The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Bioactivity and stability of endogenous fibrogenic factors in platelet‐rich fibrin
Abstract
Platelet‐rich fibrin (PRF®) is an autologous fibrin sealant (FS) enriched with a platelet concentrate (>1,000,000 platelets/μL) produced by the automated Vivostat® system and used to enhance wound healing. The effects of PRF were compared with supernatant from thrombin‐activated platelet concentrate, recombinant human platelet‐derived growth factor (rhPDGF) isoforms, and a homologous FS in cultured normal human dermal fibroblasts. Also, the release of selected endogenous growth factors from PRF and their stability against proteolytic degradation were studied. The proliferative effect of PRF exceeded that of FS and rhPDGF‐BB, although it was lower than thrombin‐activated platelet concentrate possibly due to sustained growth factor release from platelets in PRF. Anti‐PDGF antibody blocked the mitogenic effect of rhPDGF‐BB but not that of PRF in growth‐arrested fibroblasts. PRF promoted secretion of carboxyterminal propeptide of type I collagen into conditioned medium while rhPDGF‐AB had no significant effect on collagen biosynthesis. Limited proteolysis of PDGF‐AB and no proteolysis of transforming growth factor‐β1 (TGF‐β1) in PRF were observed with trypsin treatment, whereas rhPDGF‐AB and rhTGF‐β1 in bovine serum albumin, matching the total protein concentration of PRF, were almost completely degraded after 24 hours at 37 °C. To conclude, PRF provides sustained release and protection against proteolytic degradation of endogenous fibrogenic factors important for wound healing.
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Cites
Protease inhibitors protect growth factor activity in chronic wounds
Wlaschek, M., Peus, D., Achterberg, V., Meyer-Ingold, W., & Scharffetter-Kochanek, K. (1997) · British Journal of Dermatology · doi:10.1111/j.1365-2133.1997.tb03804.x · Cited by 81 · cited 2×
“This may be advantageous in the treatment of chronic wounds characterized by high proteinase activity.(14) These findings together with the observed fibrogenic properties indicate that PRF may be a useful adjuvant in the management of problematic wounds.”
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Cited by
Masuki, H., Okudera, T., Watanebe, T., Suzuki, M., Nishiyama, K., Okudera, H., Nakata, K., Uematsu, K., Su, C.-Y., & Kawase, T. (2016) · International Journal of Implant Dentistry · doi:10.1186/s40729-016-0052-4 · Cited by 459
Awad, M. E., Hussein, K. A., Helwa, I., Abdelsamid, M. F., Aguilar-Perez, A., Mohsen, I., Hunter, M., Hamrick, M. W., Isales, C. M., Elsalanty, M., et al. (2019) · Stem Cells International · doi:10.1155/2019/3826054 · Cited by 39
Metadata
- Authors
- Lundquist, R., Dziegiel, M. H., & Ågren, M. S.
- Venue
- Wound Repair and Regeneration
- Publisher
- Wiley
- Published
- 2008-02-13
- Volume
- 16
- Issue
- 3
- Pages
- 356-363
- ISSN
- 1067-1927 (ISSN-L)
- 1524-475X
- OpenAlex
- W2075540043
- Cited by
- 173
- References
- 1
- FWCI
- 5.15
- Type
- journal article
- Language
- en
- Open access
- closed
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- Lundquist, R., Dziegiel, M. H., & Ågren, M. S. (2008). Bioactivity and stability of endogenous fibrogenic factors in platelet‐rich fibrin. Wound Repair and Regeneration. https://doi.org/10.1111/j.1524-475x.2007.00344.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
