Health-related quality of life measured with EQ-5D in patients treated for depression in primary care
Open accessAbstract
Objective The objective of the present study was to assess the impact of depression on patients' health-related quality of life (HRQL) with the EQ-5D instrument over 6 months while on antidepressant treatment.Methods A total of 447 patients were recruited at 56 primary care centers to this naturalistic longitudinal observational study. Patients older than 18 years with depressive symptoms, and who initiated an antidepressant therapy because of depression were included in the study. Data on patients' sociodemographics, daily activity, and quality of life (EQ-5D) were collected using questionnaires completed during outpatient general practitioner visits for a follow-up period of 6 months.Results The mean EQ-5D utility score at baseline was 0.47 (0.44-0.49). Milder cases of depression reported a health utility of 0.60, whereas moderately and severely depressed patients reported utility values of 0.46 and 0.27, respectively (P < 0.01). At end of follow up the average utility was 0.69 (0.67-0.72), corresponding to an increase of 0.23 over 6 months (P < 0.01). Regression analyses showed that, all else equal, patients who were on sick leave were associated with 10% lower utility.Conclusions Depression has a substantial impact on HRQL. Our results indicate that treatments for depression are associated with significant improvement in EQ-5D index score over a course of 6 months. Self-reported patient valuations are important outcomes for cost-utility analysis of new treatments for depression and the present study provides important evidence for future economic evaluations.
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The EQ-5D-5L is widely used and responsive to treatment.
“The instrument is widely used and responsive to treatment (Sobocki et al., 2007).”
From The efficacy of automated feedback after internet-based depression screening: Study protocol of the German, three-armed, randomised controlled trial DISCOVER (2021) · cites this paper as Sobocki et al., 2007
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“The instrument is widely used and responsive to treatment (Sobocki et al., 2007).”
Method
- Authors
- Sobocki, P., Ekman, M., Ågren, H., Krakau, I., Runeson, B., Mårtensson, B., & Jönsson, B.
- Affiliations
- Karolinska Institutet (SE)
- Karolinska University Hospital (SE)
- Stockholm School of Economics (SE)
- Venue
- Value in Health
- Publisher
- Elsevier BV
- Published
- 2007-03
- Volume
- 10
- Issue
- 2
- Pages
- 153-160
- ISSN
- 1098-3015 (ISSN-L)
- OpenAlex
- W1963551867
- Cited by
- 157
- References
- 30
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 5 · 2023: 4 · 2022: 12 · 2021: 11 · 2020: 7 · 2019: 8 · 2018: 8 · 2017: 7 · 2016: 10 · 2015: 8 · 2014: 13 · 2013: 11 · 2012: 10
- FWCI
- 22.29
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Value in Health (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Economics, Econometrics and Finance › Economics and Econometrics › Health Systems, Economic Evaluations, Quality of Life
- Social Sciences › Psychology › Social Psychology › Mental Health Treatment and Access
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Keywords
- depression, health-related quality of life, EQ-5D, antidepressant treatment, primary care, health utility, sick leave, depression severity, cost-utility analysis, economic evaluation
- MeSH terms
- Adolescent, Adult, Aged, Aged, 80 and over, Antidepressive Agents, Cost-Benefit Analysis, Demography, Depressive Disorder, Female, Humans, Male, Middle Aged, Primary Health Care, Prospective Studies, Quality of Life, Surveys and Questionnaires, Socioeconomic Factors, Sweden, Time Factors, Treatment Outcome, Sickness Impact Profile, Quality-Adjusted Life Years
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