Predictive Factors for Relapse in Patients on Buprenorphine Maintenance
Open accessAbstract
Background and Objectives: Despite the dramatic increase in the use of buprenorphine for the treatment of opioid dependence, clinical outcomes of this treatment approach continue to need evaluation. This study examines factors associated with relapse and retention during buprenorphine treatment in a sample of opioid dependent outpatients. Methods: In a retrospective chart review of 62 patients with opioid dependence, relapse was determined by self‐report, urine toxicology screens, and by checking the state controlled substance monitoring database. Data was analyzed using two‐way tests of association and logistic regression. Results: Patients with comorbid anxiety disorders, active benzodiazepine use (contrary to clinic policy), or active alcohol abuse, were significantly more likely to relapse. Patients who relapsed were also more likely to be on a higher buprenorphine maintenance dose. Conclusion: This study identifies relapse risk factors during buprenorphine treatment for opioid dependence. Future research is needed to determine whether modifying these factors may lead to improved treatment outcomes. (Am J Addict 2014;23:62–67)
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Anxiety disorders can increase risk of relapse among patients undergoing buprenorphine/naloxone treatment.
“anxiety disorders can increase risk of relapse among patients undergoing buprenorphine/naloxone treatment 49,50.”
Anxiety and chronic pain diagnoses co-occur at a high rate, particularly among the OUD population.
“Anxiety and chronic pain diagnoses co-occur at a high rate, particularly among the OUD population”
From Effects of a trauma-informed mindful recovery program on comorbid pain, anxiety, and substance use during primary care buprenorphine treatment: A proof-of-concept study (2023) · cites this paper as [49]
The Results and Discussion report anxiety disorders among patients receiving buprenorphine for opioid dependence, but they examine anxiety in relation to relapse, not chronic pain. Searches for chronic pain and pain diagnoses found no passage assessing whether anxiety and chronic pain diagnoses co-occur or how often they do so. (LLM, conf=0.76)
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- Authors
- Ferri, M., Finlayson, A. J. R., Wang, L., & Martin, P. R.
- Affiliations
- Vanderbilt University (US)
- Corresponding author
- Ferri, Michael
- Venue
- The American Journal on Addictions
- Publisher
- Wiley
- Published
- 2013-12-27
- Volume
- 23
- Issue
- 1
- Pages
- 62-67
- ISSN
- 1055-0496 (ISSN-L)
- 1521-0391
- PMC
- PMC3922612
- OpenAlex
- W1657517065
- Cited by
- 66
- References
- 14
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 3 · 2023: 7 · 2022: 9 · 2021: 10 · 2020: 5 · 2019: 6 · 2018: 2 · 2017: 5 · 2016: 6 · 2015: 3 · 2014: 2
- FWCI
- 3.74
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- American Journal on Addictions (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Center for Research Resources (UL1RR024975)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Opioid Use Disorder Treatment
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Opioid Use
- Keywords
- buprenorphine maintenance, opioid use disorder, relapse, relapse risk factors, treatment retention, anxiety disorders, benzodiazepine use, alcohol abuse, outpatients
- MeSH terms
- Adult, Buprenorphine, Female, Humans, Male, Narcotic Antagonists, Opioid-Related Disorders, Recurrence, Retrospective Studies, Risk Factors, Treatment Outcome, Young Adult, Maintenance Chemotherapy
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