A Comparison of Self‐reported Quality of Life between Patients with Epilepsy and Neurocardiogenic Syncope
Abstract
Summary: Epilepsy and neurocardiogenic syncope share a final common pathway of loss of consciousness and consequent social disruption. We compared 52 patients with syncope, 96 with epilepsy and 100 controls. Epilepsy and syncope patients expressed significantly higher levels of anxiety and depression and reported significantly less good quality of life (QoL) compared with controls. There were no significant differences on any of the QoL parameters measured between the syncope and epilepsy patients. These findings suggest the main contributor to poor QoL in epilepsy may be the unpredictable loss of control that is the hallmark of the condition.
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Quality of life is reduced with recurrent syncope.
“QoL is reduced with recurrent syncope (725–733), as demonstrated in studies that compared patients with and without syncope (727,731).”
From 2017 ACC/AHA/HRS Guideline for the Evaluation and Management of Patients With Syncope (2017) · cites this paper as [731]
There is consistent evidence that syncope is associated with worse function on multiple domains of quality of life, such as perceptions of low overall physical health; perception of mental health, including increased fear, somatization, depression, and anxiety; and impairment in activities of daily living, such as driving, working, and attending school.
“There is consistent evidence that syncope is associated with worse function on multiple domains of QoL, such as perceptions of low overall physical health (725,730,734); perception of mental health, including increased fear, somatization, depression, and anxiety (725,727,728,731,734); and impairment in activities of daily living, such as driving, working, and attending school.”
From 2017 ACC/AHA/HRS Guideline for the Evaluation and Management of Patients With Syncope (2017) · cites this paper as [731]
Quality of life is reduced with recurrent syncope, as demonstrated in studies that compared patients with and without syncope.
“QoL is reduced with recurrent syncope (397–405), as demonstrated in studies that compared patients with and without syncope (399,405).”
From 2017 ACC/AHA/HRS Guideline for the Evaluation and Management of Patients With Syncope: Executive Summary (2017) · cites this paper as [403]
Cites
Normative data for the HADS from a large non-clinical sample
Crawford, J. R., Henry, J. D., Crombie, C., & Taylor, E. P. (2001) · British Journal of Clinical Psychology · doi:10.1348/014466501163904 · Cited by 815 · cited 4× · see citing works
“United Kingdom normative data is available for the HADS (Crawford et al., 2001) and in a nonclinical sample 12.6% scored 11 or above on the anxiety scale and 3.6% scored 11 or above on the depression scale.”
MethodInfluentialImpairment of physical and psychosocial function in recurrent syncope
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2017 ACC/AHA/HRS Guideline for the Evaluation and Management of Patients With Syncope
Shen, W.-K., Sheldon, R. S., Benditt, D. G., Cohen, M. I., Forman, D. E., Goldberger, Z. D., Grubb, B. P., Hamdan, M. H., Krahn, A. D., Link, M. S., et al. (2017) · Heart Rhythm · doi:10.1016/j.hrthm.2017.03.004 · Cited by 484 · see citing works
2017 ACC/AHA/HRS Guideline for the Evaluation and Management of Patients With Syncope
Shen, W.-K., Sheldon, R. S., Benditt, D. G., Cohen, M. I., Forman, D. E., Goldberger, Z. D., Grubb, B. P., Hamdan, M. H., Krahn, A. D., Link, M. S., et al. (2017) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2017.03.003 · Cited by 327 · see citing works
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Epidemiology of Syncope/Collapse in Younger and Older Western Patient Populations
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Recurrent Postural Vasovagal Syncope: Sympathetic Nervous System Phenotypes
Vaddadi, G., Guo, L., Esler, M., Socratous, F., Schlaich, M., Chopra, R., Eikelis, N., Lambert, G., Trauer, T., & Lambert, E. (2011) · Circulation: Arrhythmia and Electrophysiology · doi:10.1161/circep.111.962332 · Cited by 54 · see citing works
The effect of self-management training on health-related quality of life in patients with epilepsy
Yadegary, M. A., Maemodan, F. G., Nayeri, N. D., & Ghanjekhanlo, A. (2015) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2015.04.051 · Cited by 32 · see citing works
- Authors
- Santhouse, J., Carrier, C., Arya, S., Fowler, H., & Duncan, S.
- Affiliations
- Salford Royal Hospital (GB)
- Royal Albert Edward Infirmary (GB)
- Corresponding author
- Duncan, Susan
- ORCID
- Duncan, Susan
- Venue
- Epilepsia
- Publisher
- Wiley
- Published
- 2007-03-13
- Volume
- 48
- Issue
- 5
- Pages
- 1019-1022
- ISSN
- 0013-9580 (ISSN-L)
- 1528-1167
- OpenAlex
- W1991447793
- Cited by
- 57
- References
- 3
- Citations by year
- 2026: 1 · 2024: 1 · 2022: 4 · 2021: 4 · 2020: 1 · 2019: 3 · 2018: 2 · 2017: 8 · 2016: 2 · 2015: 1 · 2014: 8 · 2013: 5 · 2012: 3
- FWCI
- 2.01
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Epilepsia (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Epilepsy research and treatment
- Health Sciences › Medicine › Surgery › Cardiovascular Syncope and Autonomic Disorders
- Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
- Keywords
- epilepsy, vasovagal syncope, quality of life, anxiety, depression, loss of consciousness, social disruption, self-reported outcomes
- MeSH terms
- Adult, Anxiety Disorders, Attitude to Health, Depressive Disorder, Diagnosis, Differential, Epilepsy, Female, Humans, Internal-External Control, Male, Quality of Life, Surveys and Questionnaires, Comorbidity, Sickness Impact Profile, Syncope, Vasovagal, Personal Autonomy
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