Progesterone therapy in women with complex partial and secondary generalized seizures
Abstract
This open trial assessed the effects of adjunctive progesterone therapy on seizure frequency in 25 women with catamenial exacerbation of complex partial (CPS) and secondary generalized motor (SGMS) seizures. Progesterone was well tolerated by 23 of the 25 women and had readily reversible dose-related side effects of asthenia and emotional depression in two. Eighteen women (72%) experienced a decline in seizure frequency during a 3-month treatment period compared with the 3 months prior to therapy (p < 0.01). Average daily CPS frequency declined by 54% (p < 0.01), SGMS by 58% (p < 0.02).
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Clinical trials have been conducted with progesterone, the synthetic progestin norethisterone, and the gonadotropin antagonist goserelin.
“while clinical trials have also been conducted with progesterone, the synthetic progestin norethisterone, and the gonadotropin antagonist goserelin [54,147].”
From Fibromyalgia pathogenesis explained by a neuroendocrine multistable model (2024) · cites this paper as [54]
Cited by
Sorted by citations
Neuroactive steroids: mechanisms of action and neuropsychopharmacological perspectives.
Rupprecht, R., & Holsboer, F. (1999) · Trends in Neurosciences · doi:10.1016/s0166-2236(99)01399-5 · Cited by 663 · see citing works
GABAA receptor α4 subunit suppression prevents withdrawal properties of an endogenous steroid
Smith, S. S., Gong, Q. H., Hsu, F.-C., Markowitz, R. S., ffrench-Mullen, J. M. H., & Li, X. (1998) · Nature · doi:10.1038/31948 · Cited by 564 · see citing works
Neurosteroids: Endogenous Role in the Human Brian and Therapeutic Potentials
Reddy, D. (2010) · Progress in Brain Research · doi:10.1016/b978-0-444-53630-3.00008-7 · Cited by 556 · see citing works
“Although natural neurosteroid can be used for therapeutic purpose in patients with epilepsy (Herzog, 1995; 1999), certain obstacles prevent the clinical use of endogenously occurring neurosteroids.”
BackgroundThree Patterns of Catamenial Epilepsy
Herzog, A. G., Klein, P., & Rand, B. (1997) · Epilepsia · doi:10.1111/j.1528-1157.1997.tb01197.x · Cited by 507 · see citing works
Self-citationConcas, A., Mostallino, M. C., Porcu, P., Follesa, P., Barbaccia, M., Trabucchi, M., Purdy, R., Grisenti, P., & Biggio, G. (1998) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.95.22.13284 · Cited by 432 · see citing works
Neuroactive steroids: mechanisms of action and neuropsychopharmacological properties
Rupprecht, R. (2003) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(02)00064-1 · Cited by 427 · see citing works
The role of allopregnanolone in depression and anxiety.
Schüle, C., Nothdurfter, C., & Rupprecht, R. (2014) · Progress in neurobiology · doi:10.1016/j.pneurobio.2013.09.003 · Cited by 289 · see citing works
The Influence of Gonadal Hormones on Neuronal Excitability, Seizures, and Epilepsy in the Female
Scharfman, H., & MacLusky, N. (2006) · Epilepsia · doi:10.1111/j.1528-1167.2006.00672.x · Cited by 238 · see citing works
Ovarian hormones and cortical excitability. An rTMS study in humans.
Inghilleri, M., Conte, A., Currá, A., Frasca, V., Lorenzano, C., & Berardelli, A. (2004) · Clinical Neurophysiology · doi:10.1016/j.clinph.2003.12.003 · Cited by 227 · see citing works
Best Practice Guidelines for the Management of Women with Epilepsy
Crawford, P. (2005) · Epilepsia · doi:10.1111/j.1528-1167.2005.00323.x · Cited by 211 · see citing works
“Over the past decade, there has been some research on hormonal manipulation, with the aim of increasing relative progesterone concentrations or converting anovulatory to ovulatory cycles (21,22).”
BackgroundCatamenial epilepsy: definition, prevalence pathophysiology and treatment.
Herzog, A. (2008) · Seizure · doi:10.1016/j.seizure.2007.11.014 · Cited by 198 · see citing works
Self-citationFinasteride, a 5α-Reductase Inhibitor, Blocks the Anticonvulsant Activity of Progesterone in Mice
Kokate, T., Banks, M. K., Magee, T., Yamaguchi, S., & Rogawski, M. (1999) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)38006-1 · Cited by 169 · see citing works
The role of neurosteroids in the pathophysiology and treatment of catamenial epilepsy
Reddy, D. S. (2009) · Epilepsy Research · doi:10.1016/j.eplepsyres.2009.02.017 · Cited by 167 · see citing works
“In clinical studies progesterone has been found to reduce seizures (Backtrom et al., 1984; Herzog, 1995; 1999).”
BackgroundInfluentialNeurosteroid Withdrawal Model of Perimenstrual Catamenial Epilepsy
Reddy, D., Kim, H., & Rogawski, M. A. (2001) · Epilepsia · doi:10.1046/j.1528-1157.2001.10100.x · Cited by 167 · see citing works
Crawford, P., & Duncan, S. (2012) · Handbook of Clinical Neurology · doi:10.1016/b978-0-444-52899-5.00026-5 · Cited by 166 · see citing works
Progesterone therapy in women with epilepsy: A 3-year follow-up
Herzog, A. (1999) · Neurology · doi:10.1212/wnl.52.9.1917-a · Cited by 163 · see citing works
Self-citationNeuroactive steroids: molecular mechanisms of action and implications for neuropsychopharmacology.
Rupprecht, R., di Michele, F., Hermann, B., Ströhle, A., Lancel, M., Romeo, E., & Holsboer, F. (2001) · Brain research. Brain research reviews · doi:10.1016/s0165-0173(01)00123-0 · Cited by 159 · see citing works
Progesterone vs placebo therapy for women with epilepsy
Herzog, A., Fowler, K. M., Smithson, S., Kalayjian, L., Heck, C., Sperling, M., Liporace, J., Harden, C., Dworetzky, B., Pennell, P., et al. (2012) · Neurology · doi:10.1212/wnl.0b013e318259e1f9 · Cited by 155 · see citing works
Self-citationNeuroprotection by ovarian hormones in animal models of neurological disease
Hoffman, G., Merchenthaler, I., & Zup, S. (2006) · Endocrine · doi:10.1385/endo:29:2:217 · Cited by 149 · see citing works
Neurosteroid Replacement Therapy for Catamenial Epilepsy
Reddy, D., & Rogawski, M. (2009) · Neurotherapeutics · doi:10.1016/j.nurt.2009.01.006 · Cited by 148 · see citing works
Frequency of catamenial seizure exacerbation in women with localization‐related epilepsy
Herzog, A. G., Harden, C. L., Liporace, J., Pennell, P., Schomer, D., Sperling, M., Fowler, K. M., Nikolov, B., Shuman, S., & Newman, M. (2004) · Annals of Neurology · doi:10.1002/ana.20214 · Cited by 148 · see citing works
“If hormones may play a role in pathogenesis, there may also be a role for hormones in therapy.(7,8) Identification of a cohort of women whose seizures occur in relation to reproductive hormone changes, that is, women with catamenial epilepsy, also may identify the women who may respond most notably to adjunctive hormo…”
BackgroundSelf-citationReddy, D., & Rogawski, M. (2000) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)39026-3 · Cited by 148 · see citing works
“Our results are consistent with two recent clinical studies in women with epilepsy (Herzog, 1986, 1995) that demonstrated a lack of diminution in the anticonvulsant activity of chronically administered progesterone, which produces anticonvulsant effects via conversion to the neurosteroid…”
ResultReddy, D. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2004.08.002 · Cited by 142 · see citing works
Hoffman, G., Moore, N., Fiskum, G., & Murphy, A. (2003) · Experimental Neurology · doi:10.1016/s0014-4886(03)00104-3 · Cited by 139 · see citing works
“Indeed, the effects observed with progesterone form the basis for progesterone treatment of women with catemenial epilepsy (Bauer, 2001; Bonuccelli et al., 1989; Herzog, 1995; Herzog et al., 1997; Holmes et al., 2001; Morrell, 1992, 1999; Murri and Galli, 1997).”
Role of neurosteroids in catamenial epilepsy.
Reddy, D. (2004) · Epilepsy Research · doi:10.1016/j.eplepsyres.2004.09.003 · Cited by 137 · see citing works
Neuroactive steroids in affective disorders: target for novel antidepressant or anxiolytic drugs?
Schüle, C., Eser, D., Baghai, T., Nothdurfter, C., Kessler, J., & Rupprecht, R. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.03.025 · Cited by 134 · see citing works
“Therapeutic potential of synthetic neurosteroids In fact, neuroactive steroids such as progesterone have been used in the treatment of patients suffering from epilepsy (Herzog, 1995, 1999).”
BackgroundVágnerová, K., Koerner, I., & Hurn, P. (2008) · Anesthesia and Analgesia · doi:10.1213/ane.0b013e31817326a5 · Cited by 130 · see citing works
Enhanced anticonvulsant activity of neuroactive steroids in a rat model of catamenial epilepsy
Reddy, D. S., & Rogawski, M. A. (2001) · Epilepsia · doi:10.1046/j.1528-1157.2001.10200.x · Cited by 130 · see citing works
Harden, C. L., Herzog, A. G., Nikolov, B. G., Koppel, B., Christos, P. J., Fowler, K. M., Labar, D., & Hauser, W. A. (2006) · Epilepsia · doi:10.1111/j.1528-1167.2006.00507.x · Cited by 125 · see citing works
“Statistically significant findings in openlabel investigations suggest that natural progesterone supplement may reduce seizure frequency in women with catamenial epilepsy (19,20).”
BackgroundSelf-citationReddy, D., & Rogawski, M. (2000) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)39152-9 · Cited by 121 · see citing works
“Although natural progesterone therapy benefits some women with catamenial epilepsy ( Herzog, 1986, 1995 ), it may be associated with undesired hormonal side effects.”
BackgroundNeuroendocrine considerations in the treatment of men and women with epilepsy
Harden, C., & Pennell, P. (2013) · Lancet Neurology · doi:10.1016/s1474-4422(12)70239-9 · Cited by 120
Crawford, P., Appleton, R. E., Betts, T., Duncan, J. S., Guthrie, E., & Morrow, J. I. (1999) · Seizure · doi:10.1053/seiz.1999.0295 · Cited by 119 · see citing works
Sex differences in models of temporal lobe epilepsy: role of testosterone.
Mejias-Aponte, C., Jiménez-Rivera, C., & Segarra, A. (2002) · Brain Research · doi:10.1016/s0006-8993(02)02691-4 · Cited by 116 · see citing works
Neuroactive steroids and seizure susceptibility.
Beyenburg, S., Stoffel-Wagner, B., Bauer, J., Watzka, M., Blümcke, I., Bidlingmaier, F., & Elger, C. (2001) · Epilepsy Research · doi:10.1016/s0920-1211(01)00194-2 · Cited by 115 · see citing works
Progesterone's role in neuroprotection, a review of the evidence.
Deutsch, E. R., Espinoza, T., Atif, F., Woodall, E., Kaylor, J., & Wright, D. (2013) · Brain Research · doi:10.1016/j.brainres.2013.07.014 · Cited by 113 · see citing works
“In another 25‐woman study utilizing PROG as adjunctive therapy for catamenial seizures, 18 of the women experienced a decline in seizure frequency (Herzog, 1995).”
Frye, C., & Scalise, T. (2000) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(99)00068-2 · Cited by 113 · see citing works
Foldvary-Schaefer, N., & Falcone, T. (2003) · Neurology · doi:10.1212/wnl.61.6_suppl_2.s2 · Cited by 104 · see citing works
Role of hormones and neurosteroids in epileptogenesis
Reddy, D. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00115 · Cited by 103 · see citing works
“In many men with epilepsy, testosterone deficiency is an unusually common clinical observation (Macphee et al., 1988; Herzog, 1991; El-Khayat et al., 2003).”
BackgroundNovel therapeutic approaches for disease-modification of epileptogenesis for curing epilepsy
Clossen, B., & Reddy, D. (2017) · Biochimica et Biophysica Acta - Molecular Basis of Disease · doi:10.1016/j.bbadis.2017.02.003 · Cited by 102 · see citing works
Progesterone withdrawal I: pro-convulsant effects.
Moran, M. H., & Smith, S. (1998) · Brain Research · doi:10.1016/s0006-8993(98)00782-3 · Cited by 101 · see citing works
Pennell, P. (2009) · Neurologic clinics · doi:10.1016/j.ncl.2009.08.005 · Cited by 99 · see citing works
“[34] of 25 women with medically-refractory temporal lobe epilepsy included women with either anovulatory or ovulatory cycles and with the associated catamenial patterns.”
BackgroundAgís-Balboa, R. C., Guidotti, A., & Pinna, G. (2014) · Psychopharmacology · doi:10.1007/s00213-014-3567-5 · Cited by 92 · see citing works
“…2009, 2011 ), such as depression, anxiety, PTSD, premenstrual dysphoria, postpartum depression, and even schizophrenia, but also in several neurological disorders (Herzog 1995; Reddy 2011; Luchetti et al. 2011; Follesa et al. 2006), including epilepsy, Alzheimer's disease, and alcohol withdrawal.”
Valproate and the Polycystic Ovarian Syndrome: Final Thoughts
Herzog, A. G., & Schachter, S. (2001) · Epilepsia · doi:10.1046/j.1528-1157.2001.33500.x · Cited by 92
Self-citationPsychoneuroendocrine aspects of temporolimbic epilepsy. Part II: Epilepsy and reproductive steroids.
Herzog, A. (1999) · Psychosomatics · doi:10.1016/s0033-3182(99)71255-7 · Cited by 87 · see citing works
“complex partial and 58% for secondary generalized seizures over 3 months.(63) Several mechanisms have been postulated to explain”
BackgroundSelf-citationFrye, C., Rhodes, M. E., Walf, A., & Harney, J. (2002) · Epilepsia · doi:10.1046/j.1528-1157.43.s.5.19.x · Cited by 85 · see citing works
Gonadal hormones affect neuronal vulnerability to excitotoxin-induced degeneration
Azcoitia, Í., Fernández-Galaz, C., Sierra, A., & Garcia-Segura, L. (1999) · Journal of Neurocytology · doi:10.1023/a:1007025219044 · Cited by 85 · see citing works
Gangisetty, O., & Reddy, D. S. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.07.037 · Cited by 84 · see citing works
Gonadal, adrenal, and neuroactive steroids' role in ictal activity.
Rhodes, M. E., Harney, J., & Frye, C. (2004) · Brain Research · doi:10.1016/j.brainres.2003.12.023 · Cited by 82 · see citing works
Seizures, hormones and sexuality.
Lambert, M. V. (2001) · Seizure · doi:10.1053/seiz.2000.0512 · Cited by 82 · see citing works
Estrogens and Epilepsy: Why Are We So Excited?
Velíšková, J. (2007) · The Neuroscientist · doi:10.1177/1073858406295827 · Cited by 81
Neuroendocrine aspects of catamenial epilepsy
Reddy, D. (2012) · Hormones and Behavior · doi:10.1016/j.yhbeh.2012.04.016 · Cited by 79 · see citing works
“Previous open-label studies suggest that the cyclic administration of adjunctive natural P supplement may lessen seizure frequency by over 50% in the majority of women with catamenially-exacerbated, intractable seizures (Herzog, 1995; 1999).”
BackgroundMenstrual disorders in women with epilepsy
Herzog, A. (2006) · Neurology · doi:10.1212/wnl.66.66_suppl_3.s23 · Cited by 73 · see citing works
Self-citationLack of anticonvulsant tolerance to the neuroactive steroid pregnanolone in mice.
Kokate, T., Yamaguchi, S., Pannell, L. K., Rajamani, U., Carroll, D. M., Grossman, A., & Rogawski, M. A. (1998) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)37827-9 · Cited by 70 · see citing works
Monaghan, E., McAuley, J., & Data, J. (1999) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.8.10.1663 · Cited by 68 · see citing works
Treatment of Epilepsy in Women of Reproductive Age
McAuley, J., & Anderson, G. (2002) · Clinical Pharmacokinetics · doi:10.2165/00003088-200241080-00002 · Cited by 67 · see citing works
“[27-34] Some women with epilepsy experience more frequent or severe seizures before or during menstruation.”
BackgroundSeizure course during pregnancy in catamenial epilepsy
Cagnetti, C., Lattanzi, S., Foschi, N., Provinciali, L., & Silvestrini, M. (2014) · Neurology · doi:10.1212/wnl.0000000000000619 · Cited by 66
Tuveri, A., Paoletti, A. M., Orrù, M., Melis, G. B. B., Marotto, M. F., Zedda, P., Marrosu, F., Sogliano, C., Marra, C., Biggio, G., et al. (2008) · Epilepsia · doi:10.1111/j.1528-1167.2008.01555.x · Cited by 63 · see citing works
Hormonal and gestational parameters in female rats submitted to the pilocarpine model of epilepsy.
Amado, D., & Cavalheiro, E. (1998) · Epilepsy Research · doi:10.1016/s0920-1211(98)00057-6 · Cited by 63
Hormonal Effects on Epilepsy in Women
Klein, P., & Herzog, A. G. (1998) · Epilepsia · doi:10.1111/j.1528-1157.1998.tb02602.x · Cited by 62 · see citing works
Self-citationZhu, Y.-H., Xu, Z.-W., Gao, J., Ji, W.-H., & Zhang, J. (2020) · Biosensors & bioelectronics · doi:10.1016/j.bios.2020.112210 · Cited by 60
Neurosteroid regulation of GABAA receptors: a role in catamenial epilepsy
Joshi, S., & Kapur, J. (2018) · Brain Research · doi:10.1016/j.brainres.2018.02.031 · Cited by 60 · see citing works
“…reports of a few clinical studies showing suppression of catamenial seizures by progesterone treatment and one anecdotal study, in which a woman on progesterone therapy experienced more seizures when she was treated with finasteride for male pattern baldness (Herzog, 1995;Herzog and Frye, 2003).”
BackgroundNeurosteroids and GABAergic signaling in health and disease
MacKenzie, G., & Maguire, J. (2012) · Biomolecular Concepts · doi:10.1515/bmc-2012-0033 · Cited by 60 · see citing works
“Progesterone has been used as an add-on therapy for the treatment of catamenial epilepsy (144, 145) , with some success.”
Erden, V., Yangin, Z., Erkalp, K., Delatioğlu, H., Bahçeci, F., & Seyhan, A. (2005) · Anesthesia and Analgesia · doi:10.1213/01.ane.0000168271.76090.63 · Cited by 60 · see citing works
“They are anticonvulsant ( 6 ), and at large doses they induce a state of general anesthesia (7).”
BackgroundFrye, C., & Rhodes, M. E. (2005) · Pharmacology, Biochemistry and Behavior · doi:10.1016/j.pbb.2005.06.016 · Cited by 59 · see citing works
Neuroactive steroids and central nervous system disorders.
Wang, M.-D., Bäckström, T., Sundström, I., Wahlström, G., Olsson, T., Zhu, D., Johansson, I., Björn, I., & Bixo, M. (2001) · International review of neurobiology · doi:10.1016/s0074-7742(01)46071-5 · Cited by 58 · see citing works
Treatment of Women with Epilepsy
Pack, A., & Morrell, M. (2002) · Seminars in neurology · doi:10.1055/s-2002-36648 · Cited by 57
Ali, A. (2018) · Seminars in neurology · doi:10.1055/s-0038-1646947 · Cited by 56 · see citing works
Fox, H., Hong, K., Paliwal, P., Morgan, P. T., & Sinha, R. (2007) · Psychopharmacology · doi:10.1007/s00213-007-0936-3 · Cited by 56 · see citing works
“…the premenstrual phase may be because of the fact that the late-luteal phase has been characterized by endogenous progesterone withdrawal in humans (Herzog 1995; Moran et al. 1998) and associated with both increased anxiety (Gallo and Smith 1993; Smith et al. 1998) and insensitivity to the…”
BackgroundDisease-modifying activity of progesterone in the hippocampus kindling model of epileptogenesis
Reddy, D., Gangisetty, O., & Briyal, S. (2010) · Neuropharmacology · doi:10.1016/j.neuropharm.2010.08.017 · Cited by 55 · see citing works
“P has long been known to have antiseizure activity in animalmodels (Selye,1942; Craig,1966; Kokate et al.,1999; Frye and Scalise, 2000; Reddy et al., 2004), and in clinical studies (Bäckström et al.,1984;Herzog,1995,1999).”
BackgroundNonconvulsive Status Epilepticus versus Triphasic Encephalopathy
Fernández-Torre, J. L. (2007) · Epilepsia · doi:10.1111/j.1528-1167.2007.01009_7.x · Cited by 54
“…metabolites, such as allopregnanolone, which have anticonvulsant activity in animal models by acting as positive allosteric modulators at the GABAA receptor (Kokate et al., 1994; Herzog, 1995; Reddy, Epilepsia, Vol. 48, No. 5, 2007 2001; Lonsdale and Burnham, 2003; Scharfman and MacLusky, 2006).”
Stoffel-Wagner, B., Beyenburg, S., Watzka, M., Blümcke, I., Bauer, J., Schramm, J., Bidlingmaier, F., & Elger, C. (2000) · Epilepsia · doi:10.1111/j.1528-1157.2000.tb00133.x · Cited by 54 · see citing works
A novel therapeutic approach for treatment of catamenial epilepsy
Joshi, S., Sun, H.-Y., Rajasekaran, K., Williamson, J. M., Perez-Reyes, E., & Kapur, J. (2017) · Neurobiology of Disease · doi:10.1016/j.nbd.2017.12.009 · Cited by 52 · see citing works
Reproductive hormonal changes and catamenial pattern in adolescent females with epilepsy
El-khayat, H., Soliman, N. A., Tomoum, H., Omran, M. A., Elwakad, A. S., & Shatla, R. (2008) · Epilepsia · doi:10.1111/j.1528-1167.2008.01622.x · Cited by 50
“This may be because mesial temporal lobe structures, such as the amygdala, have extensive interconnections with the arcuate, preoptic nuclei, and the hypothalamus, which are involved in the regulation of gonadotropin hormone (Herzog, 1995; Morrell, 1999).”
BackgroundPolycystic ovarian syndrome in women with epilepsy: Epileptic or iatrogenic?
Herzog, A. G. (1996) · Annals of Neurology · doi:10.1002/ana.410390503 · Cited by 50 · see citing works
Self-citationGonadal steroids regulate GABAA receptor subunit mRNA expression in NT2-N neurons.
Pierson, R. C., Lyons, A. M., & Greenfield, L. (2005) · Brain Research. Molecular Brain Research · doi:10.1016/j.molbrainres.2004.10.047 · Cited by 49 · see citing works
Diagnosis and management of catamenial seizures: a review
Verrotti, A., D’Egidio, C., Agostinelli, S., Verrotti, C., & Pavone, P. (2012) · International Journal of Women's Health · doi:10.2147/ijwh.s28872 · Cited by 47 · see citing works
“42,43 Seizures decrease in the mid-luteal phase when serum progesterone levels are high, and increase premenstru-ally when there is a fall in progesterone levels and serum progesterone/estrogen ratio.”
Women with epilepsy: hormonal issues from menarche through menopause.
Cramer, J., Gordon, J., Schachter, S., & Devinsky, O. (2007) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2007.03.007 · Cited by 47 · see citing works
“Estrogen can be a very potent proconvulsant, whereas progesterone can be anticonvulsant [12–14].”
BackgroundSexual hormones and epilepsy: threat and opportunities
Herzog, A., & Fowler, K. M. (2005) · Current Opinion in Neurology · doi:10.1097/01.wco.0000162859.42218.fd · Cited by 46
Self-citationManaging Epilepsy in Women of Childbearing Age
Crawford, P. (2009) · Drug Safety · doi:10.2165/00002018-200932040-00004 · Cited by 46 · see citing works
“In women with catamenial epilepsy, progesterone produced a decrease in seizure frequency([16]) but norethisterone failed to show any antiepileptic benefit.”
Hormones and Cognition: Current Concepts and Issues in Neuropsychology
Erlanger, D., Kutner, K., & Jacobs, A. R. (1999) · Neuropsychology Review · doi:10.1023/a:1021634622577 · Cited by 44 · see citing works
“Indeed, studies have demonstrated that progesterone has significant anticonvulsant effects (Herzog, 1995).”
BackgroundHerbison, A. (2001) · Progress in brain research · doi:10.1016/s0079-6123(01)33003-0 · Cited by 44 · see citing works
Progesterone exacerbates striatal stroke injury in progesterone-deficient female animals
Murphy, S. J., Traystman, R., Hurn, P., & Duckles, S. (2000) · Stroke · doi:10.1080/13697130008500101 · Cited by 43
Female issues in epilepsy: a critical review.
Luef, G. (2009) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2009.02.023 · Cited by 41 · see citing works
Hormonal therapies: Progesterone
Herzog, A. (2009) · Neurotherapeutics · doi:10.1016/j.nurt.2009.01.009 · Cited by 40 · see citing works
“Progesterone was more efficacious when administered during the entire second half of the cycle, rather than just premenstrually, and then tapered and discontinued gradually over 3 or 4 days at the end of the cycle.(61) Failure to taper gradually premenstrually can result in rebound seizure exacerbation.”
BackgroundInfluentialSelf-citationGuille, C., Spencer, S., Cavus, I., & Epperson, C. N. (2008) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2008.02.004 · Cited by 40 · see citing works
“[102] administered progesterone lozenges, 200 mg three times daily, on Days 23 to 25 of each menstrual cycle to women with perimenstrual seizure exacerbation, and on Days 15 to 25 of each menstrual cycle to women with luteal phase seizure exacerbation.”
BackgroundMethodVariation of Seizure Frequency with Ovulatory Status of Menstrual Cycles
Herzog, A. G., Fowler, K. M., Sperling, M. R., Liporace, J., Kalayjian, L., Heck, C., Krauss, G., Dworetzky, B. A., & Pennell, P. (2011) · Epilepsia · doi:10.1111/j.1528-1167.2011.03194.x · Cited by 39 · see citing works
“…Philadelphia, Pennsylvania, U.S.A.; zKeck School of Medicine, University of Southern California, Los Angeles, California, U.S.A.; xDepartment of Neurology, University of Maryland, Baltimore, Maryland, U.S.A.; and{Department of Neurology, Brigham and Women’s Hospital, Boston, Massachusetts, U.S.A.”
BackgroundSelf-citationMass spectrometric assay and physiological-pharmacological activity of androgenic neurosteroids.
Reddy, D. (2008) · Neurochemistry International · doi:10.1016/j.neuint.2007.05.019 · Cited by 38 · see citing works
“…shown to play a significant role in the pathophysiology of brain disorders such as generalized anxiety disorder, depression, epilepsy and stress (Herzog, 1995; Reddy et al., 2001; Smith et al., 1998; Monteleone et al., 2000; Purdy et al., 1991; Reddy and Rogawski, 2002; Dong et al., 2001; Reddy…”
BackgroundTheophylline increases “on” time in advanced parkinsonian patients
Kostić, V., Svetel, M., Šternić, N., Dragašević, N., & Przedborski, S. (1999) · Neurology · doi:10.1212/wnl.52.9.1916 · Cited by 38
The Effects of Epilepsy and Its Treatment on Sexual and Reproductive Function
Penovich, P. E. (2000) · Epilepsia · doi:10.1111/j.1528-1157.2000.tb01524.x · Cited by 37 · see citing works
Chapter 3 Hormonal Influences on Seizures
Frye, C. (2008) · International review of neurobiology · doi:10.1016/s0074-7742(08)00003-2 · Cited by 35 · see citing works
Tominaga, K., Yamauchi, A., Shuto, H., Niizeki, M., Makino, K., Oishi, R., & Kataoka, Y. (2001) · European Journal of Pharmacology · doi:10.1016/s0014-2999(01)01377-2 · Cited by 34 · see citing works
Pharmacotherapeutic Issues for Women of Childbearing Age with Epilepsy
Chang, S.-I., & McAuley, J. (1998) · The Annals of Pharmacotherapy · doi:10.1345/aph.17253 · Cited by 34 · see citing works
2005 AES Annual Course: Evidence Used to Treat Women with Epilepsy
Pennell, P. (2006) · Epilepsia · doi:10.1111/j.1528-1167.2006.00660.x · Cited by 33
“Open-label studies of progesterone supplementation have shown promising results (4,5).”
BackgroundReddy, D., & Ramanathan, G. (2012) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2012.05.024 · Cited by 31 · see citing works
Special Considerations for Women with Epilepsy
Yerby, M. (2000) · Pharmacotherapy · doi:10.1592/phco.20.12.159s.35249 · Cited by 31
“A natural progesterone lozenge is available; 100–200 mg 3–4 times/day, with target progesterone levels of 5–25 ng/ml is recommended.(31) Many women experience side effects including sedation, depression, breast tenderness, weight gain, and vaginal spotting when taking progesterone, thereby limiting its utility.”
BackgroundNeuroactive steroids in neuropsychopharmacology.
Rupprecht, R., & Holsboer, F. (2001) · International review of neurobiology · doi:10.1016/s0074-7742(01)46072-7 · Cited by 31 · see citing works
Pack, A. M. (2010) · Epilepsia · doi:10.1111/j.1528-1167.2010.02631.x · Cited by 30
“Two open-label trials of 200 mg natural progesterone lozenges also found significant improvement in seizure frequency (>50% reduction) (Herzog, 1995, 1999).”
BackgroundInfluence of sex hormones on brain excitability and epilepsy
Verrotti, A., Latini, G., Manco, R., de Simone, M., & Chiarelli, F. (2007) · Journal of Endocrinological Investigation · doi:10.1007/bf03350821 · Cited by 30
Infusion of 3α,5α-THP to the pontine reticular formation attenuates PTZ-induced seizures☆
Frye, C., Manjarrez, J., & Camacho-Arroyo, I. (2000) · doi:10.1016/s0006-8993(00)02897-3 · Cited by 30
Pharmacotherapy of catamenial epilepsy
Reddy, D. (2005) · Indian Journal of Pharmacology · doi:10.4103/0253-7613.16851 · Cited by 29 · see citing works
“Average monthly seizure frequency was reportedly reduced by 54% to 68% during the 3 month treatment period.([31]) A 3 year follow-up report finds that 15 of the women continued on”
Background
- Authors
- Herzog, A. G.
- Affiliations
- Beth Israel Deaconess Medical Center (US)
- Corresponding author
- Herzog, Andrew G.
- ORCID
- Herzog, Andrew G.
- Venue
- Neurology
- Published
- 1995-09
- Volume
- 45
- Issue
- 9
- Pages
- 1660-1662
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W2011191676
- Cited by
- 218
- References
- 0
- Citations by year
- 2025: 3 · 2024: 2 · 2023: 4 · 2022: 2 · 2021: 4 · 2020: 7 · 2019: 1 · 2018: 4 · 2017: 3 · 2016: 3 · 2015: 3 · 2014: 6 · 2013: 15 · 2012: 9
- FWCI
- 4.65
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Epilepsy research and treatment
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pharmacological Effects and Toxicity Studies
- Health Sciences › Medicine › Physiology › Diet and metabolism studies
- Keywords
- progesterone therapy, adjunctive therapy, complex partial seizures, seizure frequency, women, menstrual cycle, adverse drug reactions
- MeSH terms
- Adolescent, Adult, Epilepsy, Generalized, Female, Humans, Progesterone, Epilepsy, Complex Partial
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
