Cited by 311Bacterial biofilms and quorum sensingWound Healing and TreatmentsAntimicrobial Resistance in Staphylococcus

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Staphylococcal biofilms impair wound healing by delaying reepithelialization in a murine cutaneous wound model

Schierle, Clark F., De la Garza, Mauricio, Mustoe, Thomas A., Galiano, Robert D.·2009·Wound Repair and Regeneration

DOI 10.1111/j.1524-475x.2009.00489.x

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Abstract

Bacterial biofilms have gained increasing visibility in recent years as a ubiquitous form of survival for microorganisms in myriad environments. A number of in vivo models exist for the study of biofilms in the setting of medically relevant implanted foreign bodies. Growing evidence has demonstrated the presence of bacterial biofilms in the setting of a number of chronic wound states including pressure sores, diabetic foot ulcers, and venous stasis ulcers. Here we present a novel murine cutaneous wound system that directly demonstrates delayed reepithelialization caused by the presence of a bacterial biofilm. We established biofilms using either Staphylococcus aureus or Staphylococcus epidermidis in splinted cutaneous punch wounds created on the backs of normal C57Bl6/J mice. Wound reepithelialization was significantly delayed by bacterial biofilms. This effect was specifically dependent on the ability of the bacteria to form biofilms as demonstrated by exogenous administration of biofilm inhibiting peptides and the use of mutant Staphylococcus spp. deficient in biofilm formation. This represents the first direct evidence for the effect of bacterial biofilms on cutaneous wound healing.

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Abbreviations: MAM, Multivalent Adhesion Molecule; MRSA, methicillin-resistant Staphylococcus aureus; ABC, Acinetobacter baumannii-calcoaceticus complex; ESBL, extended spectrum β-lactamase; EPEC, enteropathogenic Escherichia coli; MDR, multidrug-resistant; MOI, multiplicity of infection
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Authors: Schierle, C. F., De la Garza, M., Mustoe, T. A., & Galiano, R. D.
Affiliations: Northwestern University (US)
Corresponding author: Galiano, Robert D.
ORCID: Mustoe, Thomas A.
Galiano, Robert D.
Venue: Wound Repair and Regeneration
Publisher: Wiley
Published: 2009-05
Volume: 17
Issue: 3
Pages: 354-359
ISSN: 1067-1927 (ISSN-L)
1524-475X
DOI: 10.1111/j.1524-475x.2009.00489.x
OpenAlex: W1986560085
Cited by: 311
References: 43
Citations by year: 2026: 3 · 2025: 12 · 2024: 17 · 2023: 20 · 2022: 20 · 2021: 25 · 2020: 19 · 2019: 22 · 2018: 28 · 2017: 21 · 2016: 26 · 2015: 12 · 2014: 18 · 2013: 21 · 2012: 23
FWCI: 6.15
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 19 d)
Locations: Wound Repair and Regeneration (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
Health Sciences › Medicine › Surgery › Wound Healing and Treatments
Health Sciences › Medicine › Infectious Diseases › Antimicrobial Resistance in Staphylococcus
Keywords: bacterial biofilms, Staphylococcus aureus, Staphylococcus epidermidis, skin wound healing, re-epithelialization, chronic wounds, pressure ulcers, diabetic foot ulcer, venous leg ulcers
MeSH terms: Animals, Disease Models, Animal, Male, Mice, Inbred C57BL, Skin, Staphylococcal Infections, Staphylococcus aureus, Staphylococcus epidermidis, Wound Healing, Wound Infection, Wounds and Injuries, Biofilms, Mice

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Staphylococcal biofilms impair wound healing by delaying reepithelialization in a murine cutaneous wound model

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