The DOI matches its Crossref record; 21 of the 22 references it cites were found in a registry or an index.
Vagus Nerve Stimulation for Treatment of Partial Seizures: 1. A Controlled Study of Effect on Seizures
Abstract
Summary: Vagus nerve stimulation (VNS) was shown to reduce seizure frequency in refractory epilepsy patients in two pilot studies. Based on these results, a multicenter, prospectively randomized, parallel, double‐blind study of patients with refractory partial seizures was initiated. After a 12–week baseline period, identical vagus nerve stimulators were implanted and patients randomized to either a high or low 14–week VNS treatment paradigm. The primary objective was to demonstrate that high VNS (therapeutic parameters) was more effective in reducing partial seizure frequency than was low VNS (less or noneffective parameters). Patients continued receiving antiepileptic drugs (AEDs) with plasma concentrations held constant throughout the study. We report results of the first 67 patients to exit the 14‐week acute phase. After 14 weeks of VNS, 31 patients receiving high VNS experienced a mean seizure frequency percentage reduction of 30.9%, which was statistically significant as compared with the mean seizure frequency percentage reduction of 11.3% in 36 patients receiving low VNS (p = 0.029, t test; p = 0.036, Wilcoxon rank‐sum test). In addition to the significant intra group p‐values, mean seizure frequency percentage change reached statistical significance for high VNS (p < 0.001) but not low VNS (p = 0.072) as compared with baseline. Twelve of 31 (38.7%) patients receiving high VNS achieved at least 50% reduction in seizure frequency whereas 7 of 36 (19.4%) patients receiving low VNS experienced at least 50% reduction after 14 weeks. The implant procedure and VNS therapy were well tolerated. Our study confirmed the effectiveness of VNS as treatment for epilepsy patients with refractorypartial seizures.
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In the citing paper
“Ben-Menachem et al. used a frequency of typically 30 Hz for 14 weeks in human vagus nerve stimulation [83]”
From Safety of long-term electrical peripheral nerve stimulation: review of the state of the art (2019) · cites this paper as [83]
In the citing paper
“Ben-Menachem et al. stimulated the vagus nerve with amplitudes up to 3 mA using cuff electrodes [83].”
From Safety of long-term electrical peripheral nerve stimulation: review of the state of the art (2019) · cites this paper as [83]
Citations
Cites
Penry, J. K., & Dean, J. C. (1990) · Epilepsia · doi:10.1111/j.1528-1157.1990.tb05848.x · Cited by 474
Inhibition of Experimental Seizures in Canines by Repetitive Vagal Stimulation
Zabara, J. (1992) · Epilepsia · doi:10.1111/j.1528-1157.1992.tb01751.x · Cited by 398
Effects of Vagal Stimulation on Experimentally Induced Seizures in Rats
Woodbury, D. M., & Woodbury, J. W. (1990) · Epilepsia · doi:10.1111/j.1528-1157.1990.tb05852.x · Cited by 369
Rutecki, P. A. (1990) · Epilepsia · doi:10.1111/j.1528-1157.1990.tb05843.x · Cited by 341
Vagus Nerve Stimulation for Treatment of Partial Seizures: 2. Safety, Side Effects, and Tolerability
Ramsay, R. E., Uthman, B. M., Augustinsson, L.-E., Upton, A. R. M., Naritoku, D. K., Willis, J. K., Treig, T., Barolat, G., Wernicke, J. F., & First International Vagus Nerve Stimulation Study Group (1994) · Epilepsia · doi:10.1111/j.1528-1157.1994.tb02483.x · Cited by 260
Self-citationGeorge, R. E., Salinsky, M., Kuzniecky, R., Rosenfeld, W. E., Bergen, D. C., Tarver, W. B., Wernicke, J. F., & First International Vagus Nerve Stimulation Study Group (1994) · Epilepsia · doi:10.1111/j.1528-1157.1994.tb02484.x · Cited by 197
Self-citationFeasibility and Safety of Vagal Stimulation In Monkey Model
Lockard, J. S., Congdon, W. C., & DuCharme, L. L. (1990) · Epilepsia · doi:10.1111/j.1528-1157.1990.tb05844.x · Cited by 189
Peripheral control of hypersynchronous discharge in epilepsy
Zabara, J. (1985) · Electroencephalography and Clinical Neurophysiology · doi:10.1016/0013-4694(85)90626-1 · Cited by 163
Surgical Technique for Implantation of the Neurocybernetic Prosthesis
Reid, S. A. (1990) · Epilepsia · doi:10.1111/j.1528-1157.1990.tb05847.x · Cited by 143
Electrophysiological Studies of Cervical Vagus Nerve Stimulation in Humans: I. EEG Effects
Hammond, E. J., Uthman, B. M., Reid, S. A., & Wilder, B. J. (1992) · Epilepsia · doi:10.1111/j.1528-1157.1992.tb01752.x · Cited by 132
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Research works printed but not linked: 9
- Ben‐Menachem E, 1991, The effects of vagus nerve stimulation on concentrations in the CSF of 5‐hydroxy indoleacetic acid, homovanillic acid, GABA, and other amino acids in patients with partial epilepsy, Epilepsia, 32, 90
- George RE, 1991, Efficacy of vagus nerve stimulation for treatment of partial seizures: preliminary report of five patients, Epilepsia, 32, 80
- Martin WH, 1991, Electrically evoked vagus nerve potentials in humans, Epilepsia, 32, 53
- Naritoku DK, 1991, Chronic vagus nerve stimulation prolongs the latency of the thalamocortical (N20) response of somatosensory evoked potentials, Epilepsia, 32, 85
- Penry JK, 1991, Vagus nerve stimulation for seizure control: long‐term observation, Epilepsiu, 32, 59
- Ramsay RE, 1991, Efficacy of vagus nerve stimulation in partial seizures: double‐blind comparison of two stimulus paradigms, Epilepsia, 32, 90
- SAS Institute, Inc, 1988, SAS/STAT user's guide, release 6.03 ed
- Uthman B, 1991, Safety and tolerability of vagus nerve stimulation, Epilepsia, 32, 90
- Zabara J, 1987, Controlling seizures by changing GABA receptor sensitivity, Epilepsia, 28, 604
Cited by
Sorted by citations
Vagus nerve stimulation therapy for partial-onset seizures
Handforth, A., DeGiorgio, C. M., Schachter, S. C., Uthman, B. M., Naritoku, D. K., Tecoma, E. S., Henry, T. R., Collins, S. D., Vaughn, B. V., Gilmartin, R. C., et al. (1998) · Neurology · doi:10.1212/wnl.51.1.48 · Cited by 1,107
Self-citationGroves, D. A., & Brown, V. J. (2005) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2005.01.004 · Cited by 677
Enhanced recognition memory following vagus nerve stimulation in human subjects
Clark, K., Naritoku, D., Smith, D. C., Browning, R., & Jensen, R. A. (1999) · Nature Neuroscience · doi:10.1038/4600 · Cited by 575
Sackeim, H. (2001) · Neuropsychopharmacology · doi:10.1016/s0893-133x(01)00271-8 · Cited by 568
Vagus-nerve stimulation for the treatment of epilepsy
Ben-Menachem, E. (2002) · The Lancet Neurology · doi:10.1016/s1474-4422(02)00220-x · Cited by 560
Self-citation
Metadata
- Authors
- Ben‐Menachem, E., Mañon‐Espaillat, R., Ristanovic, R., Wilder, B. J., Stefan, H., Mirza, W., Tarver, W. B., Wernicke, J. F., & First International Vagus Nerve Stimulation Study Group
- Affiliations
- University of Gothenburg (SE)
- Rush University Medical Center (US)
- Universitätsklinikum Erlangen (DE)
- Saint Louis University (US)
- Corresponding author
- Wernicke, J. F.
- Venue
- Epilepsia
- Publisher
- Wiley
- Published
- 1994-05
- Volume
- 35
- Issue
- 3
- Pages
- 616-626
- ISSN
- 0013-9580 (ISSN-L)
- 1528-1167
- OpenAlex
- W2022305238
- Cited by
- 683
- References
- 22
- Citations by year
- 2026: 21 · 2025: 31 · 2024: 24 · 2023: 30 · 2022: 28 · 2021: 33 · 2020: 26 · 2019: 21 · 2018: 31 · 2017: 16 · 2016: 27 · 2015: 42 · 2014: 20 · 2013: 35 · 2012: 26
- FWCI
- 2.88
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Epilepsia (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Neurology › Vagus Nerve Stimulation Research
- Health Sciences › Medicine › Clinical Neurology › Epilepsy research and treatment
- Health Sciences › Medicine › Clinical Neurology › Deep Brain Stimulation and Movement Disorders
- Keywords
- vagus nerve stimulation, drug-resistant epilepsy, focal seizures, seizure frequency reduction, high-frequency stimulation, low-frequency stimulation, antiepileptic drugs, implantable neurostimulator, treatment tolerability
- MeSH terms
- Adolescent, Adult, Aged, Anticonvulsants, Child, Combined Modality Therapy, Double-Blind Method, Electrodes, Implanted, Electric Stimulation Therapy, Epilepsies, Partial, Equipment Design, Female, Follow-Up Studies, Humans, Magnetics, Male, Medical Records, Middle Aged, Prospective Studies, Severity of Illness Index, Vagus Nerve, Treatment Outcome, Prostheses and Implants
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