The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Antimicrobial tolerance and the significance of persister cells in recalcitrant chronic wound biofilms
Abstract
The application of antimicrobials in the management of wounds is a complex procedure requiring appropriate clinical decision making, judgment and a thorough understanding of antimicrobial therapies, together with their potential disadvantages. There is considerable direct and indirect evidence for the presence of bacterial biofilms in the chronic wound bed, and it has been demonstrated that bacteria within these biofilms may exhibit both specific and nonspecific antimicrobial tolerance. The antimicrobial tolerance of biofilms is a major concern in the treatment of both infected and nonhealing chronic wounds and an understanding of the mechanisms involved is of fundamental importance in managing wound infections and developing future wound management strategies. The aim of this review is therefore to provide an overview of our current understanding of the mechanisms by which bacteria in wound biofilms can resist conventional antibiotic and antibacterial therapies which is very important to wound healing.
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Citations
Cites
Persister cells, dormancy and infectious disease
Lewis, K. (2007) · Nature Reviews Microbiology · doi:10.1038/nrmicro1557 · Cited by 2,052
Anderl, J. N., Franklin, M. J., & Stewart, P. S. (2000) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.44.7.1818-1824.2000 · Cited by 958
Microscopic and physiologic evidence for biofilm-associated wound colonization in vivo
Davis, S. C., Ricotti, C., Cazzaniga, A., Welsh, E., Eaglstein, W. H., & Mertz, P. M. (2008) · Wound Repair and Regeneration · doi:10.1111/j.1524-475x.2007.00303.x · Cited by 393
Microbial diversity in chronic open wounds
Frank, D. N., Wysocki, A., Specht‐Glick, D. D., Rooney, A., Feldman, R. A., St. Amand, A. L., Pace, N. R., & Trent, J. D. (2009) · Wound Repair and Regeneration · doi:10.1111/j.1524-475x.2009.00472.x · Cited by 123
Cited by
Consensus guidelines for the identification and treatment of biofilms in chronic nonhealing wounds
Schultz, G., Bjarnsholt, T., James, G. A., Leaper, D. J., McBain, A. J., Malone, M., Stoodley, P., Swanson, T., Tachi, M., Wolcott, R. D., et al. (2017) · Wound Repair and Regeneration · doi:10.1111/wrr.12590 · Cited by 337
Baker, P., Hill, P. J., Snarr, B. D., Alnabelseya, N., Pestrak, M. J., Lee, M. J., Jennings, L. K., Tam, J., Melnyk, R. A., Parsek, M. R., et al. (2016) · Science Advances · doi:10.1126/sciadv.1501632 · Cited by 284
Prevention and treatment of Staphylococcus aureus biofilms
Bhattacharya, M., Wozniak, D. J., Stoodley, P., & Hall-Stoodley, L. (2015) · Expert Review of Anti-infective Therapy · doi:10.1586/14787210.2015.1100533 · Cited by 265
Inhibitors of bacterial H 2 S biogenesis targeting antibiotic resistance and tolerance
Shatalin, K., Nuthanakanti, A., Kaushik, A., Shishov, D., Peselis, A., Shamovsky, I., Pani, B., Lechpammer, M., Vasilyev, N., Shatalina, E., et al. (2021) · Science · doi:10.1126/science.abd8377 · Cited by 259
Evolving strategies for preventing biofilm on implantable materials
Shah, S. R., Tatara, A. M., D'Souza, R. N., Mikos, A. G., & Kasper, F. K. (2013) · Materials Today · doi:10.1016/j.mattod.2013.05.003 · Cited by 99
Metadata
- Authors
- Percival, S. L., Hill, K. E., Malic, S., Thomas, D. W., & Williams, D. W.
- Venue
- Wound Repair and Regeneration
- Publisher
- Wiley
- Published
- 2011-01
- Volume
- 19
- Issue
- 1
- Pages
- 1-9
- ISSN
- 1067-1927 (ISSN-L)
- 1524-475X
- OpenAlex
- W1924457892
- Cited by
- 173
- References
- 4
- FWCI
- 5.41
- Type
- journal article
- Language
- en
- Open access
- closed
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- The paper
- Percival, S. L., Hill, K. E., Malic, S., Thomas, D. W., & Williams, D. W. (2011). Antimicrobial tolerance and the significance of persister cells in recalcitrant chronic wound biofilms. Wound Repair and Regeneration. https://doi.org/10.1111/j.1524-475x.2010.00651.x
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
