Cited by 63Epilepsy research and treatmentPharmacological Effects and Toxicity StudiesMenstrual Health and Disorders

Reduced serum level of THDOC, an anticonvulsant steroid, in women with perimenstrual catamenial epilepsy

Tuveri, Antonella, Paoletti, Anna Maria, Orrù, Marisa, Melis, Gian Benedetto B., Marotto, Maria Francesca, Zedda, Pierina, Marrosu, Francesco, Sogliano, Cristiana +3 more·2008·Epilepsia

Abstract

Summary: Purpose: Seizure exacerbation in catamenial epilepsy (CE) is associated with the decrease in progesterone secretion and increase in estradiol secretion during the premenstrual period. Moreover, experimental evidence suggests that tetrahydrodeoxycorticosterone (THDOC), a positive modulator of the type A receptor for γ‐aminobutyric acid (GABA), and dehydroepiandrosterone sulfate (DHEAS), a negative modulator of this receptor, might play a crucial role in modulating seizure frequency during the menstrual cycle. Following these studies it seems of interest to investigate possible variations, among other hormonal parameters, of THDOC and DHEAS in CE patients. Methods: The serum concentrations of progesterone (P4), pregnenolone, allopregnanolone (AP), THDOC, DHEAS, cortisol, and DHEAS/cortisol ratio were measured throughout the menstrual cycle at the 7th, 11th, 15th, 19th, 23rd, and 27th day from the onset of spontaneous menstrual blood loss in young premenopausal women with CE (n = 17) and age‐matched controls (n = 13). Results: At each time of the study, the serum concentration of THDOC and the DHEAS/cortisol ratio were lower (p < 0.05) in women with CE than in control women. The concentrations of P4, pregnenolone, and AP did not differ between the two groups of subjects. Conclusions: The reduced serum concentration of THDOC and the reduced DHEAS/cortisol ratio detected throughout the menstrual cycle in women with CE might play a role in CE. Moreover, the peculiar pattern of CE seizure exacerbation might suggest that these neuroendocrine variations are worth investigating in other epileptic syndromes, particularly in those characterized by relevant and uncontrolled variations in seizure frequency.

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Crossref · 10.1111/j.1528-1167.2008.01555.x

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  • Catamenial epilepsy is characterized by perimenstrual seizure exacerbation, involving altered levels of anticonvulsant THDOC, proconvulsant DHEA-S and cortisol, and premenstrual allopregnanolone withdrawal.

    “In this context, one of the most investigated condition is catamenial epilepsy, characterized by perimenstrual seizure exacerbation, involving altered levels of anticonvulsant THDOC, proconvulsant DHEA-S and cortisol [146], and premenstrual allopregnanolone withdrawal [147].”

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Authors
Tuveri, A., Paoletti, A. M., Orrù, M., Melis, G. B. B., Marotto, M. F., Zedda, P., Marrosu, F., Sogliano, C., Marra, C., Biggio, G., & Concas, A.
Affiliations
University of Cagliari (IT)
Corresponding author
Concas, Alessandra
Venue
Epilepsia
Publisher
Wiley
Published
2008-07
Volume
49
Issue
7
Pages
1221-1229
ISSN
  • 0013-9580 (ISSN-L)
  • 1528-1167
OpenAlex
W2088783016
Cited by
63
References
55
Citations by year
2026: 3 · 2025: 3 · 2024: 2 · 2023: 4 · 2022: 1 · 2021: 1 · 2020: 3 · 2019: 1 · 2018: 1 · 2017: 4 · 2016: 5 · 2015: 2 · 2014: 5 · 2013: 7 · 2012: 5
FWCI
3.74
Type
journal article
Language
en
Open access
closed
Locations
  • Epilepsia (publishedVersion)
  • PubMed (publishedVersion)
  • UNICA IRIS Institutional Research Information System (University of Cagliari) (submittedVersion)
Funders
Università di Cagliari
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Epilepsy research and treatment
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pharmacological Effects and Toxicity Studies
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Menstrual Health and Disorders
Keywords
catamenial epilepsy, tetrahydrodeoxycorticosterone, dehydroepiandrosterone sulfate, menstrual cycle, progesterone, allopregnanolone, pregnenolone, GABA-A receptor modulation, seizure exacerbation
MeSH terms
Adult, Anticonvulsants, Dehydroepiandrosterone, Desoxycorticosterone, Electroencephalography, Epilepsy, Estradiol, Female, Humans, Hydrocortisone, Pregnanolone, Pregnenolone, Premenstrual Syndrome, Progesterone, Body Mass Index, Premenopause, Receptors, GABA

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