The societal cost of depression: Evidence from 10,000 Swedish patients in psychiatric care
Abstract
Objective Depression cost studies have mainly taken a primary care perspective and should be completed with cost estimates from psychiatric care. The objectives of this study were to estimate the societal per-patient cost of depression in specialized psychiatric care in Sweden, and to relate costs to disease severity, depressive episodes, hospitalization, and patient functioning.Methods Retrospective resource use data in inpatient and outpatient care for 2006-2008, as well as ICD-10 diagnoses and Global Assessment of Functioning (GAF), were obtained from the Northern Stockholm psychiatric clinic (covering half of Stockholm's population aged 18 years and above). As a complement, data from national registers on pharmaceuticals and sick leave were used in order to estimate the societal cost of depression.Results Based on 10,430 patients (63% women), the mean annual per-patient cost was €17,279 in 2008. The largest cost item was indirect costs due to productivity losses (88%), followed by outpatient care (6%). Patients with mild and severe depression had average costs of €14,200 and €21,500, respectively. Total costs were substantially higher during depressive episodes, among patients with co-morbid psychosis or anxiety, for hospitalized patients, and for patients with poor functioning.Limitations Primary care costs and costs for reduced productivity at work were not included.Conclusions The main cost item among depression patients in psychiatric care was indirect costs. Costs were higher than previously reported for primary care, and strongly related to hospitalization, depressive episodes, and low functioning. This suggests that effective treatment that avoids depressive episodes and hospitalization may reduce society's costs for depression.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Impairments in psychosocial functioning, notably decrements in work productivity, are key determinants of major depressive disorder-related societal costs.
“This finding is particularly important when considering that impairments in psychosocial functioning, notably decrements in work productivity, are key determinants of MDD-related societal costs [13].”
From Cognitive remission: a novel objective for the treatment of major depression? (2016) · cites this paper as [13]
Cites
An Introduction to the Bootstrap
Efron, B., & Tibshirani, R. J. (1994) · doi:10.1201/9780429246593 · Cited by 40,500 · see citing works
An Introduction to the Bootstrap
Efron, B., & Tibshirani, R. J. (1993) · doi:10.1007/978-1-4899-4541-9 · Cited by 21,230 · see citing works
Rush, A. J., Trivedi, M. H., Wisniewski, S. R., Nierenberg, A. A., Stewart, J. W., Warden, D., Niederehe, G., Thase, M. E., Lavori, P. W., Lebowitz, B. D., et al. (2006) · American Journal of Psychiatry · doi:10.1176/ajp.2006.163.11.1905 · Cited by 5,643 · cited 1× · see citing works
“In the Sequenced Treatment Alternatives to Relieve Depression (STARnD) study, for example, only 37% of the patients achieved remission with firstline treatment (Rush et al., 2006). ll rights reserved. partment of Health Econom8 49; fax: þ46 8 553 295 88.”
Diagnostic and Statistical Manual of Mental Disorders ( DSM ‐ IV ‐ TR )
Segal, D. L. (2010) · Wiley eBooks · doi:10.1002/9780470479216.corpsy0271 · Cited by 4,683 · see citing works
International Statistical Classification of Diseases and Related Health Problems
Eisfeld, J. (2014) · TSQ Transgender Studies Quarterly · doi:10.1215/23289252-2399740 · Cited by 3,570 · see citing works
International Statistical Classification of Diseases and Related Health Problems 10th Revision
(2013) · Oxford University Press eBooks · doi:10.1093/med/9780199669493.005.0005 · Cited by 2,066 · see citing works
Wettermark, B., Hammar, N., MichaelFored, C., Leimanis, A., Olausson, P. O., Bergman, U., Persson, I. R., Sundström, A., Westerholm, B., & Rosén, M. (2006) · Pharmacoepidemiology and Drug Safety · doi:10.1002/pds.1294 · Cited by 1,868 · see citing works
Size and burden of mental disorders in Europe—a critical review and appraisal of 27 studies
Wittchen, H.-U., & Jacobi, F. (2005) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2005.04.012 · Cited by 1,503 · cited 3× · see citing works
“Although there is variability in the epidemiological literature, the 12-month prevalence in a number of relatively large studies varied from 2.1 to 10.1% (Wittchen and Jacobi, 2005).”
BackgroundInfluentialThe Journal of Mental Health Policy and Economics
(2006) · The Journal of Mental Health Policy and Economics · doi:10.1002/(issn)1099-176x · Cited by 1,255 · see citing works
The friction cost method for measuring indirect costs of disease
Koopmanschap, M. A., Rutten, F., van Ineveld, B. M., & Roijen, L. H. (1995) · Journal of Health Economics · doi:10.1016/0167-6296(94)00044-5 · Cited by 1,141 · see citing works
Cost-of-Illness Methodology: A Guide to Current Practices and Procedures
Hodgson, T. A., & Meiners, M. R. (1982) · The Milbank Memorial Fund Quarterly Health and Society · doi:10.2307/3349801 · Cited by 672 · see citing works
Population-based study of first onset and chronicity in major depressive disorder
Eaton, W. W., Shao, H., Nestadt, G., Lee, B. H., Bienvenu, O. J., & Zandi, P. (2008) · Archives of General Psychiatry · doi:10.1001/archpsyc.65.5.513 · Cited by 612 · see citing works
Sobocki, P., Jönsson, B., Angst, J., & Rehnberg, C. (2006) · PubMed · Cited by 533 · see citing works
Spijker, J., De Graaf, R., Bijl, R. V., Beekman, A. T. F., Ormel, J., & Nolen, W. A. (2002) · British Journal of Psychiatry · doi:10.1192/bjp.181.3.208 · Cited by 514 · see citing works
Birnbaum, H. G., Kessler, R. C., Kelley, D., Ben-Hamadi, R., Joish, V. N., & Greenberg, P. E. (2010) · Depression and Anxiety · doi:10.1002/da.20580 · Cited by 380 · see citing works
Cost-of-illness studies of depression
Luppa, M., Heinrich, S., Angermeyer, M. C., König, H., & Riedel-Heller, S. G. (2006) · Journal of Affective Disorders · doi:10.1016/j.jad.2006.07.017 · Cited by 356 · see citing works
Cost of illness studies: What is good about them?
Rice, D. P. (2000) · Injury Prevention · doi:10.1136/ip.6.3.177 · Cited by 349 · see citing works
Cost-effectiveness of Practice-Initiated Quality Improvement for Depression
Schoenbaum, M., Unützer, J., Sherbourne, C. D., Duan, N., Rubenstein, L. V., Miranda, J. M., Meredith, L. S., Carney, M. F., & Wells, K. B. (2001) · JAMA · doi:10.1001/jama.286.11.1325 · Cited by 330 · see citing works
Ten arguments for a societal perspective in the economic evaluation of medical innovations
Jönsson, B. (2009) · The European Journal of Health Economics · doi:10.1007/s10198-009-0173-2 · Cited by 262 · see citing works
Size and burden of depressive disorders in Europe
Paykel, E. S., Brugha, T. S., & Fryers, T. (2005) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2005.04.008 · Cited by 262 · see citing works
Evaluating the cost-effectiveness of vaccination programmes: a dynamic perspective
Edmunds, W. J., Medley, G. F., & Nokes, D. J. (1999) · Statistics in Medicine · doi:10.1002/(sici)1097-0258(19991215)18:23 · Cited by 202 · see citing works
Recovery From Major Depression: A 10-Year Prospective Follow-up Across Multiple Episodes
Solomon, D. A. (1997) · Archives of General Psychiatry · doi:10.1001/archpsyc.1997.01830230033005 · Cited by 199 · see citing works
Pao, M., & Kazak, A. E. (2014) · Oxford University Press eBooks · doi:10.1093/med/9780199335114.003.0012 · Cited by 198 · see citing works
The friction cost method: A comment
Johannesson, M., & Karlsson, G. (1997) · Journal of Health Economics · doi:10.1016/s0167-6296(97)00006-4 · Cited by 171 · see citing works
Estimating Costs in the Economic Evaluation of Medical Technologies
Luce, B. R., & Elixhauser, A. (1990) · International Journal of Technology Assessment in Health Care · doi:10.1017/s026646230000893x · Cited by 158 · see citing works
Sobocki, P., Ekman, M., Ågren, H., Krakau, I., Runeson, B., Mårtensson, B., & Jönsson, B. (2007) · Value in Health · doi:10.1111/j.1524-4733.2006.00162.x · Cited by 157 · see citing works
Self-citationThe economic burden of depression in Sweden from 1997 to 2005
Sobocki, P., Lekander, I., Borgström, F., Ström, O., & Runeson, B. (2006) · European Psychiatry · doi:10.1016/j.eurpsy.2006.10.006 · Cited by 141 · see citing works
McLaughlin, T. P., Khandker, R. K., Kruzikas, D. T., & Tummala, R. (2006) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v67n0803 · Cited by 105 · see citing works
Gaynes, B. N., Rush, A. J., Trivedi, M. H., Wisniewski, S. R., Balasubramani, G. K., McGrath, P. J., Thase, M. E., Klinkman, M., Nierenberg, A. A., Yates, W. R., et al. (2008) · Journal of General Internal Medicine · doi:10.1007/s11606-008-0522-3 · Cited by 97 · see citing works
The use of population based registers in psychiatric research
Allebeck, P. (2009) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.2009.01474.x · Cited by 76 · see citing works
Gaynes, B. N., Rush, A. J., Trivedi, M. H., Wisniewski, S. R., Balasubramani, G. K., Spencer, D. C., Petersen, T., Klinkman, M. S., Warden, D., Schneider, R. K., et al. (2005) · General Hospital Psychiatry · doi:10.1016/j.genhosppsych.2004.10.003 · Cited by 72 · see citing works
A Community Study of Depression Treatment and Employment Earnings
Zhang, M., ROST, K. M., Fortney, J. C., & Smith, G. R. (1999) · Psychiatric Services · doi:10.1176/ps.50.9.1209 · Cited by 70 · see citing works
Cost of depression: effect of adherence and treatment response
von Knorring, L., Åkerblad, A.-C., Bengtsson, F., Carlsson, Å., & Ekselius, L. (2006) · European Psychiatry · doi:10.1016/j.eurpsy.2006.04.005 · Cited by 58 · cited 4× · see citing works
“The total costs in our study were higher than in the Swedish studies by Norinder et al. (2000) and Sobocki et al. (2007b; 2007c), but lower than in the study by von Knorring et al. (2006).”
BackgroundMethodResultInfluentialCare-Seeking Pattern among Persons with Depression and Anxiety: A Population-Based Study in Sweden
Wallerblad, A., Möller, J., & Forsell, Y. (2012) · International Journal of Family Medicine · doi:10.1155/2012/895425 · Cited by 51 · see citing works
Resource use and costs associated with patients treated for depression in primary care
Sobocki, P., Ekman, M., Ågren, H., Krakau, I., Runeson, B., Mårtensson, B., & Jönsson, B. (2006) · The European Journal of Health Economics · doi:10.1007/s10198-006-0008-3 · Cited by 40 · see citing works
Self-citationThe Economic Burden of Psychiatric Disorders in Sweden
Tiainen, A., & Rehnberg, C. (2009) · International Journal of Social Psychiatry · doi:10.1177/0020764009106140 · Cited by 15 · see citing works
Norinder, A., Nordling, S., & Häggström, L. (2000) · PubMed · Cited by 12 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Ahern, E., & Semkovska, M. (2017) · Neuropsychology · doi:10.1037/neu0000319 · Cited by 321 · see citing works
Cognitive remission: a novel objective for the treatment of major depression?
Bortolato, B., Miskowiak, K. W., Köhler, C. A., Maes, M., Fernandes, B. S., Berk, M., & Carvalho, A. F. (2016) · BMC Medicine · doi:10.1186/s12916-016-0560-3 · Cited by 252 · see citing works
Depression and violence: a Swedish population study
Fazel, S., Wolf, A., Chang, Z., Larsson, H., Goodwin, G. M., & Lichtenstein, P. (2015) · The Lancet Psychiatry · doi:10.1016/s2215-0366(14)00128-x · Cited by 245 · see citing works
The Association Between Air Pollution and Onset of Depression Among Middle-Aged and Older Women
Kioumourtzoglou, M., Power, M. C., Hart, J. E., Okereke, O. I., Coull, B. A., Laden, F., & Weisskopf, M. G. (2016) · American Journal of Epidemiology · doi:10.1093/aje/kww163 · Cited by 216 · see citing works
Cognitive dysfunction in major depressive disorder: a state-of-the-art clinical review
Bortolato, B., Carvalho, A., & McIntyre, R. (2015) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527313666141130203823 · Cited by 181 · see citing works
Birney, A. J., Gunn, R., Russell, J. K., & Ary, D. V. (2016) · JMIR mHealth and uHealth · doi:10.2196/mhealth.4231 · Cited by 159 · see citing works
“In addition, the economic costs of subclinical depression are considerable, approximately two-thirds the per capita costs of major depression [15-18].”
Lundberg, J., Cars, T., Lööv, S., Söderling, J. K., Sundström, J., Tiihonen, J., Levál, A., Gannedahl, A., Björkholm, C., Själin, M., et al. (2022) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2022.3860 · Cited by 168 · see citing works
Heritability of Perinatal Depression and Genetic Overlap With Nonperinatal Depression
Viktorin, A., Meltzer-Brody, S. E., Kuja‐Halkola, R., Sullivan, P. F., Landén, M., Lichtenstein, P., & Magnusson, P. K. E. (2015) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2015.15010085 · Cited by 151 · see citing works
Self-citationLappalainen, P., Langrial, S., Oinas-Kukkonen, H., Tolvanen, A., & Lappalainen, R. (2015) · Behavior Modification · doi:10.1177/0145445515598142 · Cited by 115 · see citing works
Depression in the House: The Effects of Household Air Pollution from Solid Fuel Use in China
Liu, Y., Chen, X., & Yan, Z. (2019) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2019.134706 · Cited by 103 · see citing works
Chiu, M., Lebenbaum, M., Cheng, J. M., de Oliveira, C., & Kurdyak, P. A. (2017) · PLoS ONE · doi:10.1371/journal.pone.0184268 · Cited by 86 · see citing works
Andrade-Gómez, E., Martínez‐Gómez, D., Rodríguez‐Artalejo, F., & García‐Esquinas, E. (2018) · Depression and Anxiety · doi:10.1002/da.22804 · Cited by 73 · see citing works
Vortioxetine for cognitive enhancement in major depression: From animal models to clinical research
Bennabi, D., Haffen, E., & Van Waes, V. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00771 · Cited by 75 · see citing works
Wang, R., Xue, D., Liu, Y., Liu, P., & Chen, H. (2018) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph15061160 · Cited by 72 · see citing works
Suicidal risk and executive functions in major depressive disorder: a study protocol
Roca, M., del Amo, A. R.-L., Serra, P. R., Pérez-Ara, M. Á., Castro, A., Roman‐Juan, J., Garcı́a-Toro, M., Pazo, P. G., & Gili, M. (2019) · BMC Psychiatry · doi:10.1186/s12888-019-2233-1 · Cited by 69 · see citing works
Evaluating the economic impact of screening and treatment for depression in the workplace
Evans-Lacko, S. E., Koeser, L., Knapp, M. R. J., Longhitano, C., Zohar, J., & Kuhn, K. (2016) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2016.03.005 · Cited by 64 · see citing works
The societal cost of bipolar disorder in Sweden
Ekman, M., Granström, O., Omérov, S., Jacob, J., & Landén, M. (2013) · Social Psychiatry and Psychiatric Epidemiology · doi:10.1007/s00127-013-0724-9 · Cited by 62 · see citing works
Self-citationAssociations Between Supportive Leadership Behavior and the Costs of Absenteeism and Presenteeism
Schmid, J. A., Jarczok, M. N., Sonntag, D., Herr, R. M., Fischer, J. E., & Schmidt, B. (2016) · Journal of Occupational and Environmental Medicine · doi:10.1097/jom.0000000000000919 · Cited by 62 · see citing works
Uppsala Longitudinal Adolescent Depression Study (ULADS)
Alaie, I., Philipson, A., Ssegonja, R., Hagberg, L., Feldman, I., Sampaio, F., Möller, M., Arinell, H., Ramklint, M., Päären, A., et al. (2019) · BMJ Open · doi:10.1136/bmjopen-2018-024939 · Cited by 63 · see citing works
Clements, C. C., Karlsson, R., Lu, Y., Juréus, A., Rück, C., Andersson, E., Boberg, J., Pedersen, N. L., Bulik, C. M., Nordenskjöld, A., et al. (2021) · Molecular Psychiatry · doi:10.1038/s41380-020-00984-0 · Cited by 58 · see citing works
Self-citationGloger, S., Martínez, P., Behn, A. J., Chacón, M. V., Cottin, M., de Medina, D. D., & Vöhringer, P. A. (2021) · European Journal of Psychotraumatology · doi:10.1080/20008198.2021.1874600 · Cited by 58 · see citing works
Jha, M. K., Minhajuddin, A., Greer, T. L., Carmody, T. J., Rush, A. J., & Trivedi, M. H. (2016) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2016.16020176 · Cited by 52 · see citing works
Evans-Lacko, S. E., & Knapp, M. R. J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0091053 · Cited by 51 · see citing works
Ervasti, J. M., Vahtera, J., Virtanen, P., Pentti, J., Oksanen, T., Ahola, K., Mika Kivimaki, B., & Virtanen, M. (2014) · Scandinavian Journal of Work Environment & Health · doi:10.5271/sjweh.3424 · Cited by 49 · see citing works
Chang, Q., Xia, Y., Bai, S., Zhang, X., Liu, Y., Yao, D., Xu, X., & Zhao, Y. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.564815 · Cited by 44 · see citing works
Tønning, M. L., Faurholt‐Jepsen, M., Frost, M. M., Martiny, K., Tuxen, N., Rosenberg, N., Busk, J., Winther, O., Melbye, S. A., Thaysen‐Petersen, D., et al. (2020) · Journal of Affective Disorders · doi:10.1016/j.jad.2020.12.141 · Cited by 42 · see citing works
Industrialization, indoor and ambient air quality, and elderly mental health
Ao, C., Dong, Y., & Kuo, P.-F. (2021) · China Economic Review · doi:10.1016/j.chieco.2021.101676 · Cited by 42 · see citing works
Müller, G., Bombana, M., Heinzel-Gutenbrenner, M., Kleindienst, N., Bohus, M., Lyssenko, L., & Vonderlin, R. (2021) · BMC Public Health · doi:10.1186/s12889-021-10637-8 · Cited by 40 · see citing works
Cost-Utility Analyses of Cognitive-Behavioural Therapy of Depression: A Systematic Review
Brettschneider, C., Djadran, H., Härter, M. C., Löwe, B., Riedel-Heller, S. G., & König, H. (2014) · Psychotherapy and Psychosomatics · doi:10.1159/000365150 · Cited by 40 · see citing works
Hoorelbeke, K., den Bergh, N. V., Raedt, R. D., Wichers, M., & Koster, E. H. W. (2021) · Clinical Psychological Science · doi:10.1177/2167702620979775 · Cited by 39 · see citing works
Krauth, C., Stahmeyer, J. T., Petersen, J. J., Freytag, A., Gerlach, F. M., & Gensichen, J. S. (2014) · Depression Research and Treatment · doi:10.1155/2014/730891 · Cited by 36 · see citing works
Evans-Lacko, S., & Knapp, M. (2018) · BMJ Open · doi:10.1136/bmjopen-2018-021795 · Cited by 35 · see citing works
Duevel, J. A., Hasemann, L., Peña-Longobardo, L. M., Rodríguez-Sánchez, B., Aranda-Reneo, I., Oliva-Moreno, J., López-Bastida, J., & Greiner, W. (2020) · Health Economics Review · doi:10.1186/s13561-020-00288-7 · Cited by 34 · see citing works
Ssegonja, R., Alaie, I., Philipson, A., Hagberg, L., Sampaio, F., Möller, M., von Knorring, L., Sarkadi, A., Langenskiöld, S., von Knorring, A., et al. (2019) · Journal of Affective Disorders · doi:10.1016/j.jad.2019.07.077 · Cited by 35 · see citing works
Ehsanifar, M., Montazeri, Z., Salami, M., Rafati, M., & Wang, J. (2022) · Environmental Science and Pollution Research · doi:10.1007/s11356-022-23882-0 · Cited by 28 · see citing works
Higher handgrip strength predicts a lower risk of depressive symptoms in rural Chinese populations
Zhao, Z., Ji, C., Liu, Y., Gao, S., & Xia, Y. (2020) · Journal of Affective Disorders · doi:10.1016/j.jad.2020.03.028 · Cited by 27 · see citing works
Nunes, C. S. A., Maes, M. H. J., Roomruangwong, C., Moraes, J. B., Bonifácio, K. L., Vargas, H. O., Barbosa, D. S., Anderson, G., de Melo, Drozdstoj, S., et al. (2018) · Journal of Evaluation in Clinical Practice · doi:10.1111/jep.12918 · Cited by 26 · see citing works
Loerbroks, A., Bosch, J. A., Mommersteeg, P. M. C., Herr, R. M., Angerer, P., & Li, J. (2014) · European Journal of Epidemiology · doi:10.1007/s10654-014-9926-z · Cited by 25 · see citing works
Kerstis, B., Åslund, C., & Sonnby, K. (2018) · Upsala Journal of Medical Sciences · doi:10.1080/03009734.2018.1439552 · Cited by 25 · see citing works
Screening fathers for postpartum depression can be cost-effective: An example from Sweden
Asper, M. M., Hallén, N., Lindberg, L., Månsdotter, A., Carlberg, M., & Wells, M. B. (2018) · Journal of Affective Disorders · doi:10.1016/j.jad.2018.07.044 · Cited by 25 · see citing works
The cost of mental disorders in Denmark: a register-based study
Christensen, M. K., McGrath, J. J., Momen, N. C., Whiteford, H., Weye, N., Agerbo, E., Pedersen, C. B., Mortensen, P. B., Plana‐Ripoll, O., & Iburg, K. M. (2022) · npj Mental Health Research · doi:10.1038/s44184-022-00001-y · Cited by 24 · see citing works
Opsahl, T., Ahrenfeldt, L. J., Möller, S., & Hvidt, N. C. (2019) · Public Health · doi:10.1016/j.puhe.2019.07.011 · Cited by 24 · see citing works
Lundberg, J., Cars, T., Lööv, S., Söderling, J. K., Tiihonen, J., Levál, A., Gannedahl, A., Björkholm, C., Själin, M., & Hellner, C. (2022) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.13414 · Cited by 24 · see citing works
Benevolence – Associations With Stress, Mental Health, and Self-Compassion at the Workplace
Andersson, C., Stenfors, C. U. D., Lilliengren, P., Einhorn, S., & Osika, W. (2021) · Frontiers in Psychology · doi:10.3389/fpsyg.2021.568625 · Cited by 22 · see citing works
Societal costs of fetal alcohol syndrome in Sweden
Ericson, L., Magnusson, L., & Hovstadius, B. (2016) · The European Journal of Health Economics · doi:10.1007/s10198-016-0811-4 · Cited by 22 · see citing works
Holst, A., Ginter, A., Björkelund, C., Hange, D., Petersson, E., Svenningsson, I., Westman, J., André, M., Wikberg, C., Wallin, L., et al. (2018) · BMJ Open · doi:10.1136/bmjopen-2018-024741 · Cited by 22 · see citing works
The Social Cost of Major Depression. A Systematic Review
Coretti, S., Rumi, F., & Cicchetti, A. (2019) · Review of European Studies · doi:10.5539/res.v11n1p73 · Cited by 22 · see citing works
Improvements in Workplace Productivity in Working Patients With Major Depressive Disorder
Chokka, P. R., Tvistholm, A. H., Bougie, J. K., Clerzius, G., & Ettrup, A. (2020) · Journal of Occupational and Environmental Medicine · doi:10.1097/jom.0000000000001805 · Cited by 20 · see citing works
Koshikawa, Y., Nishida, K., Yamane, T., Yoshimura, M., Onohara, A., Ueda, S., Ishii, R., Kinoshita, T., & Morishima, Y. (2022) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.13364 · Cited by 18 · see citing works
Papalexi, E., Galanopoulos, A., Roukas, D., Argyropoulos, I., Michopoulos, I., Douzenis, A., Gkolia, I., Fotiadis, P., Kontis, D., & Zervas, I. M. (2022) · Journal of Affective Disorders · doi:10.1016/j.jad.2022.07.009 · Cited by 18 · see citing works
Wang, G., Tan, K. H. X., Ren, H., & Hammer-Helmich, L. (2020) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s230403 · Cited by 18 · see citing works
European Union investment and countries’ involvement in mental health research between 2007 and 2013
Hazo, J., Gervaix, J., Gandré, C., Brunn, M., Leboyer, M., & Chevreul, K. (2016) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.12584 · Cited by 17 · see citing works
Impact of initial medication non-adherence to SSRIs on medical visits and sick leaves
Aznar‐Lou, I., Iglesias-González, M., Gil‐Girbau, M., Serrano‐Blanco, A., Fernández, A., Peñarrubia‐María, M. T., Sabés-Figuera, R., Murrugarra-Centurión, A. G., March-Pujol, M., Bolívar-Prados, M., et al. (2017) · Journal of Affective Disorders · doi:10.1016/j.jad.2017.09.057 · Cited by 17 · see citing works
Molarius, A., & Metsini, A. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph18189778 · Cited by 19 · see citing works
Mercedes, B. P. D. C., da Silva, E. N., Carregaro, R. L., & Miasso, A. I. (2022) · Expert Review of Pharmacoeconomics & Outcomes Research · doi:10.1080/14737167.2023.2154659 · Cited by 16 · see citing works
Tablet-Based Screening of Depressive Symptoms in Quito, Ecuador: Efficiency in Primary Care
Grunauer, M., Schrock, D., Fabara, E. E., Jimenez, G., Miller, A., Lai, Z., Kilbourne, A. M., & McInnis, M. G. (2014) · International Journal of Family Medicine · doi:10.1155/2014/845397 · Cited by 16 · see citing works
Christensen, M. K., McGrath, J. J., Momen, N. C., Weye, N., Agerbo, E., Pedersen, C. B., Plana‐Ripoll, O., & Iburg, K. M. (2022) · Australian & New Zealand Journal of Psychiatry · doi:10.1177/00048674221129184 · Cited by 16 · see citing works
Rosario-Hernández, E., Rovira-Millán, L. V., Merino‐Soto, C., & Angulo-Ramos, M. (2023) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2023.1024676 · Cited by 15 · see citing works
Wu, J., Grande, G., Triolo, F., Pyko, A., Sjöberg, L., Ljungman, P. L. S., Eneroth, K., Bellander, T., & Rizzuto, D. (2023) · Environmental Pollution · doi:10.1016/j.envpol.2023.122394 · Cited by 16 · see citing works
Wang, P., Yan, F., Dong, J., Wang, S., Shi, Y., Zhu, M., Zuo, Y., Ma, H., Xue, R., Zhai, D., et al. (2023) · Physical Chemistry Chemical Physics · doi:10.1039/d2cp05676c · Cited by 14 · see citing works
Gerber, M., Cody, R., Beck, J., Brand, S., Donath, L., Eckert, A., Faude, O., Hatzinger, M., Imboden, C., Kreppke, J.-N., et al. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12103370 · Cited by 15 · see citing works
Polygenic risk scores of lithium response and treatment resistance in major depressive disorder
Xiong, Y., Karlsson, R., Song, J., Kowalec, K., Rück, C., Sigström, R., Jönsson, L., Clements, C. C., Andersson, E., Boberg, J., et al. (2023) · Translational Psychiatry · doi:10.1038/s41398-023-02602-3 · Cited by 14 · see citing works
Self-citationStenfors, C. U. D., Rådmark, L., Stengård, J., Klein, Y., Osika, W., & Hanson, L. L. M. (2024) · Landscape and Urban Planning · doi:10.1016/j.landurbplan.2024.105109 · Cited by 15 · see citing works
Prevalence of musculoskeletal disorders and its relation to depression among workers in kindergarten
Pirbalouti, M. G., Shariat, A., Sangelaji, B., Taghavi, M., & Kamaliyeh, N. G. (2017) · Work · doi:10.3233/wor-172648 · Cited by 14 · see citing works
Tsai, S., Chiu, Y.-W., Weng, Y., & Yang, C. (2020) · Journal of Toxicology and Environmental Health · doi:10.1080/15287394.2020.1801544 · Cited by 14 · see citing works
Hakulinen, C. A., Böckerman, P., Pulkki-Råbäck, L., Virtanen, M., & Elovainio, M. J. (2020) · Occupational and Environmental Medicine · doi:10.1136/oemed-2020-106660 · Cited by 13 · see citing works
Denche-Zamorano, Á. M., My works are correct, B. M. I. A. A. I. S. R. L. M. T. I. D. A.-M., Gómez-Galán, R., Franco-García, J. M., Carlos‐Vivas, J., Mendoza-Muñoz, M., Rojo-Ramos, J., Vega-Muñoz, A., Contreras-Barraza, N., Gianikellis, K., et al. (2022) · Healthcare · doi:10.3390/healthcare10081442 · Cited by 13 · see citing works
Lytsy, P., Hallqvist, J., Alexanderson, K. A. E., & Åhs, A. (2019) · Nordic Journal of Psychiatry · doi:10.1080/08039488.2019.1649723 · Cited by 11 · see citing works
Cost-effectiveness of supported employment adapted for people with affective disorders
Saha, S., Bejerholm, U., Gerdtham, U., & Jarl, J. (2018) · Nordic Journal of Psychiatry · doi:10.1080/08039488.2017.1422801 · Cited by 13 · see citing works
Xia, Y., Liu, Y., Zhang, S., Zhang, Q., Liu, L., Meng, G., Wu, H., Sun, S., Wang, X., Zhou, M., et al. (2020) · British Journal Of Nutrition · doi:10.1017/s0007114520003566 · Cited by 13 · see citing works
El abordaje de la depresión en el ámbito del trabajo: recomendaciones clave
Leal, E. C., Regás, P. I., Gili, M., Lahera, G., González, J. S., & Ruiz, J. S. (2016) · Psiquiatría Biológica · doi:10.1016/j.psiq.2016.08.003 · Cited by 11 · see citing works
Cost-Effectiveness of a Web-Based Program for Residual Depressive Symptoms: Mindful Mood Balance
Boggs, J. M., Ritzwoller, D. P., Beck, A. L., Dimidjian, S., & Segal, Z. V. (2021) · Psychiatric Services · doi:10.1176/appi.ps.202000419 · Cited by 11 · see citing works
Mental health shame and presenteeism: Results from a German online survey
Sander, C., Dogan-Sander, E., Fischer, J. E., & Schomerus, G. (2023) · Psychiatry Research Communications · doi:10.1016/j.psycom.2023.100102 · Cited by 10 · see citing works
Johanson, S., Oestergaard, L. G., Bejerholm, U., Nygren, C., van Tulder, M. W., & Zingmark, M. (2023) · Scandinavian Journal of Occupational Therapy · doi:10.1080/11038128.2023.2200576 · Cited by 11 · see citing works
High occupational level is associated with poor response to treatment of depression
Mandelli, L., Serretti, A., Souery, D., Mendlewicz, J., Kasper, S. F., Montgomery, S., & Zohar, J. (2016) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2016.05.002 · Cited by 10 · see citing works
Xiong, Y., Krebs, K., Jermy, B. S., Karlsson, R., Pasman, J. A., Nguyen, T.-D., Gong, T., Kowalec, K., Rück, C., Sigström, R., et al. (2025) · Molecular Psychiatry · doi:10.1038/s41380-025-03084-z · Cited by 12 · see citing works
Self-citationThe economic burden of inpatient care of depression in Poznan (Poland) and Kiel (Germany) in 2016
Zaprutko, T., Göder, R., Kus, K., Pałys, W., Rybakowski, F., & Nowakowska, E. (2018) · PLoS ONE · doi:10.1371/journal.pone.0198890 · Cited by 8 · see citing works
Wang, P., Jing, C., Pei, Y., Lu, M., Xu, X., Pei, Q., & Yan, F. (2021) · Technology and Health Care · doi:10.3233/thc-218024 · Cited by 7 · see citing works
Drivers of and Solutions for the Overuse of Antidepressant Medication in Pediatric Populations
Cosgrove, L., Morrill, Z., Yusif, M., Vaswani, A., Cathcart, S. C., Troeger, R., & Karter, J. M. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.00017 · Cited by 7 · see citing works
Sonnby, K. (2014) · KTH Publication Database DiVA (KTH Royal Institute of Technology) · Cited by 7 · see citing works
Stenmark, L., Kellner, C. H., Landén, M., Larsson, I., Msghina, M., & Nordenskjöld, A. (2021) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.13373 · Cited by 6 · see citing works
Self-citationGöteson, A., Clements, C. C., Juréus, A., Joas, E., Larsson, J. H., Karlsson, R., Nordenskjöld, A., Pålsson, E., & Landén, M. (2022) · Biological Psychiatry Global Open Science · doi:10.1016/j.bpsgos.2022.11.005 · Cited by 6 · see citing works
Self-citationCivardi, S. C., Besana, F., Miacca, G. C., Mazzoni, F., Arienti, V., Politi, P., Brondino, N., & Olivola, M. (2024) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2024.1371139 · Cited by 7 · see citing works
How Bereaved Parents Experience Public, Self Stigma Years After a Child’s Death
Heo, S.-J., Kim, Y. A., Lee, D. H., & Shin, J. Y. (2022) · OMEGA - Journal of Death and Dying · doi:10.1177/00302228221100902 · Cited by 3 · see citing works
Nyman, C. S., Basar, K. M. N., Hultqvist, J., & Bertilsson, M. (2024) · BMC Public Health · doi:10.1186/s12889-023-17577-5 · Cited by 3 · see citing works
The contribution of unpaid labour to poor mental health in the Swedish working population
Molarius, A., Granström, F., & Ervin, J. (2025) · SSM - Population Health · doi:10.1016/j.ssmph.2025.101864 · Cited by 2 · see citing works
Frontiers in Mental Health and the Environment
Helbich, M. (2018) · MDPI eBooks · doi:10.3390/books978-3-03897-391-1 · Cited by 2 · see citing works
Sugawara, N., Yasui‐Furukori, N., Tsuji, T., Hayashi, S., Ajisawa, Y., Ochiai, T., Imagawa, H., & Shimoda, K. (2020) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s274608 · Cited by 1 · see citing works
Coenen, T., Maerevoet, M., Chen, S., Brouwer, M. D., Hoecke, S. V., Koster, E. H. W., Abeele, M. V., & Bombeke, K. (2025) · JMIR mhealth and uhealth · doi:10.2196/67141 · Cited by 2 · see citing works
Laux, G. (2017) · Springer eBooks · doi:10.1007/978-3-662-49295-6_67 · Cited by 1 · see citing works
Yu-fang, W., Yuhua, C., Jiexuan, L., Tinghong, H., & Youzhen, C. (2025) · Psychology in the Schools · doi:10.1002/pits.23555 · Cited by 1 · see citing works
Kuga, A., Otsubo, T., Tsuji, T., Hayashi, S., Imagawa, H., Fujikoshi, S., & Escobar, R. (2019) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s195445 · Cited by 1 · see citing works
Mood disorders and consequences of pharmacological treatment
Viktorin, A. (2015) · Figshare
Neurotransmitter Receptor Genotypes Associated with Mental and Behavioral Disorders
Varoğlu, E., Şeytanoğlu, A., Asilmaz, E., & Taneri, B. (2017) · Personalized Medicine · doi:10.2217/pme-2016-0100
Treating depression with activation
Nyström, M. B. T. (2018) · KTH Publication Database DiVA (KTH Royal Institute of Technology)
Laux, G. (2016) · Springer eBooks · doi:10.1007/978-3-642-45028-0_67-1
Lloyd‐Williams, H., Spencer, L. H., & Edwards, R. T. (2022) · Research Square · doi:10.21203/rs.3.rs-1532626/v1
Kishi, T., Sato, C., & Yamauchi, K. (2025) · Acta Psychologica · doi:10.1016/j.actpsy.2025.105850
- Authors
- Ekman, M., Granström, O., Omérov, S., Jacob, J., & Landén, M.
- Affiliations
- AstraZeneca (Sweden) (SE)
- Stockholm Health Care Services (SE)
- Karolinska Institutet (SE)
- Corresponding author
- Ekman, M.
- ORCID
- Venue
- Journal of Affective Disorders
- Publisher
- Elsevier BV
- Published
- 2013-09
- Volume
- 150
- Issue
- 3
- Pages
- 790-797
- ISSN
- 0165-0327 (ISSN-L)
- OpenAlex
- W2021790406
- Cited by
- 101
- References
- 37
- Citations by year
- 2025: 5 · 2024: 3 · 2023: 8 · 2022: 12 · 2021: 11 · 2020: 11 · 2019: 10 · 2018: 11 · 2017: 5 · 2016: 12 · 2015: 5 · 2014: 7 · 2013: 1
- FWCI
- 12.48
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Affective Disorders (publishedVersion)
- PubMed (publishedVersion)
- Funders
- AstraZeneca
- Topics
- Social Sciences › Psychology › Social Psychology › Mental Health Treatment and Access
- Social Sciences › Economics, Econometrics and Finance › Economics and Econometrics › Health Systems, Economic Evaluations, Quality of Life
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Keywords
- depression, social costs, psychiatric nursing, indirect costs, productivity loss, sick leave, hospitalization, depressive episodes, Global Assessment of Functioning, disease severity, comorbidities, psychiatric inpatients and outpatients
- MeSH terms
- Adolescent, Adult, Aged, Aged, 80 and over, Ambulatory Care, Major Depressive Disorder, Depressive Disorder, Major, Female, Health Resources, Hospitalization, Humans, Male, Middle Aged, Primary Health Care, Retrospective Studies, Sweden, Comorbidity, Health Care Costs, Cost of Illness, Sick Leave, International Classification of Diseases, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review