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vasa and nanos expression patterns in a sea anemone and the evolution of bilaterian germ cell specification mechanisms

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Extavour, Cassandra G., Pang, Kevin, Matus, David Q., Martindale, Mark Q.·2005·Evolution & Development
DOI 10.1111/j.1525-142x.2005.05023.x
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Abstract

Summary Most bilaterians specify primordial germ cells (PGCs) during early embryogenesis using either inherited cytoplasmic germ line determinants (preformation) or induction of germ cell fate through signaling pathways (epigenesis). However, data from nonbilaterian animals suggest that ancestral metazoans may have specified germ cells very differently from most extant bilaterians. Cnidarians and sponges have been reported to generate germ cells continuously throughout reproductive life, but previous studies on members of these basal phyla have not examined embryonic germ cell origin. To try to define the embryonic origin of PGCs in the sea anemone Nematostella vectensis , we examined the expression of members of the vasa and nanos gene families, which are critical genes in bilaterian germ cell specification and development. We found that vasa and nanos family genes are expressed not only in presumptive PGCs late in embryonic development, but also in multiple somatic cell types during early embryogenesis. These results suggest one way in which preformation in germ cell development might have evolved from the ancestral epigenetic mechanism that was probably used by a metazoan ancestor.

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  • Expression domains in Nematostella occur with apparent bilateral symmetry, including a left-right plane of symmetry.

    “The expression domains occur with apparent bilaterial symmetry, i.e., reflecting distinct directed axes both along and perpendicular to the main body axis, and with a left-right plane of symmetry (27)(28)(29).”

    From Sea Anemone Genome Reveals Ancestral Eumetazoan Gene Repertoire and Genomic Organization (2007) · cites this paper as [28]

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Authors
Extavour, C. G., Pang, K., Matus, D. Q., & Martindale, M. Q.
Affiliations
  • University of Cambridge (GB)
  • University of Hawaiʻi at Mānoa (US)
Corresponding author
  • Extavour, Cassandra G.
  • Martindale, Mark Q.
ORCID
Venue
Evolution & Development
Publisher
Wiley
Published
2005-05
Volume
7
Issue
3
Pages
201-215
ISSN
  • 1520-541X (ISSN-L)
  • 1525-142X
DOI
10.1111/j.1525-142x.2005.05023.x
OpenAlex
W2149086579
Cited by
144
References
90
Citations by year
2025: 2 · 2024: 7 · 2023: 3 · 2022: 3 · 2021: 3 · 2020: 4 · 2019: 3 · 2018: 3 · 2017: 7 · 2016: 15 · 2015: 6 · 2014: 7 · 2013: 6 · 2012: 12
FWCI
4.66
Type
journal article
Language
en
Open access
Licence
Locations
  • Evolution & Development (publishedVersion)
  • PubMed (publishedVersion)
  • Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
Funders
  • National Science Foundation
  • Biotechnology and Biological Sciences Research Council (BBS/B/07586)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
  • Physical Sciences › Earth and Planetary Sciences › Paleontology › Marine Invertebrate Physiology and Ecology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Planarian Biology and Electrostimulation
Keywords
Vasa, Nanos, primordial germ cells, germ cell specification, Nematostella vectensis, sea anemone, preformation, epigenesis, somatic expression, early embryonic development, Cnidaria
MeSH terms
Amino Acid Sequence, Animals, Cloning, Molecular, Biological Evolution, Female, Germ Cells, Mesentery, Molecular Sequence Data, Phylogeny, Reproduction, Sea Anemones, Sequence Alignment, Gene Expression Regulation, Developmental, Evolution, Molecular, Body Patterning, RNA Helicases

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