The outcome of pregnancy resulting from clomiphene-induced ovulation
Abstract
The outcome of pregnancy was studied in all women conceiving after ovulation induction with clomiphene at the gynaecological endocrine clinics operating in 2 Tasmanian cities. In 156 pregnancies where details were available, the main findings were: abortion rate 10.3%; multiple pregnancy rate 4.1%; congenital abnormality rate 3.6%; and perinatal mortality rate 3.5%. The results are compared with other reported series.
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Clomiphene citrate has been used for over four decades and several studies have shown that its use is not associated with an increased risk of congenital malformation.
“Clomiphene citrate has been used for over four decades and several studies have shown that its use is not associated with an increased risk of congenital malformation (8 -10).”
From Congenital malformations among 911 newborns conceived after infertility treatment with letrozole or clomiphene citrate (2006) · cites this paper as [8]
Cites
Induction of Ovulation with MRL/41: Preliminary Report
Greenblatt, R. B. (1961) · JAMA · doi:10.1001/jama.1961.03040410001001 · Cited by 343 · see citing works
Garcia, J., Jones, G. S., & Wentz, A. C. (1977) · Fertility and Sterility · doi:10.1016/s0015-0282(16)42670-1 · Cited by 233 · see citing works
Outcome of Pregnancy After Induced Ovulation
Hack, M. (1972) · JAMA · doi:10.1001/jama.1972.03200100043009 · Cited by 89 · see citing works
ANENCEPHALY AND OVULATION STIMULATION
Dyson, J. L., & Kohler, H. G. (1973) · The Lancet · doi:10.1016/s0140-6736(73)90576-x · Cited by 77 · see citing works
Gestational Outcome of Clomiphene-Related Conceptions
Adashi, E. Y., Rock, J. A., Sapp, K. C., Martin, E. J., Wentz, A. C., & Jones, G. S. (1979) · Fertility and Sterility · doi:10.1016/s0015-0282(16)44051-3 · Cited by 76 · see citing works
Outcome of Pregnancy After Clomiphene Therapy
Åhlgren, M., Källén, B. A. J., & Rannevik, G. (1976) · Acta Obstetricia Et Gynecologica Scandinavica · doi:10.3109/00016347609158516 · Cited by 75 · see citing works
Update on the safety and efficacy of clomiphene citrate as a therapeutic agent.
Rh, A., & Rb, G. (1976) · PubMed · Cited by 60 · see citing works
ANENCEPHALY AND OVULATION STIMULATION
Sandler, B. (1973) · The Lancet · doi:10.1016/s0140-6736(73)93222-4 · Cited by 47 · see citing works
OVULATION STIMULATION AND DEFECTS OF NEURAL-TUBE CLOSURE
Field, B., & Kerr, C. B. (1974) · The Lancet · doi:10.1016/s0140-6736(74)90246-3 · Cited by 44 · see citing works
CONGENITAL ABNORMALITIES ASSOCIATED WITH MATERNAL CLOMIPHENE INGESTION
Berman, P. (1975) · The Lancet · doi:10.1016/s0140-6736(75)90281-0 · Cited by 25 · see citing works
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Tulandi, T., Martin, J., Al-Fadhli, R., Kabli, N., Forman, R., Hitkari, J., Librach, C., Greenblatt, E., & Casper, R. F. (2006) · Fertility and Sterility · doi:10.1016/j.fertnstert.2006.03.014 · Cited by 370 · see citing works
- Authors
- Correy, J. F., Marsden, D. E., & Schokman, F. C. M.
- Affiliations
- University of Tasmania (AU)
- Venue
- Australian and New Zealand Journal of Obstetrics and Gynaecology
- Publisher
- Wiley
- Published
- 1982-02
- Volume
- 22
- Issue
- 1
- Pages
- 18-21
- ISSN
- 0004-8666 (ISSN-L)
- 1479-828X
- OpenAlex
- W2013863973
- Cited by
- 47
- References
- 10
- Citations by year
- 2025: 1 · 2022: 3 · 2020: 2 · 2018: 4 · 2015: 2 · 2014: 1 · 2013: 4
- FWCI
- 2.81
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Australian and New Zealand Journal of Obstetrics and Gynaecology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Assisted Reproductive Technology and Twin Pregnancy
- Health Sciences › Medicine › Reproductive Medicine › Reproductive Health and Technologies
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Health and Contraception
- Keywords
- clomiphene citrate, ovulation induction, pregnancy outcomes, abortion rates, multiple pregnancy, congenital malformations, perinatal mortality, assisted reproduction
- MeSH terms
- Abnormalities, Drug-Induced, Abortion, Spontaneous, Birth Weight, Clomiphene, Female, Fetal Death, Humans, Infant, Newborn, Infant, Premature, Male, Ovulation Induction, Pregnancy, Pregnancy Complications, Pregnancy, Multiple
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