10.1159/000475804 · Cited by 29
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Effect of dihydroartemisinin on UHRF1 gene expression in human prostate cancer PC-3 cells
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Properties of Different Varieties of Durian
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“There are many studies explaining the essential role of polyphenolics derived from fruits in the regulation of epigenetic modifications, resulting in antiproliferative protection [42,62].”
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Self-citationIn Search of Panacea—Review of Recent Studies Concerning Nature-Derived Anticancer Agents
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BackgroundPhenolic compounds and epigenetic mechanisms regulating gene expression: effects on human health
Lorente-Cebrián, S., Costa, A. G. V., Castillo-Rivas, J., Castro, M., Arbonés-Mainar, J. M., Goñi, S., Remón, S., Aranaz, P., López, V., Martín-Burriel, I., et al. (2025) · Journal of physiology and biochemistry · doi:10.1007/s13105-025-01105-7 · Cited by 25
“The regulation of polyphenols on DNMTs could be either mediated through direct (binding) interaction (f. i., epigallocatechin-3-gallate [117] but also as an indirect effects of polyphenols on other signaling pathways such as cellular redox state and/or inflammation (f. i., curcumin [69, 102]).”
Ge, X., Sun, Y., Kong, J., Mao, M., Yu, H., Arora, A., Suppavorasatit, I., & Wang, Y. (2022) · Journal of Food Science and Technology · doi:10.1007/s13197-022-05591-1 · Cited by 24
“RF has multiple protective effects with anti-oxidant, anti-aging, anti-inflammatory, and anticancer properties (Powers 2003; Stefanska et al. 2012).”
BackgroundEpi-nutrients for cancer prevention: Molecular mechanisms and emerging insights
Bakrim, S., Omari, N. E., Yaagoubi, O. M. E., Khalid, A., Abdalla, A. N., Hamza, S. M. A., Ibrahim, S. E., Atifi, F., Zaid, Y., Bouyahya, A., et al. (2025) · Cell Biology and Toxicology · doi:10.1007/s10565-025-10054-2 · Cited by 27
Arif, T., Stern, O., Pittala, S., Caspi, V. C., & Shoshan‐Barmatz, V. (2019) · Cells · doi:10.3390/cells8111330 · Cited by 22
Dietary Selenium Regulates microRNAs in Metabolic Disease: Recent Progress
Huang, X., Dong, Y., Li, T., Xiong, W., Zhang, X., Wang, P., & Huang, J. (2021) · Nutrients · doi:10.3390/nu13051527 · Cited by 21
“Abnormal miRNA expression is driven by genetic and epigenetic factors, which are implicated in cancer occurrence and development, and this may be reversed by a variety of dietary components [72].”
Background
Metadata
- Authors
- Stefanska, B., Karlic, H., Varga, F., Fabianowska‐Majewska, K., & Haslberger, A.
- Affiliations
- Hanusch Hospital (AT)
- Medical University of Lodz (PL)
- Venue
- British Journal of Pharmacology
- Publisher
- Wiley
- Published
- 2012-08-22
- Volume
- 167
- Issue
- 2
- Pages
- 279-297
- ISSN
- 0007-1188 (ISSN-L)
- 1476-5381
- PMC
- PMC3481038
- OpenAlex
- W1753288383
- Cited by
- 200
- References
- 252
- Citations by year
- 2026: 8 · 2025: 11 · 2024: 10 · 2023: 6 · 2022: 16 · 2021: 13 · 2020: 13 · 2019: 22 · 2018: 8 · 2017: 22 · 2016: 18 · 2015: 20 · 2014: 12 · 2013: 13 · 2012: 8
- FWCI
- 1.55
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- British Journal of Pharmacology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Uniwersytet Łódzki
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Nutrition, Genetics, and Disease
- Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
- Keywords
- epigenetics, cancer prevention, dietary bioactive compounds, DNA methylation, histone modifications, non-coding RNA, one-carbon metabolism, S-adenosylmethionine, folic acid, resveratrol, sirtuins, histone acetyltransferase, vitamin D, microRNA, cancer therapy
- MeSH terms
- Antineoplastic Agents, Food Analysis, Humans, Neoplasms, Gene Expression Regulation, Neoplastic, Epigenesis, Genetic
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