Cited by 105Epilepsy research and treatmentSubstance Abuse Treatment and OutcomesForensic Toxicology and Drug Analysis

Alcohol and drugs in epilepsy: Pathophysiology, presentation, possibilities, and prevention

Leach, John Paul, Mohanraj, Rajiv, Borland, William·2012·Epilepsia

Abstract

Summary: The potentially serious outcomes from ingestion of and dependence on toxins make this an important topic for epileptologists. We must be aware of the potential for harm from compounds that may be freely available, yet patients may try to conceal their use. Problematic compounds may cause seizures either acutely or on withdrawal: Their use may reduce effectiveness of antiepileptic drugs, or may simply promote and enhance chaotic lifestyles. Any or all of these factors may worsen seizure control or even directly cause seizures. This article highlights the pathophysiology behind provoked seizures, provides clues to diagnosis, and then outlines the steps that clinicians should take to reduce the deleterious effects of toxic compounds.

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Registry

Crossref · 10.1111/j.1528-1167.2012.03613.x

Cites

89 of 89 references verified0 citation errors · 0 not checkable

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  • Alcohol use may affect the clinical course of pre-existing epilepsy either by changes in anti-epileptic drug pharmacokinetics or by non-compliance with prescribed medication.

    “In addition, alcohol use may affect the clinical course of pre‐existing epilepsy either by changes in anti‐epileptic drug pharmacokinetics or by non‐compliance with prescribed medication 236, 237.”

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Authors
Leach, J. P., Mohanraj, R., & Borland, W.
Affiliations
  • Southern General Hospital (GB)
  • Salford Royal Hospital (GB)
  • Gartnavel General Hospital (GB)
Corresponding author
Leach, John Paul
Venue
Epilepsia
Publisher
Wiley
Published
2012-09
Volume
53
Issue
s4
Pages
48-57
ISSN
  • 0013-9580 (ISSN-L)
  • 1528-1167
OpenAlex
W1553610755
Cited by
105
References
91
Citations by year
2026: 3 · 2025: 5 · 2024: 7 · 2023: 5 · 2022: 6 · 2021: 21 · 2020: 11 · 2019: 4 · 2018: 9 · 2017: 8 · 2016: 6 · 2015: 10 · 2014: 7 · 2013: 2 · 2012: 1
FWCI
0.86
Type
journal article
Language
en
Open access
closed
Locations
  • Epilepsia (publishedVersion)
  • PubMed (publishedVersion)
  • Research Explorer (The University of Manchester) (submittedVersion)
  • ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (submittedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Epilepsy research and treatment
  • Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Forensic Toxicology and Drug Analysis
Keywords
alcohol, drugs, epilepsy, provoked seizures, substance use, withdrawal seizures, antiepileptic drug interactions, seizure control, pathophysiology, prevention, diagnosis
MeSH terms
Alcohol Drinking, Ethanol, Alcoholism, Benzodiazepines, Marijuana Abuse, Central Nervous System Depressants, Epilepsy, gamma-Aminobutyric Acid, Heroin Dependence, Humans, Ketamine, Seizures, Substance-Related Disorders, Amphetamine-Related Disorders, Cocaine-Related Disorders, Alcohol Withdrawal Seizures

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