The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
Mitochondria in traumatic brain injury and mitochondrial‐targeted multipotential therapeutic strategies
Open accessAbstract
Traumatic brain injury (TBI) is a major health and socioeconomic problem throughout the world. It is a complicated pathological process that consists of primary insults and a secondary insult characterized by a set of biochemical cascades. The imbalance between a higher energy demand for repair of cell damage and decreased energy production led by mitochondrial dysfunction aggravates cell damage. At the cellular level, the main cause of the secondary deleterious cascades is cell damage that is centred in the mitochondria. Excitotoxicity, Ca 2+ overload, reactive oxygen species (ROS), Bcl‐2 family, caspases and apoptosis inducing factor (AIF) are the main participants in mitochondria‐centred cell damage following TBI. Some preclinical and clinical results of mitochondria‐targeted therapy show promise. Mitochondria‐ targeted multipotential therapeutic strategies offer new hope for the successful treatment of TBI and other acute brain injuries.
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Cites
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NRF2 as a Therapeutic Target in Neurodegenerative Diseases
Brandes, M. S., & Gray, N. E. (2020) · ASN Neuro · doi:10.1177/1759091419899782 · Cited by 297
Molecular mechanisms of cognitive dysfunction following traumatic brain injury
Walker, K. R., & Tesco, G. (2013) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2013.00029 · Cited by 265
Simmons, J. D., Lee, Y.-L., Mulekar, S., Kuck, J. L., Brevard, S. B., Gonzalez, R. P., Gillespie, M. N., & Richards, W. O. (2013) · Annals of Surgery · doi:10.1097/sla.0b013e3182a4ea46 · Cited by 259
Altered Mitochondrial Dynamics and TBI Pathophysiology
Fischer, T. D., Hylin, M. J., Zhao, J., Moore, A. N., Waxham, M. N., & Dash, P. K. (2016) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2016.00029 · Cited by 160
Sigma-1 receptor: a potential therapeutic target for traumatic brain injury
Shi, M., Chen, F., Chen, Z., Yang, W., Yue, S., Zhang, J., & Chen, X. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.685201 · Cited by 58
Self-citationMarino, Y., Inferrera, F., D'Amico, R., Impellizzeri, D., Cordaro, M., Siracusa, R., Gugliandolo, E., Fusco, R., Cuzzocrea, S., & Di Paola, R. (2024) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2024.167301 · Cited by 33
Metadata
- Authors
- Cheng, G., Kong, R., Zhang, L., & Zhang, J.
- Venue
- British Journal of Pharmacology
- Publisher
- Wiley
- Published
- 2012-09-25
- Volume
- 167
- Issue
- 4
- Pages
- 699-719
- ISSN
- 0007-1188 (ISSN-L)
- 1476-5381
- OpenAlex
- W1578695981
- Cited by
- 343
- References
- 35
- FWCI
- 7.85
- Type
- journal article
- Language
- en
- Open access
- bronze
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